%% This BibTeX bibliography file in UTF-8 format was created using Papers. %% http://mekentosj.com/papers/ @misc{Michailidis:2007, author = {G Michailidis}, journal = {Miscellaneous}, title = {Multilevel Homogeneity Analysis}, year = {2007}, date-added = {2010-01-10 11:33:19 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Michailidis-2007-Miscellaneous_Multilevel%20Homogenei.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1940}, rating = {0} } @article{Arpinelli:2006p4450, author = {Fabio Arpinelli and Francesco Bamfi}, journal = {Health Qual Life Outcomes}, title = {The FDA guidance for industry on PROs: the point of view of a pharmaceutical company}, abstract = {The importance of the patients point of view on their health status is widely recognised. Patient-reported outcomes is a broad term encompassing a large variety of different health data reported by patients, as symptoms, functional status, Quality of Life and Health-Related Quality of Life. Measurements of Health-Related Quality of Life have been developed during many years of researches, and a lot of validated questionnaires exist. However, few attempts have been made to standardise the evaluation of instruments characteristics, no recommendations are made about interpretation on Health-Related Quality of Life results, especially regarding the clinical significance of a change leading a therapeutic approach. Moreover, the true value of Health-Related Quality of Life evaluations in clinical trials has not yet been completely defined. An important step towards a more structured and frequent use of Patient-Reported Outcomes in drug development is represented by the FDA Guidance, issued on February 2006. In our paper we aim to report some considerations on this Guidance. Our comments focus especially on the characteristics of instruments to use, the Minimal Important Difference, and the methods to calculate it. Furthermore, we present the advantages and opportunities of using the Patient-Reported Outcomes in drug development, as seen by a pharmaceutical company. The Patient-Reported Outcomes can provide additional data to make a drug more competitive than others of the same pharmacological class, and a well demonstrated positive impact on the patient' health status and daily life might allow a higher price and/or the inclusion in a reimbursement list. Applying extensively the FDA Guidance in the next trials could lead to a wider culture of subjective measurement, and to a greater consideration for the patient's opinions on his/her care. Moreover, prescribing doctors and payers could benefit from subjective information to better define the value of drugs.}, affiliation = {Health Technology Assessment, Medical Department, GSK S.p.A. Verona, Italy. fabio.a.arpinelli@gsk.com}, pages = {85}, volume = {4}, year = {2006}, month = {Jan}, language = {eng}, keywords = {Drug Industry, Guidelines as Topic, Self Concept, United States, Sickness Impact Profile, Attitude to Health, Quality of Life, Clinical Trials as Topic, Outcome Assessment (Health Care), United States Food and Drug Administration, Humans}, date-added = {2010-01-29 21:36:54 +0100}, date-modified = {2010-01-29 21:36:55 +0100}, doi = {10.1186/1477-7525-4-85}, pii = {1477-7525-4-85}, pmid = {17076891}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Arpinelli-2006-Health%20and%20Quality%20of%20Life%20Outcomes_The%20FDA%20guidance%20for.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p4450}, rating = {0} } @article{Galfalvy:2009p9649, author = {Hanga Galfalvy and Yung-Yu Huang and Maria A Oquendo and Dianne Currier and J John Mann}, journal = {J Affect Disord}, title = {Increased risk of suicide attempt in mood disorders and TPH1 genotype}, abstract = {BACKGROUND: The tryptophan hydroxylase 1 (TPH1) gene is reported to be associated with suicidal behavior. This has not been confirmed by prospective studies of suicide and clinical or biological mediators of this genetic risk have not been identified. METHODS: 343 subjects (Caucasian, African-American, Hispanic) presenting with a Major Depressive Episode were genotyped for polymorphisms A218C in intron 7 and A-6526G in the promoter region of TPH1, and monitored for suicide attempts for up to one year. Clinical correlates of suicidal behavior and CSF-HIAA, HVA and MHPG levels were explored as possible mediators of genetic risk. Analyses were adjusted for ethnicity. RESULTS: The AA genotype on intron 7 and the AA genotype on the promoter (both more prevalent in Caucasians) predicted suicide attempts during the 1 year follow-up, and were associated with past attempts of high medical lethality, regardless of ethnicity. The intron 7 genotype was associated with fewer reported reasons for living, and lower impulsivity. Haplotype analysis indicated significant increase in risk of suicide attempts for subjects with four risk alleles. TPH1 genotype was not associated with CSF metabolite levels. LIMITATIONS: The TPH1 gene is likely one of several genes associated with suicidal behavior. Power to detect differential genotype effects by ethnicity is low. CONCLUSIONS: Polymorphisms of TPH1 may assist in identifying a subgroup of mood disorder patients that is at higher risk for suicidal behavior.}, affiliation = {Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University,; and New York State Psychiatric Institute, New York, NY 10032, USA. hcg2002@columbia.edu}, number = {3}, pages = {331--8}, volume = {115}, year = {2009}, month = {Jun}, language = {eng}, keywords = {Adolescent, Haplotypes, African Americans, Homovanillic Acid, Tryptophan Hydroxylase, Depressive Disorder: Major, Female, Sex Factors, Hydroxyindoleacetic Acid, Humans, European Continental Ancestry Group, Hispanic Americans, Mood Disorders, Young Adult, Male, Prospective Studies, Methoxyhydroxyphenylglycol, Polymorphism: Single Nucleotide, Risk Factors, Middle Aged, Bipolar Disorder, Aged, Adult, Genetic Predisposition to Disease, Suicide: Attempted, New York}, date-added = {2010-03-25 14:53:49 +0100}, date-modified = {2010-03-25 14:53:49 +0100}, doi = {10.1016/j.jad.2008.09.019}, pii = {S0165-0327(08)00370-4}, pmid = {18977032}, URL = {http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T2X-4TTDYRV-1&_user=2432700&_coverDate=06%252F30%252F2009&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000057263&_version=1&_urlVersion=0&_userid=2432700&md5=73227bbe6d5fb35916d066219d279467}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Galfalvy-2009-J%20Affect%20Disord_Increased%20risk%20of%20su.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p9649}, rating = {0} } @article{Cumming:2008, author = {G Cumming and S Finch}, journal = {American Psychologist}, title = {Inference by eye: Confidence intervals, and how to read pictures of data}, year = {2008}, date-added = {2010-01-10 11:33:21 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1995}, rating = {0} } @article{Rothman:2008p12312, author = {A J Rothman and P J Bickel and E Levina and J Zhu}, journal = {Electronic Journal of Statistics}, title = {Sparse permutation invariant covariance estimation}, abstract = {The paper proposes a method for constructing a sparse estimator for the inverse covariance (concentration) matrix in high-dimensional settings. The estimator uses a penalized normal likelihood approach and forces sparsity by using a lasso-type penalty. We establish a rate of con- vergence in the Frobenius norm as both data dimension p and sample size n are allowed to grow, and show that the rate depends explicitly on how sparse the true concentration matrix is. We also show that a correlation- based version of the method exhibits better rates in the operator norm. We also derive a fast iterative algorithm for computing the estimator, which relies on the popular Cholesky decomposition of the inverse but produces a permutation-invariant estimator. The method is compared to other es- timators on simulated data and on a real data example of tumor tissue classification using gene expression data.}, pages = {494--515}, volume = {2}, year = {2008}, date-added = {2010-06-12 09:29:19 +0200}, date-modified = {2010-06-12 09:32:25 +0200}, doi = {10.1214/08-EJS176}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Rothman-2008-Electronic%20Journal%20of%20Statistics_Sparse%20permutation%20i.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12312}, rating = {0} } @article{ChicoLibran:2006p11396, author = {Eliseo Chico Libr{\'a}n}, journal = {Span J Psychol}, title = {Personality dimensions and subjective well-being}, abstract = {This work examines the association between personality dimensions (extraversion and neuroticism) and subjective well-being. Subjective well-being is associated both with extraversion and neuroticism, and currently, neuroticism is generally considered the more important. A total of 368 students from the University of Rovira i Virgili completed the Extraversion and Neuroticism subscales of the revised Eysenck Personality Questionnaire (Eysenck, Eysenck, and Barrett, 1985), the Satisfaction with Life Scale (SWLS; Diener, Emmons, Larsen, and Griffin, 1985), and the Positive and Negative Affect Scale (Watson, Clark, and Tellegen, 1988). Regression analyses revealed the personality variable of neuroticism as one of the most important correlates of subjective well-being. Regression analyses also showed that 44% of the variance of subjective well-being was accounted for by neuroticism, whereas extraversion only explained 8% of the variance.}, affiliation = {Universidad Rovira i Virgili, Facultad de Psicolog{\'\i}a, Carretera de Valls s/n, 43007 Tarragona, Spain. eliseo.chico@urv.net}, number = {1}, pages = {38--44}, volume = {9}, year = {2006}, month = {May}, language = {eng}, keywords = {Personal Satisfaction, Male, Neurotic Disorders, Extraversion (Psychology), Affect, Regression Analysis, Female, Questionnaires, Adult, Humans, Personality, Multivariate Analysis}, date-added = {2010-05-01 16:28:02 +0200}, date-modified = {2010-07-29 19:53:35 +0200}, pmid = {16673621}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Chico%20Libr%C3%A1n-2006-Span%20J%20Psychol_Personality%20dimensio.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11396}, rating = {0} } @article{Rufer:2010p7834, author = {M Rufer and R Albrecht and O Schmidt and J Zaum and U Schnyder and I Hand and C Mueller-Pfeiffer}, journal = {Eur Psychiatry}, title = {Changes in quality of life following cognitive-behavioral group therapy for panic disorder}, abstract = {BACKGROUND: Data about quality of life (QoL) are important to estimate the impact of diseases on functioning and well-being. The present study was designed to assess the association of different aspects of panic disorder (PD) with QoL and to examine the relationship between QoL and symptomatic outcome following brief cognitive-behavioral group therapy (CBGT). METHOD: The sample consisted of 55 consecutively recruited outpatients suffering from PD who underwent CBGT. QoL was assessed by the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36) at baseline, post-treatment and six months follow-up. SF-36 baseline scores were compared with normative data obtained from a large German population sample. RESULTS: Agoraphobia, disability, and worries about health were significantly associated with decreased QoL, whereas frequency, severity and duration of panic attacks were not. Treatment responders showed significantly better QoL than non-responders. PD symptom reduction following CBGT was associated with considerable improvement in emotional and physical aspects of QoL. However, the vitality subscale of the SF-36 remained largely unchanged over time. CONCLUSIONS: Our results are encouraging for cognitive-behavior therapists who treat patients suffering from PD in groups, since decrease of PD symptoms appears to be associated with considerable improvements in QoL. Nevertheless, additional interventions designed to target specific aspects of QoL, in particular vitality, may be useful to enhance patients' well-being.}, affiliation = {Department of Psychiatry, University Hospital of Z{\"u}rich, Culmannstrasse 8, 8091 Z{\"u}rich, Switzerland. michael.rufer@usz.ch}, number = {1}, pages = {8--14}, volume = {25}, year = {2010}, month = {Jan}, language = {eng}, date-added = {2010-03-17 21:01:33 +0100}, date-modified = {2010-03-17 21:01:34 +0100}, doi = {10.1016/j.eurpsy.2009.05.003}, pii = {S0924-9338(09)00084-4}, pmid = {19545979}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Rufer-2010-Eur%20Psychiatry_Changes%20in%20quality%20o.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7834}, rating = {0} } @article{Thompson:2002, author = {B Thompson}, journal = {Journal of Counseling and Development}, title = {"Statistical," "practical," and "clinical": How many kinds of significance do counselors need to consider?}, pages = {64--71}, volume = {80}, year = {2002}, date-added = {2010-01-10 11:33:21 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2017}, rating = {0} } @article{Yu:2008p2904, author = {Wei Yu and Melinda Clyne and Siobhan M Dolan and Ajay Yesupriya and Anja Wulf and Tiebin Liu and Muin J Khoury and Marta Gwinn}, journal = {BMC Bioinformatics}, title = {GAPscreener: an automatic tool for screening human genetic association literature in PubMed using the support vector machine technique}, abstract = {BACKGROUND: Synthesis of data from published human genetic association studies is a critical step in the translation of human genome discoveries into health applications. Although genetic association studies account for a substantial proportion of the abstracts in PubMed, identifying them with standard queries is not always accurate or efficient. Further automating the literature-screening process can reduce the burden of a labor-intensive and time-consuming traditional literature search. The Support Vector Machine (SVM), a well-established machine learning technique, has been successful in classifying text, including biomedical literature. The GAPscreener, a free SVM-based software tool, can be used to assist in screening PubMed abstracts for human genetic association studies. RESULTS: The data source for this research was the HuGE Navigator, formerly known as the HuGE Pub Lit database. Weighted SVM feature selection based on a keyword list obtained by the two-way z score method demonstrated the best screening performance, achieving 97.5% recall, 98.3% specificity and 31.9% precision in performance testing. Compared with the traditional screening process based on a complex PubMed query, the SVM tool reduced by about 90% the number of abstracts requiring individual review by the database curator. The tool also ascertained 47 articles that were missed by the traditional literature screening process during the 4-week test period. We examined the literature on genetic associations with preterm birth as an example. Compared with the traditional, manual process, the GAPscreener both reduced effort and improved accuracy. CONCLUSION: GAPscreener is the first free SVM-based application available for screening the human genetic association literature in PubMed with high recall and specificity. The user-friendly graphical user interface makes this a practical, stand-alone application. The software can be downloaded at no charge.}, affiliation = {National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA. WYu@cdc.gov}, pages = {205}, volume = {9}, year = {2008}, month = {Jan}, language = {eng}, keywords = {Chromosome Mapping, Artificial Intelligence, Periodicals as Topic, Natural Language Processing, PubMed, Software, Linkage (Genetics), Humans, Pattern Recognition: Automated, Genome: Human}, date-added = {2010-01-13 15:01:08 +0100}, date-modified = {2010-01-13 15:01:08 +0100}, doi = {10.1186/1471-2105-9-205}, pii = {1471-2105-9-205}, pmid = {18430222}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Yu-2008-BMC%20Bioinformatics_GAPscreener%20an%20auto.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2904}, rating = {0} } @article{Berthoz:2008p13995, author = {Sylvie Berthoz and Michele Wessa and Gayannee Kedia and Bruno Wicker and Julie Gr{\`e}zes}, journal = {Can J Psychiatry}, title = {Cross-cultural validation of the empathy quotient in a French-speaking sample}, abstract = {OBJECTIVE: The Empathy Quotient (EQ) is a self-report that was developed to measure the cognitive and affective aspects of empathy. We further evaluated its validity in 2 studies. METHOD: The psychometric qualities of the French version of the EQ, and its correspondence with 2 other measures of empathy (Interpersonal Reactivity Index and the Empathy Scale of the Impulsiveness-Venturesomeness-Empathy Questionnaire), and with dimensions of the emotional state (depression and anxiety), were evaluated in a sample of 410 students (201 men and 209 women). Second, the clinical validity of the EQ was investigated in participants expected to have dysfunctional empathy. For this purpose, EQ scores of 16 people with autistic spectrum disorder (ASD) were collected. RESULTS: The EQ showed satisfying internal, convergent, test-retest and discriminant validity. The confirmatory factorial analyses suggested a 3-factor structure offered a good fit to the data. The women's superiority in empathy was replicated. As expected, the ASD EQ scores were very low. CONCLUSION: This study provides further evidence that the EQ is reliable in this population and should be recommended to estimate empathy problems, notably in individuals with troubled interpersonal interaction patterns.}, affiliation = {Department of Psychiatry for Adolescents and Young Adults, Institut Mutualiste Montsouris, University Rene Descartes, Paris, France. sylvie.berthoz@imm.fr}, number = {7}, pages = {469--77}, volume = {53}, year = {2008}, month = {Jul}, language = {eng}, keywords = {Factor Analysis: Statistical, Empathy, Language, Cross-Cultural Comparison, Female, France, Canada, Male, Adult, Reproducibility of Results, Humans}, date-added = {2010-08-04 09:22:53 +0200}, date-modified = {2010-08-04 09:22:54 +0200}, pmid = {18674405}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Berthoz-2008-Can%20J%20Psychiatry_Cross-cultural%20valid.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13995}, rating = {0} } @article{Strobl:2009p8187, author = {C Strobl}, journal = {The R Journal}, title = {Party on!}, abstract = {Random forests are one of the most popular statistical learning algorithms, and a variety of methods for fitting random forests and related recursive partitioning approaches is available in R. This paper points out two impor- tant features of the random forest implementa- tion cforest available in the party package: The resulting forests are unbiased and thus prefer- able to the randomForest implementation avail- able in randomForest if predictor variables are of different types. Moreover, a conditional per- mutation importance measure has recently been added to the party package, which can help eval- uate the importance of correlated predictor vari- ables. The rationale of this new measure is illus- trated and hands-on advice is given for the usage of recursive partitioning tools in R.}, volume = {1/2}, year = {2009}, date-added = {2010-03-20 19:52:08 +0100}, date-modified = {2010-07-29 19:53:30 +0200}, pii = {2073-4859}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Strobl-2009-The%20R%20Journal_Party%20on!.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8187}, rating = {0} } @misc{Zou:2004, author = {H Zou and T Hastie and R Tibshirani}, journal = {Miscellaneous}, title = {Sparse principal component analysis}, year = {2004}, month = {Apr}, date-added = {2010-01-10 11:33:18 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Zou-2004-Miscellaneous_Sparse%20principal%20com.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2061}, rating = {0} } @article{Mosimann:2002p5478, author = {Urs P Mosimann and Susanne C Marr{\'e} and Stefan Werlen and Wolfgang Schmitt and Christian W Hess and Hans U Fisch and Thomas E Schlaepfer}, journal = {Arch Gen Psychiatry}, title = {Antidepressant effects of repetitive transcranial magnetic stimulation in the elderly: correlation between effect size and coil-cortex distance}, number = {6}, pages = {560--1}, volume = {59}, year = {2002}, month = {Jun}, language = {eng}, keywords = {Tomography: X-Ray Computed, Brain, Treatment Outcome, Psychiatric Status Rating Scales, Methods, Aged, Cerebral Cortex, Transcranial Magnetic Stimulation, Humans, Depressive Disorder}, date-added = {2010-02-12 14:38:43 +0100}, date-modified = {2010-02-12 14:38:44 +0100}, pii = {ylt0602-1}, pmid = {12044199}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Mosimann-2002-Arch%20Gen%20Psychiatry_Antidepressant%20effec.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5478}, rating = {0} } @article{Mathias:2007p8433, author = {Susan D Mathias and James B Bussel and James N George and Robert McMillan and Gary J Okano and Janet L Nichol}, journal = {Health Qual Life Outcomes}, title = {A disease-specific measure of health-related quality of life for use in adults with immune thrombocytopenic purpura: its development and validation}, abstract = {BACKGROUND: No validated disease-specific measures are available to assess health-related quality of life (HRQoL) in adult subjects with immune thrombocytopenic purpura (ITP). Therefore, we sought to develop and validate the ITP-Patient Assessment Questionnaire (ITP-PAQ) for adult subjects with ITP. METHODS: Information from literature reviews, focus groups with subjects, and clinicians were used to develop 50 ITP-PAQ items. Factor analyses were conducted to develop the scale structure and reduce the number of items. The final 44-item ITP-PAQ, which includes ten scales [Symptoms (S), Bother-Physical Health (B), Fatigue/Sleep (FT), Activity (A), Fear (FR), Psychological Health (PH), Work (W), Social Activity (SA), Women's Reproductive Health (RH), and Overall (QoL)], was self-administered to adult ITP subjects at baseline and 7-10 days later. Test-retest reliability, internal consistency reliability, construct and known groups validity of the final ITP-PAQ were evaluated. RESULTS: Seventy-three subjects with ITP completed the questionnaire twice. Test-retest reliability, as measured by the intra-class correlation, ranged from 0.52-0.90. Internal consistency reliability was demonstrated with Cronbach's alpha for all scales above the acceptable level of 0.70 (range: 0.71-0.92), except for RH (0.66). Construct validity, assessed by correlating ITP-PAQ scales with established measures (Short Form-36 v.1, SF-36 and Center for Epidemiologic Studies Depression Scale, CES-D), was demonstrated through moderate correlations between the ITP-PAQ SA and SF-36 Social Function scales (r = 0.67), and between ITP-PAQ PH and SF-36 Mental Health Scales (r = 0.63). Moderate to strong inter-scale correlations were reported between ITP-PAQ scales and the CES-D, except for the RH scale. Known groups validity was evaluated by comparing mean scores for groups that differed clinically. Statistically significant differences (p < 0.01) were observed when subjects were categorized by treatment status [S, FT, B, A, PH, and QoL, perceived effectiveness of ITP treatment [S], and time elapsed since ITP diagnosis [PH]. CONCLUSION: Results provide preliminary evidence of the reliability and validity of the ITP-PAQ in adult subjects with ITP. Further work should be conducted to assess the responsiveness and to estimate the minimal clinical important difference of the ITP-PAQ to more fully understand the impact of ITP and its treatments on HRQoL.}, affiliation = {Ovation Research Group, 188 Embarcadero, San Francisco, CA 94105, USA. smathias@ovation.org}, pages = {11}, volume = {5}, year = {2007}, month = {Jan}, language = {eng}, keywords = {Middle Aged, Male, Reproducibility of Results, Questionnaires, Humans, Female, Factor Analysis: Statistical, Adult, Purpura: Thrombocytopenic, Quality of Life, Splenectomy}, date-added = {2010-03-21 17:53:06 +0100}, date-modified = {2010-03-21 17:53:06 +0100}, doi = {10.1186/1477-7525-5-11}, pii = {1477-7525-5-11}, pmid = {17316442}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Mathias-2007-Health%20and%20Quality%20of%20Life%20Outcomes_A%20disease-specific%20m.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8433}, rating = {0} } @article{Bigos:2010p5732, author = {Kristin L Bigos and Daniel R Weinberger}, journal = {Neuroimage}, title = {Imaging genetics-days of future past}, abstract = {Imaging genetics provides a unique tool with which to explore and evaluate the functional impact of brain-relevant genetic polymorphisms with the potential to understand their impact on behavior. Because statistical association with clinical diagnosis does not establish biological significance nor identify a mechanism of risk, imaging genetics is a uniquely valuable strategy for extending statistical evidence with biological data. Applications include identifying biologic mechanisms and pathways that mediate individual differences in complex behaviors and vulnerability to disease, and conversely identifying genes that contribute to functional variation in brain circuitry. Additionally, neuroimaging genetics can validate data that suggest an association with psychiatric illness as well as providing evidence of the mechanism of risk. This review also outlines several critical principles of imaging genetics including a rational approach to the selection of candidate genes, the selection of task paradigms that could be plausibly linked to the biology of the gene of interest, and careful control of non-genetic factors. The future of imaging genetics holds great promise for brain research and for biologic validation of genetic validation in CNS disorders, but a disciplined application of the basic principles outlined in this review is critical.}, affiliation = {Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, Division of Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, MSC 1379, Bethesda, MD 20892, USA.}, pages = {}, year = {2010}, month = {Jan}, language = {ENG}, date-added = {2010-02-15 20:28:26 +0100}, date-modified = {2010-03-21 19:31:42 +0100}, doi = {10.1016/j.neuroimage.2010.01.035}, pii = {S1053-8119(10)00055-8}, pmid = {20080192}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5732}, rating = {4} } @article{Meinshausen:2010p12329, author = {N Meinshausen}, title = {Hierarchical Testing of Variable Importance}, abstract = {Abstract. tion of relevant variables. Variable selection suffers from instability and the power to detect relevant variables is typically low if predictor variables are highly correlated. When taking the multiplicity of the testing problem into account, the power diminishes even further. To gain power and insight, it can be advantageous to look for influence not at the level of individual variables but rather at the level of clusters of highly correlated variables. We propose a hierarchical approach. Variable importance is first tested at the coarsest level, corresponding to the global null hypothesis. If possible, the method tries then to attribute any effect to smaller sub-clusters or even individual variables. The smallest possible clusters which still exhibit a significant influence on the response variable are retained. It is shown that the proposed testing procedure controls the family-wise error rate at a pre- specified level, simultaneously over all resolution levels. The method has comparable power to Bonferroni-Holm on the level of individual variables and dramatically larger power for coarser resolution levels. The best resolution level is selected adaptively.}, date-added = {2010-06-12 10:06:22 +0200}, date-modified = {2010-06-12 10:07:49 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Meinshausen--_Hierarchical%20Testing.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12329}, rating = {4} } @article{Ghosh:2009p905, author = {D Ghosh}, title = {Discrete nonparametric algorithms for outlier detection with genomic data}, abstract = {In high-throughput studies involving genetic data such as from gene expression microarrays, differential expression analysis between two or more experimental conditions has been a very common analytical task. Much of the resulting literature on multiple comparisons has paid relatively little attention to the choice of test statistic. In this article, we focus on the issue of choice of test statistic based on a special pattern of differential expression. The approach here is based on recasting multiple comparisons procedures for assessing outlying expression values. A major complication is that the resulting p-values are discrete; some theoretical properties of sequential testing procedures in this context are explored. We propose the use of q-value estimation procedures in this setting. Data from a gene expression profiling experiment in prostate cancer are used to illustrate the methodology.}, affiliation = {Penn State University}, year = {2009}, date-added = {2010-01-03 18:39:30 +0100}, date-modified = {2010-01-03 18:40:35 +0100}, URL = {http://works.bepress.com/debashis_ghosh/38}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Ghosh-2009-_Discrete%20nonparametr.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p905}, rating = {0} } @article{Shapiro:2000, author = {Alexander Shapiro and Jos M F Ten Berge}, journal = {Psychometrika}, title = {The asymptotic bias of minimum trace factor analysis, with applications to the greatest lower bound to reliability}, number = {3}, pages = {413--425}, volume = {65}, year = {2000}, date-added = {2010-01-10 11:33:24 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Shapiro-2000-Psychometrika_The%20asymptotic%20bias.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1924}, rating = {0} } @article{Benjamini:2009p2899, author = {Yoav Benjamini and Yulia Gavrilov}, journal = {arXiv}, title = {A simple forward selection procedure based on false discovery rate control}, abstract = { We propose the use of a new false discovery rate (FDR) controlling procedure as a model selection penalized method, and compare its performance to that of other penalized methods over a wide range of realistic settings: nonorthogonal design matrices, moderate and large pool of explanatory variables, and both sparse and nonsparse models, in the sense that they may include a small and large fraction of the potential variables (and even all). The comparison is done by a comprehensive simulation study, using a quantitative framework for performance comparisons in the form of empirical minimaxity relative to a "random oracle": the oracle model selection performance on data dependent forward selected family of potential models. We show that FDR based procedures have good performance, and in particular the newly proposed method, emerges as having empirical minimax performance. Interestingly, using FDR level of 0.05 is a global best. }, annote = {Published in: Annals of Applied Statistics 2009, Vol. 3, No. 1, 179-198 Published in at http://dx.doi.org/10.1214/08-AOAS194 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org)}, eprint = {0905.2819v1}, volume = {stat.AP}, year = {2009}, month = {Jan}, keywords = {stat.AP}, date-added = {2010-01-13 14:59:31 +0100}, date-modified = {2010-01-13 14:59:31 +0100}, doi = {10.1214/08-AOAS194}, pmid = {0905.2819v1}, URL = {http://arxiv.org/abs/0905.2819v1}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Benjamini-2009-arXiv_A%20simple%20forward%20sel.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2899}, rating = {0} } @article{Bradlow:1999p12797, author = {E T Bradlow and H Wainer and X Wang}, journal = {Psychometrika}, title = {A bayesian random effects model for testlets}, abstract = {Standard item response theory (IRT) models fit to dichotomous examination responses ignore the fact that sets of items (testlets) often come from a single common stimuli (e.g. a reading comprehension passage). In this setting, all items given to an examinee are unlikely to be conditionally independent (given examinee proficiency). Models that assume conditional independence will overestimate the precision with which examinee proficiency is measured. Overstatement of precision may lead to inaccurate inferences such as prematurely ending an examination in which the stopping rule is based on the estimated standard error of examinee proficiency (e.g., an adaptive test). To model examinations that may be a mixture of independent items and testlets, we modified one standard IRT model to include an additional random effect for items nested within the same testlet. We use a Bayesian framework to facilitate posterior inference via a Data Augmented Gibbs Sampler (DAGS; Tanner {\&} Wong, 1987). The modified and standard IRT models are both applied to a data set from a disclosed form of the SAT. We also provide simulation results that indicates that the degree of precision bias is a function of the variability of the testlet effects, as well as the testlet design.}, number = {2}, pages = {153--168}, volume = {64}, year = {1999}, date-added = {2010-06-18 21:19:14 +0200}, date-modified = {2010-06-18 21:20:45 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Bradlow-1999-Psychometrika_A%20bayesian%20random%20ef.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12797}, rating = {0} } @article{Goldberg:2006p13886, author = {L R Goldberg and J A Johnson and H W Eber and R Hogan and M C Ashton and C R Cloninger and H G Gough}, journal = {Journal of Research in Personality}, title = {The international personality item pool and the future of public-domain personality measures}, abstract = {Seven experts on personality measurement here discuss the viability of public-domain personality measures, focusing on the International Personality Item Pool (IPIP) as a prototype. Since its incep- tion in 1996, the use of items and scales from the IPIP has increased dramatically. Items from the IPIP have been translated from English into more than 25 other languages. Currently over 80 publications using IPIP scales are listed at the IPIP Web site (http://ipip.ori.org), and the rate of IPIP- related publications has been increasing rapidly. The growing popularity of the IPIP can be attrib- uted to Wve factors: (1) It is cost free; (2) its items can be obtained instantaneously via the Internet; (3) it includes over 2000 items, all easily available for inspection; (4) scoring keys for IPIP scales are provided; and (5) its items can be presented in any order, interspersed with other items, reworded, translated into other languages, and administered on the World Wide Web without asking permis- sion of anyone. The unrestricted availability of the IPIP raises concerns about possible misuse by unqualiWed persons, and the freedom of researchers to use the IPIP in idiosyncratic ways raises the possibility of fragmentation rather than scientiWc uniWcation in personality research.}, pages = {84--96}, volume = {40}, year = {2006}, date-added = {2010-07-29 18:05:48 +0200}, date-modified = {2010-07-29 18:08:09 +0200}, doi = {10.1016/j.jrp.2005.08.007}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Goldberg-2006-Journal%20of%20Research%20in%20Personality_The%20international%20pe.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13886}, rating = {3} } @article{McArdle:2003p7206, author = {John J McArdle and Fumiaki Hamagami}, journal = {Behav Genet}, title = {Structural equation models for evaluating dynamic concepts within longitudinal twin analyses}, abstract = {A great deal of prior research using structural equation models has focused on longitudinal analyses and biometric analyses. Some of this research has even considered the simultaneous analysis of both kinds of analytic problems. The key benefits of these kinds of analyses come from the estimation of novel parameters, such as the heritability of changes. This paper discusses some recent extensions of longitudinal multivariate models that can be informative within biometric designs. In the methods section we review a previous latent growth structural equation analysis of the New York Twin (NYT) longitudinal data (from McArdle et al., 1998). In the models section we recast this growth model in terms of latent difference scores, add several new dynamic components, including coupling parameters, and consider biometric components and examine model stability. In the results section we present new univariate and bivariate dynamic estimates and tests of various dynamic hypotheses for the NYT data, and we consider a few ways to interpret the age-related biometric components of these models. In the discussion we consider our limitations and present suggestions for future dynamic-genetic research.}, affiliation = {Department of Psychology, University of Virginia, Charlottesville, VA, USA. jjm@virginia.edu}, number = {2}, pages = {137--59}, volume = {33}, year = {2003}, month = {Mar}, language = {eng}, keywords = {Twin Studies as Topic, Models: Theoretical, Longitudinal Studies, Humans, Intelligence Tests}, date-added = {2010-03-08 19:21:53 +0100}, date-modified = {2010-07-29 20:09:07 +0200}, pii = {460863}, pmid = {14574148}, local-url = {file://localhost/Users/chl/Dropbox/Papers/McArdle-2003-Behav%20Genet_Structural%20equation.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7206}, rating = {0} } @inproceedings{Thomas:2002c, author = {D R Thomas and A Cyr}, journal = {Proceedings}, title = {Applying item response theory methods to complex survey data}, year = {2002}, date-added = {2010-01-10 11:33:10 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Thomas-2002-Proceedings_Applying%20item%20respon.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2182}, rating = {0} } @article{Pereda:2005p12023, author = {Ernesto Pereda and Rodrigo Quian Quiroga and Joydeep Bhattacharya}, journal = {Prog Neurobiol}, title = {Nonlinear multivariate analysis of neurophysiological signals}, abstract = {Multivariate time series analysis is extensively used in neurophysiology with the aim of studying the relationship between simultaneously recorded signals. Recently, advances on information theory and nonlinear dynamical systems theory have allowed the study of various types of synchronization from time series. In this work, we first describe the multivariate linear methods most commonly used in neurophysiology and show that they can be extended to assess the existence of nonlinear interdependence between signals. We then review the concepts of entropy and mutual information followed by a detailed description of nonlinear methods based on the concepts of phase synchronization, generalized synchronization and event synchronization. In all cases, we show how to apply these methods to study different kinds of neurophysiological data. Finally, we illustrate the use of multivariate surrogate data test for the assessment of the strength (strong or weak) and the type (linear or nonlinear) of interdependence between neurophysiological signals.}, affiliation = {Department of Basic Physics, College of Physics and Mathematics, University of La Laguna, Avda. Astrof{\'\i}sico Fco. S{\'a}nchez s/n, 38205 La Laguna, Tenerife, Spain. eperdepa@ull.es}, number = {1-2}, pages = {1--37}, volume = {77}, year = {2005}, month = {Jan}, language = {eng}, keywords = {Nonlinear Dynamics, Neurophysiology, Signal Processing: Computer-Assisted, Multivariate Analysis, Electroencephalography, Diagnosis: Computer-Assisted, Neurons, Computer Simulation, Animals, Models: Statistical, Humans, Models: Neurological, Action Potentials, Data Interpretation: Statistical}, date-added = {2010-05-24 10:16:05 +0200}, date-modified = {2010-05-24 10:16:06 +0200}, doi = {10.1016/j.pneurobio.2005.10.003}, pii = {S0301-0082(05)00119-X}, pmid = {16289760}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Pereda-2005-Prog%20Neurobiol_Nonlinear%20multivaria.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12023}, rating = {0} } @article{Lochner:2005p13007, author = {Christine Lochner and Sian M J Hemmings and Craig J Kinnear and Dana J H Niehaus and Daniel G Nel and Valerie A Corfield and Johanna C Moolman-Smook and Soraya Seedat and Dan J Stein}, journal = {Compr Psychiatry}, title = {Cluster analysis of obsessive-compulsive spectrum disorders in patients with obsessive-compulsive disorder: clinical and genetic correlates}, abstract = {BACKGROUND: Comorbidity of certain obsessive-compulsive spectrum disorders (OCSDs; such as Tourette's disorder) in obsessive-compulsive disorder (OCD) may serve to define important OCD subtypes characterized by differing phenomenology and neurobiological mechanisms. Comorbidity of the putative OCSDs in OCD has, however, not often been systematically investigated. METHODS: The Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition , Axis I Disorders-Patient Version as well as a Structured Clinical Interview for Putative OCSDs (SCID-OCSD) were administered to 210 adult patients with OCD (N = 210, 102 men and 108 women; mean age, 35.7 +/- 13.3). A subset of Caucasian subjects (with OCD, n = 171; control subjects, n = 168), including subjects from the genetically homogeneous Afrikaner population (with OCD, n = 77; control subjects, n = 144), was genotyped for polymorphisms in genes involved in monoamine function. Because the items of the SCID-OCSD are binary (present/absent), a cluster analysis (Ward's method) using the items of SCID-OCSD was conducted. The association of identified clusters with demographic variables (age, gender), clinical variables (age of onset, obsessive-compulsive symptom severity and dimensions, level of insight, temperament/character, treatment response), and monoaminergic genotypes was examined. RESULTS: Cluster analysis of the OCSDs in our sample of patients with OCD identified 3 separate clusters at a 1.1 linkage distance level. The 3 clusters were named as follows: (1) "reward deficiency" (including trichotillomania, Tourette's disorder, pathological gambling, and hypersexual disorder), (2) "impulsivity" (including compulsive shopping, kleptomania, eating disorders, self-injury, and intermittent explosive disorder), and (3) "somatic" (including body dysmorphic disorder and hypochondriasis). Several significant associations were found between cluster scores and other variables; for example, cluster I scores were associated with earlier age of onset of OCD and the presence of tics, cluster II scores were associated with female gender and childhood emotional abuse, and cluster III scores were associated with less insight and with somatic obsessions and compulsions. However, none of these clusters were associated with any particular genetic variant. CONCLUSION: Analysis of comorbid OCSDs in OCD suggested that these lie on a number of different dimensions. These dimensions are partially consistent with previous theoretical approaches taken toward classifying OCD spectrum disorders. The lack of genetic validation of these clusters in the present study may indicate the involvement of other, as yet untested, genes. Further genetic and cluster analyses of comorbid OCSDs in OCD may ultimately contribute to a better delineation of OCD endophenotypes.}, affiliation = {MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg, 7505, Cape Town, South Africa. cl2@sun.ac.za}, number = {1}, pages = {14--9}, volume = {46}, year = {2005}, month = {Jan}, language = {eng}, keywords = {Genotype, Tourette Syndrome, Adult, Adolescent, Questionnaires, Interview: Psychological, Trichotillomania, Female, Polymorphism: Genetic, Comorbidity, Obsessive-Compulsive Disorder, Male, Cluster Analysis, Monoamine Oxidase, Middle Aged, Self-Injurious Behavior, Severity of Illness Index, Humans, Aged, Gambling, Serotonin, Impulse Control Disorders}, date-added = {2010-06-25 22:37:34 +0200}, date-modified = {2010-07-29 19:24:13 +0200}, doi = {10.1016/j.comppsych.2004.07.020}, pmid = {15714189}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Lochner-2005-Compr%20Psychiatry_Cluster%20analysis%20of.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13007}, rating = {0} } @article{Suhr:2005p4092, author = {D D Suhr}, journal = {SUGI 30}, title = {Principal Component Analysis vs. Exploratory Factor Analysis}, abstract = {Principal Component Analysis (PCA) and Exploratory Factor Analysis (EFA) are both variable reduction techniques and sometimes mistaken as the same statistical method. However, there are distinct differences between PCA and EFA. Similarities and differences between PCA and EFA will be examined. Examples of PCA and EFA with PRINCOMP and FACTOR will be illustrated and discussed.}, number = {203-30}, year = {2005}, date-added = {2010-01-19 23:21:05 +0100}, date-modified = {2010-01-19 23:21:40 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Suhr-2005-SUGI%2030_Principal%20Component.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p4092}, rating = {0} } @article{Cella:2005p13616, author = {David Cella}, journal = {J Support Oncol}, title = {Quality of life outcomes: measurement and intervention}, number = {2}, pages = {133--4}, volume = {3}, year = {2005}, month = {Jan}, language = {eng}, keywords = {Outcome Assessment (Health Care), Quality of Life, Meta-Analysis as Topic, Melanoma, Review Literature as Topic, Humans}, date-added = {2010-07-07 21:18:43 +0200}, date-modified = {2010-07-07 21:18:43 +0200}, pmid = {15796445}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Cella-2005-J%20Support%20Oncol_Quality%20of%20life%20outc.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13616}, rating = {0} } @article{vanAbswoude:2004p3420, author = {A A H van Abswoude and J K Vermunt and B T Hemker and L Andries van der Ark}, journal = {Applied Psychological Measurement}, title = {Mokken Scale Analysis Using Hierarchical Clustering Procedures}, abstract = {Mokken scale analysis (MSA) can be used to assess and build unidimensional scales from an item pool that is sensitive to multiple dimensions. These scales satisfy a set of scaling conditions, one of which follows from the model of monotone homogeneity. An important drawback of the MSA program is that the sequential item selection and scale construction procedure may not find the dominant underlying dimensionality of the responses to a set of items. The authors investigated alternative hierarchical item selection procedures and compared the performance of four hierarchical methods and the sequential clustering method in the MSA context. The results showed that hierarchical clustering methods can improve the search process of the dominant dimensionality of a data matrix. In particular, the complete linkage and scale linkage methods were promising in finding the dimensionality of the item response data from a set of items.}, number = {5}, pages = {332--354}, volume = {28}, year = {2004}, date-added = {2010-01-15 14:56:14 +0100}, date-modified = {2010-07-29 20:42:55 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/van%20Abswoude-2004-Applied%20Psychological%20Measurement_Mokken%20Scale%20Analysi.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3420}, rating = {0} } @article{Sparapani:2008p2366, author = {R A Sparapani and P W Laud}, title = {A Recent History of Bayesian Statistical Software}, year = {2008}, date-added = {2010-01-10 13:42:25 +0100}, date-modified = {2010-01-10 13:43:04 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Sparapani-2008-_A%20Recent%20History%20of.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2366}, rating = {0} } @article{Gal:2003p3697, author = {I Gal and M van Groenestijn and M Manly and M J Schmitt and D Tout}, title = {Adult numeracy and its assessment in the ALL survey: A conceptual framework and pilot results}, year = {2003}, date-added = {2010-01-16 20:49:34 +0100}, date-modified = {2010-01-16 20:50:26 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Gal-2003-_Adult%20numeracy%20and%20i.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3697}, rating = {0} } @article{Boughton:2001p11153, author = {K A Boughton and D A Klinger and M J Gierl}, journal = {Annual meeting of the National Council on Measurement in Education}, title = {Effects of Random Rater Error on Parameter Recovery of the Generalized Partial Credit Model and Graded Response Model}, year = {2001}, date-added = {2010-04-25 19:20:17 +0200}, date-modified = {2010-07-29 19:15:08 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Boughton-2001-Annual%20meeting%20of%20the%20National%20Council%20on%20Measurement%20in%20Education_Effects%20of%20Random%20Ra-1.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11153}, rating = {0} } @article{Palomo:2004p7563, author = {Tomas Palomo and R M Kostrzewa and R J Beninger and T Archer}, journal = {Neurotox Res}, title = {Gene-environment interplay in alcoholism and other substance abuse disorders: expressions of heritability and factors influencing vulnerability}, abstract = {Factors that confer predisposition and vulnerability for alcoholism and other substance abuse disorders may be described usefully within the gene-environment interplay framework. Thus, it is postulated that heritability provides a major contribution not only to alcohol but also to other substances of abuse. Studies of evoked potential amplitude reduction have provided a highly suitable and testable method for the assessment of both environmentally-determined and heritable characteristics pertaining to substance use and dependence. The different personal attributes that may co-exist with parental influence or exist in a shared, monozygotic relationship contribute to the final expression of addiction. In this connection, it appears that personality disorders are highly prevalent co-morbid conditions among addicted individuals, and, this co-morbidity is likely to be accounted for by multiple complex etiological relationships, not least in adolescent individuals. Co-morbidity associated with deficient executive functioning may be observed too in alcohol-related aggressiveness and crimes of violence. The successful intervention into alcohol dependence and craving brought about by baclofen in both human and animal studies elucidates glutamatergic mechanisms in alcoholism whereas the role of the dopamine transporter, in conjunction with both the noradrenergic and serotonergic transporters, are implicated in cocaine dependence and craving. The role of the cannabinoids in ontogeny through an influence upon the expression of key genes for the development of neurotransmitter systems must be considered. Finally, the particular form of behaviour/characteristic outcome due to childhood circumstance may lie with biological, gene-based determinants, for example individual characteristics of monoamine oxidase (MAO) activity levels, thereby rendering simple predictive measures both redundant and misguiding.}, affiliation = {Servicio Psiqui{\'a}trico, Hospital Universitario 12 de Octubre, Avda. de C{\'o}rdoba s/n, 28041 Madrid, Spain.}, number = {5}, pages = {343--61}, volume = {6}, year = {2004}, month = {Jan}, language = {eng}, keywords = {Alcoholism, gamma-Aminobutyric Acid, Personality, Humans, Event-Related Potentials: P300, Violence, Substance-Related Disorders, Biogenic Monoamines}, date-added = {2010-03-14 10:56:49 +0100}, date-modified = {2010-03-14 10:56:49 +0100}, pmid = {15545018}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Palomo-2004-Neurotox%20Res_Gene-environment%20int.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7563}, rating = {0} } @article{Bullinger:1993p8436, author = {M Bullinger and R Anderson and D Cella and Neil K Aaronson}, journal = {Qual Life Res}, title = {Developing and evaluating cross-cultural instruments from minimum requirements to optimal models}, abstract = {In the age of increased international collaboration in medical research, the necessity of having at hand cross-culturally applicable instruments for the assessment of health-related quality of life (HRQL) in clinical trials has been voiced. Several important theoretical bases leading to cultural bias in HRQL measurement include differences in definitions of HRQL across national and cultural contexts, levels of observation relied upon to indicate HRQL states, and the significance or weight placed upon the various HRQL states or dimensions measured. Despite a growing literature on the development and evaluation of existing HRQL measures in other cultures, comprehensive sets of procedures or requirements for the international part of development and evaluation are lacking. This paper reviews major approaches to developing international HRQL measures, and discusses various methods and criteria that have been recommended for evaluating measurement equivalence in comparisons of research across national and cultural contexts. A summary of recent trends and advances in international HRQL assessment is presented.}, affiliation = {Institute for Medical Psychology, University of Munich, Germany.}, number = {6}, pages = {451--9}, volume = {2}, year = {1993}, month = {Dec}, language = {eng}, keywords = {Psychometrics, Health Surveys, International Cooperation, Evaluation Studies as Topic, Cross-Cultural Comparison, Bias (Epidemiology), Reproducibility of Results, Research, Translating, Quality of Life, Questionnaires}, date-added = {2010-03-21 17:55:27 +0100}, date-modified = {2010-07-29 20:13:56 +0200}, pmid = {8161979}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Bullinger-1993-Qual%20Life%20Res_Developing%20and%20evalu.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8436}, rating = {5} } @article{Hesterberg:2008p2319, author = {T Hesterberg and N H Choi and L Meier and C Fraley}, journal = {Statistics Surveys}, title = {Least angle and l1 penalized regression: A review}, abstract = {Least Angle Regression is a promising technique for variable selection applications, offering a nice alternative to stepwise regression. It provides an explanation for the similar behavior of LASSO (l1-penalized regression) and forward stagewise regression, and provides a fast imple- mentation of both. The idea has caught on rapidly, and sparked a great deal of research interest. In this paper, we give an overview of Least Angle Regression and the current state of related research.}, pages = {61--93}, volume = {2}, year = {2008}, date-added = {2010-01-10 12:37:18 +0100}, date-modified = {2010-01-10 12:38:46 +0100}, doi = {10.1214/08-SS035}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Hesterberg-2008-Statistics%20Surveys_Least%20angle%20and%20l1%20p.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2319}, rating = {0} } @article{Gomez:2009p13089, author = {V Gomez and F Krings and A Bangerter and A Grob}, journal = {Journal of Research in Personality}, title = {The influence of personality and life events on subjective well-being from a life span perspective}, abstract = {We investigate the relation between personality (Big Five) and positive and negative life events as pre- dictors of subjective well-being (SWB) in a sample of 766 young, middle-aged, and old adults. Analyses comprised data on personality, SWB, and reconstructed positive and negative life events. Results for the total sample indicate a strong relation between neuroticism and SWB, and an important influence of reconstructed life events on SWB with a stronger effect for negative as compared to positive events. Age differences in the prediction of SWB emerge for personality and life events: extraversion is only a predictor of SWB in young adults and the effect of neuroticism is more pronounced in old adults. More- over, the influence of negative life events on SWB is stronger in young and middle-aged adults as com- pared to old adults. These results emphasize the need to study dispositional and situational variables across the life span in order to better understand the underlying mechanisms of SWB.}, pages = {345--354}, volume = {43}, year = {2009}, date-added = {2010-06-26 10:19:06 +0200}, date-modified = {2010-07-29 19:36:11 +0200}, doi = {10.1016/j.jrp.2008.12.014}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Gomez-2009-Journal%20of%20Research%20in%20Personality_The%20influence%20of%20per.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13089}, rating = {0} } @article{Hoh:2001p1608, author = {J Hoh and A Wille and J Ott}, journal = {Genome Res}, title = {Trimming, weighting, and grouping SNPs in human case-control association studies}, abstract = {The search for genes underlying complex traits has been difficult and often disappointing. The main reason for these difficulties is that several genes, each with rather small effect, might be interacting to produce the trait. Therefore, we must search the whole genome for a good chance to find these genes. Doing this with tens of thousands of SNP markers, however, greatly increases the overall probability of false-positive results, and current methods limiting such error probabilities to acceptable levels tend to reduce the power of detecting weak genes. Investigating large numbers of SNPs inevitably introduces errors (e.g., in genotyping), which will distort analysis results. Here we propose a simple strategy that circumvents many of these problems. We develop a set-association method to blend relevant sources of information such as allelic association and Hardy-Weinberg disequilibrium. Information is combined over multiple markers and genes in the genome, quality control is improved by trimming, and an appropriate testing strategy limits the overall false-positive rate. In contrast to other available methods, our method to detect association to sets of SNP markers in different genes in a real data application has shown remarkable success.}, affiliation = {Laboratory of Statistical Genetics, Rockefeller University, New York, New York 10021, USA.}, number = {12}, pages = {2115--9}, volume = {11}, year = {2001}, month = {Dec}, language = {eng}, keywords = {Polymorphism: Single Nucleotide, Case-Control Studies, Humans, Phenotype, Linkage Disequilibrium, Models: Statistical, Models: Genetic, Genotype}, date-added = {2010-01-07 17:04:30 +0100}, date-modified = {2010-01-07 17:04:30 +0100}, doi = {10.1101/gr.204001}, pmid = {11731502}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Hoh-2001-Genome%20Res_Trimming%20weighting.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1608}, rating = {0} } @article{Burdick:2006p2483, author = {Katherine E Burdick and Todd Lencz and Birgit Funke and Christine T Finn and Philip R Szeszko and John M Kane and Raju Kucherlapati and Anil K Malhotra}, journal = {Hum Mol Genet}, title = {Genetic variation in DTNBP1 influences general cognitive ability}, abstract = {Human intelligence is a trait that is known to be significantly influenced by genetic factors, and recent linkage data provide positional evidence to suggest that a region on chromosome 6p, previously associated with schizophrenia, may be linked to variation in intelligence. The gene for dysbindin-1 (DTNBP1) is located at 6p and has also been implicated in schizophrenia, a neuropsychiatric disorder characterized by cognitive dysfunction. We report an association between DTNBP1 genotype and general cognitive ability (g) in two independent cohorts, including 213 patients with schizophrenia or schizo-affective disorder and 126 healthy volunteers. These data suggest that DTNBP1 genetic variation influences human intelligence.}, affiliation = {Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Albert Einstein College of Medicine, Glen Oaks, NY 11004, USA. kburdick@lij.edu}, number = {10}, pages = {1563--8}, volume = {15}, year = {2006}, month = {May}, language = {eng}, keywords = {Chromosomes: Human: Pair 6, Psychotic Disorders, Genotype, Humans, Intelligence, Carrier Proteins, Genetic Markers, Adult, Cognition, Aged, Genetic Variation, Female, Schizophrenic Psychology, Middle Aged, Schizophrenia, Male}, date-added = {2010-01-12 13:31:49 +0100}, date-modified = {2010-07-29 19:28:52 +0200}, doi = {10.1093/hmg/ddi481}, pii = {ddi481}, pmid = {16415041}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Burdick-2006-Hum%20Mol%20Genet_Genetic%20variation%20in.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2483}, rating = {0} } @article{Petersen:2008p3004, author = {Maya L Petersen and Mark J van der Laan and Sonia Napravnik and Joseph J Eron and Richard D Moore and Steven G Deeks}, journal = {AIDS}, title = {Long-term consequences of the delay between virologic failure of highly active antiretroviral therapy and regimen modification}, abstract = {OBJECTIVES: Current treatment guidelines recommend immediate modification of antiretroviral therapy in HIV-infected individuals with incomplete viral suppression. These recommendations have not been tested in observational studies or large randomized trials. We evaluated the consequences of delayed modification following virologic failure. DESIGN/METHODS: We used prospective data from two clinical cohorts to estimate the effect of time until regimen modification following first regimen failure on all-cause mortality. The impact of regimen type was also assessed. As the effect of delayed switching can be confounded if patients with a poor prognosis modify therapy earlier than those with a good prognosis, we used a statistical methodology - marginal structural models - to control for time-dependent confounding. RESULTS: A total of 982 patients contributed 3414 person-years of follow-up following first regimen failure. Delay until treatment modification was associated with an elevated hazard of all-cause mortality among patients failing a reverse transcriptase inhibitor-based regimen (hazard ratio per additional 3 months delay = 1.23, 95% confidence interval: 1.08, 1.40), but appeared to have a small protective effect among patients failing a protease inhibitor-based regimen (hazard ratio per additional 3 months delay = 0.93, 95% confidence interval: 0.87, 0.99). CONCLUSION: Delay in modification after failure of regimens that do not contain a protease inhibitor is associated with increased mortality. Protease inhibitor-based regimens are less dependent on early versus delayed switching strategies. Efforts should be made to minimize delay until treatment modification in resource-poor regions, where the majority of patients are starting reverse transcriptase inhibitor-based regimens and HIV RNA monitoring may not be available.}, affiliation = {Division of Biostatistics, Berkeley School of Public Health, Berkeley, California 94720, USA. mayaliv@berkeley.edu}, number = {16}, pages = {2097--106}, volume = {22}, year = {2008}, month = {Oct}, language = {eng}, keywords = {Middle Aged, Antiretroviral Therapy: Highly Active, United States, HIV Infections, Drug Resistance: Viral, Treatment Outcome, CD4 Lymphocyte Count, HIV Protease Inhibitors, Drug Administration Schedule, Treatment Failure, Female, Humans, Reverse Transcriptase Inhibitors, Male, Adult, Anti-HIV Agents}, date-added = {2010-01-13 23:14:35 +0100}, date-modified = {2010-07-29 19:12:25 +0200}, doi = {10.1097/QAD.0b013e32830f97e2}, pii = {00002030-200810180-00007}, pmid = {18832873}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Petersen-2008-AIDS_Long-term%20consequenc.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3004}, rating = {0} } @article{Huebner:2010p4183, author = {A Huebner}, journal = {Practical Assessment Research \{\&} Evaluation}, title = {An Overview of Recent Developments in Cognitive Diagnostic Computer Adaptive Assessments}, abstract = {Cognitive diagnostic modeling has become an exciting new field of psychometric research. These models aim to diagnose examinees' mastery status of a group of discretely defined skills, or attributes, thereby providing them with detailed information regarding their specific strengths and weaknesses. Combining cognitive diagnosis with computer adaptive assessments has emerged as an important part of this new field. This article aims to provide practitioners and researchers with an introduction to and overview of recent developments in cognitive diagnostic computer adaptive assessments.}, number = {3}, volume = {15}, year = {2010}, date-added = {2010-01-21 07:52:03 +0100}, date-modified = {2010-07-29 19:44:42 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Huebner-2010-Practical%20Assessment%20Research%20%20&%20Evaluation_An%20Overview%20of%20Recen.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p4183}, rating = {0} } @techreport{Brown:2005, author = {N J S Brown}, journal = {Techreport}, title = {The Multidimensional Measure of Conceptual Complexity}, affiliation = {BEAR Center}, year = {2005}, month = {Apr}, date-added = {2010-01-10 11:33:20 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Brown-2005-Techreport_The%20Multidimensional.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1912}, rating = {0} } @article{Mokkink:2010p10574, author = {Lidwine B Mokkink and Caroline B Terwee and Donald L Patrick and Jordi Alonso and Paul W Stratford and Dirk L Knol and Lex M Bouter and Henrica C W de Vet}, journal = {Qual Life Res}, title = {The COSMIN checklist for assessing the methodological quality of studies on measurement properties of health status measurement instruments: an international Delphi study}, abstract = {BACKGROUND: Aim of the COSMIN study (COnsensus-based Standards for the selection of health status Measurement INstruments) was to develop a consensus-based checklist to evaluate the methodological quality of studies on measurement properties. We present the COSMIN checklist and the agreement of the panel on the items of the checklist. METHODS: A four-round Delphi study was performed with international experts (psychologists, epidemiologists, statisticians and clinicians). Of the 91 invited experts, 57 agreed to participate (63%). Panel members were asked to rate their (dis)agreement with each proposal on a five-point scale. Consensus was considered to be reached when at least 67% of the panel members indicated 'agree' or 'strongly agree'. RESULTS: Consensus was reached on the inclusion of the following measurement properties: internal consistency, reliability, measurement error, content validity (including face validity), construct validity (including structural validity, hypotheses testing and cross-cultural validity), criterion validity, responsiveness, and interpretability. The latter was not considered a measurement property. The panel also reached consensus on how these properties should be assessed. CONCLUSIONS: The resulting COSMIN checklist could be useful when selecting a measurement instrument, peer-reviewing a manuscript, designing or reporting a study on measurement properties, or for educational purposes.}, affiliation = {Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands, w.mokkink@vumc.nl.}, pages = {}, year = {2010}, month = {Feb}, language = {ENG}, date-added = {2010-04-07 11:40:01 +0200}, date-modified = {2010-07-29 19:48:31 +0200}, doi = {10.1007/s11136-010-9606-8}, pmid = {20169472}, URL = {http://www.springerlink.com/content/76u6574071x7v084/}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Mokkink-2010-Qual%20Life%20Res_The%20COSMIN%20checklist.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p10574}, rating = {0} } @article{Sarkar:2008p4357, author = {Sanat K Sarkar}, journal = {arXiv}, title = {Generalizing Simes' test and Hochberg's stepup procedure}, abstract = { In a multiple testing problem where one is willing to tolerate a few false rejections, procedure controlling the familywise error rate (FWER) can potentially be improved in terms of its ability to detect false null hypotheses by generalizing it to control the {\$}k{\$}-FWER, the probability of falsely rejecting at least {\$}k{\$} null hypotheses, for some fixed {\$}k>1{\$}. Simes' test for testing the intersection null hypothesis is generalized to control the {\$}k{\$}-FWER weakly, that is, under the intersection null hypothesis, and Hochberg's stepup procedure for simultaneous testing of the individual null hypotheses is generalized to control the {\$}k{\$}-FWER strongly, that is, under any configuration of the true and false null hypotheses. The proposed generalizations are developed utilizing joint null distributions of the {\$}k{\$}-dimensional subsets of the {\$}p{\$}-values, assumed to be identical. The generalized Simes' test is proved to control the {\$}k{\$}-FWER weakly under the multivariate totally positive of order two (MTP{\$}_2{\$}) condition [J. Multivariate Analysis 10 (1980) 467-498] of the joint null distribution of the {\$}p{\$}-values by generalizing the original Simes' inequality. It is more powerful to detect {\$}k{\$} or more false null hypotheses than the original Simes' test when the {\$}p{\$}-values are independent. A stepdown procedure strongly controlling the {\$}k{\$}-FWER, a version of generalized Holm's procedure that is different from and more powerful than [Ann. Statist. 33 (2005) 1138-1154] with independent {\$}p{\$}-values, is derived before proposing the generalized Hochberg's procedure. The strong control of the {\$}k{\$}-FWER for the generalized Hochberg's procedure is established in situations where the generalized Simes' test is known to control its {\$}k{\$}-FWER weakly. }, annote = {Published in: Annals of Statistics 2008, Vol. 36, No. 1, 337-363 Published in at http://dx.doi.org/10.1214/009053607000000550 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org)}, eprint = {0803.1961v1}, volume = {math.ST}, year = {2008}, month = {Jan}, keywords = {math.ST, stat.TH, 62J15 (Primary)}, date-added = {2010-01-27 18:30:00 +0100}, date-modified = {2010-01-27 18:30:00 +0100}, doi = {10.1214/009053607000000550}, pmid = {0803.1961v1}, URL = {http://arxiv.org/abs/0803.1961v1}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p4357}, rating = {0} } @article{Matsunaga:2010p9139, author = {Miki Matsunaga and Yasumasa Okamoto and Shin-Ichi Suzuki and Akiko Kinoshita and Shinpei Yoshimura and Atsuo Yoshino and Yoshihiko Kunisato and Shigeto Yamawaki}, journal = {BMC Psychiatry}, title = {Psychosocial functioning in patients with treatment-resistant depression after group cognitive behavioral therapy}, abstract = {ABSTRACT: BACKGROUND: Although patients with Treatment Resistant Depression (TRD) often have impaired social functioning, few studies have investigated the effectiveness of psychosocial treatment for these patients. We examined whether adding group cognitive behavioral therapy (group-CBT) to medication would improve both the depressive symptoms and the social functioning of patient with mild TRD, and whether any improvements would be maintained over one year. METHODS: Forty-three patients with TRD were treated with 12 weekly sessions of group-CBT. Patients were assessed with the Global Assessment of Functioning scale (GAF), the 36-item Short-Form Health Survey (SF-36), the Hamilton Rating Scale for Depression (HRSD), the Dysfunctional Attitudes Scale (DAS), and the Automatic Thought Questionnaire-Revised (ATQ-R) at baseline, at the termination of treatment, and at the 12-month follow-up. RESULTS: Thirty-eight patients completed treatment; five dropped out. For the patients who completed treatment, post-treatment scores on the GAF and SF-36 were significantly higher than baseline scores. Scores on the HRSD, DAS, and ATQ-R were significantly lower after the treatment. Thus patients improved on all measurements of psychosocial functioning and mood symptoms. Twenty patients participated in the 12-month follow-up. Their improvements for psychosocial functioning, depressive symptoms, and dysfunctional cognitions were sustained at 12 months following the completion of group-CBT. CONCLUSIONS: These findings suggest a positive effect that the addition of cognitive behavioural group therapy to medication on depressive symptoms and social functioning of mildly depressed patients, showing treatment resistance.}, number = {1}, pages = {22}, volume = {10}, year = {2010}, month = {Mar}, language = {ENG}, date-added = {2010-03-22 13:31:09 +0100}, date-modified = {2010-03-22 13:31:09 +0100}, doi = {10.1186/1471-244X-10-22}, pii = {1471-244X-10-22}, pmid = {20230649}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Matsunaga-2010-BMC%20Psychiatry_Psychosocial%20functio-1.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p9139}, rating = {0} } @article{Harris:2006p4601, author = {M Harris and J Richters}, journal = {Social research Briefs}, title = {Psychosocial aspects of living with hepatitis C}, affiliation = {National Centre in HIV Social Research, University of New South Wales}, volume = {8}, year = {2006}, date-added = {2010-01-29 22:34:19 +0100}, date-modified = {2010-01-29 22:35:08 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Harris-2006-Social%20research%20Briefs_Psychosocial%20aspects.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p4601}, rating = {0} } @article{Kornr:2007p8368, author = {Hege Korn{\o}r and Hilmar Nordvik}, journal = {BMC Psychiatry}, title = {Five-factor model personality traits in opioid dependence}, abstract = {BACKGROUND: Personality traits may form a part of the aetiology of opioid dependence. For instance, opioid dependence may result from self-medication in emotionally unstable individuals, or from experimenting with drugs in sensation seekers. The five factor model (FFM) has obtained a central position in contemporary personality trait theory. The five factors are: Neuroticism, Extraversion, Openness to Experience, Agreeableness and Conscientiousness. Few studies have examined whether there is a distinct personality pattern associated with opioid dependence. METHODS: We compared FFM personality traits in 65 opioid dependent persons (mean age 27 years, 34% females) in outpatient counselling after a minimum of 5 weeks in buprenorphine replacement therapy, with those in a non-clinical, age- and sex-matched sample selected from a national database. Personality traits were assessed by a Norwegian version of the Revised NEO Personality Inventory (NEO PI-R), a 240-item self-report questionnaire. Cohen's d effect sizes were calculated for the differences in personality trait scores. RESULTS: The opioid-dependent sample scored higher on Neuroticism, lower on Extraversion and lower on Conscientiousness (d = -1.7, 1.2 and 1.7, respectively) than the controls. Effects sizes were small for the difference between the groups in Openness to experience scores and Agreeableness scores. CONCLUSION: We found differences of medium and large effect sizes between the opioid dependent group and the matched comparison group, suggesting that the personality traits of people with opioid dependence are in fact different from those of non-clinical peers.}, affiliation = {Norwegian Knowledge Centre for the Health Services, Olavsplass, Oslo, Norway. hege.kornor@kunnskapssenteret.no}, pages = {37}, volume = {7}, year = {2007}, month = {Jan}, language = {eng}, keywords = {Outpatients, Personality Assessment, Case-Control Studies, Female, Adult, Male, Models: Psychological, Personality, Humans, Opioid-Related Disorders}, date-added = {2010-03-21 13:01:26 +0100}, date-modified = {2010-07-11 09:52:52 +0200}, doi = {10.1186/1471-244X-7-37}, pii = {1471-244X-7-37}, pmid = {17683593}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Korn%C3%B8r-2007-BMC%20Psychiatry_Five-factor%20model%20pe.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8368}, rating = {3} } @article{Borrmann:2008p6471, author = {Steffen Borrmann and Tim Peto and Robert W Snow and Win Gutteridge and Nicholas J White}, journal = {PLoS Med}, title = {Revisiting the design of phase III clinical trials of antimalarial drugs for uncomplicated Plasmodium falciparum malaria}, affiliation = {Steffen Borrmann is with the Kenya Medical Research Institute, Wellcome Trust Research Programme, Centre for Geographical Medicine Research, Coast, Kilifi, Kenya. sborrmann@kilifi.kemri-wellcome.org}, number = {11}, pages = {e227}, volume = {5}, year = {2008}, month = {Nov}, language = {eng}, keywords = {Humans, Survival Analysis, Animals, Drug Therapy: Combination, Plasmodium falciparum, Clinical Trials: Phase III as Topic, Treatment Outcome, Malaria: Falciparum, Antimalarials, Recurrence}, date-added = {2010-02-23 08:35:37 +0100}, date-modified = {2010-07-29 19:43:47 +0200}, doi = {10.1371/journal.pmed.0050227}, pii = {07-PLME-PF-0212}, pmid = {19018658}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Borrmann-2008-PLoS%20Med_Revisiting%20the%20desig.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6471}, rating = {0} } @article{Eggen:1998aa, author = {T J H M Eggen}, title = {On the Loss of Information in Conditional Maximum Likelihood Estimation of Item Parameters}, abstract = {In item response models of the Rasch type (Fischer {\&} Molenaar, 1995), item parameters are often estimated by the conditional maximum likelihood (CML) method. This paper addresses the loss of information in CML estimation by using the information concept of F-information (Liang, 1983). This concept makes it possible to specify the conditions for no loss of information and to define a quantification of information loss. For the dichotomous Rasch model, the derivations will be given in detail to show the use of the F-information concept for making efficiency comparisons for different estimation methods. It is shown that by using CML for item parameter estimation, some information is almost always lost. But compared to JML (joint maximum likelihood) as well as to MML (marginal maximum likelihood) the loss is very small. The reported efficiency of CML to JML and to MML in several comparisons is always larger than 93%, and in tests with a length of 20 items or more, larger than 99%.}, year = {1998}, month = {Sep}, date-added = {2010-01-03 19:39:02 +0100}, date-modified = {2010-01-03 19:39:03 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Eggen-1998-_On%20the%20Loss%20of%20Infor.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1224}, rating = {0} } @article{Griffiths:2006p8373, author = {Kathleen M Griffiths and Yoshibumi Nakane and Helen Christensen and Kumiko Yoshioka and Anthony F Jorm and Hideyuki Nakane}, journal = {BMC Psychiatry}, title = {Stigma in response to mental disorders: a comparison of Australia and Japan}, abstract = {BACKGROUND: There are few national or cross-cultural studies of the stigma associated with mental disorders. Australia and Japan have different systems of psychiatric health care, and distinct differences in cultural values, but enjoy similar standards of living. This study seeks to compare the nature and extent of stigma among the public in the two countries. METHODS: A household survey of the public was conducted in each country using similar methodologies. The Australian study comprised a national survey of 3998 adults aged over 18 years. The Japanese survey involved 2000 adults aged 20 to 69 from 25 regional sites distributed across the country. Interviewees reported their personal attitudes (personal stigma, social distance) and perceptions of the attitudes of others (perceived stigma, perceived discrimination) in the community with respect to four case vignettes. These vignettes described a person with: depression; depression with suicidal ideation; early schizophrenia; and chronic schizophrenia. RESULTS: Personal stigma and social distance were typically greater among the Japanese than the Australian public whereas the reverse was true with respect to the perception of the attitudes and discriminatory behaviour of others. In both countries, personal stigma was significantly greater than perceived stigma. The public in both countries showed evidence of greater social distance, greater personal stigma and greater perceived stigma for schizophrenia (particularly in its chronic form) than for depression. There was little evidence of a difference in stigma for depression with and without suicide for either country. However, social distance was greater for chronic compared to early schizophrenia for the Australian public. CONCLUSION: Stigmatising attitudes were common in both countries, but negative attitudes were greater among the Japanese than the Australian public. The results suggest that there is a need to implement national public awareness interventions tailored to the needs of each country. The current results provide a baseline for future tracking of national stigma levels in each country.}, affiliation = {Centre for Mental Health Research, The Australian National University, Canberra, ACT, 0200, Australia. kathy.griffiths@anu.edu.au}, pages = {21}, volume = {6}, year = {2006}, month = {Jan}, language = {eng}, keywords = {Male, Mental Disorders, Middle Aged, Australia, Cross-Cultural Comparison, Aged, Female, Data Collection, Humans, Public Opinion, Prejudice, Social Conditions, Adult, Japan}, date-added = {2010-03-21 13:05:04 +0100}, date-modified = {2010-03-21 13:05:04 +0100}, doi = {10.1186/1471-244X-6-21}, pii = {1471-244X-6-21}, pmid = {16716231}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Griffiths-2006-BMC%20Psychiatry_Stigma%20in%20response%20t.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8373}, rating = {0} } @article{AgasiIdenburg:2010p7357, author = {Carla Agasi-Idenburg and Miranda Velthuis and Harriet Wittink}, journal = {Journal of Clinical Epidemiology}, title = {Quality criteria and user-friendliness in self-reported questionnaires on cancer-related fatigue: a review}, abstract = {OBJECTIVE: Cancer-related fatigue (CRF) is a distressing, persistent, subjective sense of tiredness or exhaustion that occurs in 70-100% of cancer patients. The purpose of this review was to provide an overview of the quality of research performed on existing CRF self-report questionnaires and compare their reported psychometric properties and user-friendliness. METHODS: Database searches of CINAHL, Cochrane Library, EMBASE, MEDLINE, Scopus, PEDro, and PsycINFO were undertaken to find published scales. Standardized criteria were used to assess quality and user-friendliness. RESULTS: Thirty-five articles were included that described 18 questionnaires-seven one-dimensional questionnaires and 11 multidimensional questionnaires. The mean item count was 20.8 (range: 3-83). The mean overall score of the one-dimensional questionnaires was 10.4 of a maximum of 18 points (range: 7.6-14.3). The mean overall score of the multidimensional questionnaires was 9.4 of a maximum of 18 points (range: 4.3-14.4). CONCLUSION: Recommendations were made for the selection of a scale. We argue in favor of repeatedly reassessing psychometric properties of even established questionnaires to ensure they comply with evermore increasing stringent quality criteria.}, affiliation = {Department of Physiotherapy, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands; University of Applied Sciences, Utrecht, The Netherlands.}, pages = {}, year = {2010}, month = {Feb}, language = {ENG}, date-added = {2010-03-10 20:28:07 +0100}, date-modified = {2010-03-10 20:28:07 +0100}, doi = {10.1016/j.jclinepi.2009.08.027}, pii = {S0895-4356(09)00313-8}, pmid = {20172691}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Agasi-Idenburg-2010-Journal%20of%20Clinical%20Epidemiology_Quality%20criteria%20and-1.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7357}, rating = {0} } @article{GonzalezSaiz:2009p12788, author = {Francisco Gonz{\'a}lez-Saiz and Oscar Lozano Rojas and Ioseba Iraurgi Castillo}, journal = {Curr Drug Abuse Rev}, title = {Measuring the impact of psychoactive substance on health-related quality of life: an update}, abstract = {BACKGROUND: The number of publications dealing with measurement of the quality of life and health in the area of drug dependence has increased in recent years. Its main application is as an indicator of the effectiveness of intervention in harm reduction, although there are also comparative and methodological studies. DATA SOURCES AND STUDY SELECTION: The literature was reviewed to identify studies on abuse or substance dependence and HRQoL. The bibliographic sources used for the review are PubMed, EMBASE, CINAHL and PsycInfo. Additional articles were identified from references to relevant articles. RESULTS: 111 articles were identified. The HRQoL of people who abuse or are dependent on substances is lower than the general population. The presence of physical and psychiatric comorbidity also affects patients dependent on opiates, and substitution programs improve HRQoL. CONCLUSION: The measurement of HRQoL in the area of drug dependence is a suitable complement for finding out the deterioration caused by substance use, abuse or dependence. It is also a useful indicator for evaluating therapeutic results in this population.}, affiliation = {Fundaci{\'o}n Andaluza para Atenci{\'o}n e Incorporaci{\'o}n Social, Junta de Andaluc{\'\i}a, Sevilla, EU, Spain. pacogonzalez@comcadiz.com}, number = {1}, pages = {5--10}, volume = {2}, year = {2009}, month = {Jan}, language = {eng}, keywords = {Humans, Harm Reduction, Diagnosis: Dual (Psychiatry), Substance-Related Disorders, Quality of Life, Opioid-Related Disorders}, date-added = {2010-06-18 21:02:13 +0200}, date-modified = {2010-06-18 21:02:13 +0200}, pmid = {19630733}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Gonz%C3%A1lez-Saiz-2009-Curr%20Drug%20Abuse%20Rev_Measuring%20the%20impact.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12788}, rating = {0} } @phdthesis{Hamon:2000, author = {Agn{\`e}s Hamon}, journal = {PhD Thesis}, title = {Mod{\`e}le de Rasch et validation de questionnaires de qualit{\'e} de vie}, affiliation = {Universit{\'e} de Bretagne Sud}, year = {2000}, date-added = {2010-01-10 11:33:22 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Hamon-2000-PhD%20Thesis_Mod%C3%A8le%20de%20Rasch%20et%20v.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1865}, rating = {0} } @article{Ligtvoet:2010p13812, author = {R Ligtvoet and L Andries van der Ark and J M te Marvelde and K Sijtsma}, journal = {Educational and Psychological Measurement}, title = {Investigating an Invariant Item Ordering for Polytomously Scored Items}, abstract = {This article discusses the concept of an invariant item ordering (IIO) for polytom- ously scored items and proposes methods for investigating an IIO in real test data. Method manifest IIO is proposed for assessing whether item response functions intersect. Coefficient HT is defined for polytomously scored items. Given that an IIO holds, coefficient HT expresses the accuracy of the item ordering. Method manifest IIO and coefficient HT are used together to analyze a real data set. Topics for future research are discussed.}, year = {2010}, date-added = {2010-07-29 12:35:57 +0200}, date-modified = {2010-07-29 20:42:55 +0200}, doi = {10.1177/0013164409355697}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Ligtvoet-2010-Educational%20and%20Psychological%20Measurement_Investigating%20an%20Inv.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13812}, rating = {0} } @article{Foltz:1998, author = {Peter W Foltz and Walter Kintsch and Thomas K Landauer}, journal = {Discourse Processes}, title = {The measurement of textual coherence with latent semantic analysis}, number = {2\{\&}3}, pages = {285--307}, volume = {25}, year = {1998}, date-added = {2010-01-10 11:33:24 +0100}, date-modified = {2010-07-29 19:25:23 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Foltz-1998-Discourse%20Processes_The%20measurement%20of%20t.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2201}, rating = {0} } @article{Cheung:2006p11616, author = {V Cheung and I Givoni and D Dueck and B J Frey}, title = {Factorgrams: A tool for visualizing multi-way associations in biological data}, abstract = {Effective visualization of biological data is often critical for subsequent analy- sis. The popular clustergram/dendrogram visualization rearranges rows and columns of a data matrix so as to highlight clusters of similar responses, but assumes each row or column belongs to only one cluster and cannot associate each row or column with multiple clusters. Such multi-way associations oc- cur frequently, e.g., when a gene plays multiple biological roles. We describe the 'factorgram' visualization, which rearranges the data into an expanded view, associating each row (or column) with multiple clusters of rows (or columns) and elucidating potentially new biological relationships. Factor- grams for mouse gene expression and yeast synthetic-lethal gene-interaction datasets detect a larger number of statistically-significant clusters than clus- tergrams, plus a larger number of clusters enriched for gene ontology annota- tions. Experimentally-verified associations previously identified by manual rearrangement of rows and columns not grouped together by clustergrams, are readily identified by the factorgram.}, year = {2006}, date-added = {2010-05-11 21:45:42 +0200}, date-modified = {2010-05-11 21:46:35 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Cheung-2006-_Factorgrams%20A%20tool.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11616}, rating = {0} } @article{Ponce:2009p2490, author = {Guillermo Ponce and Roc{\'\i}o P{\'e}rez-Gonz{\'a}lez and Mar{\'\i}a Arag{\"u}{\'e}s and Tom{\'a}s Palomo and Roberto Rodr{\'\i}guez-Jim{\'e}nez and Miguel Angel Jim{\'e}nez-Arriero and Janet Hoenicka}, journal = {Neurotox Res}, title = {The ANKK1 kinase gene and psychiatric disorders}, abstract = {The TaqIA single nucleotide polymorphism (SNP, rs1800497), which is located in the gene that codes for the putative kinase ANKK1 (ANKK1) near the termination codon of the D2 dopamine receptor gene (DRD2; chromosome 11q22-q23), is the most studied genetic variation in a broad range of psychiatric disorders and personality traits. A large number of individual genetic association studies have found that the TaqIA SNP is linked to alcoholism and antisocial traits. In addition, it has also been related to other conditions such as schizophrenia, eating disorders, and some behavioral childhood disorders. The TaqIA A1 allele is mainly associated with addictions, antisocial disorders, eating disorders, and attention-deficit/hyperactivity disorders, while the A2 allele occurs more frequently in schizophrenic and obsessive-compulsive patients. Current data show that the TaqIA polymorphism may be a marker of both DRD2 and ANKK1 genetic variants. ANKK1 would belong to a family of kinases involved in signal transduction. This raises the question of whether signaling players intervene in the pathophysiology of psychiatric disorders. Basic research on the ANKK1 protein and its putative interaction with the D2 dopamine receptor could shed light on this issue.}, affiliation = {Unidad de Alcoholismo y Patolog{\'\i}a Dual, Servicio de Psiquiatr{\'\i}a, Hospital Universitario, 12 de Octubre, Av. de C{\'o}rdoba s/n, Madrid, E-28041, Spain.}, number = {1}, pages = {50--9}, volume = {16}, year = {2009}, month = {Jul}, language = {eng}, date-added = {2010-01-12 13:33:10 +0100}, date-modified = {2010-01-13 10:06:59 +0100}, doi = {10.1007/s12640-009-9046-9}, pmid = {19526298}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Ponce-2009-Neurotox%20Res_The%20ANKK1%20kinase%20gen.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2490}, rating = {3} } @article{Quene:2008p3544, author = {H Quen{\'e} and H van den Bergh}, title = {Examples of mixed-effects modeling with crossed random effects and with binomial data}, abstract = {Psycholinguistic data are often analyzed with repeated-measures analyses of variance (ANOVA), but this paper argues that mixed-effects (multilevel) models provide a better alternative method. First, models are discussed in which the two random factors of participants and items are crossed, and not nested. Traditional ANOVAs are compared against these crossed mixed-effects models, for simulated and real data. Results indicate that the mixed-effects method has a lower risk of capitalization on chance (Type I error). Second, mixed-effects models of logistic regression (generalized linear mixed models, GLMM) are discussed and demonstrated with simulated binomial data. Mixed-effects models effectively solve the ``language-as-fixed-effect-fallacy'', and have several other advantages. In conclusion, mixed-effects models provide a superior method for analyzing psycholinguistic data.}, year = {2008}, date-added = {2010-01-15 20:57:13 +0100}, date-modified = {2010-01-15 20:58:01 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Quen%C3%A9-2008-_Examples%20of%20mixed-ef.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3544}, rating = {0} } @article{Houseman:2006p10006, author = {E Andr{\'e}s Houseman and Brent A Coull and Rebecca A Betensky}, journal = {Biometrics}, title = {Feature-specific penalized latent class analysis for genomic data}, abstract = {Genomic data are often characterized by a moderate to large number of categorical variables observed for relatively few subjects. Some of the variables may be missing or noninformative. An example of such data is loss of heterozygosity (LOH), a dichotomous variable, observed on a moderate number of genetic markers. We first consider a latent class model where, conditional on unobserved membership in one of k classes, the variables are independent with probabilities determined by a regression model of low dimension q. Using a family of penalties including the ridge and LASSO, we extend this model to address higher-dimensional problems. Finally, we present an orthogonal map that transforms marker space to a space of "features" for which the constrained model has better predictive power. We demonstrate these methods on LOH data collected at 19 markers from 93 brain tumor patients. For this data set, the existing unpenalized latent class methodology does not produce estimates. Additionally, we show that posterior classes obtained from this method are associated with survival for these patients.}, affiliation = {Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, Massachusetts 02115, USA. ahousema@hsph.harvard.edu}, number = {4}, pages = {1062--70}, volume = {62}, year = {2006}, month = {Dec}, language = {eng}, keywords = {Loss of Heterozygosity, Genes: Tumor Suppressor, Brain Neoplasms, Genetic Markers, Genomics, Likelihood Functions, Humans, Biometry, Models: Statistical, Data Interpretation: Statistical}, date-added = {2010-03-31 19:48:28 +0200}, date-modified = {2010-03-31 19:48:34 +0200}, doi = {10.1111/j.1541-0420.2006.00566.x}, pii = {BIOM566}, pmid = {17156280}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Houseman-2006-Biometrics_Feature-specific%20pen.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p10006}, rating = {4} } @article{Miettunen:2008p4368, author = {Jouko Miettunen and Erika Lauronen and Liisa Kantoj{\"a}rvi and Juha Veijola and Matti Joukamaa}, journal = {Psychiatry Res}, title = {Inter-correlations between Cloninger's temperament dimensions-- a meta-analysis}, abstract = {The Temperament and Character Inventory (TCI) was developed to measure the following temperament dimensions: novelty seeking (NS), harm avoidance (HA), reward dependence (RD) and persistence (P). These four dimensions of temperament were originally proposed to be independent of one another. In this study the inter-relationships between the dimensions were studied with meta-analytic techniques. We also studied the effects of sociodemographic factors (location of the study, mean age and gender distribution) on correlations between temperament dimensions. We searched studies on healthy (non-clinical) populations that used the TCI (version 9), and that had a required sample size of at least 100. The search resulted in 16 articles. The resulted pooled correlation coefficient was medium level between NS and HA (-0.27). Correlations were small for HA-P (-0.20), NS-P (-0.14), NS-RD (0.10), RD-P (0.05) and HA-RD (0.04). In meta-regression, the correlation NS-P was significantly affected by the location of the study (Asian/other) and by the gender distribution of the sample. In the HA-P correlation, the mean age of the sample affected the correlation. In conclusion, we found a medium level negative correlation between NS and HA; other correlations between the dimensions were small. These findings mainly support Cloninger's theory of independent dimensions.}, affiliation = {Department of Psychiatry, Oulu University and Oulu University Hospital, PO Box 5000, Oulu, Finland. jouko.miettunen@oulu.fi}, number = {1}, pages = {106--14}, volume = {160}, year = {2008}, month = {Jul}, language = {eng}, keywords = {Sex Distribution, Age Distribution, Sample Size, Aged, Female, Adult, Male, Character, Continental Population Groups, Research Design, Aged: 80 and over, Diagnostic and Statistical Manual of Mental Disorders, Middle Aged, Cross-Cultural Comparison, Temperament, Adolescent, Control Groups, Humans, Psychometrics, Personality Inventory, Reproducibility of Results, Personality Assessment}, date-added = {2010-01-28 16:30:42 +0100}, date-modified = {2010-01-28 16:30:42 +0100}, doi = {10.1016/j.psychres.2007.05.003}, pii = {S0165-1781(07)00150-3}, pmid = {18513802}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Miettunen-2008-Psychiatry%20Res_Inter-correlations%20b.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p4368}, rating = {0} } @article{Zee:1998p5984, author = {B C Zee}, journal = {Stat Med}, title = {Growth curve model analysis for quality of life data}, abstract = {There is increasing interest in measuring health related quality of life in cancer clinical trials. Most quality of life data are measured repeatedly over a fixed time schedule to capture changes and to reflect relative advantages of study treatments. A multivariate repeated measures model is usually used to analyse this type of data. However, one of the difficulties of this analysis is that quality of life may be affected by the occurrence of some critical events experienced by patients. We may separate a patient's lifetime during study into different 'health states'. The duration of these health states may vary among patients, and may relate to the efficacy of the study treatment. In some cases quality of life data may be missing due to one of the many different types of missing data mechanisms specific for a health state. It is reasonable to assume that the missing data mechanism for a treatment arm is homogeneous within a defined health state, and to control for the potential confounding effect to appropriately assess the impact of treatment on the quality of life. In this paper, we propose a growth curve model conditional on a time-dependent variable of defined health states in order to assess the overall treatment effect while taking into account occurrences of missing data and measurements from irregular visits. A specific contrast can be drawn within the overall model for testing a specific hypothesis without relying on the analysis of subgroups of patients based on a smaller number of repeated measurements. Quality of life data from a recently completed small-cell lung cancer randomized trial are used to illustrate this method.}, affiliation = {National Cancer Institute of Canada Clinical Trials Group, Queen's University, Kingston, Ontario. zeeb@ncic.ctg.queensu.ca}, number = {5-7}, pages = {757--66}, volume = {17}, year = {1998}, month = {Jan}, language = {eng}, keywords = {Clinical Trials as Topic, Antineoplastic Combined Chemotherapy Protocols, Humans, Longitudinal Studies, Models: Statistical, Lung Neoplasms, Quality of Life, Carcinoma: Small Cell, Health Status, Neoplasms, Research Design}, date-added = {2010-02-18 23:30:36 +0100}, date-modified = {2010-02-18 23:30:36 +0100}, pii = {10.1002/(SICI)1097-0258(19980315/15)17:5/7<757::AID-SIM819>3.0.CO;2-N}, pmid = {9549821}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5984}, rating = {0} } @article{Suarez-Falcon:2003, author = {J C Suarez-Falcon and C A W Glas}, journal = {British Journal of Mathematical {\&} Statistical Psychology}, title = {Evaluation of Global Testing Procedures for item fit to the Rasch Model}, abstract = {Two types of global testing procedures for item fit to the Rasch model were evaluated using simulation studies. The first type incorporates three tests based on first-order statistics: van den Wollenberg's Q(1) test, Glas's R(1) test, and Andersen's LR test. The second type incorporates three tests based on second-order statistics: van den Wollenberg's Q(2) test, Glas's R(2) test, and a non-parametric test proposed by Ponocny. The Type I error rates and the power against the violation of parallel item response curves, unidimensionality and local independence were analysed in relation to sample size and test length. In general, the outcomes indicate a satisfactory performance of all tests, except the Q(2) test which exhibits an inflated Type I error rate. Further, it was found that both types of tests have power against all three types of model violation. A possible explanation is the interdependencies among the assumptions underlying the model.}, pages = {127--143}, volume = {56}, year = {2003}, date-added = {2010-01-10 11:33:18 +0100}, date-modified = {2010-07-29 19:22:13 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Suarez-Falcon-2003-British%20Journal%20of%20Mathematical%20&%20Statistical%20Psychology_Evaluation%20of%20Global.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1881}, rating = {0} } @article{Simeoni:2007p6628, author = {Marie-Claude Simeoni and Silke Schmidt and Holger Muehlan and David Debensason and Monika Bullinger and DISABKIDS Group}, journal = {Qual Life Res}, title = {Field testing of a European quality of life instrument for children and adolescents with chronic conditions: the 37-item DISABKIDS Chronic Generic Module}, abstract = {OBJECTIVES: The aim of this study was to shorten the Health-Related Quality of Life (HRQL) DISABKIDS Chronic Generic Measure (DCGM) for children and adolescents and to test its reliability, construct, and external validity. STUDY DESIGN: 1153 children and adolescents (8-16 years) with chronic health conditions (asthma, arthritis, epilepsy, cerebral palsy, diabetes, atopic dermatitis, cystic fibrosis) and their family were recruited from different paediatric clinical settings in seven European countries. A two-time assessment comprised reports on sociodemographics, health status and HRQL of children/adolescents. RESULTS: The 37-item DCGM describes six dimensions (Independence, Physical Limitation, Emotion, Social Inclusion, Social Exclusion and Treatment) confirmed by Confirmatory Factor Analysis, multi-item scaling and item-goodness of fit to Rasch model. Internal consistency (Cronbach's alpha: 0.70-0.87) and test-retest reliability (ICC: 0.71-0.83) were satisfactory. Correlations between DCGM-37 and other HRQL instruments were the highest between dimensions evaluating similar concepts. Regarding discriminant validity of the DCGM-37, girls and older adolescents reported lower emotional we ll-being. Children belonging to families with low level of affluence and those with severe health conditions were found to have worse HRQL in all domains. CONCLUSION: Reliability, construct validity as well as convergent and discriminant validity of the DCGM-37 were shown.}, affiliation = {Public Health Department, University Hospital of Marseille, Marseille, France. marie-claude.simeoni@medecine.univ-mrs.fr}, number = {5}, pages = {881--93}, volume = {16}, year = {2007}, month = {Jun}, language = {eng}, keywords = {Questionnaires, Female, Culture, Europe, Demography, Adolescent, Male, Chronic Disease, Psychometrics, Sickness Impact Profile, Humans, Quality of Life, Child}, date-added = {2010-03-03 20:34:08 +0100}, date-modified = {2010-07-29 19:48:29 +0200}, doi = {10.1007/s11136-007-9188-2}, pmid = {17404899}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Simeoni-2007-Qual%20Life%20Res_Field%20testing%20of%20a%20E.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6628}, rating = {0} } @article{Bertschy:2010p7837, author = {G Bertschy and E Haffen and N Gervasoni and M Gex-Fabry and C Osiek and D Marra and J-M Aubry and G Bondolfi}, journal = {Eur Psychiatry}, title = {Self-rated residual symptoms do not predict 1-year recurrence of depression}, abstract = {BACKGROUND: Residual depressive symptoms are generally documented as a risk factor for recurrence. In the absence of a specific instrument for the assessment of residual symptoms, a new 25-item Depression Residual Symptom Scale (DRSS) was elaborated and tested for recurrence prediction over a 1-year follow-up. SAMPLING AND METHODS: Fifty-nine patients in remission after a major depressive episode (MDE) were recruited in two centres. They were assessed with the DRSS and the Montgomery-Asberg Depression Rating Scale (MADRS) at inclusion and followed for 1 year according to a seminaturalistic design. The DRSS included specific depressive symptoms and subjective symptoms of vulnerability, lack of return to usual self and premorbid level of functioning. RESULTS: Severity of residual symptoms was not significantly associated with increased risk of recurrence. However, DRSS score was significantly higher among patients with three or more episodes than one to two episodes. Number of previous episodes and treatment interruption were not identified as significant predictors of recurrence. CONCLUSION: The proposed instrument is not predictive of depressive recurrence, but is sensitive to increased perception of vulnerability associated with consecutive episodes. Limitations include small sample size, seminaturalistic design (no standardisation of treatment) and content of the instrument.}, affiliation = {Division of adult psychiatry, Department of psychiatry, University Hospitals of Geneva, 2, chemin du Petit-Bel-Air, 1225 Ch{\^e}ne-Bourg, Geneva, Switzerland. gilles.bertschy@hcuge.ch}, number = {1}, pages = {52--7}, volume = {25}, year = {2010}, month = {Jan}, language = {eng}, date-added = {2010-03-17 21:01:55 +0100}, date-modified = {2010-03-17 21:01:58 +0100}, doi = {10.1016/j.eurpsy.2009.05.009}, pii = {S0924-9338(09)00116-3}, pmid = {19695844}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Bertschy-2010-Eur%20Psychiatry_Self-rated%20residual.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7837}, rating = {3} } @article{Ohaeri:2007p8392, author = {Jude U Ohaeri and Abdel W Awadalla and Abdul-Hamid M El-Abassi and Anila Jacob}, journal = {BMC Med Res Methodol}, title = {Confirmatory factor analytical study of the WHOQOL-Bref: experience with Sudanese general population and psychiatric samples}, abstract = {BACKGROUND: The widespread international use of the 26-item WHO Quality of Life Instrument (WHOQOL-Bref) necessitates the assessment of its factor structure across cultures. For, alternative factor models may provide a better explanation of the data than the WHO 4- and 6-domain models. The objectives of the study were: to assess the factor structure of the WHOQOL-Bref in a Sudanese general population sample; and use confirmatory factor analysis (CFA) and path analysis (PA) to see how well the model thus generated fits into the WHOQOL-Bref data of Sudanese psychiatric patients and their family caregivers. METHOD: In exploratory factor analysis (FA) with all items, data from 623 general population subjects were used to generate a 5-domain model. In CFA and PA, the model was tested on the data of 300 psychiatric outpatients and their caregivers, using four goodness of fit (GOF) criteria in Analysis of Moment Structures (AMOS). In the path relationships for our model, the dependent variable was the item on overall QOL (OQOL). For the WHO 6-domain model, the general facet on health and QOL was the dependent variable. RESULTS: Two of the five factors ("personal relations" and "environment") from our FA were similar to the WHO's. In CFA, the four GOF criteria were met by our 5-domain model and WHO's 4-domain model on the psychiatric data. In PA, these two models met the GOF criteria on the general population data. The direct predictors of OQOL were our factors: "life satisfaction" and "sense of enjoyment". For the general facet, predictors were WHO domains: "environment", "physical health" and "independence'. CONCLUSION: The findings support the credentials of WHO's 4-domain model as a universal QOL construct; and the impression that analysis of WHOQOL-Bref could benefit from including all the items in FA and using OQOL as a dependent variable. The clinical significance is that by more of such studies, a combination of domains from the WHO models and the local models would be generated and used to develop rigorous definitions of QOL, from which primary targets for subjective QOL interventions could be delineated that would have cross-cultural relevance.}, affiliation = {Department of Psychiatry, Psychological Medicine Hospital, Gamal Abdul Naser Road, Safat, Kuwait. judeohaeri@hotmail.com}, pages = {37}, volume = {7}, year = {2007}, month = {Jan}, language = {eng}, keywords = {World Health Organization, Cross-Cultural Comparison, Humans, Questionnaires, Sudan, Interpersonal Relations, Quality of Life, Happiness, Social Environment, Female, Caregivers, Psychometrics, Adult, Personal Satisfaction, Mental Disorders, Activities of Daily Living, Middle Aged, Culture, Factor Analysis: Statistical, Male}, date-added = {2010-03-21 13:08:56 +0100}, date-modified = {2010-04-25 21:32:11 +0200}, doi = {10.1186/1471-2288-7-37}, pii = {1471-2288-7-37}, pmid = {17678527}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Ohaeri-2007-BMC%20Med%20Res%20Methodol_Confirmatory%20factor.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8392}, rating = {4} } @article{Preston:2000p13747, author = {C C Preston and A M Colman}, journal = {Acta Psychol (Amst)}, title = {Optimal number of response categories in rating scales: reliability, validity, discriminating power, and respondent preferences}, abstract = {Using a self-administered questionnaire, 149 respondents rated service elements associated with a recently visited store or restaurant on scales that differed only in the number of response categories (ranging from 2 to 11) and on a 101-point scale presented in a different format. On several indices of reliability, validity, and discriminating power, the two-point, three-point, and four-point scales performed relatively poorly, and indices were significantly higher for scales with more response categories, up to about 7. Internal consistency did not differ significantly between scales, but test-retest reliability tended to decrease for scales with more than 10 response categories. Respondent preferences were highest for the 10-point scale, closely followed by the seven-point and nine-point scales. Implications for research and practice are discussed.}, affiliation = {Department of General Practice and Primary Health Care, University of Leicester, UK.}, number = {1}, pages = {1--15}, volume = {104}, year = {2000}, month = {Mar}, language = {eng}, keywords = {Questionnaires, Adult, Reproducibility of Results, Adolescent, Psychological Tests, Humans, Observer Variation, Female, Male, Psychometrics}, date-added = {2010-07-24 12:34:06 +0200}, date-modified = {2010-07-24 12:34:19 +0200}, pii = {S0001-6918(99)00050-5}, pmid = {10769936}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Preston-2000-Acta%20Psychol%20(Amst)_Optimal%20number%20of%20re.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13747}, rating = {4} } @article{Miglioretti:2004, author = {D L Miglioretti and P J Heagerty}, journal = {Biostatistics}, title = {Marginal modeling of multilevel binary data with time varying covariates}, number = {3}, pages = {381--398}, volume = {5}, year = {2004}, date-added = {2010-01-03 19:37:35 +0100}, date-modified = {2010-01-03 19:37:35 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Miglioretti-2004-Biostatistics_Marginal%20modeling%20of.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1120}, rating = {0} } @inproceedings{Camiz:2005, author = {S Camiz and J Pag{\`e}s}, journal = {Proceedings}, title = {Application de l'analyse factorielle multiple pour le traitement de caract{\`e}res en {\'e}chelle dans les enqu{\^e}tes}, year = {2005}, date-added = {2010-01-10 11:33:20 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Camiz-2005-Proceedings_Application%20de%20l'ana.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1917}, rating = {0} } @article{Borsboom:2002p5475, author = {D Borsboom and Gideon J Mellenbergh and van Heerden J}, journal = {Applied Psychological Measurement}, title = {Different Kinds of DIF: A Distinction Between Absolute and Relative Forms of Measurement Invariance and Bias}, abstract = {In this article, a distinction is made between absolute and relative measurement. Absolute measurement refers to the measurement of traits on a group-invariant scale, and relative measurement refers to the within-group measurement of traits, where the scale of measurement is expressed in terms of the within-group position on a trait. Relative measurement occurs, for example, if an item induces a within-group comparison in respondents. These distinctions are discussed within the framework of measurement invariance, differentiating between absolute and relative forms of measurement invariance and bias. It is shown that items for relative measurement will produce bias as classically defined if the mean and/or variance of the trait distribution differ between groups. This form of bias, however, does not result from multidimensionality but from the fact that measurement is on a relative scale. A logistic regression procedure for the detection of relative measurement invariance and bias is proposed, as well as a model that allows for the incorporation of items for relative measurement in test analysis. Implications of the distinction between absolute and relative measurement are discussed and prove to be especially relevant for the domain of personality research.}, affiliation = {Department of Psychological Methods, University of Amsterdam}, number = {4}, pages = {433--450}, volume = {26}, year = {2002}, date-added = {2010-02-12 14:17:58 +0100}, date-modified = {2010-02-12 14:24:48 +0100}, doi = {10.1177/014662102237798}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Borsboom-2002-Applied%20Psychological%20Measurement_Different%20Kinds%20of%20D.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5475}, rating = {0} } @article{Ono:1999p12130, author = {Y Ono and K Yoshimura and H Mizushima and H Manki and G Yagi and S Kanba and J Nathan and M Asai}, journal = {Psychol Rep}, title = {Environmental and possible genetic contributions to character dimensions of personality}, abstract = {The relationship between dimensions of personality characteristics and the perceived rearing attitude of parents in the Japanese population were investigated. The scores on a measure of perceived parental attitude of 153 normal female students, measured on the Parker Parental Bonding Instrument, were correlated with personality features from the Japanese version of the Cloninger Temperament and Character Inventory. Self-directedness, especially the subclasses of Responsibility vs Blaming and Congruent Second Nature vs Incongruent Habits, was significantly related to high scores on Maternal Care and low scores on Maternal Overprotection. The subscale of Self-acceptance vs Self-striving correlated only with low scores on Maternal Overprotection. Paternal Care was only related to the total scale scores on Self-directedness. Results suggest that some personality traits may be related to the perceived attitudes of parents, especially of the mother, during childhood.}, affiliation = {Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.}, number = {2}, pages = {689--96}, volume = {84}, year = {1999}, month = {Apr}, language = {eng}, keywords = {Adolescent, Environment, Parenting, Personality Development, Adult, Genetics, Female, Japan, Personality Inventory, Humans, Character}, date-added = {2010-05-30 10:18:31 +0200}, date-modified = {2010-05-30 10:18:31 +0200}, pmid = {10335084}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12130}, rating = {0} } @article{Gold:1991p5170, author = {K F Gold and B O Muth{\'e}n}, journal = {American Educational Research Association Meeting}, title = {Extensions of covariance structure analysis: Hierarchical modeling of multidimensional achievement data}, year = {1991}, date-added = {2010-02-07 12:35:31 +0100}, date-modified = {2010-07-29 19:13:13 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Gold-1991-American%20Educational%20Research%20Association%20Meeting_Extensions%20of%20covari.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5170}, rating = {0} } @misc{Zhang:1996, author = {J Zhang and D D Boos}, journal = {Miscellaneous}, title = {Generalized Cochran-Mantel-Haenszel Test Statistics for Correlated Categorical Data}, year = {1996}, date-added = {2010-01-10 11:33:09 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Zhang-1996-Miscellaneous_Generalized%20Cochran.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1873}, rating = {0} } @article{Faraone:1994p6674, author = {S V Faraone and M T Tsuang}, journal = {Am J Psychiatry}, title = {Measuring diagnostic accuracy in the absence of a "gold standard"}, abstract = {OBJECTIVE: As the nation debates issues of national health care reform, psychiatrists seek equal status with other medical colleagues. To defend psychiatry in the national arena, the accuracy of psychiatric diagnoses must be measured. Indexes of accuracy such as sensitivity and specificity provide valuable information, yet they are rarely computed because there is no "gold standard" with which to compare them. The goal of this article is to show how this problem can be overcome and to encourage nosologists to use accuracy statistics in assessing the adequacy of psychiatric diagnoses. METHOD: The authors reviewed the literature on medical decision making to find methodological approaches to assessing diagnostic accuracy in the absence of gold standards. RESULTS: A lack of such standards is not unique to psychiatry and has been addressed with a variety of novel analytic procedures. Although these methods differ in many respects, each recognizes that the conventional 2 x 2 table of interrater agreement does not provide enough data for estimating diagnostic accuracy. After defining the data needed, each method provides a mathematical model that estimates accuracy statistics and the prevalence of a disorder. Most of these methods are variants of latent class analysis. The authors reanalyzed data from one of the reviewed papers to show that similar inferences about accuracy of diagnoses could be drawn from a conventional latent class analysis. CONCLUSIONS: There are potential pitfalls in using latent structure methods, but their cautious use would provide valuable information for psychiatric nosology. These methods supplement, but do not replace, data about outcome, family history, laboratory studies, and other validating criteria in making accurate diagnoses.}, affiliation = {Harvard Institute of Psychiatric Epidemiology and Genetics, Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center, Boston.}, number = {5}, pages = {650--7}, volume = {151}, year = {1994}, month = {May}, language = {eng}, keywords = {Male, Female, Reproducibility of Results, ROC Curve, Humans, Mental Disorders, Sex Factors, Prevalence, Sensitivity and Specificity}, date-added = {2010-03-05 22:07:51 +0100}, date-modified = {2010-07-29 19:51:28 +0200}, pmid = {8166304}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6674}, rating = {0} } @article{Zhu:2006p8396, author = {Bin Zhu and Stephen D Walter and Peter L Rosenbaum and Dianne J Russell and Parminder Raina}, journal = {BMC Med Res Methodol}, title = {Structural equation and log-linear modeling: a comparison of methods in the analysis of a study on caregivers' health}, abstract = {BACKGROUND: In this paper we compare the results in an analysis of determinants of caregivers' health derived from two approaches, a structural equation model and a log-linear model, using the same data set. METHODS: The data were collected from a cross-sectional population-based sample of 468 families in Ontario, Canada who had a child with cerebral palsy (CP). The self-completed questionnaires and the home-based interviews used in this study included scales reflecting socio-economic status, child and caregiver characteristics, and the physical and psychological well-being of the caregivers. Both analytic models were used to evaluate the relationships between child behaviour, caregiving demands, coping factors, and the well-being of primary caregivers of children with CP. RESULTS: The results were compared, together with an assessment of the positive and negative aspects of each approach, including their practical and conceptual implications. CONCLUSION: No important differences were found in the substantive conclusions of the two analyses. The broad confirmation of the Structural Equation Modeling (SEM) results by the Log-linear Modeling (LLM) provided some reassurance that the SEM had been adequately specified, and that it broadly fitted the data.}, affiliation = {Centre for Clinical Epidemiology and Community Studies, Sir Mortimer B, Davis-Jewish General Hospital, Montreal, Quebec, Canada. bzhu@epid.jgh.mcgill.ca}, pages = {49}, volume = {6}, year = {2006}, month = {Jan}, language = {eng}, keywords = {Linear Models, Male, Ontario, Cross-Sectional Studies, Disabled Children, Female, Social Support, Questionnaires, Health Status, Child, Cerebral Palsy, Humans, Self Concept, Logistic Models, Family, Socioeconomic Factors, Caregivers, Adaptation: Psychological, Adult}, date-added = {2010-03-21 13:35:23 +0100}, date-modified = {2010-03-21 13:35:23 +0100}, doi = {10.1186/1471-2288-6-49}, pii = {1471-2288-6-49}, pmid = {17038188}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Zhu-2006-BMC%20Med%20Res%20Methodol_Structural%20equation.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8396}, rating = {0} } @article{Glas:1988a, author = {C A W Glas}, journal = {Journal of Educational Statistics}, title = {The Rasch model and multi-stage testing}, pages = {45--52}, volume = {13}, year = {1988}, date-added = {2010-01-10 11:33:18 +0100}, date-modified = {2010-07-29 19:33:53 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Glas-1988-Journal%20of%20Educational%20Statistics_The%20Rasch%20model%20and.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2138}, rating = {0} } @article{Cavallo:2009p6601, author = {Sabrina Cavallo and Debbie Ehrmann Feldman and Bonnie Swaine and Garbis Meshefedjian and Peter N Malleson and Ciar{\'a}n M Duffy}, journal = {Pediatric rheumatology online journal}, title = {Is parental coping associated with quality of life in juvenile idiopathic arthritis?}, abstract = {ABSTRACT: Parents of children with a chronic condition such as juvenile arthritis must cope with greater demands than those living with a healthy child. They must adopt different behaviours in order to lessen the impact on the family structure. Parental coping refers to the parent's specific cognitive and behavioural efforts to reduce or manage a demand on the family system. The aims of this study were: to describe coping in a cohort of parents of children with JIA; to determine whether quality of life is associated with parental coping; to explore whether socio-demographic factors such as child's age, family socioeconomic status and family structure are associated with parental coping. One hundred eighty-two parents caring for a child with JIA completed a postal survey at three times over a one-year period, which included the Juvenile Arthritis Quality of Life Questionnaire (JAQQ), the Coping Health Inventory for Parents (CHIP) and questionnaires describing socio-demographic characteristics. Linear mixed models were employed to analyse the association between the child's quality of life and parental coping. Mean total QoL scores (JAQQ) showed that children experienced difficulty in completing specified activities at most just below 25% of the time and results fall off slightly following the 6 month time point. Mean parental coping scores for the CHIP subscales at baseline were 38.4 +/- 9.0, 33.4 +/- 11.6, 16.5 +/- 6.1, for Maintaining Family Integration (maximum score 57), Maintaining Social Support (maximum score 54) and Understanding the Medical Situation (maximum score 24), respectively. Understanding the Medical Situation was deemed most useful. The child's QoL was associated with parental coping. Parents of children with greater psychosocial dysfunction used more coping behaviours related to Understanding the Medical Situation (beta coefficient, 0.73; 95% CI, 0.01, 1.45). These findings underscore the importance of helping parents of children with JIA better understand their child's medical situation.}, affiliation = {Ecole de R{\'e}adaptation, Facult{\'e} de M{\'e}decine, Universit{\'e} de Montr{\'e}al, the Montreal Children's Hospital, Groupe de Recherche Interdisciplinaire en Sant{\'e} and the Public Health Department, Montreal, Quebec, Canada. debbie.feldman@umontreal.ca.}, pages = {7}, volume = {7}, year = {2009}, month = {Jan}, language = {eng}, date-added = {2010-03-03 19:41:38 +0100}, date-modified = {2010-03-03 19:41:38 +0100}, doi = {10.1186/1546-0096-7-7}, pii = {1546-0096-7-7}, pmid = {19284585}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Cavallo-2009-Pediatric%20rheumatology%20online%20journal_Is%20parental%20coping%20a.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6601}, rating = {0} } @article{Zong:2010p13750, author = {Ji-Gang Zong and Xiao-Yan Cao and Yuan Cao and Yan-Fang Shi and Yu-Na Wang and Chao Yan and John Rz Abela and Yi-Qun Gan and Qi-Yong Gong and Raymond Ck Chan}, journal = {Health Qual Life Outcomes}, title = {Coping flexibility in college students with depressive symptoms}, abstract = {ABSTRACT: BACKGROUND: The current study explored the prevalence of depressed mood among Chinese undergraduate students and examined the coping patterns and degree of flexibility of flexibility of such patterns associated with such mood. METHODS: A set of questionnaire assessing coping patterns, coping flexibility, and depressive symptoms were administered to 428 students (234 men and 194 women). RESULTS: A total of 266 participants both completed the entire set of questionnaires and reported a frequency of two or more stressful life events (the criterion needed to calculate variance in perceived controllability). Findings showed that higher levels of depressive symptoms were significantly associated with higher levels of both event frequency (r = .368, p < .001) and event impact (r = .245, p < .001) and lower levels of perceived controllability (r = -.261, p < .001), coping effectiveness (r = -.375, p < .001), and ratio of strategy to situation fit (r = -.108, p < .05). Depressive symptoms were not significantly associated with cognitive flexibility (variance of perceived controllability; r = .031, p = .527), Gender was not a significant moderator of any of the reported associations. CONCLUSIONS: Findings indicate that Chinese university students with depressive symptoms reported experiencing a greater number of negative events than did non-depressed university students. In addition, undergraduates with depressive symptoms were more likely than other undergraduates to utilize maladaptive coping methods. Such findings highlight the potential importance of interventions aimed at helping undergraduate students with a lower coping flexibility develop skills to cope with stressful life events.}, number = {1}, pages = {66}, volume = {8}, year = {2010}, month = {Jul}, language = {ENG}, date-added = {2010-07-24 12:42:20 +0200}, date-modified = {2010-07-24 12:42:21 +0200}, doi = {10.1186/1477-7525-8-66}, pii = {1477-7525-8-66}, pmid = {20626865}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Zong-2010-Health%20and%20Quality%20of%20Life%20Outcomes_Coping%20flexibility%20i-1.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13750}, rating = {0} } @article{Holte:1993p2806, author = {R C Holte}, journal = {Machine Learning}, title = {Very Simple Classification Rules Perform Well on Most Commonly Used Datasets}, pages = {63--91}, volume = {11}, year = {1993}, date-added = {2010-01-13 14:50:43 +0100}, date-modified = {2010-01-13 14:51:26 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Holte-1993-Machine%20Learning_Very%20Simple%20Classifi.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2806}, rating = {0} } @article{Levy:2009p14059, author = {Yonata Levy and Richard P Ebstein}, journal = {J Child Psychol Psychiatry}, title = {Research review: crossing syndrome boundaries in the search for brain endophenotypes}, abstract = {The inherent imprecision of behavioral phenotyping is the single most important factor contributing to the failure to discover the biological factors that are involved in psychiatric and neurodevelopmental disorders (e.g., Bearden {\&} Freimer, 2006). In this review article we argue that in addition to an appreciation of the inherent complexity at the biological level, a rather urgent task facing behavioral scientists involves a reconsideration of the role that clinical syndromes play in psychological theorizing, as well as in research into the biological basis of cognition and personality. Syndrome heterogeneity, cross-syndrome similarities and syndrome comorbidities question the relevance of syndromes to biological research. It is suggested that the search for brain endophenotypes, intermediate between genes and behavior, should be based on cross-syndrome, trait classification. Cohort selection should rest on behavioral homogeneity, enabling, when necessary, syndrome heterogeneity.}, affiliation = {Psychology Department, Hebrew University, Jerusalem, Israel. msyonata@huji.ac.il}, number = {6}, pages = {657--68}, volume = {50}, year = {2009}, month = {Jun}, language = {eng}, keywords = {Personality Disorders, Comorbidity, Syndrome, Genotype, Cognition Disorders, Developmental Disabilities, Child, Autistic Disorder, Brain, Attention Deficit Disorder with Hyperactivity, Phenotype, Humans, Language Disorders}, date-added = {2010-08-18 10:08:21 +0200}, date-modified = {2010-08-18 10:08:21 +0200}, doi = {10.1111/j.1469-7610.2008.01986.x}, pii = {JCPP1986}, pmid = {19175806}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Levy-2009-J%20Child%20Psychol%20Psychiatry_Research%20review%20cro.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p14059}, rating = {0} } @article{Wu:2009p1485, author = {Zhijin Wu}, journal = {Stat Methods Med Res}, title = {A review of statistical methods for preprocessing oligonucleotide microarrays}, abstract = {Microarrays have become an indispensable tool in biomedical research. This powerful technology not only makes it possible to quantify a large number of nucleic acid molecules simultaneously, but also produces data with many sources of noise. A number of preprocessing steps are therefore necessary to convert the raw data, usually in the form of hybridisation images, to measures of biological meaning that can be used in further statistical analysis. Preprocessing of oligonucleotide arrays includes image processing, background adjustment, data normalisation/transformation and sometimes summarisation when multiple probes are used to target one genomic unit. In this article, we review the issues encountered in each preprocessing step and introduce the statistical models and methods in preprocessing.}, affiliation = {Center for Statistical Sciences and Department of Community Health, Brown University, RI 02912, USA. zhijin_wu@brown.edu}, number = {6}, pages = {533--41}, volume = {18}, year = {2009}, month = {Dec}, language = {eng}, date-added = {2010-01-07 12:25:42 +0100}, date-modified = {2010-01-07 12:25:42 +0100}, doi = {10.1177/0962280209351924}, pii = {18/6/533}, pmid = {20048383}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Wu-2009-Stat%20Methods%20Med%20Res_A%20review%20of%20statisti.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1485}, rating = {0} } @article{Yuan:2009p7376, author = {Yuhong Yuan and Richard H Hunt}, journal = {Am J Gastroenterol}, title = {Systematic reviews: the good, the bad, and the ugly}, abstract = {Systematic reviews systematically evaluate and summarize current knowledge and have many advantages over narrative reviews. Meta-analyses provide a more reliable and enhanced precision of effect estimate than do individual studies. Systematic reviews are invaluable for defining the methods used in subsequent studies, but, as retrospective research projects, they are subject to bias. Rigorous research methods are essential, and the quality depends on the extent to which scientific review methods are used. Systematic reviews can be misleading, unhelpful, or even harmful when data are inappropriately handled; meta-analyses can be misused when the difference between a patient seen in the clinic and those included in the meta-analysis is not considered. Furthermore, systematic reviews cannot answer all clinically relevant questions, and their conclusions may be difficult to incorporate into practice. They should be reviewed on an ongoing basis. As clinicians, we need proper methodological training to perform good systematic reviews and must ask the appropriate questions before we can properly interpret such a review and apply its conclusions to our patients. This paper aims to assist in the reading of a systematic review.}, affiliation = {Division of Gastroenterology, Department of Medicine, McMaster University Health Science Centre, Hamilton, Ontario, Canada.}, number = {5}, pages = {1086--92}, volume = {104}, year = {2009}, month = {May}, language = {eng}, keywords = {Review Literature as Topic, Research Design, Randomized Controlled Trials as Topic, Gastroenterology, Reproducibility of Results, Female, Humans, Bias (Epidemiology), Male, Sensitivity and Specificity, Evidence-Based Medicine, Meta-Analysis as Topic}, date-added = {2010-03-10 20:34:32 +0100}, date-modified = {2010-03-10 20:34:32 +0100}, doi = {10.1038/ajg.2009.118}, pii = {ajg2009118}, pmid = {19417748}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7376}, rating = {0} } @article{Ziegenhagen:2007p10908, author = {U Ziegenhagen}, journal = {The PracTEX Journal}, title = {LATEX Document Management with Subversion}, abstract = {From the single-author composition of a Bachelor thesis to the creation of a book by a team there are many occasions, where version management of a document may be helpful. With the aim of overcoming the shortcomings of CVS (Concurrent Version System) the Subversion version control system was implemented. In this article I will describe the Subversion setup on Windows and Linux systems, the elementary steps of document management and various LATEX packages working hand in hand with Subversion.}, volume = {3}, year = {2007}, date-added = {2010-04-11 21:27:03 +0200}, date-modified = {2010-07-29 19:52:56 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Ziegenhagen-2007-The%20PracTEX%20Journal_LATEX%20Document%20Manag.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p10908}, rating = {0} } @article{Janes:2008p5209, author = {Holly Janes and Margaret S Pepe}, journal = {Am J Epidemiol}, title = {Adjusting for covariates in studies of diagnostic, screening, or prognostic markers: an old concept in a new setting}, abstract = {The concept of covariate adjustment is well established in therapeutic and etiologic studies. However, it has received little attention in the growing area of medical research devoted to the development of markers for disease diagnosis, screening, or prognosis, where classification accuracy, rather than association, is of primary interest. In this paper, the authors demonstrate the need for covariate adjustment in studies of classification accuracy, discuss methods for adjusting for covariates, and distinguish covariate adjustment from several other related, but fundamentally different, uses for covariates. They draw analogies and contrasts throughout with studies of association.}, affiliation = {Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. hjanes@scharp.org}, number = {1}, pages = {89--97}, volume = {168}, year = {2008}, month = {Jul}, language = {eng}, keywords = {Tumor Markers: Biological, Randomized Controlled Trials as Topic, Prostatic Neoplasms, Humans, Sensitivity and Specificity, Prostate-Specific Antigen, Epidemiologic Methods, ROC Curve, Middle Aged, Aged, Male}, date-added = {2010-02-08 19:26:23 +0100}, date-modified = {2010-02-08 19:26:23 +0100}, doi = {10.1093/aje/kwn099}, pii = {kwn099}, pmid = {18477651}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Janes-2008-Am%20J%20Epidemiol_Adjusting%20for%20covari.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5209}, rating = {0} } @article{Yuan:2009p12319, author = {X Yuan}, journal = {20th International Symposium of Mathematical Program- ming}, title = {Alternating direction methods for sparse covariance selection}, abstract = {The mathematical model of the widely-used sparse covariance selection problem (SCSP) is an NP-hard combinatorial problem, whereas it can be well approximately by a convex relaxation problem whose maximum likelihood estimation is penalized by the L1 norm. This convex relaxation problem, however, is still numerically challenging, especially for large-scale cases. Recently, some efficient first-order methods inspired by Nesterov's work have been proposed to solve the convex relaxation problem of SCSP. This paper is to apply the well-known alternating direction method (ADM), which is also a first-order method, to solve the convex relaxation of SCSP. Due to the full exploitation to the separable structure of a simple reformulation of the convex relaxation problem, the ADM approach is very efficient for solving large-scale SCSP. Our preliminary numerical results show that the ADM approach substantially outperforms existing first-order methods for SCSP.}, year = {2009}, date-added = {2010-06-12 09:37:43 +0200}, date-modified = {2010-06-12 09:38:27 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Yuan-2009-20th%20International%20Symposium%20of%20Mathematical%20Program-%20ming_Alternating%20directio.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12319}, rating = {0} } @article{Stephenson:2006p5654, author = {Michael T Stephenson and R Lance Holbert and Rick S Zimmerman}, journal = {Health Commun}, title = {On the use of structural equation modeling in health communication research}, abstract = {Structural equation modeling (SEM) is a multivariate technique suited for testing proposed relations between variables. In this article, the authors discuss the potential for SEM as a tool to advance health communication research both statistically and conceptually. Specifically, the authors discuss the advantages that latent variable modeling in SEM affords researchers by extracting measurement error. In addition, they argue that SEM is useful in understanding communication as a complex set of relations between variables. Moreover, the authors articulate the possibility for examining communication as an agent, mediator, and an outcome. Finally, they review the application of SEM to recursive models, interactions, and confirmatory factor analysis.}, affiliation = {Department of Communication, Texas A{\&}M University, College Station, 77843-4234, USA. mstephenson@tamu.edu}, number = {2}, pages = {159--67}, volume = {20}, year = {2006}, month = {Jan}, language = {eng}, keywords = {Research Design, Humans, Factor Analysis: Statistical, Models: Statistical, Health Education, Communication}, date-added = {2010-02-12 20:20:16 +0100}, date-modified = {2010-02-12 20:20:17 +0100}, doi = {10.1207/s15327027hc2002_7}, pmid = {16965253}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Stephenson-2006-Health%20Commun_On%20the%20use%20of%20struct.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5654}, rating = {0} } @article{Biau:2008p13231, author = {G Biau and L Devroye and G Lugosi}, journal = {Journal of Machine Learning}, title = {Consistency of Random Forests and Other Averaging Classifiers}, abstract = {In the last years of his life, Leo Breiman promoted random forests for use in classification. He suggested using averaging as a means of obtaining good discrimination rules. The base classifiers used for averaging are simple and randomized, often based on random samples from the data. He left a few questions unanswered regarding the consistency of such rules. In this paper, we give a number of theorems that establish the universal consistency of averaging rules. We also show that some popular classifiers, including one suggested by Breiman, are not universally consistent.}, pages = {2015--2033}, volume = {9}, year = {2008}, date-added = {2010-07-01 17:26:53 +0200}, date-modified = {2010-07-29 19:34:45 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Biau-2008-Journal%20of%20Machine%20Learning_Consistency%20of%20Rando.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13231}, rating = {0} } @article{Randi:2010p6031, author = {Judi Randi and Tina Newman and Elena L Grigorenko}, journal = {J Autism Dev Disord}, title = {Teaching Children with Autism to Read for Meaning: Challenges and Possibilities}, abstract = {The purpose of this literature review is to examine what makes reading for understanding especially challenging for children on the autism spectrum, most of whom are skilled at decoding and less skilled at comprehension. This paper first summarizes the research on reading comprehension with a focus on the cognitive skills and processes that are involved in gaining meaning from text and then reviews studies of reading comprehension deficits in children on the spectrum. The paper concludes with a review of reading comprehension interventions for children on the spectrum. These children can especially benefit from interventions addressing particular cognitive processes, such as locating antecedent events, generating and answering questions, locating referents, and rereading to repair understanding.}, affiliation = {University of New Haven, West Haven, CT, USA.}, pages = {}, year = {2010}, month = {Jan}, language = {ENG}, date-added = {2010-02-19 17:00:11 +0100}, date-modified = {2010-02-19 17:00:11 +0100}, doi = {10.1007/s10803-010-0938-6}, pmid = {20101452}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6031}, rating = {0} } @article{Michaelides:2008p3062, author = {M P Michaelides}, journal = {Practical Assessment Research \{\&} Evaluation}, title = {An Illustration of a Mantel-Haenszel Procedure to Flag Misbehaving Common Items in Test Equating}, abstract = {In this study the Mantel-Haenszel procedure, widely used in studies for identifying differential item functioning, is proposed as an alternative to the delta-plot method and applied in a test-equating context for flagging common items that behave differentially across cohorts of examinees. The Mantel-Haenszel procedure has the advantage of conditioning on ability when making comparisons of performance of two examinee groups on an item. There are schemes for interpreting the effect size of differential performance, which can inform the decision as to whether to retain those items in the common-item pool, or to discard them. Data from a statewide assessment are analyzed to illustrate the use of this procedure. Advantages of this methodology are discussed and limitations regarding test design that may make its application difficult are described.}, number = {7}, volume = {13}, year = {2008}, date-added = {2010-01-14 11:28:22 +0100}, date-modified = {2010-07-29 19:44:42 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Michaelides-2008-Practical%20Assessment%20Research%20%20&%20Evaluation_An%20Illustration%20of%20a.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3062}, rating = {0} } @article{Odent:2010p7675, author = {Michel Odent}, journal = {Med Hypotheses}, title = {Attention deficit hyperactivity disorder (ADHD) and obesity: two facets of the same disease?}, abstract = {We hypothesize that when two pathological conditions or personality traits share the same critical period for gene-environment interaction, we should expect further similarities, particularly from clinical and pathophysiological perspectives. They should therefore be considered as two facets of the same disease. To test this hypothesis we compiled data included in the Primal Health Research Database. This database (www.primalhealthresearch.com) is specialised in studies exploring correlations between what happens during the 'primal period' (fetal life, perinatal period and year following birth) and what happens later on in life in terms of health and personality traits. After mentioning the links between autism and anorexia nervosa, we explore more in depth the links between attention deficit hyperactivity disorder (ADHD) and obesity. We suggest from such examples that the nature of an environmental factor is often less important than the timing of the interaction. We conclude that the concept of gene expression, combined with Primal Health Research, might lead to reconsider conventional nosological classifications. Some previously well-defined pathological entities should be included into the framework of multifaceted diseases. On the other hand some existing pathological entities should be dismantled.}, affiliation = {Primal Health Research Centre, 72 Savernake Road, London NW3 2JR, UK. modent@aol.com}, number = {1}, pages = {139--41}, volume = {74}, year = {2010}, month = {Jan}, language = {eng}, date-added = {2010-03-15 23:48:13 +0100}, date-modified = {2010-03-15 23:48:13 +0100}, doi = {10.1016/j.mehy.2009.07.020}, pii = {S0306-9877(09)00510-6}, pmid = {19665851}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7675}, rating = {0} } @article{Dowell:2010p11483, author = {Robin D Dowell and Owen Ryan and An Jansen and Doris Cheung and Sudeep Agarwala and Timothy Danford and Douglas A Bernstein and P Alexander Rolfe and Lawrence E Heisler and Brian Chin and Corey Nislow and Guri Giaever and Patrick C Phillips and Gerald R Fink and David K Gifford and Charles Boone}, journal = {Science}, title = {Genotype to phenotype: a complex problem}, abstract = {We generated a high-resolution whole-genome sequence and individually deleted 5100 genes in Sigma1278b, a Saccharomyces cerevisiae strain closely related to reference strain S288c. Similar to the variation between human individuals, Sigma1278b and S288c average 3.2 single-nucleotide polymorphisms per kilobase. A genome-wide comparison of deletion mutant phenotypes identified a subset of genes that were conditionally essential by strain, including 44 essential genes unique to Sigma1278b and 13 unique to S288c. Genetic analysis indicates the conditional phenotype was most often governed by complex genetic interactions, depending on multiple background-specific modifiers. Our comprehensive analysis suggests that the presence of a complex set of modifiers will often underlie the phenotypic differences between individuals.}, affiliation = {Computer Science and Artificial Intelligence Laboratory, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.}, number = {5977}, pages = {469}, volume = {328}, year = {2010}, month = {Apr}, language = {eng}, date-added = {2010-05-01 17:27:19 +0200}, date-modified = {2010-07-29 19:50:10 +0200}, doi = {10.1126/science.1189015}, pii = {328/5977/469}, pmid = {20413493}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Dowell-2010-Science_Genotype%20to%20phenotyp.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11483}, rating = {0} } @article{Haley:2006p7365, author = {Stephen M Haley and Pengsheng Ni and Ronald K Hambleton and Mary D Slavin and Alan M Jette}, journal = {Journal of Clinical Epidemiology}, title = {Computer adaptive testing improved accuracy and precision of scores over random item selection in a physical functioning item bank}, abstract = {BACKGROUND AND OBJECTIVE: Measuring physical functioning (PF) within and across postacute settings is critical for monitoring outcomes of rehabilitation; however, most current instruments lack sufficient breadth and feasibility for widespread use. Computer adaptive testing (CAT), in which item selection is tailored to the individual patient, holds promise for reducing response burden, yet maintaining measurement precision. We calibrated a PF item bank via item response theory (IRT), administered items with a post hoc CAT design, and determined whether CAT would improve accuracy and precision of score estimates over random item selection. METHODS: 1,041 adults were interviewed during postacute care rehabilitation episodes in either hospital or community settings. Responses for 124 PF items were calibrated using IRT methods to create a PF item bank. We examined the accuracy and precision of CAT-based scores compared to a random selection of items. RESULTS: CAT-based scores had higher correlations with the IRT-criterion scores, especially with short tests, and resulted in narrower confidence intervals than scores based on a random selection of items; gains, as expected, were especially large for low and high performing adults. CONCLUSION: The CAT design may have important precision and efficiency advantages for point-of-care functional assessment in rehabilitation practice settings.}, affiliation = {Department of Rehabilitation Sciences, Sargent College of Health and Rehabilitation Sciences, Boston University, 635 Commanwealth Ave, Boston, MA 02215, USA. smhaley@bu.edu}, number = {11}, pages = {1174--82}, volume = {59}, year = {2006}, month = {Nov}, language = {eng}, keywords = {Aged: 80 and over, Confidence Intervals, Reproducibility of Results, Activities of Daily Living, Software, Female, Adult, Humans, Recovery of Function, Adolescent, Male, Rehabilitation, Factor Analysis: Statistical, Aged, Middle Aged, Outcome Assessment (Health Care)}, date-added = {2010-03-10 20:30:58 +0100}, date-modified = {2010-03-10 20:30:58 +0100}, doi = {10.1016/j.jclinepi.2006.02.010}, pii = {S0895-4356(06)00112-0}, pmid = {17027428}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Haley-2006-Journal%20of%20Clinical%20Epidemiology_Computer%20adaptive%20te.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7365}, rating = {0} } @article{Yao:2008p13193, author = {Jianchao Yao and Chunqi Chang and Mari L Salmi and Yeung Sam Hung and Ann Loraine and Stanley J Roux}, journal = {BMC Bioinformatics}, title = {Genome-scale cluster analysis of replicated microarrays using shrinkage correlation coefficient}, abstract = {BACKGROUND: Currently, clustering with some form of correlation coefficient as the gene similarity metric has become a popular method for profiling genomic data. The Pearson correlation coefficient and the standard deviation (SD)-weighted correlation coefficient are the two most widely-used correlations as the similarity metrics in clustering microarray data. However, these two correlations are not optimal for analyzing replicated microarray data generated by most laboratories. An effective correlation coefficient is needed to provide statistically sufficient analysis of replicated microarray data. RESULTS: In this study, we describe a novel correlation coefficient, shrinkage correlation coefficient (SCC), that fully exploits the similarity between the replicated microarray experimental samples. The methodology considers both the number of replicates and the variance within each experimental group in clustering expression data, and provides a robust statistical estimation of the error of replicated microarray data. The value of SCC is revealed by its comparison with two other correlation coefficients that are currently the most widely-used (Pearson correlation coefficient and SD-weighted correlation coefficient) using statistical measures on both synthetic expression data as well as real gene expression data from Saccharomyces cerevisiae. Two leading clustering methods, hierarchical and k-means clustering were applied for the comparison. The comparison indicated that using SCC achieves better clustering performance. Applying SCC-based hierarchical clustering to the replicated microarray data obtained from germinating spores of the fern Ceratopteris richardii, we discovered two clusters of genes with shared expression patterns during spore germination. Functional analysis suggested that some of the genetic mechanisms that control germination in such diverse plant lineages as mosses and angiosperms are also conserved among ferns. CONCLUSION: This study shows that SCC is an alternative to the Pearson correlation coefficient and the SD-weighted correlation coefficient, and is particularly useful for clustering replicated microarray data. This computational approach should be generally useful for proteomic data or other high-throughput analysis methodology.}, affiliation = {Institute for Cellular and Molecular Biology and Department of Mathematics, University of Texas at Austin, Austin, Texas 78712, USA. jcyao@mail.utexas.edu}, pages = {288}, volume = {9}, year = {2008}, month = {Jan}, language = {eng}, keywords = {Genomics, Germination, Confidence Intervals, Probability, Computer Simulation, Pteridaceae, Oligonucleotide Array Sequence Analysis, Research Design, Saccharomyces cerevisiae, Cluster Analysis, Gene Expression, Computational Biology, Gene Expression Profiling, Artificial Intelligence}, date-added = {2010-07-01 15:27:54 +0200}, date-modified = {2010-07-01 15:27:54 +0200}, doi = {10.1186/1471-2105-9-288}, pii = {1471-2105-9-288}, pmid = {18564431}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Yao-2008-BMC%20Bioinformatics_Genome-scale%20cluster.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13193}, rating = {0} } @article{Balbi:2006p12033, author = {S Balbi and M Misuraca}, journal = {8emes Journ{\'e}es internationales d'Analyse statistique des Donn{\'e}es Textuelles}, title = {Rotated Canonical Correlation Analysis for Multilingual Corpora}, abstract = {This paper aims at proposing the joint use of Canonical Correlation Analysis and Procrustes Rotations (RCA), when we deal with a text and its translation into another language. The basic idea is representing words in the two different natural languages on a common reference space. The main characteristic of this space is to be lan- guage independent, although Procrustes Rotation is performed transforming the lexical table derived from trans- lation by minimizing its distance from the lexical table belonging to the original corpus, while the subsequent Canonical Correlation Analysis treats symmetrically the two word sets. The most interesting RCA feature is building a unique reference space for representing the correlation structure in the data, inducing the two systems of canonical factors to lie on the same space. These graphical representations enables us to read distances be- tween corresponding points in terms of different way of translating the same word in relation with the general context defined by the canonical variates. Trying to understand the distances between matched points could rep- resent an useful tool for enriching lexical resources in a translation procedure. In this paper we propose the com- parison of the most frequent content bearing words in the two languages, analyzing one year (2003) of Le Monde Diplomatique and its Italian edition.}, year = {2006}, date-added = {2010-05-24 10:28:39 +0200}, date-modified = {2010-05-24 10:29:21 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Balbi-2006-8emes%20Journe%CC%81es%20internationales%20d%E2%80%99Analyse%20statistique%20des%20Donne%CC%81es%20Textuelles_Rotated%20Canonical%20Co.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12033}, rating = {0} } @article{Mathers:2004p13489, author = {William D Mathers and Dongseok Choi}, journal = {Arch Ophthalmol}, title = {Cluster analysis of patients with ocular surface disease, blepharitis, and dry eye}, abstract = {OBJECTIVE: To develop a classification system for blepharitis and dry eye based on a classification-tree model of a large group of subjects who were given a variety of objective physiologic tests. METHODS: We evaluated 513 subjects, some healthy and some with blepharitis and dry eye,with tests for tear volume, tear flow, and tear turnover and the Schirmer test for dry eye. Meibomian gland function was evaluated by meibomian gland lipid expression for lipid volume and lipid viscosity, evaporation, and eyelid transillumination for meibomian gland drop out. We subjected these data to cluster analysis and formulated a classification tree. MAIN OUTCOME MEASURE: The outcome measure of this study was the statistically valid groups of subjects with and without ocular surface symptoms identified by their physiologic characteristics. RESULTS: Cluster analysis most successfully grouped subjects by initially dividing them into 2 groups based on the presence or absence of gland drop out and then by lipid viscosity and volume, Schirmer test results, and evaporation. The analysis created 9 categories. This division created an objective classification system that was found to have clinical relevance. Normal subjects were distributed across several groups. CONCLUSIONS: Using a classification tree, blepharitis and dry eye can be classified with objective physiologic tests into clinically relevant groups that have common characteristics. The analysis establishes the central role of meibomian gland dysfunction in blepharitis and demonstrates the diverse characteristics of the normal population.}, affiliation = {Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland 97201, USA. mathersw@ohsu.edu}, number = {11}, pages = {1700--4}, volume = {122}, year = {2004}, month = {Nov}, language = {eng}, keywords = {Meibomian Glands, Middle Aged, Humans, Fluorophotometry, Eyelid Diseases, Dry Eye Syndromes, Adult, Blepharitis, Osmolar Concentration, Decision Trees, Male, Tears, Female, Cluster Analysis}, date-added = {2010-07-01 22:23:51 +0200}, date-modified = {2010-07-01 22:23:51 +0200}, doi = {10.1001/archopht.122.11.1700}, pii = {122/11/1700}, pmid = {15534133}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Mathers-2004-Arch%20Ophthalmol_Cluster%20analysis%20of.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13489}, rating = {0} } @article{Thompson:2008p3528, author = {G L Thompson}, journal = {Tutorial in Quantitative Methods for Psychology}, title = {Eliminating Aggregation Bias in Experimental Research: Random Coefficient Analysis as an Alternative to Performing a `by‐subjects' and/or `by‐items' ANOVA}, abstract = {Experimental psychologists routinely simplify the structure of their data by computing means for each experimental condition so that the basic assumptions of regression/ANOVA are satisfied. Typically, these means represent the performance (e.g. reaction time or RT) of a participant over several items that share some target characteristic (e.g. Mean RT for high‐frequency words). Regrettably, analyses based on such aggregated data are biased toward rejection of the null hypothesis, inflating Type‐I error beyond the nominal level. A preferable strategy for analyzing such data is random coefficient analysis (RCA), which can be performed using a simple method proposed by Lorch {\&} Myers (1990). An easy to use SPSS implementation of this method is presented using a concrete example. In addition, a technique for evaluating the magnitude of potential aggregation bias in a dataset is demonstrated. Finally, suggestions are offered concerning the reporting of RCA results in empirical articles.}, number = {1}, pages = {21--34}, volume = {4}, year = {2008}, date-added = {2010-01-15 15:53:05 +0100}, date-modified = {2010-07-29 19:54:44 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Thompson-2008-Tutorial%20in%20Quantitative%20Methods%20for%20Psychology_Eliminating%20Aggregat.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3528}, rating = {0} } @article{Rinaldo:2010p12315, author = {A Rinaldo}, title = {Properties and Refinements of The Fused Lasso}, abstract = {We consider estimating an unknown signal, which is both blocky and sparse, corrupted by additive noise. We study three interrelated least squares procedures and their asymptotic properties. The first procedure is the fused lasso, put forward by Friedman et al. (2007), which we modify into a different estimator, called the fused adaptive lasso, with better properties. The other two estimators we discuss solve least squares problems on sieves, one constraining the maximal l1 norm and the maximal total variation seminorm, the other restricting the number of blocks and the number of of nonzero coordinates of the signal. We derive conditions for the recovery of the true block partition and the true sparsity patterns by the fused lasso and the fused adaptive lasso, and convergence rates for the sieve estimators, explicitly in terms of the constraining parameters.}, date-added = {2010-06-12 09:34:21 +0200}, date-modified = {2010-06-12 09:35:03 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Rinaldo--_Properties%20and%20Refin.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12315}, rating = {0} } @article{Danoff:2006p4541, author = {Ann Danoff and Oona Khan and David W Wan and Lainie Hurst and Daniel Cohen and Craig T Tenner and Edmund J Bini}, journal = {Am J Gastroenterol}, title = {Sexual dysfunction is highly prevalent among men with chronic hepatitis C virus infection and negatively impacts health-related quality of life}, abstract = {OBJECTIVES: Although sexual dysfunction has been reported in patients with hepatitis C virus (HCV) infection, little is known about this association. The aims of this study were to determine the prevalence of sexual dysfunction among men with chronic HCV infection and to evaluate the impact of sexual dysfunction on health-related quality of life (HRQOL). METHODS: We prospectively enrolled 112 HCV positive men and 239 HCV negative controls, and all patients completed validated questionnaires to assess sexual function (Brief Male Sexual Function Inventory [BMSFI]), depression (Beck Depression Inventory), and HRQOL (Medical Outcomes Study Short Form-36). The BMSFI assessed sexual drive, erection, ejaculation, sexual problem assessment, and overall sexual satisfaction. RESULTS: HCV positive men had significantly more sexual dysfunction than control subjects across all five domains of the BMFSI. In addition, HCV-infected men were significantly more likely than controls to not be sexually satisfied (53.6% vs 28.9%, p<0.001) and this remained statistically significant after adjusting for age, race, and other potential confounding variables (OR=3.36; 95% CI, 1.59-7.13). In the 241 individuals without depression, HCV positive men were significantly more likely to not be sexually satisfied as compared with control subjects (47.5% vs 11.0%, p<0.001). HCV-infected men who were not sexually satisfied scored significantly worse in six of eight domains of HRQOL as compared with HCV-infected men who were sexually satisfied. CONCLUSIONS: Sexual dysfunction is highly prevalent in men with chronic HCV infection, is independent of depression, and is associated with a marked reduction in HRQOL.}, affiliation = {Division of Endocrinology, VA New York Harbor Healthcare System, and NYU School of Medicine, New York, New York 10010, USA.}, number = {6}, pages = {1235--43}, volume = {101}, year = {2006}, month = {Jun}, language = {eng}, keywords = {Hepatitis C: Chronic, Male, Logistic Models, Prospective Studies, Sexual Dysfunction: Physiological, Questionnaires, Aged, Humans, Prevalence, Chi-Square Distribution, Depression, Sexual Dysfunctions: Psychological, Middle Aged, Quality of Life, Statistics: Nonparametric}, date-added = {2010-01-29 22:29:45 +0100}, date-modified = {2010-01-29 22:29:45 +0100}, doi = {10.1111/j.1572-0241.2006.00544.x}, pii = {AJG544}, pmid = {16771944}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p4541}, rating = {0} } @article{Lenroot:2009p5757, author = {Rhoshel K Lenroot and James E Schmitt and Sarah J Ordaz and Gregory L Wallace and Michael C Neale and Jason P Lerch and Kenneth S Kendler and Alan C Evans and Jay N Giedd}, journal = {Hum Brain Mapp}, title = {Differences in genetic and environmental influences on the human cerebral cortex associated with development during childhood and adolescence}, abstract = {In this report, we present the first regional quantitative analysis of age-related differences in the heritability of cortical thickness using anatomic MRI with a large pediatric sample of twins, twin siblings, and singletons (n = 600, mean age 11.1 years, range 5-19). Regions of primary sensory and motor cortex, which develop earlier, both phylogenetically and ontologically, show relatively greater genetic effects earlier in childhood. Later developing regions within the dorsal prefrontal cortex and temporal lobes conversely show increasingly prominent genetic effects with maturation. The observation that regions associated with complex cognitive processes such as language, tool use, and executive function are more heritable in adolescents than children is consistent with previous studies showing that IQ becomes increasingly heritable with maturity(Plomin et al. 1997: Psychol Sci 8:442-447). These results suggest that both the specific cortical region and the age of the population should be taken into account when using cortical thickness as an intermediate phenotype to link genes, environment, and behavior.}, affiliation = {Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-9692, USA. lenrootr@mail.nih.gov}, number = {1}, pages = {163--74}, volume = {30}, year = {2009}, month = {Jan}, language = {eng}, keywords = {Cognition, Gene Expression Regulation: Developmental, Age Factors, Aging, Temporal Lobe, Female, Somatosensory Cortex, Intelligence, Humans, Magnetic Resonance Imaging, Child: Preschool, Prefrontal Cortex, Male, Young Adult, Child, Inheritance Patterns, Adolescent, Motor Cortex, Environment, Cerebral Cortex, Phenotype}, date-added = {2010-02-15 20:29:49 +0100}, date-modified = {2010-02-15 20:29:49 +0100}, doi = {10.1002/hbm.20494}, pmid = {18041741}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5757}, rating = {0} } @article{Bechger:2001p14009, author = {Timo M Bechger and Wies Akkermans}, journal = {Psychometrika}, title = {A note on the equivalence of the graded response model and the sequential model}, number = {3}, pages = {461--464}, volume = {66}, year = {2001}, date-added = {2010-08-04 09:34:29 +0200}, date-modified = {2010-08-04 09:35:42 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Bechger-2001-Psychometrika_A%20note%20on%20the%20equiva.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p14009}, rating = {0} } @article{Rueda:2008p2976, author = {O M Rueda and R Diaz-Uriarte}, journal = {COBRA Preprint Series}, title = {Finding Recurrent Regions of Copy Number Variation: A Review}, abstract = {Copy number variation (CNV) in genomic DNA is linked to a variety of human diseases, and array-based CGH (aCGH) is currently the main technology to lo- cate CNVs. Although many methods have been developed to analyze aCGH from a single array/subject, disease-critical genes are more likely to be found in regions that are common or recurrent among subjects. Unfortunately, finding recurrent CNV regions remains a challenge. We review existing methods for the identifi- cation of recurrent CNV regions. The working definition of ``common'' or ``recurrent'' region differs between methods, leading to approaches that use different types of input (discretized output from a previous CGH segmentation analysis or intensity ratios), or that incorporate to varied degrees biological considerations (which play a role in the identification of ``interesting'' regions and in the details of null models used to assess statistical significance). Very few approaches use and/or return probabilities, and code is not easily available for several methods. We suggest that finding recurrent CNVs could benefit from reframing the problem in a biclustering context. We also emphasize that, when analyzing data from complex diseases with significant among-subject heterogeneity, methods should be able to identify CNVs that affect only a subset of subjects. We make some recommendations about choice among existing methods, and we suggest further methodological research.}, number = {42}, year = {2008}, date-added = {2010-01-13 23:07:39 +0100}, date-modified = {2010-01-13 23:08:40 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Rueda-2008-COBRA%20Preprint%20Series_Finding%20Recurrent%20Re.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2976}, rating = {0} } @article{Stojanovski:2010p5657, author = {E Stojanovski and K Mengersen}, title = {Bayesian Structural Equation Models: A Health Application}, date-added = {2010-02-12 20:21:28 +0100}, date-modified = {2010-06-24 12:35:44 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Stojanovski--_Bayesian%20Structural.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5657}, read = {Yes}, rating = {0} } @article{Williams:1994p6828, author = {L J Williams and P J Holahan}, journal = {Structural Equation Modeling}, title = {Parsimony-based fit indices for multiple-indicator models: Do they work?}, number = {2}, pages = {161--189}, volume = {1}, year = {1994}, date-added = {2010-03-05 22:33:16 +0100}, date-modified = {2010-07-29 19:51:13 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Williams-1994-Structural%20Equation%20Modeling_Parsimony-based%20fit.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6828}, rating = {0} } @article{Reverter:1997p7855, author = {A Reverter and C J Kaiser}, journal = {J Anim Sci}, title = {The role of different pedigree structures on the sampling variance of heritability estimates}, abstract = {A computer-intensive process was performed to simulate 12,600 data sets each with n = 5,000 individuals from distinct pedigree structures to assess the effect of pedigree information on the sampling variance of heritability (h2) estimates. Pedigree structures were determined by varying the proportion of foundation animals (PF), percentage replacement rates for males (RM) and females (RF), and ratio of females to male (F2M). A 2(3) factorial design was modeled; levels of RM and RF were 10 and 20%, and levels of F2M were 10 and 20. For each of the eight cells, 60 foundation animals were simulated, each with 10 replicates. The required mating seasons (MS) to obtain the number of individuals was simulated based on PF and F2M. A REML algorithm was used to estimate h2 and its associated SE. The effect of all factors was analyzed in a regression model with linear and quadratic components for PF. An alternative model with MS replacing PF was also investigated. There was a non-monotonic association (P < .01) between PF and h2 SE. The minimum h2 SE occurred when PF ranged from 20 to 40%. Here, the proportion of first-generation progeny was near its maximum with rapid increases in the proportion of subsequent descendants. Among the class effects, F2M yielded the highest mean square (P < .001). When considering more than one MS, h2 SE was positively associated (P < .01) with RF and F2M and negatively associated with RM. Results suggest that h2 is most accurately estimated when there is performance information on many animals closely related to foundation animals.}, affiliation = {Animal Genetics and Breeding Unit, University of New England, Armidale, NSW, Australia.}, number = {9}, pages = {2355--61}, volume = {75}, year = {1997}, month = {Sep}, language = {eng}, keywords = {Male, Seasons, Models: Genetic, Models: Statistical, Computer Simulation, Pedigree, Animals, Female, Genetic Variation, Algorithms, Breeding}, date-added = {2010-03-17 21:02:20 +0100}, date-modified = {2010-07-29 19:31:49 +0200}, pmid = {9303453}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Reverter-1997-J%20Anim%20Sci_The%20role%20of%20differen.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7855}, rating = {0} } @article{Taguchi:2005p885, author = {Y-H Taguchi and Y Oono}, journal = {Bioinformatics}, title = {Relational patterns of gene expression via non-metric multidimensional scaling analysis}, abstract = {MOTIVATION: Microarray experiments result in large-scale data sets that require extensive mining and refining to extract useful information. We demonstrate the usefulness of (non-metric) multidimensional scaling (MDS) method in analyzing a large number of genes. Applying MDS to the microarray data is certainly not new, but the existing works are all on small numbers (< 100) of points to be analyzed. We have been developing an efficient novel algorithm for non-metric MDS (nMDS) analysis for very large data sets as a maximally unsupervised data mining device. We wish to demonstrate its usefulness in the context of bioinformatics (unraveling relational patterns among genes from time series data in this paper). RESULTS: The Pearson correlation coefficient with its sign flipped is used to measure the dissimilarity of the gene activities in transcriptional response of cell-cycle-synchronized human fibroblasts to serum. These dissimilarity data have been analyzed with our nMDS algorithm to produce an almost circular relational pattern of the genes. The obtained pattern expresses a temporal order in the data in this example; the temporal expression pattern of the genes rotates along this circular arrangement and is related to the cell cycle. For the data we analyze in this paper we observe the following. If an appropriate preparation procedure is applied to the original data set, linear methods such as the principal component analysis (PCA) could achieve reasonable results, but without data preprocessing linear methods such as PCA cannot achieve a useful picture. Furthermore, even with an appropriate data preprocessing, the outcomes of linear procedures are not as clear-cut as those by nMDS without preprocessing.}, affiliation = {Department of Physics, Faculty of Science and Technology, Chuo University, 1-13-27 Kasuga, Tokyo 112-8551, Japan. tag@granular.com}, number = {6}, pages = {730--40}, volume = {21}, year = {2005}, month = {Mar}, language = {eng}, keywords = {Numerical Analysis: Computer-Assisted, Humans, Models: Biological, Cells: Cultured, Fibroblasts, Gene Expression Profiling, Oligonucleotide Array Sequence Analysis, Transcription Factors, Models: Genetic, Signal Transduction, Models: Statistical, Gene Expression Regulation, Pattern Recognition: Automated, Algorithms}, date-added = {2010-01-03 18:25:24 +0100}, date-modified = {2010-01-03 18:25:24 +0100}, doi = {10.1093/bioinformatics/bti067}, pii = {bti067}, pmid = {15509613}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Taguchi-2005-Bioinformatics_Relational%20patterns.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p885}, rating = {0} } @article{Maxwell:2008p10044, author = {Scott E Maxwell and Ken Kelley and Joseph R Rausch}, journal = {Annual Review of Psychology}, title = {Sample size planning for statistical power and accuracy in parameter estimation}, abstract = {This review examines recent advances in sample size planning, not only from the perspective of an individual researcher, but also with regard to the goal of developing cumulative knowledge. Psychologists have traditionally thought of sample size planning in terms of power analysis. Although we review recent advances in power analysis, our main focus is the desirability of achieving accurate parameter estimates, either instead of or in addition to obtaining sufficient power. Accuracy in parameter estimation (AIPE) has taken on increasing importance in light of recent emphasis on effect size estimation and formation of confidence intervals. The review provides an overview of the logic behind sample size planning for AIPE and summarizes recent advances in implementing this approach in designs commonly used in psychological research.}, affiliation = {Department of Psychology, University of Notre Dame, Notre Dame, Indiana 46556, USA. smaxwell@nd.edu}, pages = {537--63}, volume = {59}, year = {2008}, month = {Jan}, language = {eng}, keywords = {Confidence Intervals, Sampling Studies, Linear Models, Psychology, Humans, Models: Psychological}, date-added = {2010-03-31 20:15:36 +0200}, date-modified = {2010-03-31 20:15:37 +0200}, doi = {10.1146/annurev.psych.59.103006.093735}, pmid = {17937603}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Maxwell-2008-Annual%20Review%20of%20Psychology_Sample%20size%20planning.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p10044}, rating = {0} } @webpage{Thompson:1998a, author = {B Thompson}, title = {Five methodology errors in educational research: The pantheon of statistical significance and other faux pas}, year = {1998}, month = {Apr}, date-added = {2010-01-10 11:33:22 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, URL = {http://www.coe.tamu.edu/~bthompson/aeraaddr.htm}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1869}, rating = {0} } @article{Ashton:2009p13931, author = {Michael C Ashton and Kibeom Lee and Lewis R Goldberg and Reinout E de Vries}, journal = {Pers Soc Psychol Rev}, title = {Higher order factors of personality: do they exist?}, abstract = {Scales that measure the Big Five personality factors are often substantially intercorrelated. These correlations are sometimes interpreted as implying the existence of two higher order factors of personality. The authors show that correlations between measures of broad personality factors do not necessarily imply the existence of higher order factors and might instead be due to variables that represent same-signed blends of orthogonal factors. Therefore, the hypotheses of higher order factors and blended variables can only be tested with data on lower level personality variables that define the personality factors. The authors compared the higher order factor model and the blended variable model in three participant samples using the Big Five Aspect Scales, and found better fit for the latter model. In other analyses using the HEXACO Personality Inventory, they identified mutually uncorrelated markers of six personality factors. The authors conclude that correlations between personality factor scales can be explained without postulating any higher order dimensions of personality.}, affiliation = {Department of Psychology, Brock University, St. Catharines, Ontario, Canada. mashton@ brocku.ca}, number = {2}, pages = {79--91}, volume = {13}, year = {2009}, month = {May}, language = {eng}, keywords = {Humans, Factor Analysis: Statistical, Personality Inventory, Personality, Psychometrics, Personality Assessment, Questionnaires, Models: Statistical, Statistics as Topic, Models: Psychological}, date-added = {2010-07-29 18:58:45 +0200}, date-modified = {2010-07-29 18:58:48 +0200}, doi = {10.1177/1088868309338467}, pii = {1088868309338467}, pmid = {19458345}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Ashton-2009-Pers%20Soc%20Psychol%20Rev_Higher%20order%20factors.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13931}, rating = {4} } @article{Skinner:1950, author = {BF Skinner}, journal = {Psychological Review}, title = {Are theories of learning necessary?}, pages = {193--216}, volume = {57}, year = {1950}, date-added = {2010-01-03 19:34:17 +0100}, date-modified = {2010-01-03 19:34:18 +0100}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p948}, rating = {0} } @article{Liang:2010p13624, author = {T Liang}, title = {An Assessment of The Nonparametric Approach for Evaluating The Fit of Item Response Models}, year = {2010}, date-added = {2010-07-07 21:23:13 +0200}, date-modified = {2010-07-07 21:23:43 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Liang-2010-_An%20Assessment%20of%20The.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13624}, rating = {0} } @article{Mechelli:2009p3437, author = {Andrea Mechelli and Stefania Tognin and Philip K McGuire and Diana Prata and Giuseppe Sartori and Paolo Fusar-Poli and Stephane De Brito and Ahmad R Hariri and Essi Viding}, journal = {Biol Psychiatry}, title = {Genetic vulnerability to affective psychopathology in childhood: a combined voxel-based morphometry and functional magnetic resonance imaging study}, abstract = {BACKGROUND: The majority of affective psychopathology is rooted early in life and first emerges during childhood and adolescence. However, little is known about how genetic vulnerability affects brain structure and function in childhood since the vast majority of studies published so far have been conducted on adult participants. The present investigation examined for the first time the effects of catechol-O-methyltransferase (COMT) valine (val) 158 methionine (met) (val158met) polymorphism, which has been shown to moderate predisposition to negative mood and affective disorders, on brain structure and function in children. METHODS: Voxel-based morphometry and functional magnetic resonance imaging were used to measure gray matter volume and emotional reactivity in 50 children aged between 10 and 12 years. We tested the hypothesis that met158 allele affects structural brain development and confers heightened reactivity within the affective frontolimbic circuit in children. RESULTS: The met158 allele was positively associated with gray matter volume in the left hippocampal head where genotype accounted for 59% of interindividual variance. In addition, the met158 allele was positively associated with neuronal responses to fearful relative to neutral facial expressions in the right parahippocampal gyrus where genotype accounted for 14% of the interindividual variance. CONCLUSIONS: These results indicate that the met158 allele is associated with increased gray matter volume and heightened reactivity during emotional processing within the limbic system in children as young as 10 to 12 years of age. These findings are consistent with the notion that genetic factors affect brain function to moderate vulnerability to affective psychopathology from childhood.}, affiliation = {Department of Psychology, Institute of Psychiatry, PO Box 67, Division of Psychological Medicine and Psychiatry, King's College London, 103 Denmark Hill, London SE5 8AF, United Kingdom. a.mechelli@iop.kcl.ac.uk}, number = {3}, pages = {231--7}, volume = {66}, year = {2009}, month = {Aug}, language = {eng}, keywords = {Methionine, Brain, Polymorphism: Genetic, Reaction Time, Valine, Magnetic Resonance Imaging, Catechol O-Methyltransferase, Twin Studies as Topic, Male, Neuropsychological Tests, Photic Stimulation, Longitudinal Studies, Child, Image Processing: Computer-Assisted, Brain Mapping, Affective Disorders: Psychotic, Genotype, Oxygen, Humans}, date-added = {2010-01-15 15:18:42 +0100}, date-modified = {2010-01-15 15:18:42 +0100}, doi = {10.1016/j.biopsych.2009.01.033}, pii = {S0006-3223(09)00156-5}, pmid = {19278671}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3437}, rating = {0} } @techreport{Festy:2008, author = {P Festy and L Prokofieva}, journal = {Techreport}, title = {MESURES, FORMES ET FACTEURS DE LA PAUVRET{\'E}. APPROCHES COMPARATIVES}, affiliation = {INED}, year = {2008}, date-added = {2010-01-10 11:33:18 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Festy-2008-Techreport_MESURES%20FORMES%20ET%20F.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2090}, rating = {0} } @article{Davis:2007p9021, author = {Elise Davis and Caroline Nicolas and Elizabeth Waters and Kay Cook and Lisa Gibbs and Angela Gosch and Ulrike Ravens-Sieberer}, journal = {Qual Life Res}, title = {Parent-proxy and child self-reported health-related quality of life: using qualitative methods to explain the discordance}, abstract = {BACKGROUND: Although parent-proxy reports of health-related quality of life (HRQOL) are only moderately correlated with child reported HRQOL, it remains unknown why these scores differ. The aim of this study was to use a qualitative methodology to examine why parents and children report different levels of HRQOL. METHOD: The sample consisted of 15 parent-child pairs. A think-aloud technique was used where parents and children were given a generic HRQOL instrument (KIDSCREEN) and instructed to share their thoughts with the interviewer. Qualitative analyses were conducted to assess whether parents and children base their answer on different experiences or reasoning, have different response styles, or interpret the items differently. RESULTS: There was discordance between parents and children, in terms of rating scale and in terms of the reasoning for their answer. Children tended to have different response styles to parents, where for example, children tended to provide extreme scores (highest or lowest score) and base their response on one single example, more than parents. Parents and children interpreted the meaning of the items very similarly. DISCUSSION: This study provides evidence to suggest that discordance among parent-child pairs on KIDSCREEN scores may be as a result of different reasoning and different response styles, rather than interpretation of items. These findings have important implications when parent-proxy reported HRQOL is used to guide clinical/treatment decisions.}, affiliation = {School of Health and Social Development, Faculty of Health, Medicine, Nursing and Behavioural Sciences, Deakin University, Burwood, Victoria, 3125, Australia. elise.davis@deakin.edu.au}, number = {5}, pages = {863--71}, volume = {16}, year = {2007}, month = {Jun}, language = {eng}, keywords = {Victoria, Proxy, Quality of Life, Psychometrics, Adult, Parents, Reproducibility of Results, Parent-Child Relations, Self Disclosure, Child Psychology, Male, Female, Child Rearing, Adolescent, Humans, Qualitative Research, Pilot Projects, Questionnaires, Interviews as Topic, Child}, date-added = {2010-03-22 13:14:23 +0100}, date-modified = {2010-07-29 19:48:31 +0200}, doi = {10.1007/s11136-007-9187-3}, pmid = {17351822}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Davis-2007-Qual%20Life%20Res_Parent-proxy%20and%20chi.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p9021}, rating = {0} } @article{Rauch:2008p7867, author = {W A Rauch and K Schweizer and H Moosbrugger}, journal = {European Journal of Psychology of Education}, title = {An IRT Analysis of the Personal Optimism Scale}, abstract = {In this study the psychometric properties of the Personal Optimism scale of the POSO-E questionnaire (Schweizer {\&} Koch, 2001) for the assessment of dispositional optimism are evaluated by applying Samejima's (1969) graded response model, a parametric item response theory (IRT) model for polytomous data. Model fit is extensively evaluated via fit checks on the lower-order margins of the contingency table of observed and expected responses and visual checks of fit plots comparing observed and expected category response functions. The model proves appropriate for the data; a small amount of misfit is interpreted in terms of previous research using other measures for optimism. Item parameters and information functions show that optimism can be measured accurately, especially at moderately low to middle levels of the latent trait scale, and particularly by the negatively worded items.}, number = {1}, pages = {49--56}, volume = {24}, year = {2008}, date-added = {2010-03-20 19:03:55 +0100}, date-modified = {2010-07-29 19:26:41 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Rauch-2008-European%20Journal%20of%20Psychology%20of%20Education_An%20IRT%20Analysis%20of%20t.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7867}, rating = {0} } @article{Mackay:2009p11225, author = {T F C Mackay}, journal = {Journal of Biology}, title = {Genetic analysis of quantitative traits }, number = {23}, volume = {8}, year = {2009}, date-added = {2010-04-25 21:28:31 +0200}, date-modified = {2010-04-25 21:29:18 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Mackay-2009-Journal%20of%20Biology_Genetic%20analysis%20of.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11225}, rating = {0} } @article{Niccols:2002p8599, author = {A Niccols and A Latchman}, journal = {The British Journal of Developmental Disabilities}, title = {STABILITY OF THE BAYLEY MENTAL SCALE OF INFANT DEVELOPMENT WITH HIGH RISK INFANTS}, number = {94}, pages = {3--13}, volume = {48}, year = {2002}, date-added = {2010-03-22 00:23:00 +0100}, date-modified = {2010-03-22 00:23:52 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Niccols-2002-The%20British%20Journal%20of%20Developmental%20Disabilities_STABILITY%20OF%20THE%20BAY.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8599}, rating = {0} } @article{Kim:2006p3913, author = {Sung Kim and Keyan Zhao and Rong Jiang and John Molitor and Justin O Borevitz and Magnus Nordborg and Paul Marjoram}, journal = {Genetics}, title = {Association mapping with single-feature polymorphisms}, abstract = {We develop methods for exploiting "single-feature polymorphism" data, generated by hybridizing genomic DNA to oligonucleotide expression arrays. Our methods enable the use of such data, which can be regarded as very high density, but imperfect, polymorphism data, for genomewide association or linkage disequilibrium mapping. We use a simulation-based power study to conclude that our methods should have good power for organisms like Arabidopsis thaliana, in which linkage disequilibrium is extensive, the reason being that the noisiness of single-feature polymorphism data is more than compensated for by their great number. Finally, we show how power depends on the accuracy with which single-feature polymorphisms are called.}, affiliation = {Department of Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089-2910, USA.}, number = {2}, pages = {1125--33}, volume = {173}, year = {2006}, month = {Jun}, language = {eng}, keywords = {Haplotypes, Data Interpretation: Statistical, Genetic Markers, Cluster Analysis, Algorithms, Linkage Disequilibrium, Arabidopsis, Chromosome Mapping, Models: Genetic, Polymorphism: Genetic, Alleles}, date-added = {2010-01-16 21:05:05 +0100}, date-modified = {2010-01-16 21:05:05 +0100}, doi = {10.1534/genetics.105.052720}, pii = {genetics.105.052720}, pmid = {16510789}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3913}, rating = {0} } @article{Vickers:2001, author = {AJ Vickers and Douglas G Altman}, journal = {British Medical Journal}, title = {Analysing controlled trials with baseline and follow up measurements}, abstract = {In many randomised trials researchers measure a continuous variable at baseline and again as an outcome assessed at follow up. Baseline measurements are common in trials of chronic conditions where researchers want to see whether a treatment can reduce pre-existing levels of pain, anxiety, hypertension, and the like. Statistical comparisons in such trials can be made in several ways. Comparison of follow up (post-treatment) scores will give a result such as "at the end of the trial, mean pain scores were 15 mm (95% confidence interval 10 to 20 mm) lower in the treatment group." Alternatively a change score can be calculated by subtracting the follow up score from the baseline score, leading to a statement such as "pain reductions were 20 mm (16 to 24 mm) greater on treatment than control." If the average baseline scores are the same in each group the estimated treatment effect will be the same using these two simple approaches. If the treatment is effective the statistical significance of the treatment effect by the two methods will depend on the correlation between baseline and follow up scores. If the correlation is low using the change score will add variation and the follow up score is more likely to show a significant result. Conversely, if the correlation is high using only the follow up score will lose information and the change score is more likely to be significant. It is incorrect, however, to choose whichever analysis gives a more significant finding. The method of analysis should be specified in the trial protocol.}, pages = {1123--1124}, volume = {323}, year = {2001}, date-added = {2010-01-03 19:36:10 +0100}, date-modified = {2010-07-29 20:20:56 +0200}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1048}, rating = {0} } @article{Igl:2010p5370, author = {Wilmar Igl and Asa Johansson and James F Wilson and Sarah H Wild and Ozren Polasek and Caroline Hayward and Veronique Vitart and Nicholas Hastie and Pavao Rudan and Carsten Gnewuch and Gerd Schmitz and Thomas Meitinger and Peter P Pramstaller and Andrew A Hicks and Ben A Oostra and Cornelia M van Duijn and Igor Rudan and Alan Wright and Harry Campbell and Ulf Gyllensten and EUROSPAN Consortium}, journal = {PLoS Genet}, title = {Modeling of environmental effects in genome-wide association studies identifies SLC2A2 and HP as novel loci influencing serum cholesterol levels}, abstract = {Genome-wide association studies (GWAS) have identified 38 larger genetic regions affecting classical blood lipid levels without adjusting for important environmental influences. We modeled diet and physical activity in a GWAS in order to identify novel loci affecting total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride levels. The Swedish (SE) EUROSPAN cohort (N(SE) = 656) was screened for candidate genes and the non-Swedish (NS) EUROSPAN cohorts (N(NS) = 3,282) were used for replication. In total, 3 SNPs were associated in the Swedish sample and were replicated in the non-Swedish cohorts. While SNP rs1532624 was a replication of the previously published association between CETP and HDL cholesterol, the other two were novel findings. For the latter SNPs, the p-value for association was substantially improved by inclusion of environmental covariates: SNP rs5400 (p(SE,unadjusted) = 3.6 x 10(-5), p(SE,adjusted) = 2.2 x 10(-6), p(NS,unadjusted) = 0.047) in the SLC2A2 (Glucose transporter type 2) and rs2000999 (p(SE,unadjusted) = 1.1 x 10(-3), p(SE,adjusted) = 3.8 x 10(-4), p(NS,unadjusted) = 0.035) in the HP gene (Haptoglobin-related protein precursor). Both showed evidence of association with total cholesterol. These results demonstrate that inclusion of important environmental factors in the analysis model can reveal new genetic susceptibility loci.}, affiliation = {Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, Uppsala, Sweden. wilmar.igl@genpat.uu.se}, number = {1}, pages = {e1000798}, volume = {6}, year = {2010}, month = {Jan}, language = {eng}, date-added = {2010-02-11 09:22:46 +0100}, date-modified = {2010-02-11 09:22:46 +0100}, doi = {10.1371/journal.pgen.1000798}, pmid = {20066028}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Igl-2010-PLoS%20Genet_Modeling%20of%20environm.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5370}, rating = {0} } @article{Maisto:2010p13384, author = {Stephen A Maisto and Kathleen McGinnis and Robert Cook and Joseph Conigliaro and Kendall Bryant and Amy C Justice}, journal = {AIDS Behav}, title = {Factor structure of Leigh's (1990) alcohol sex expectancies scale in individuals in treatment for HIV disease}, abstract = {The purpose of this study was to validate the use of Leigh's (1990) alcohol sex expectancies scale among HIV-infected individuals presenting for treatment as a way to facilitate research on sexual risk reduction among individuals in that population. The participants were 944 men who presented for treatment at infectious disease or general medicine clinics across 8 different VA Medical Center sites. A total of 534 of these men were HIV-positive and 410 were HIV-negative. The total sample was randomly divided in half within each HIV group to form exploratory (Sample 1) and confirmatory (Sample 2) subsamples. A principal components factor analysis with oblique rotation of the original 13-item Leigh scale within each HIV group in Sample 1 revealed a 2-factor (7 and 4 items, respectively) solution that was consistent across both HIV groups. These factors were named "More Open to Sexual Pleasure" (Factor 1) and "Reduced Inhibitions about Sex (Factor 2)." A confirmatory factor analysis of the 11-item, 2-factor solution on the full Sample 2 showed a modest fit to the data, excellent internal consistency reliability of both factors, a high correlation between the factors, and strong evidence for construct validity. These results were interpreted as supporting the use of the 11-item, 2-factor version of Leigh's scale in studies of clinical samples of HIV-positive adults, and directions for research on further scale refinement are discussed.}, affiliation = {Department of Psychology, Syracuse University, Syracuse, NY 13244, USA. samaisto@syr.edu}, number = {1}, pages = {174--80}, volume = {14}, year = {2010}, month = {Feb}, language = {eng}, keywords = {Alcohol Drinking, Sexual Behavior, Humans, Factor Analysis: Statistical, Ethnic Groups, Prevalence, Middle Aged, Male, HIV Infections, Risk-Taking, Follow-Up Studies, Questionnaires, Risk Factors, HIV Seropositivity, Reproducibility of Results, Female}, date-added = {2010-07-01 19:24:23 +0200}, date-modified = {2010-07-01 19:24:23 +0200}, doi = {10.1007/s10461-008-9457-2}, pmid = {18791863}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Maisto-2010-AIDS%20Behav_Factor%20structure%20of.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13384}, rating = {0} } @article{Guinot:2001p4081, author = {C Guinot and J Latreille and M Tenenhaus}, journal = {Chemometrics and Intelligent Laboratory Systems}, title = {PLS Path modelling and multiple table analysis. Application to the cosmetic habits of women in Ile-de-France}, abstract = {Many statistical methods can be used to study data presented in the form of J blocks of variables observed on the same subjects. The most well-known methods are the following: Horst's generalised canonical correlation analysis, Carroll's gen- eralised canonical correlation analysis, Escofier and Page`s' multiple factor analysis and second order confirmatory factor analysis. The aim of all these methods is to identify a common structure among the J data tables. The partial least squares {\v Z}PLS. Path modelling approach of Herman Wold can also be used on this type of data. Generalised canonical correlation analyses of Horst and Carroll and multiple factor analysis are special cases of PLS Path modelling, but this approach also leads to new useful methods. In the first part of this paper, we briefly review PLS Path modelling, then we look in greater detail at the specific case of tables without structural relations. In the second part, we have applied PLS Path modelling to a study of the cosmetic habits of women in the Ile-de-France region. Lohmo ̈ller's LVPLS software release 1.8 allowed us to carry out the application without too many difficulties.}, pages = {247--259}, volume = {58}, year = {2001}, date-added = {2010-01-19 15:59:53 +0100}, date-modified = {2010-01-19 16:00:55 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Guinot-2001-Chemometrics%20and%20Intelligent%20Laboratory%20Systems_PLS%20Path%20modelling%20a.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p4081}, rating = {0} } @article{Novartis:2006p1719, author = {Novartis}, title = {Guidance for the Use of Bayesian Statistics in Medical Device Clinical Trials}, year = {2006}, date-added = {2010-01-09 20:26:46 +0100}, date-modified = {2010-01-09 20:27:17 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Novartis-2006-_Guidance%20for%20the%20Use.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1719}, rating = {0} } @article{Schroeder:2001p4354, author = {J C Schroeder and C R Weinberg}, journal = {Am J Epidemiol}, title = {Use of missing-data methods to correct bias and improve precision in case-control studies in which cases are subtyped but subtype information is incomplete}, abstract = {Histologic and genetic markers can sometimes make it possible to refine a disease into subtypes. In a case-control study, an attempt to subcategorize a disease in this way can be important to elucidating its etiology if the subtypes tend to result from distinct causal pathways. Using subtyped case outcomes, one can carry out either a case-case analysis to investigate etiologic heterogeneity or do polytomous logistic regression to estimate odds ratios specific to subtypes. Unfortunately, especially when such an analysis is undertaken after the study has been completed, it may be compromised by the unavailability of tissue specimens, resulting in missing subtype data for many enrolled cases. The authors propose that one can more fully use the available data, including that provided by cases with missing subtype, by using the expectation-maximization algorithm to estimate risk parameters. For illustration, they apply the method to a study of non-Hodgkin's lymphoma in the midwestern United States. The simulations then demonstrate that, under assumptions likely to hold in many settings, the approach eliminates bias that would arise if unclassified cases were ignored and also improves the precision of estimation. Under the same assumptions, empirical confidence interval coverage is consistent with the nominal 95%.}, affiliation = {Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC27709, USA. schroed1@niehs.nih.gov}, number = {10}, pages = {954--62}, volume = {154}, year = {2001}, month = {Nov}, language = {eng}, keywords = {Likelihood Functions, Algorithms, Analysis of Variance, Bias (Epidemiology), Outcome Assessment (Health Care), Odds Ratio, Lymphoma: Non-Hodgkin, Humans, Computer Simulation, Case-Control Studies, Models: Statistical, Midwestern United States}, date-added = {2010-01-27 18:27:46 +0100}, date-modified = {2010-01-27 18:27:46 +0100}, pmid = {11700251}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Schroeder-2001-Am%20J%20Epidemiol_Use%20of%20missing-data.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p4354}, rating = {0} } @article{Kloosterman:2010p7566, author = {Bjorn Kloosterman and Marian Oortwijn and Jan Uitdewilligen and Twan America and Ric de Vos and Richard G F Visser and Christian W B Bachem}, journal = {BMC Genomics}, title = {From QTL to candidate gene: Genetical genomics of simple and complex traits in potato using a pooling strategy}, abstract = {ABSTRACT: BACKGROUND: Utilization of the natural genetic variation in traditional breeding programs remains a major challenge in crop plants. The identification of candidate genes underlying, or associated with, phenotypic trait QTLs is desired for effective marker assisted breeding. With the advent of high throughput -omics technologies, screening of entire populations for association of gene expression with targeted traits is becoming feasible but remains costly. Here we present the identification of novel candidate genes for different potato tuber quality traits by employing a pooling approach reducing the number of hybridizations needed. Extreme genotypes for a quantitative trait are collected and the RNA from contrasting bulks is then profiled with the aim of finding differentially expressed genes. RESULTS: We have successfully implemented the pooling strategy for potato quality traits and identified candidate genes associated with potato tuber flesh color and tuber cooking type. Elevated expression level of a dominant allele of the beta-carotene hydroxylase (bch) gene was associated with yellow flesh color through mapping of the gene under a major QTL for flesh color on chromosome 3. For a second trait, a candidate gene with homology to a tyrosine-lysine rich protein (TLRP) was identified based on allele specificity of the probe on the microarray. TLRP was mapped on chromosome 9 in close proximity to a QTL for potato cooking type strengthening its significance as a candidate gene. Furthermore, we have performed a profiling experiment targeting a polygenic trait, by pooling individual genotypes based both on phenotypic and marker data, allowing the identification of candidate genes associated with the two different linkage groups. CONCLUSIONS: A pooling approach for RNA-profiling with the aim of identifying novel candidate genes associated with tuber quality traits was successfully implemented. The identified candidate genes for tuber flesh color (bch) and cooking type (tlrp) can provide useful markers for breeding schemes in the future. Strengths and limitations of the approach are discussed.}, number = {1}, pages = {158}, volume = {11}, year = {2010}, month = {Mar}, language = {ENG}, date-added = {2010-03-14 10:57:43 +0100}, date-modified = {2010-03-14 10:57:43 +0100}, doi = {10.1186/1471-2164-11-158}, pii = {1471-2164-11-158}, pmid = {20210995}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Kloosterman-2010-BMC%20Genomics_From%20QTL%20to%20candidat-1.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7566}, rating = {0} } @article{Rose:2002p7931, author = {Susan A Rose and Judith F Feldman and Jeffery J Jankowski}, journal = {Dev Psychol}, title = {Processing speed in the 1st year of life: a longitudinal study of preterm and full-term infants}, abstract = {Processing speed was assessed at 5, 7, and 12 months in full-term and preterm infants (birth-weight < 1,750 g). Speed was gauged directly in a new task by presenting infants with a series of paired faces, one that remained the same across trials and one that changed; trials continued until infants showed a consistent novelty preference. At all ages, preterms required about 20% more trials and 30% more time than full-terms to reach criterion. Among preterms, slower processing was associated with greater medical risk (e.g., respiratory distress syndrome). Developmental trajectories for speed (and attention) were similar for both groups. Thus, the deficits in processing speed previously found for preterms in childhood are already present in the 1st year of life.}, affiliation = {Department of Pediatrics, Albert Einstein College of Medicine/Children's Hospital at Montefiore, Bronx, New York 10461, USA. srose@aecom.yu.edu}, number = {6}, pages = {895--902}, volume = {38}, year = {2002}, month = {Nov}, language = {eng}, keywords = {Humans, Face, Reaction Time, Infant: Newborn, Infant, Longitudinal Studies, Prospective Studies, Concept Formation, Pattern Recognition: Visual, Attention, Discrimination Learning, Retention (Psychology), Respiratory Distress Syndrome: Newborn, Risk Factors, Male, Mental Recall, Female}, date-added = {2010-03-20 19:23:19 +0100}, date-modified = {2010-07-29 19:25:17 +0200}, pmid = {12428702}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Rose-2002-Dev%20Psychol_Processing%20speed%20in.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7931}, rating = {0} } @article{Kayaalp:2007p6066, author = {Levent Kayaalp and Aysin Dervent and Sema Saltik and Derya Uluduz and Inci Vural Kayaalp and Veysi Demirbilek and Mohammad Ghaziuddin}, journal = {Brain Dev}, title = {EEG abnormalities in West syndrome: correlation with the emergence of autistic features}, abstract = {Autism may develop in children with West syndrome. This study was conducted to determine if EEG abnormalities in patients with West syndrome predict the later onset of autism. Two groups of patients with West syndrome, older than 6 years of age, were studied. One group consisted of those with a past history of West syndrome plus autism (N=14); the control group consisted of those with a past history of West syndrome but without autism (N=14). Patients were followed at regular intervals and video-EEG recordings were done. A total of 108 (autistic group) and 123 (non-autistic group) video-EEGs were examined. The two groups were compared with respect to age, presence or absence of hypsarrhythmia, and characteristics and localization of the epileptogenic foci. chi2 and Fisher's exact tests were used. The number of patients with at least one hypsarrhythmic EEG at the age of one year or later was significantly higher in autistic subjects (86%) than in non-autistic controls (29%). The incidence of EEGs with hypsarrhythmia was also higher in the autistic group, especially in older children (autistic, 49% versus non-autistic, 18% at age 3 years and later). Frontal predominance of the primary foci on EEGs with or without hypsarrhythmia was seen in 95.3% of the autistic group and 28.8% of the non-autistic group (p=0.001). Frontal abnormalities on the EEGs, which were mainly bilateral, and the persistence of hypsarrhythmia were significantly related to the emergence of autistic behavior in patients with West syndrome. These findings suggest that paroxysmal discharges in the cortical areas undergoing rapid maturation may be involved in the development of autistic features.}, affiliation = {Istanbul University, Cerrahpasa Medical Faculty, Child Psychiatry Department, Istanbul, Turkey.}, number = {6}, pages = {336--45}, volume = {29}, year = {2007}, month = {Jul}, language = {eng}, keywords = {Age of Onset, Child, Chi-Square Distribution, Infant, Male, Electroencephalography, Child: Preschool, Functional Laterality, Female, Brain Mapping, Spasms: Infantile, Humans, Autistic Disorder}, date-added = {2010-02-19 17:03:06 +0100}, date-modified = {2010-02-19 17:03:06 +0100}, doi = {10.1016/j.braindev.2006.10.002}, pii = {S0387-7604(06)00238-5}, pmid = {17113261}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6066}, rating = {0} } @article{Vermunt:2010p11670, author = {J K Vermunt and J Magidson}, title = {Latent Class Analysis}, date-added = {2010-05-14 21:09:36 +0200}, date-modified = {2010-05-14 21:09:59 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Vermunt--_Latent%20Class%20Analysi.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11670}, read = {Yes}, rating = {0} } @article{Williams:2006p5237, author = {Christopher J Williams and Joe C Christian}, journal = {Behav Genet}, title = {Frequentist model-averaged estimators and tests for univariate twin models}, abstract = {Parameter estimates from analyses of univariate twin data usually do not reflect the uncertainty due to the model selection phase of the data analysis. To address the effect of model selection uncertainty on parameter estimates, we introduce frequentist model-averaged estimators for univariate twin data analysis that use information-theoretic criteria to assign model weights. We conduct simulation studies to examine the performance of model-averaged estimators of additive genetic variance, and for tests for additive genetic variance based on model-averaged estimators. In simulation studies with small or moderate sample sizes, model-averaged estimators of additive genetic variance typically have lower mean-squared error than either (i) estimators from individual twin models, or (ii) estimators obtained from a decision procedure where the best-fitting model from likelihood-ratio testing is used to estimate additive genetic variance. For each sample size simulated, bootstrap tests based on model-averaged estimators have higher power to detect additive genetic variance than currently-used tests in most cases.}, affiliation = {Department of Statistics, University of Idaho, Moscow, ID 83844-1104, USA. chrisw@uidaho.edu}, number = {5}, pages = {687--96}, volume = {36}, year = {2006}, month = {Sep}, language = {eng}, keywords = {Models: Genetic, Humans, Computer Simulation, Twins, Reproducibility of Results, Genetic Variation, Gene Frequency, Analysis of Variance}, date-added = {2010-02-08 19:38:00 +0100}, date-modified = {2010-07-29 20:09:06 +0200}, doi = {10.1007/s10519-006-9065-8}, pmid = {16710780}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5237}, rating = {0} } @article{Malet:2006p12769, author = {Laurent Malet and Pierre-Michel Llorca and B{\'e}r{\'e}nice Beringuier and Philippe Lehert and Bruno Falissard}, journal = {Alcohol Alcohol}, title = {AlQoL 9 for measuring quality of life in alcohol dependence}, abstract = {AIMS: Quality of life (QoL) is an important factor of outcome tracking and treatment in alcohol misuse. A 9-item QoL scale, AlQoL 9, obtained from the generic SF 36, is proposed as a measure that characterizes the QoL of alcohol-dependent patients. Our objective was to study the psychometric properties of this subscale. METHODS: AlQoL 9 was evaluated in two study groups of patients with DSM-IV diagnosis of dependence: 104 inpatients, and 114 outpatients. Severity of dependence, alcohol consumption, psychiatric, and somatic comorbidities were assessed. We studied the global properties of AlQoL 9 and its structure. RESULTS: Cronbach alpha-coefficients in both populations indicated good internal consistency (0.71 and 0.85). Test-retest intraclass coefficients for a 2-day interval in hospital were in the range 0.57-0.78. Principal component analysis found a unidimensional scale. This subscale has properties that are consistent with the concept of QoL in alcohol dependence, i.e. lowered QoL compared with the general population, influenced by gender, and depression. CONCLUSIONS: AlQoL 9 epitomizes QoL in alcohol-dependence. It gives a global measurement with good psychometric properties. It could be used in clinical practice as a diagnosis and management support instrument and may also be useful in research for evaluating treatment efficacy.}, affiliation = {Centre Hospitalier Universitaire, Department of Psychiatry-B, rue Montalembert BP 69, 63003 Clermont-Ferrand cedex 1, France. lmalet@chu-clermontferrand.fr}, number = {2}, pages = {181--7}, volume = {41}, year = {2006}, month = {Jan}, language = {eng}, keywords = {Quality of Life, Alcoholism, Middle Aged, Adolescent, Adult, Psychometrics, Male, Treatment Outcome, Questionnaires, Aged, Diagnostic and Statistical Manual of Mental Disorders, Humans, Female}, date-added = {2010-06-18 20:32:49 +0200}, date-modified = {2010-07-29 19:12:56 +0200}, doi = {10.1093/alcalc/agl001}, pii = {agl001}, pmid = {16455795}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Malet-2006-Alcohol%20Alcohol_AlQoL%209%20for%20measurin.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12769}, rating = {3} } @article{Ciuciu:2003p2316, author = {P Ciuciu and J B Poline and G Marrelec and J Idier and C Pallier and H Benali}, journal = {IEEE Transactions on Medical Imaging}, title = {Unsupervised robust non-parametric estimation of the hemodynamic response function for any fMRI experiment}, abstract = {This paper deals with the estimation of the Blood Oxygen Level-Dependent (BOLD) response to a stimulus, as measured in Functional Magnetic Resonance Imaging (fMRI) data. A precise estimation is essential for a better understanding of cerebral activations. The most recent works have used a non-parametric framework for this estimation, considering each brain region as a system characterized by its impulse response, the so-called Hemodynamic Response Function (HRF). However, the use of these techniques has remained limited since they are not well-adapted to real fMRI data. Here, we develop a threefold extension to previous works. We consider asyn- chronous event-related paradigms, account for different trial types and integrate several fMRI sessions into the estimation. These generalizations are simultaneously addressed through a badly-conditioned observation model. Bayesian formalism is used to model temporal prior information of the underlying physiological process of the brain hemodynamic response. By this way, the HRF estimate results from a tradeoff between information brought by the data and by our prior knowledge. This tradeoff is modeled with hyperparameters that are set to the maximum-likelihood estimate using an Expectation Conditional Maximization (ECM) algorithm. The proposed unsupervised approach is validated on both synthetic and real fMRI data, the latter originating from a speech perception experiment.}, number = {10}, pages = {1235--1251}, volume = {22}, year = {2003}, date-added = {2010-01-10 12:32:53 +0100}, date-modified = {2010-01-10 12:34:24 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Ciuciu-2003-IEEE%20Transactions%20on%20Medical%20Imaging_Unsupervised%20robust.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2316}, rating = {0} } @misc{Socan:2000, author = {Gregor Socan}, journal = {Miscellaneous}, title = {Assessment of reliability when test items are not essentially tau-equivalent}, year = {2000}, date-added = {2010-01-10 11:33:24 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Socan-2000-Miscellaneous_Assessment%20of%20reliab.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2147}, rating = {0} } @article{Bookman:2002p9056, author = {E B Bookman and R E Taylor and L Adams-Campbell and R A Kittles}, journal = {Mol Psychiatry}, title = {DRD4 promoter SNPs and gender effects on Extraversion in African Americans}, abstract = {There is strong evidence for genetic influences on personality traits. Interest in one such gene, the dopamine D4 receptor (DRD4) grew after an exon III polymorphism was associated with Novelty Seeking and related measures of Extraversion. However, the findings were not confirmed in later studies. Recently, a -521C/T single nucleotide polymorphism (SNP) within the promoter region of the DRD4 gene was found to be related to Novelty Seeking scores in populations from Japan and Hungary. Since little is known about the role DRD4 plays in personality in other populations we evaluated if two DRD4 promoter SNPs, -521C/T and -616C/G, were related to personality traits in African Americans. Personality traits were measured by the NEO-FFI in 71 unrelated African Americans. Genotyping was performed using PCR-RFLP. Multivariate analyses of variance (MANOVA) were performed to evaluate the effects of gender and -616 and -521 genotypes on personality traits. A significant three-way interaction effect from gender, -616 genotype, and -521 genotype was observed for Extraversion scores (F(1,54) 5.86, P < 0.02). Subsequent analyses revealed that the association was mainly due to -521C/T genotype among females (P = 0.01). This study provides further evidence that genetic variation within the DRD4 promoter and gender differences contribute to variation in Novelty Seeking behaviors such as Extraversion.}, affiliation = {Department of Genetics and Human Genetics, Howard University, Washington, DC 20060, USA.}, number = {7}, pages = {786--9}, volume = {7}, year = {2002}, month = {Jan}, language = {eng}, keywords = {Humans, Gene Frequency, Receptors: Dopamine D2, Adult, Male, Polymorphism: Single Nucleotide, Sex Factors, Extraversion (Psychology), African Continental Ancestry Group, Genotype, Receptors: Dopamine D4, Female, Promoter Regions: Genetic}, date-added = {2010-03-22 13:18:17 +0100}, date-modified = {2010-03-22 13:18:17 +0100}, doi = {10.1038/sj.mp.4001075}, pmid = {12192624}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Bookman-2002-Mol%20Psychiatry_DRD4%20promoter%20SNPs%20a.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p9056}, rating = {0} } @article{Ginkel:2007b, author = {Joost R van Ginkel and L Andries van der Ark and Klaas Sijtsma}, journal = {Multivariate Behavioral Research}, title = {Multiple Imputation of Item Scores in Test and Questionnaire Data, and Influence on Psychometric Results}, abstract = {The performance of five simple multiple imputation methods for dealing with missing data were compared. In addition, random imputation and multivariate normal imputation were used as lower and upper benchmark, respectively. Test data were simulated and item scores were deleted such that they were either missing completely at random, missing at random, or not missing at random. Cronbach's alpha, Loevinger's scalability coefficient H, and the item cluster solution from Mokken scale analysis of the complete data were compared with the corresponding results based on the data including imputed scores. The multiple-imputation methods, two-way with normally distributed errors, corrected item-mean substitution with normally distributed errors, and response function, produced discrepancies in Cronbach's coefficient alpha, Loevinger's coefficient H, and the cluster solution from Mokken scale analysis, that were smaller than the discrepancies in upper benchmark multivariate normal imputation.}, number = {2}, pages = {387--414}, volume = {42}, year = {2007}, date-added = {2010-01-10 11:33:23 +0100}, date-modified = {2010-07-29 20:42:55 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Ginkel-2007-Multivariate%20Behavioral%20Research_Multiple%20Imputation.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2023}, rating = {0} } @article{Jevtovic:2009p5147, author = {Dj Jevtovi{\'c} and V Vanovac and M Veselinovi{\'c} and D Salemovi{\'c} and J Ranin and E Stefanova}, journal = {Biomed Pharmacother}, title = {The incidence of and risk factors for HIV-associated cognitive-motor complex among patients on HAART}, abstract = {BACKGROUND: While highly active antiretroviral therapy (HAART) allows for the considerable decline in the incidence of HIV-related opportunistic infections and tumors, its effect on treating HIV infection of the brain, such as HIV-associated dementias (HADs), remains unclear. METHODS: A cross-sectional study of consecutive series of 96 patients from the Serbian HIV/AIDS cohort, treated with HAART in our HIV unit was performed to evaluate the incidence of and risk factors for cognitive/motor complex during HAART. CD4+T cell counts and pVL values at the time of neurological evaluation were parameters of the response to HAART. The mini-mental test and neurologic examination were performed at one point of time during treatment to reveal cognitive and/or motor disorders. RESULTS: After mean HAART duration of 47 months, unimpaired cognition, minor cognitive impairment, and HIV-associated dementia were recorded in 56 (58.3%), 27 (28.1%), and 13 (13.5%), respectively. Motor abnormalities had 39 (40.6%) patients. Of these, 21, 12, and 6 patients belong to the subgroups with normal cognition, minor cognitive impairment and HAD patients, respectively. Factors predictive for HAD were age over 40 (OR 3.7, 95% CI 1.07-13.28, P=0.039), and AIDS diagnosis prior to HAART initiation (OR 14.19, 95% CI 1.76-114.16, P=0.013). Conversely, factors shown to be protective against HAD were the usage of AZT and NNRTIs, as components of HAART regimens (OR 0.18, 95% CI 0.046-0.76, P=0.019, and OR 0.14, 95% CI 0.034-0.6, P=0.008). CONCLUSION: Cognitive/motor complex has still remained a significant neuropathology among late presenters and elder HIV/AIDS patients. Certain HAART regimens containing AZT, and/or NNRTIs, could be protective for these patients.}, affiliation = {HIV/AIDS Department, Institute for Infectious and Tropical Diseases, Belgrade University School of Medicine, Clinical Centre of Serbia, Bulevar Oslobodjenja 16, 11000 Belgrade, Serbia. djordjejevtovic@hotmail.com}, number = {8}, pages = {561--5}, volume = {63}, year = {2009}, month = {Sep}, language = {eng}, keywords = {Incidence, Time Factors, Motor Skills, Risk Factors, AIDS Dementia Complex, HIV Infections, Female, Adolescent, Male, Psychiatric Status Rating Scales, Middle Aged, RNA: Viral, Treatment Outcome, Odds Ratio, Neurologic Examination, Cognition, HIV, CD4 Lymphocyte Count, Young Adult, Humans, Logistic Models, Cross-Sectional Studies, Risk Assessment, Neuroprotective Agents, Viral Load, Adult, Age Factors, Anti-HIV Agents, Antiretroviral Therapy: Highly Active, Aged, Serbia}, date-added = {2010-02-05 20:19:44 +0100}, date-modified = {2010-02-05 20:19:44 +0100}, doi = {10.1016/j.biopha.2008.09.015}, pii = {S0753-3322(08)00365-X}, pmid = {19026516}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5147}, rating = {0} } @article{Rousson:2002p14018, author = {Valentin Rousson and Theo Gasser and Burkhardt Seifert}, journal = {Stat Med}, title = {Assessing intrarater, interrater and test-retest reliability of continuous measurements}, abstract = {In this paper we review the problem of defining and estimating intrarater, interrater and test-retest reliability of continuous measurements. We argue that the usual notion of product-moment correlation is well adapted in a test-retest situation, whereas the concept of intraclass correlation should be used for intrarater and interrater reliability. The key difference between these two approaches is the treatment of systematic error, which is often due to a learning effect for test-retest data. We also consider the reliability of a sum and a difference of variables and illustrate the effects on components. Further, we compare these approaches of reliability with the concept of limits of agreement proposed by Bland and Altman (for evaluating the agreement between two methods of clinical measurements) and show how product-moment correlation is related to it. We then propose new kinds of limits of agreement which are related to intraclass correlation. A test battery to study the development of neuro-motor functions in children and adolescents illustrates our purpose throughout the paper.}, affiliation = {Department of Biostatistics, Institute for Social and Preventive Medicine, University of Zurich, Sumatrastrasse 30, CH-8006 Zurich, Switzerland. rousson@ifspm.unizh.ch}, number = {22}, pages = {3431--46}, volume = {21}, year = {2002}, month = {Nov}, language = {eng}, keywords = {Child, Models: Statistical, Female, Humans, Reproducibility of Results, Motor Skills, Male, Observer Variation}, date-added = {2010-08-07 10:08:26 +0200}, date-modified = {2010-08-07 10:08:35 +0200}, doi = {10.1002/sim.1253}, pmid = {12407682}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Rousson-2002-Stat%20Med_Assessing%20intrarater.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p14018}, rating = {3} } @article{WillemsenSwinkels:2002p6196, author = {Sophie H N Willemsen-Swinkels and Jan K Buitelaar}, journal = {Psychiatr Clin North Am}, title = {The autistic spectrum: subgroups, boundaries, and treatment}, abstract = {There is consensus about the disorders that comprise the autistic spectrum, with autistic disorder, Asperger's disorder, and PDD-NOS as the most typical examples and Rett's disorder and disintegrative disorder as the other components. Important controversies regarding the precise definitions of autistic spectrum disorders and the boundaries between the milder manifestations of those disorders, particularly PDD-NOS, and non-autistic conditions have not been and cannot be resolved fully as long as there is no known biologic cause or consistent biologic or psychological marker. This includes issues as basic as whether the autistic spectrum is a predominantly unitary entity or a collection of more or less similar phenotypes with multiple, varying etiologies. This is why the highest long-term priority in the area of definite diagnosis is the search for biologic marker(s) for autism and related autism spectrum disorders [91]. In the absence of a medical test to unequivocally diagnose autism, definitions of autism and related conditions are based only on manifestations in overt behavior, with all the unreliability this entails. In the future, the discovery of biologic correlates, causes, and pathogenetic pathways will undoubtedly change the way in which autism is diagnosed and lead to a new nosology [95]. Until that time the definitions in the current versions of the classification systems should be considered in a state of evolution. The key problem of the current classification systems is the fact that the boundaries between the various disorders are fuzzy. Instead of a categorical approach, a more useful description might be that of "autistic spectrum disorder," which reflects the range of severity of symptoms. Such a dimensional understanding of PDD is useful to clinicians, who may otherwise use nonspecific terms to avoid the categorical diagnosis of autism [31]. Rutter and Schopler [96] argued for separate clinical and research schemes because clinical and research needs are different. For research purposes it is desirable to have as much direct comparability across studies as possible. The focus is on a high degree of homogeneity within diagnostic groupings. A price must be paid for this detailed specification, and the main cost lies in the proportion of cases left undiagnosed. For example, there may be good scientific reasons for a narrowly defined categorical diagnosis that includes only individuals who definitely and clearly have a specifically defined condition and excludes individuals who may have the condition. For clinicians and educators, classification helps guide the selection of treatments for an individual. From this point of view, broader diagnostic concepts may be most appropriate [95].}, affiliation = {Department of Child and Adolescent Psychiatry, University Medical Center, PO Box 85500, 3508 GA Utrecht, The Netherlands. s.h.n.willemsen@psych.azu.nl}, number = {4}, pages = {811--36}, volume = {25}, year = {2002}, month = {Dec}, language = {eng}, keywords = {Autistic Disorder, Infant, Syndrome, Child, Treatment Outcome, Humans, Diagnosis: Differential}, date-added = {2010-02-19 20:22:13 +0100}, date-modified = {2010-07-29 19:53:27 +0200}, pmid = {12462862}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6196}, rating = {0} } @article{JohnsonKozlow:2010p10008, author = {Marilyn Johnson-Kozlow and Dennis R Wahlgren and Melbourne F Hovell and Danette M Flores and Sandy Liles and C Richard Hofstetter and Jennifer Zellner and Joy M Zakarian}, journal = {Journal of Clinical Epidemiology}, title = {Adolescents validly report their exposure to secondhand smoke}, abstract = {OBJECTIVE: This study examined the validity of child-reported exposure to secondhand smoke (SHS) and investigated factors, such as child's age, which might affect accuracy of recall. STUDY DESIGN AND SETTING: Participants were drawn from a nonprobability sample of 380 families who completed baseline assessment as part of a randomized trial of an SHS reduction intervention conducted in an urban setting in Southern California. Parents and children (aged 8-13 years) retrospectively reported child's exposure to SHS using timeline followback methodology; reports were compared with child's urine cotinine. RESULTS: Validity coefficients for parents and children were comparable (r=0.58 vs. r=0.53), but parents recalled three times more exposure than children (2.2 vs. 0.8 cigarettes per day; P<0.001). Regression models predicting cotinine indicated that including child in addition to parent reports resulted in better prediction than either alone. CONCLUSION: When there is a choice, parent reports are preferable over child reports because of decreased underreporting. However, child-reported SHS exposure had adequate validity (r>0.50) and might be appropriate in some situations. Researchers might consider collecting both parent and child reports because each made a unique contribution to the prediction of cotinine.}, affiliation = {Center for Behavioral Epidemiology and Community Health, Graduate School of Public Health, San Diego State University, San Diego, CA 92123, USA.}, pages = {}, year = {2010}, month = {Mar}, language = {ENG}, date-added = {2010-03-31 20:00:04 +0200}, date-modified = {2010-03-31 20:00:04 +0200}, doi = {10.1016/j.jclinepi.2009.11.015}, pii = {S0895-4356(09)00391-6}, pmid = {20346628}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Johnson-Kozlow-2010-Journal%20of%20Clinical%20Epidemiology_Adolescents%20validly-1.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p10008}, rating = {0} } @article{Bolker:2008p2295, author = {B Bolker}, title = {GLMM simulation and p-value computation in lme4}, year = {2008}, date-added = {2010-01-10 12:09:55 +0100}, date-modified = {2010-01-10 12:10:12 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Bolker-2008-_GLMM%20simulation%20and.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2295}, rating = {0} } @article{Chavent:2007p4096, author = {M Chavent and V Kuentz and J Saracco}, journal = {Modulad}, title = {Analyse en Facteurs : pr ́esentation et comparaison des logiciels SAS, SPAD et SPSS}, abstract = {In data analysis, factorial methods are essential. These techniques can be used as an end in themselves, seeking to highlight underlying common factors in a group of variables. They can also be used as input to another analysis. Then, they consist in data dimension reduction and operate by replacing the original variables, sometimes highly correlated, by a smaller number of linearly independent variables. Factor Analysis (F.A.) is one possible method for quantitative data. This article aims at presenting in a synthetic way the F.A. model, rarely described in French books, but frequent in the Anglo-Saxon literature, and often available in softwares. The presentation of the estimation techniques for the F.A. model enables to estab- lish the existing connection between Principal Component Analysis (P.C.A.) and F.A. The usefulness of rotation techniques, which can facilitate the interpretation of the results, will also be shown. An application on crime data of American cities will be carried out and will allow to describe the results provided by three of the most used statistical softwares : SAS, SPAD and SPSS. Then it will help to clarify the vocabulary, sometimes confused for the user.}, number = {37}, year = {2007}, date-added = {2010-01-19 23:27:45 +0100}, date-modified = {2010-07-29 19:40:18 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Chavent-2007-Modulad_Analyse%20en%20Facteurs.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p4096}, rating = {0} } @article{Kendler:2003p2903, author = {Kenneth S Kendler and Carol A Prescott and John Myers and Michael C Neale}, journal = {Arch Gen Psychiatry}, title = {The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women}, abstract = {BACKGROUND: Patterns of comorbidity suggest that the common psychiatric and substance use syndromes may be divisible into 2 broad groups of internalizing and externalizing disorders. We do not know how genetic and environmental risk factors contribute to this pattern of comorbidity or whether the etiologic structure of these groups differ in men and women. METHODS: Lifetime diagnoses for 10 psychiatric syndromes were obtained at a personal interview in more than 5600 members of male-male and female-female twin pairs ascertained from a population-based registry. Multivariate twin modeling was performed using the program Mx. RESULTS: We first fit models to the following 7 syndromes: major depression, generalized anxiety disorder, phobia, alcohol dependence, drug abuse/dependence, adult antisocial behavior, and conduct disorder. The full model, which could be constrained to equality in male and female subjects, identified 2 genetic factors. The first had strongest loadings on alcohol dependence, drug abuse/dependence, adult antisocial behavior, and conduct disorder; the second, on major depression, generalized anxiety disorder, and phobia. Alcohol dependence and drug abuse/dependence had substantial disorder-specific genetic risk factors. Shared environmental factors were most pronounced for conduct disorder and adult antisocial behavior. No clear internalizing/externalizing structure was seen for the unique environmental common factors. We then fit models to 5 internalizing syndromes. The full model, which could also be constrained to equality in men and women, revealed one genetic factor loading most heavily on major depression and generalized anxiety disorder and another loading most strongly on animal and situational phobia. CONCLUSIONS: The underlying structure of the genetic and environmental risk factors for the common psychiatric and drug abuse disorders in men and women is very similar. Genetic risk factors predispose to 2 broad groups of internalizing and externalizing disorders. Within the internalizing disorders, 2 genetic factors are seen that predispose to disorders dominated by anxious-misery and fear. Substance use disorders have disorder-specific genetic risks. The externalizing disorders of conduct disorder and adult antisocial behavior are significantly influenced by the shared environment. The pattern of lifetime comorbidity of common psychiatric and substance use disorders results largely from the effects of genetic risk factors.}, affiliation = {Virginia Institute for Psychiatry and Behavioral Genetics and the Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0126, USA.}, number = {9}, pages = {929--37}, volume = {60}, year = {2003}, month = {Sep}, language = {eng}, keywords = {Genetic Predisposition to Disease, Phenotype, Middle Aged, Sex Factors, Diseases in Twins, Social Environment, Research Design, Mental Disorders, Risk Factors, Female, Models: Statistical, Humans, Prevalence, Substance-Related Disorders, Multivariate Analysis, Male, Comorbidity, Adult, Models: Genetic}, date-added = {2010-01-13 15:00:30 +0100}, date-modified = {2010-01-13 15:00:30 +0100}, doi = {10.1001/archpsyc.60.9.929}, pii = {60/9/929}, pmid = {12963675}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Kendler-2003-Arch%20Gen%20Psychiatry_The%20structure%20of%20gen.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2903}, rating = {0} } @article{Sugiura:2000p12150, author = {M Sugiura and R Kawashima and M Nakagawa and K Okada and T Sato and R Goto and K Sato and S Ono and T Schormann and K Zilles and H Fukuda}, journal = {Neuroimage}, title = {Correlation between human personality and neural activity in cerebral cortex}, abstract = {Personality traits are a variance of behavioral patterns among individuals and may reflect a variance of brain activity, but their neurobiological explanation is still a matter of debate. Cloninger proposed three dimensions of personality traits, each of which has strong correlation with activity in a specific central monoaminergic system. Although this theory has been supported by physiological and genetic studies, it is still unclear how these personality parameters are correlated with the activity of the cortical networks which control human behavior. Here we measured the regional cerebral blood flow (rCBF) at rest in 30 normal volunteers who completed the personality inventory of Cloninger. Voxel-by-voxel analysis was employed to identify cortical regions where the rCBF showed significant correlation with any of the three personality parameters. Statistically significant correlation was observed in several paralimbic and neocortical regions and was consistent with the assumed monoaminergic influence on neural activity and the distribution of its projections, in each personality dimension. The results suggest that activity in a variety of cortical regions is associated with human personality traits and lend support to Cloninger's theory concerning central monoaminergic influence on human personality traits.}, affiliation = {Department of Nuclear Medicine and Radiology, Institute of Development, Aging, and Cancer, Tohoku University, 4-1 Seiryomachi, Aoba-ku, Sendai, 980-8575, Japan.}, number = {5 Pt 1}, pages = {541--6}, volume = {11}, year = {2000}, month = {May}, language = {eng}, keywords = {Cerebral Cortex, Humans, Male, Tomography: Emission-Computed: Single-Photon, Neural Pathways, Rest, Adult, Middle Aged, Personality, Reference Values, Female, Cerebrovascular Circulation}, date-added = {2010-05-30 10:36:04 +0200}, date-modified = {2010-05-30 10:36:18 +0200}, doi = {10.1006/nimg.2000.0564}, pii = {S1053-8119(00)90564-0}, pmid = {10806039}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Sugiura-2000-Neuroimage_Correlation%20between.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12150}, rating = {4} } @article{Dennis:2008p11570, author = {S Dennis and M D Lee and A Kinnell}, journal = {Journal of Memory and Language}, title = {Bayesian analysis of recognition memory: The case of the list-length effect}, abstract = {Recognition memory experiments are an important source of empirical constraints for the- ories of memory. Unfortunately, standard methods for analyzing recognition memory data have problems that are often severe enough to prevent clear answers being obtained. A key example is whether longer lists lead to poorer recognition performance. The presence or absence of such a list-length effect is a critical test of competing item- and context-noise based theories of interference and bares on whether recognition involves ``recall-like'' com- ponents as dual process theories would contend. However, the issue has remained unre- solved, in part, because of the weaknesses of the standard analysis. In this paper, we develop a Bayesian method of analysis and apply it to new data on the list-length effect. The analysis allows us to find positive evidence in favor of a null list-length effect as pre- dicted by context noise models. The data also illustrate the importance of the contextual reinstatement process on recognition performance and show how previous work demon- strating a list-length effect may have been contaminated by reinstatement confounds. By contrasting our new method against the standard approach we highlight the advantages of the Bayesian framework when inferring the values of psychologically meaningful vari- ables, and in choosing between models representing different theoretical assumptions about memory.}, pages = {361--376}, volume = {59}, year = {2008}, date-added = {2010-05-01 17:38:35 +0200}, date-modified = {2010-05-01 17:39:18 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Dennis-2008-Journal%20of%20Memory%20and%20Language_Bayesian%20analysis%20of.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11570}, rating = {0} } @article{Wray:2010p6648, author = {Naomi R Wray and Jian Yang and Michael E Goddard and Peter M Visscher}, journal = {PLoS Genet}, title = {The Genetic Interpretation of Area under the ROC Curve in Genomic Profiling}, abstract = {Genome-wide association studies in human populations have facilitated the creation of genomic profiles which combine the effects of many associated genetic variants to predict risk of disease. The area under the receiver operator characteristic (ROC) curve is a well established measure for determining the efficacy of tests in correctly classifying diseased and non-diseased individuals. We use quantitative genetics theory to provide insight into the genetic interpretation of the area under the ROC curve (AUC) when the test classifier is a predictor of genetic risk. Even when the proportion of genetic variance explained by the test is 100%, there is a maximum value for AUC that depends on the genetic epidemiology of the disease, i.e. either the sibling recurrence risk or heritability and disease prevalence. We derive an equation relating maximum AUC to heritability and disease prevalence. The expression can be reversed to calculate the proportion of genetic variance explained given AUC, disease prevalence, and heritability. We use published estimates of disease prevalence and sibling recurrence risk for 17 complex genetic diseases to calculate the proportion of genetic variance that a test must explain to achieve AUC = 0.75; this varied from 0.10 to 0.74. We provide a genetic interpretation of AUC for use with predictors of genetic risk based on genomic profiles. We provide a strategy to estimate proportion of genetic variance explained on the liability scale from estimates of AUC, disease prevalence, and heritability (or sibling recurrence risk) available as an online calculator.}, affiliation = {Genetic Epidemiology and Queensland Statistical Genetics, Queensland Institute of Medical Research, Brisbane, Australia.}, number = {2}, pages = {e1000864}, volume = {6}, year = {2010}, month = {Feb}, language = {eng}, date-added = {2010-03-03 20:35:49 +0100}, date-modified = {2010-03-03 20:35:49 +0100}, doi = {10.1371/journal.pgen.1000864}, pmid = {20195508}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Wray-2010-PLoS%20Genet_The%20Genetic%20Interpre.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6648}, rating = {0} } @techreport{Antonietti:2004, author = {J-P Antonietti}, journal = {Techreport}, title = {Comment s'assurer de l'alignement d'un ensemble d'items}, affiliation = {Institut de Math{\'e}matiques Appliqu{\'e}es}, year = {2004}, date-added = {2010-01-10 11:33:20 +0100}, date-modified = {2010-07-29 20:42:07 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Antonietti-2004-Techreport_Comment%20s'assurer%20de.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2107}, rating = {0} } @article{HenjeBlom:2010p12781, author = {Eva C Henje Blom and Eva Serlachius and Jan-Olov Larsson and Tores Theorell and Martin Ingvar}, journal = {Health Qual Life Outcomes}, title = {Low Sense of Coherence (SOC) is a mirror of general anxiety and persistent depressive symptoms in adolescent girls - a cross-sectional study of a clinical and a non-clinical cohort}, abstract = {ABSTRACT: BACKGROUND: The Sense of Coherence (SOC) scale is assumed to measure a distinct salutogenic construct separated from measures of anxiety and depression. Our aim was to challenge this concept. METHOD: The SOC-scale, Beck's Depression Inventory (BDI), Beck's Anxiety Inventory (BAI), the emotional subscale of the Strengths and Difficulties Questionnaire (SDQ-em) and self-assessed health-related and physiological parameters were collected from a sample of non-clinical adolescent females (n=66, mean age 16.5 years with a range of 15.9-17.7 years) and from female psychiatric patients (n=73), mean age 16.8 years with a range of 14.5-18.4 years), with diagnoses of major depressive disorders (MDD) and anxiety disorders. RESULTS: The SOC scores showed high inverse correlations to BDI, BAI and SDQ-em. In the non-clinical sample the correlation coefficient was -0.86 to -0.73 and in the clinical sample -0.74 to -0.53 (p<0.001). Multiple regression models showed that BDI was the strongest predictor of SOC in the non-clinical (beta coefficient -0.47) and clinical sample (beta coefficient -0.52). The total degree of explanation of self-assessed anxiety and depression on the SOC variance estimated by multiple R2=0.74, adjusted R2=0.73 in the non-clinical sample and multiple R2=0.66, adjusted R2=0.65 in the clinical sample. Multivariate analyses failed to isolate SOC as a separate construct and the SOC-scale, BDI, BAI and SDQ-em showed similar patterns of correlations to self-reported and physiological health parameters in both samples. The SOC-scale was the most stable measure over six months. CONCLUSIONS: The SOC-scale did not appear to be a measure of a distinct salutogenic construct, but an inverse measure of persistent depressive symptoms and generalized social anxiety similar to the diagnostic criteria for major depressive disorder (MDD), dysthymic disorder, generalized anxiety disorder (GAD) or generalized social anxiety disorder (SAD) according to DSM-IV. These symptoms were better captured with SOC than by the specialized scales for anxiety and depression. Self-assessment scales that adequately identify MDD, dysthymic disorder, GAD and SAD need to be implemented. Comorbidity of these disorders is common in adolescent females and corresponds to a more severe symptomatology and impaired global function.}, number = {1}, pages = {58}, volume = {8}, year = {2010}, month = {Jun}, language = {ENG}, date-added = {2010-06-18 20:46:17 +0200}, date-modified = {2010-06-18 20:46:17 +0200}, doi = {10.1186/1477-7525-8-58}, pii = {1477-7525-8-58}, pmid = {20537185}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Henje%20Blom-2010-Health%20and%20Quality%20of%20Life%20Outcomes_Low%20Sense%20of%20Coheren-1.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12781}, rating = {0} } @article{Sugiyama:2008p14223, author = {M Sugiyama and N Rubens}, title = {Active Learning with Model Selection in Linear Regression}, abstract = {Optimally designing the location of training input points (active learning) and choosing the best model (model selection) are two important components of su- pervised learning and have been studied extensively. However, these two issues seem to have been investi- gated separately as two independent problems. If train- ing input points and models are simultaneously opti- mized, the generalization performance would be further improved. In this paper, we propose a new approach called ensemble active learning for solving the problems of active learning and model selection at the same time. We demonstrate by numerical experiments that the pro- posed method compares favorably with alternative ap- proaches such as iteratively performing active learning and model selection in a sequential manner.}, year = {2008}, date-added = {2010-08-22 21:06:45 +0200}, date-modified = {2010-08-22 21:07:49 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Sugiyama-2008-_Active%20Learning%20with.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p14223}, rating = {0} } @article{Tomer:2008p10524, author = {Rachel Tomer and Rita Z Goldstein and Gene-Jack Wang and Christopher Wong and Nora D Volkow}, journal = {Biol Psychol}, title = {Incentive motivation is associated with striatal dopamine asymmetry}, abstract = {Dopamine plays an important role in modulating incentive motivation, expressed behaviorally as approach behavior. EEG studies report association between approach behavior and asymmetric pattern of activation in anterior cortical regions (as measured by the inverse of EEG alpha power). Therefore, individual differences in incentive motivation may reflect asymmetries in dopaminergic systems. We examined this hypothesis by studying the relationship between self-reported degree of incentive motivation, and asymmetry of D2 receptor availability in healthy volunteers. Nineteen healthy participants were studied with positron emission tomography (PET) and [11C]raclopride to assess the availability of dopamine D2 receptors in left and right striatum. Incentive motivation was assessed by the Achievement scale of the Multidimensional Personality Questionnaire. The Achievement score was negatively correlated with the Asymmetry Index ([R-L]/[R+L]) of D2 receptor availability (r=-.721, p=.001), suggesting that greater positive incentive motivation is associated with higher receptor availability in the left relative to the right hemisphere.}, affiliation = {Department of Psychology {\&} Brain and Behavior Center, University of Haifa, Mount Carmel 31905, Israel. rtomer@psy.haifa.ac.il}, number = {1}, pages = {98--101}, volume = {77}, year = {2008}, month = {Jan}, language = {eng}, keywords = {Positron-Emission Tomography, Image Processing: Computer-Assisted, Adult, Individuality, Neostriatum, Functional Laterality, Humans, Motivation, Receptors: Dopamine D3, Dopamine Plasma Membrane Transport Proteins, Middle Aged, Synaptic Transmission, Dopamine Antagonists, Raclopride, Male, Receptors: Dopamine D2, Female, Dopamine, Parkinson Disease, Aged}, date-added = {2010-04-07 11:22:30 +0200}, date-modified = {2010-04-07 11:22:30 +0200}, doi = {10.1016/j.biopsycho.2007.08.001}, pii = {S0301-0511(07)00125-1}, pmid = {17868972}, URL = {http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T4T-4PF1WKH-1&_user=2432700&_coverDate=01%252F31%252F2008&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000057263&_version=1&_urlVersion=0&_userid=2432700&md5=772e07a54bc39980cdc8d7aadfb351ad}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Tomer-2008-Biol%20Psychol_Incentive%20motivation.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p10524}, rating = {0} } @article{Ginkel:2007, author = {Joost R van Ginkel and L Andries van der Ark and Klaas Sijtsma and Jeroen K Vermunt}, journal = {Computational Statistics}, title = {Two-way imputation: A bayesian method for estimating missing scores in tests and questionnaires, and an accurate approximation}, pages = {4013--4027}, volume = {51}, year = {2007}, date-added = {2010-01-10 11:33:23 +0100}, date-modified = {2010-07-29 20:42:55 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Ginkel-2007-Computational%20Statistics_Two-way%20imputation.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1856}, rating = {0} } @article{Eiser:2001p8499, author = {C Eiser and R Morse}, journal = {Health Technol Assess}, title = {Quality-of-life measures in chronic diseases of childhood}, abstract = {SCOPE OF THE REPORT: This report is concerned with the evaluation of measures broadly designed to measure quality of life (QoL) in children and adolescents, either by self-report or proxy raters. Four research questions were identified: (1) To what extent are adult measures used in the evaluation of healthcare interventions in children? (2) How appropriate are adult measures for use with children? (3) To what extent do child self-reports correspond with assessments made by parents and carers? (4) How feasible and reliable are proxy measures of QoL in different disease contexts? OBJECTIVES: (1) To review the state of the art with regard to measurement of QoL for children. (2) To make recommendations regarding the value of currently available measures for different purposes. (3) To identify further research needs. METHOD: Electronic databases were searched for the period 1980-July 1999 for articles relating to measures of QoL, health status or well-being in children (under 18 years) with chronic disease. Handsearching of relevant journals and cross-referencing with reference lists in identified articles was also carried out. Key workers in the field were contacted for additional information, and the Internet was searched for relevant websites. RESULTS: Forty-three measures were identified (19 generic and 24 disease-specific). Sixteen measures allowed for completion by children and parent/caregiver; seven only allowed for completion by a proxy, and the remainder (n = 17) allowed only for child completion. The measures were described as QoL (n = 30), health status, (n = 2), perception of illness (n = 1), life satisfaction (n = 1) and quality of well-being (n = 1). RESULTS - TO WHAT EXTENT ARE ADULT MEASURES USED IN THE EVALUATION OF HEALTHCARE INTERVENTIONS IN CHILDREN?: Three studies were identified where adult measures were used with very few changes made for children. In 11 studies involving nine separate measures of QoL, adult measures were used as a model for work with children. RESULTS - HOW APPROPRIATE ARE ADULT MEASURES FOR USE WITH CHILDREN?: Adult measures may fail to tap the specific aspects of QoL that are important to the child. Measures based on adult work impose considerable response burden for children, in terms of length, reading skills and response scale. Wording and format of adult measures may need to be modified to account for children's cognitive and language skills. More basic research is needed to determine the level of response burden that children of different ages can manage. Assessments of difficulty (e.g. reading age) need to be routinely included with information about new measures. RESULTS - TO WHAT EXTENT DO CHILD SELF-REPORTS CORRESPOND WITH ASSESSMENTS MADE BY PARENTS AND CARERS?: Fourteen studies were identified in which concor-dance between child and parent was investigated, often as part of the development of a new measure. There was some evidence for greater concordance between child and parent for physical functioning compared with social and emotional domains, but greater heterogeneity in the latter measures may contribute to inconsistent results. There was no simple relationship between concordance and moderating variables such as age, gender and illness, but this conclusion was addressed only very rarely. RESULTS - HOW FEASIBLE AND RELIABLE ARE PROXY MEASURES OF QOL IN DIFFERENT DISEASE CONTEXTS?: Only five papers fulfilled the review criteria. Evaluation is difficult because authors fail to justify their choice of measures, and do not report critical information such as completion rates or missing data. Use of existing measures can potentially eliminate the time and expense required to develop a comprehensive measure of QoL, but a full battery of standardised tests may be expensive in terms of time for administration and scoring. In addition, battery measures tend to be lengthy and therefore demanding for sick patients. They are not recommended for work with children. RECOMMENDATIONS FOR RESEARCH - MINIMUM CRITERIA FOR NEW MEASURES: A set of procedures needs to be established for the development of new measures. These need to draw on the experience gained in development of child and adult measures to date. Basic research to enhance understanding of how children interpret questions in QoL measures is recommended. We need to understand the differences in meaning of items between children and adults, and between children of different ages. Some attempt to develop measures for children of 6 years or more have been reported, and these should be further developed. (ABSTRACT TRUNCATED)}, affiliation = {Department of Pyschology, University of Sheffield, UK.}, number = {4}, pages = {1--157}, volume = {5}, year = {2001}, month = {Jan}, language = {eng}, keywords = {Self Assessment (Psychology), Quality of Life, Adolescent, Female, Chronic Disease, Child: Preschool, Male, Health Status Indicators, Health Services Research, Child, Disabled Children, Humans, Great Britain}, date-added = {2010-03-21 18:01:02 +0100}, date-modified = {2010-07-29 19:28:35 +0200}, pmid = {11262421}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8499}, rating = {0} } @article{Velez:2010p7654, author = {Lady Velez and Greta Sokoloff and Klaus A Miczek and Abraham A Palmer and Stephanie C Dulawa}, journal = {Behav Genet}, title = {Differences in aggressive behavior and DNA copy number variants between BALB/cJ and BALB/cByJ substrains}, abstract = {Some BALB/c substrains exhibit different levels of aggression. We compared aggression levels between male BALB/cJ and BALB/cByJ substrains using the resident intruder paradigm. These substrains were also assessed in other tests of emotionality and information processing including the open field, forced swim, fear conditioning, and prepulse inhibition tests. We also evaluated single nucleotide polymorphisms (SNPs) previously reported between these BALB/c substrains. Finally, we compared BALB/cJ and BALB/cByJ mice for genomic deletions or duplications, collectively termed copy number variants (CNVs), to identify candidate genes that might underlie the observed behavioral differences. BALB/cJ mice showed substantially higher aggression levels than BALB/cByJ mice; however, only minor differences in other behaviors were observed. None of the previously reported SNPs were verified. Eleven CNV regions were identified between the two BALB/c substrains. Our findings identify a robust difference in aggressive behavior between BALB/cJ and BALB/cByJ substrains, which could be the result of the identified CNVs.}, affiliation = {Department of Psychiatry and Behavioral Neuroscience, University of Chicago, 924 East 57th Street, Room R018, MC 3077, Chicago, IL, 60637, USA.}, number = {2}, pages = {201--10}, volume = {40}, year = {2010}, month = {Mar}, language = {eng}, date-added = {2010-03-15 23:24:23 +0100}, date-modified = {2010-07-29 20:09:06 +0200}, doi = {10.1007/s10519-009-9325-5}, pmid = {20033273}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Velez-2010-Behav%20Genet_Differences%20in%20aggre.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7654}, rating = {0} } @article{Schmier:1998p8811, author = {J K Schmier and K S Chan and N K Leidy}, journal = {J Asthma}, title = {The impact of asthma on health-related quality of life}, abstract = {Although a substantial body of epidemiological and economic literature on asthma exists, relatively little is known about the impact of asthma on health-related quality of life (HRQL). The purpose of this review was to synthesize results from recent studies, profile the factors influencing HRQL in asthmatics, discuss the impact of treatment on HRQL outcomes, and offer recommendations for further research. The results of this review support the premise that asthma can adversely affect the physical, psychological, and social domains of HRQL. Published data suggest that females, those from lower socioeconomic groups, and ethnic minorities experience poorer quality of life as a result of their asthma symptoms. Results of published clinical trials indicate treatment regimens can have a significant impact on HRQL outcomes. Pharmacological interventions appear to effect change primarily in the physical domain and behavioral interventions lead to improvements in both physical and psychosocial domains. Future research should focus on precise a priori delineation of research hypotheses, including the selection of primary and secondary endpoints, the clarification and consistent application of criteria for defining asthma severity, thoughtful selection of HRQL instruments appropriate for the research hypotheses and target population, and careful delineation of clinically meaningful change scores of asthma-specific outcome measures.}, affiliation = {Center for Health Outcomes Research, MEDTAP International Inc., Bethesda, Maryland 20814, USA. schmier@medtap.com}, number = {7}, pages = {585--97}, volume = {35}, year = {1998}, month = {Jan}, language = {eng}, keywords = {Quality of Life, Humans, Health Status, Asthma, Sickness Impact Profile}, date-added = {2010-03-22 12:11:34 +0100}, date-modified = {2010-03-22 12:11:35 +0100}, pmid = {9777885}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8811}, rating = {0} } @article{Suykens:2010p14293, author = {J A K Suykens and C Alzate and K Pelckmans}, journal = {Statistics Surveys}, title = {Primal and dual model representations in kernel-based learning}, abstract = {This paper discusses the role of primal and (Lagrange) dual model representations in problems of supervised and unsupervised learning. The specification of the estimation problem is conceived at the primal level as a constrained optimization problem. The constraints relate to the model which is expressed in terms of the feature map. From the conditions for optimality one jointly finds the optimal model representation and the model estimate. At the dual level the model is expressed in terms of a positive definite kernel function, which is characteristic for a support vector machine methodology. It is discussed how least squares support vector machines are playing a central role as core models across problems of regression, classification, principal component analysis, spectral clustering, canonical correlation analysis, dimensionality reduction and data visualization.}, pages = {148--183}, volume = {4}, year = {2010}, date-added = {2010-08-24 14:08:53 +0200}, date-modified = {2010-08-24 14:11:11 +0200}, doi = {10.1214/09-SS052}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Suykens-2010-Statistics%20Surveys_Primal%20and%20dual%20mode.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p14293}, rating = {0} } @article{Chao:2009p11826, author = {Herta H A Chao and Xi Luo and Jeremy L K Chang and Chiang-Shan R Li}, journal = {BMC Neurosci}, title = {Activation of the pre-supplementary motor area but not inferior prefrontal cortex in association with short stop signal reaction time--an intra-subject analysis}, abstract = {BACKGROUND: Our previous work described the neural processes of motor response inhibition during a stop signal task (SST). Employing the race model, we computed the stop signal reaction time (SSRT) to index individuals' ability in inhibitory control. The pre-supplementary motor area (preSMA), which shows greater activity in individuals with short as compared to those with long SSRT, plays a role in mediating response inhibition. In contrast, the right inferior prefrontal cortex (rIFC) showed greater activity during stop success as compared to stop error. Here we further pursued this functional differentiation of preSMA and rIFC on the basis of an intra-subject approach. RESULTS: Of 65 subjects who participated in four sessions of the SST, we identified 30 individuals who showed a difference in SSRT but were identical in other aspects of stop signal performance between the first ("early") and last two ("late") sessions. By comparing regional brain activation between the two sessions, we confirmed greater preSMA but not rIFC activity during short as compared to long SSRT session within individuals. Furthermore, putamen, anterior cerebellum and middle/posterior cingulate cortex also showed greater activity in association with short SSRT. CONCLUSION: These results are consistent with a role of medial prefrontal cortex in controlled action and inferior frontal cortex in orienting attention. We discussed these findings with respect to the process of attentional monitoring and inhibitory motor control during stop signal inhibition.}, affiliation = {Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA. herta.chao@yale.edu}, pages = {75}, volume = {10}, year = {2009}, month = {Jan}, language = {eng}, keywords = {Magnetic Resonance Imaging, Adult, Neuropsychological Tests, Female, Motor Cortex, Prefrontal Cortex, Reaction Time, Middle Aged, Humans, Male}, date-added = {2010-05-23 10:46:56 +0200}, date-modified = {2010-05-23 10:46:57 +0200}, doi = {10.1186/1471-2202-10-75}, pii = {1471-2202-10-75}, pmid = {19602259}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Chao-2009-BMC%20Neurosci_Activation%20of%20the%20pr.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11826}, rating = {0} } @article{Hays:2000, author = {R D Hays and L S Morales and S P Reise}, journal = {Med Care}, title = {Item response theory and health outcomes measurement in the 21st century.}, abstract = {Item response theory (IRT) has a number of potential advantages over classical test theory in assessing self-reported health outcomes. IRT models yield invariant item and latent trait estimates (within a linear transformation), standard errors conditional on trait level, and trait estimates anchored to item content. IRT also facilitates evaluation of differential item functioning, inclusion of items with different response formats in the same scale, and assessment of person fit and is ideally suited for implementing computer adaptive testing. Finally, IRT methods can be helpful in developing better health outcome measures and in assessing change over time. These issues are reviewed, along with a discussion of some of the methodological and practical challenges in applying IRT methods.}, affiliation = {UCLA, School of Medicine, Los Angeles, California, USA. hays\char64rand.org}, number = {9 Suppl}, pages = {II28--42}, volume = {38}, year = {2000}, month = {Sep}, language = {eng}, date-added = {2010-01-03 19:38:21 +0100}, date-modified = {2010-07-29 19:39:29 +0200}, pmid = {10982088}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Hays-2000-Med%20Care_Item%20response%20theory.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1181}, read = {Yes}, rating = {0} } @misc{Hedeker:2000, author = {D Hedeker and R J Mermelstein and B R Flay}, journal = {Miscellaneous}, title = {Application of item response theory models for longitudinal data}, year = {2000}, date-added = {2010-01-10 11:33:22 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Hedeker-2000-Miscellaneous_Application%20of%20item.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2171}, rating = {0} } @article{Fitzpatrick:2004p5881, author = {R Fitzpatrick and J M Norquist and C Jenkinson and B C Reeves and R W Morris and D W Murray and P J Gregg}, journal = {Qual Life Res}, title = {A comparison of Rasch with Likert scoring to discriminate between patients' evaluations of total hip replacement surgery}, abstract = {The purpose of this study was to examine whether there are advantages in terms of outcome assessment of using Rasch methods of scoring the 12-item Oxford Hip Score (OHS) questionnaire over conventionally Likert scores. As part of a prospective cohort study of total hip replacements in five former regions of England the OHS was sent to patients pre-operatively, at 3 months and 1 year post-operatively. Post-operative data was collected on over 5000 cases. Based on the level of satisfaction with surgery, patients were divided into satisfied and dissatisfied. Analyses were performed to test the relative precision (RP) of Rasch scoring vs. conventionally Likert scores in discriminating the groups experiencing different level of satisfaction. Considerable gains in precision were achieved with Rasch scoring methods when groups were compared 3 and 12 months post-operatively. The results from the current study suggest that in some situations there may be substantial gains in measuring health related outcomes using Rasch-based scoring methods.}, affiliation = {Department of Public Health, Institute of Health Sciences, University of Oxford, Headington, Oxford, UK. raymond.fitzpatrick@nuffield.oxford.ac.uk}, number = {2}, pages = {331--8}, volume = {13}, year = {2004}, month = {Mar}, language = {eng}, keywords = {Quality of Life, Activities of Daily Living, Patient Satisfaction, Outcome Assessment (Health Care), Arthroplasty: Replacement: Hip, England, Follow-Up Studies, Pain Measurement, Humans, Prospective Studies, Questionnaires, Psychometrics}, date-added = {2010-02-17 15:07:15 +0100}, date-modified = {2010-07-29 19:48:28 +0200}, pmid = {15085905}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Fitzpatrick-2004-Qual%20Life%20Res_A%20comparison%20of%20Rasc.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5881}, rating = {4} } @article{Symington:2002p7326, author = {Amanda Symington and Janet M Pinelli}, journal = {Adv Neonatal Care}, title = {Distilling the evidence on developmental care: a systematic review}, abstract = {PURPOSE: To determine whether developmental care interventions reduce neurodevelopmental delay, poor weight gain, length of hospital stay, length of mechanical ventilation, physiologic stress, and other clinically relevant adverse outcomes in preterm infants. SUBJECTS: Infants born at less than 37 weeks postconceptional age. This review consisted of 31 studies in 4 categories of developmental care interventions, 19 subgroups, and multiple clinical outcomes. The total sample sizes in the individual studies ranged from 16 to 259; the sample size in 18 of the studies was less than 50. DESIGN AND METHODS: A systematic review, based on the Cochrane Collaboration format, of all randomized trials in which elements of developmental care are compared with routine nursery care and that measured clinically relevant outcomes. Searches were made of MEDLINE from 1966 to July 2000. Additional databases were also searched electronically. Reference lists and bibliographies of relevant articles were hand-searched. Experts in the field were contracted. If more than one study in an outcome category existed, a meta-analysis was conducted. PRIMARY OUTCOME MEASURES: Outcome measures included the following: length of hospital stay, weight at discharge, neurodevelopment, physiologic parameters, feeding growth, sleep/wake states, age at discharge, neonatal outcomes, cost of hospital stay, and death. PRINCIPAL RESULTS: Developmental care interventions showed some benefit to preterm infants with respect to improved short-term growth outcomes, decreased respiratory support, decreased incidence of moderate to severe chronic lung disease, decreased length and cost of hospital stay, and improved neurodevelopmental outcomes to 24 months corrected age. These findings were based on 2 or 3 small trials for each outcome. Although a number of other benefits were shown, those results were from single studies with small sample sizes. The lack of blinding of the assessors of the outcome variables was a significant methodological flaw in half of the studies. The costs of the interventions and personnel were not considered in any of the studies. CONCLUSIONS: In most studies, the inclusion of multiple interventions made the determination of the effect of any single intervention difficult. Although there is evidence of some benefit of developmental care interventions overall and no major harmful effects reported, there were a large number of outcomes for which no or conflicting effects were shown. The single trials that did show a significant effect of an intervention on a major clinical outcome were based on small sample sizes, and the findings often were not supported in other small trials. Before a clear direction for practice can be supported, evidence showing more consistent effects of developmental care interventions on important short- and long-term clinical outcomes is needed. The economic impact of the implementation and maintenance of developmental care practices should be considered by individual institutions.}, affiliation = {Children's Hospital, Hamilton Health Sciences Corporation, 4A Neo, 1200 Main St West, Hamilton, ON, Canada L8N 3Z5. symington@hhsc.ca}, number = {4}, pages = {198--221}, volume = {2}, year = {2002}, month = {Aug}, language = {eng}, keywords = {Neonatal Nursing, Nursing Assessment, Male, Infant: Very Low Birth Weight, Infant: Newborn, Follow-Up Studies, Nurse-Patient Relations, Developmental Disabilities, Nurse's Role, Sensitivity and Specificity, Total Quality Management, Needs Assessment, Length of Stay, Infant: Premature, Female, Intensive Care Units: Neonatal, Humans, Infant Care, Birth Weight, Child Development}, date-added = {2010-03-10 20:21:54 +0100}, date-modified = {2010-03-10 20:21:54 +0100}, pmid = {12881934}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7326}, rating = {0} } @article{Giannakopoulos:2009p8348, author = {George Giannakopoulos and Christine Dimitrakaki and Xanthi Pedeli and Gerasimos Kolaitis and Vasiliki Rotsika and Ulricke Ravens-Sieberer and Yannis Tountas}, journal = {Health Qual Life Outcomes}, title = {Adolescents' wellbeing and functioning: relationships with parents' subjective general physical and mental health}, abstract = {BACKGROUND: This study aimed at examining the relationship between parental subjective health status and adolescents' health-related quality of life (HRQoL) as well as the role of gender, socioeconomic status, presence of chronic health care needs and social support on the above interaction. METHODS: Questionnaires were administered to a Greek nation-wide random sample of adolescents (N = 1,194) aged 11-18 years and their parents (N = 973) in 2003. Adolescents' and parents' status was assessed, together with reports of socio-economic status and level of social support. Various statistical tests were used to determine the extent to which these variables were related to each other. RESULTS AND DISCUSSION: Parental subjective mental health status was significantly correlated with adolescents' better physical and psychological wellbeing, moods and emotions, parent-child relationships, school environment and financial resources. Parental subjective physical health status was strongly associated with more positive adolescents' self-perception. Adolescents' male gender, younger age, absence of chronic health care needs, high social support, and higher family income were positively associated with better HRQoL. CONCLUSIONS: This study reinforces the importance of parental subjective health status, along with other variables, as a significant factor for the adolescents' HRQoL.}, affiliation = {Centre for Health Services Research, Department of Hygiene and Epidemiology, University of Athens Medical School, 25 Alexandroupoleos Street, 11527 Athens, Greece.}, pages = {100}, volume = {7}, year = {2009}, month = {Jan}, language = {eng}, keywords = {Adolescent Psychology, Male, Quality of Life, Qualitative Research, Social Environment, Chronic Disease, Female, Social Support, Health Status, Parents, Humans, Child, Adolescent, Greece, Questionnaires, Mental Health, Social Class, Multivariate Analysis}, date-added = {2010-03-21 12:50:39 +0100}, date-modified = {2010-03-21 12:50:52 +0100}, doi = {10.1186/1477-7525-7-100}, pii = {1477-7525-7-100}, pmid = {20003508}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Giannakopoulos-2009-Health%20and%20Quality%20of%20Life%20Outcomes_Adolescents'%20wellbei.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8348}, rating = {4} } @article{Dragomir:2009p11807, author = {Alice Dragomir and Robert C{\^o}t{\'e} and Michel White and Lyne Lalonde and Lucie Blais and Anick B{\'e}rard and Sylvie Perreault}, journal = {Value Health}, title = {Relationship between Adherence Level to Statins, Clinical Issues and Health-Care Costs in Real-Life Clinical Setting}, abstract = {ABSTRACT Objective: Statins have been shown to reduce the risk of major cardiovascular disease. We recognize that there is a major gap between the use of statins in actual practice and treatment guidelines for dyslipidemia. Low adherence to statins may have a significant impact on clinical issues and health-care costs. The objective is to evaluate the impact of low adherence to statins on clinical issues and direct health-care costs. Methods: A cohort of 55,134 patients newly treated with statins was reconstructed from the R{\'e}gie de l'Assurance Maladie du Qu{\'e}bec and Med-Echo databases. Subjects included were aged between 45 and 85, initially free of cardiovascular disease, newly treated with statins between 1999 and 2002, and followed-up for a minimum of 3 years. Adherence to statins was measured in terms of the proportion of days' supply of medication dispensed over a defined period, and categorized as >/=80% or <80%. The adjusted odds ratio (OR) of cardiovascular events between the two adherence groups was estimated using a polytomous logistic analysis. The mean costs of direct health-care services were evaluated. A two-part model was applied for hospitalization costs. Results: The mean high adherence level to statins was around to 96% during follow-up; and this value was at 42% for the low adherence level. The patients with low adherence to statins were more likely to have coronary artery disease (OR 1.07; 95% confidence interval [CI], 1.01-1.13), cerebrovascular disease (OR 1.13; 95% CI 1.03-1.25), and chronic heart failure within 3-year period of follow-up (OR 1.13; 95% CI 1.01-1.26). Low adherence to statins was also associated with an increased risk of hospitalization by 4% (OR 1.04; 95% CI 1.01-1.09). Among patients who were hospitalized, low adherence to statins was significantly associated with increase of hospitalization costs by approximately {\$}1060/patient for a 3-year period. Conclusion: Low adherence to statins was correlated with a higher risk of cardiovascular disease, hospitalization rate, and hospitalization costs. An increased level of adherence to statins agents should provide a better health status for individuals and a net economic gain.}, affiliation = {Faculty of Pharmacy, University of Montreal, Montreal, Quebec, Canada.}, pages = {}, year = {2009}, month = {Aug}, language = {ENG}, date-added = {2010-05-23 10:43:08 +0200}, date-modified = {2010-05-23 10:43:08 +0200}, doi = {10.1111/j.1524-4733.2009.00583.x}, pii = {VHE583}, pmid = {19695008}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Dragomir-2009-Value%20Health_Relationship%20between.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11807}, rating = {0} } @article{DAngiulli:2009p7011, author = {Amedeo D'Angiulli and William Warburton and Susan Dahinten and Clyde Hertzman}, journal = {PLoS ONE}, title = {Population-level associations between preschool vulnerability and grade-four basic skills}, abstract = {BACKGROUND: This is a predictive validity study examining the extent to which developmental vulnerability at kindergarten entry (as measured by the Early Development Instrument, EDI) is associated with children's basic skills in 4th grade (as measured by the Foundation Skills Assessment, FSA). METHODOLOGY/PRINCIPAL FINDINGS: Relative risk analysis was performed on a large database linking individual-level EDI ratings to the scores the same children obtained on a provincial assessment of academic skills (FSA--Foundation Skills Assessment) four years later. We found that early vulnerability in kindergarten is associated with the basic skills that underlie populations of children's academic achievement in reading, writing and math, indicating that the Early Development Instrument permits to predict achievement-related skills four years in advance. CONCLUSIONS/SIGNIFICANCE: The EDI can be used to predict children's educational trends at the population level and can help select early prevention and intervention programs targeting pre-school populations at minimum cost.}, affiliation = {Institute of Interdisciplinary Studies, Carleton University, Ottawa, Canada. amedeo@connect.carleton.ca}, number = {11}, pages = {e7692}, volume = {4}, year = {2009}, month = {Jan}, language = {eng}, date-added = {2010-03-06 19:46:51 +0100}, date-modified = {2010-03-06 19:46:51 +0100}, doi = {10.1371/journal.pone.0007692}, pmid = {19946366}, local-url = {file://localhost/Users/chl/Dropbox/Papers/D'Angiulli-2009-PLoS%20ONE_Population-level%20ass.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7011}, rating = {0} } @article{Brock:2008p12026, author = {G Brock and V Pihur and S Datta and S Datta}, journal = {Journal of Statistical Software}, title = {clValid: An R Package for Cluster Validation}, abstract = {The R package clValid contains functions for validating the results of a clustering analysis. There are three main types of cluster validation measures available, ``inter- nal'', ``stability'', and ``biological''. The user can choose from nine clustering algorithms in existing R packages, including hierarchical, K-means, self-organizing maps (SOM), and model-based clustering. In addition, we provide a function to perform the self-organizing tree algorithm (SOTA) method of clustering. Any combination of validation measures and clustering methods can be requested in a single function call. This allows the user to si- multaneously evaluate several clustering algorithms while varying the number of clusters, to help determine the most appropriate method and number of clusters for the dataset of interest. Additionally, the package can automatically make use of the biological informa- tion contained in the Gene Ontology (GO) database to calculate the biological validation measures, via the annotation packages available in Bioconductor. The function returns an object of S4 class ``clValid'', which has summary, plot, print, and additional methods which allow the user to display the optimal validation scores and extract clustering results.}, number = {4}, volume = {25}, year = {2008}, date-added = {2010-05-24 10:17:32 +0200}, date-modified = {2010-05-24 10:18:21 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Brock-2008-Journal%20of%20Statistical%20Software_clValid%20An%20R%20Packag.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12026}, rating = {5} } @article{Saunders:1993, author = {PA Saunders and JRM Copeland and ME Dewey and C Gilmore and BA Larkin and H Phaterpekar and A Scott}, journal = {Int J Epidemiol}, title = {The prevalence of dementia, depression and neurosis in later life: The Liverpool MRC-ALPHA study}, abstract = {Prevalence rates for psychiatric disorders in the elderly are presented from the initial cross-sectional stage of a longitudinal community study of the incidence of dementia in the city of Liverpool. Together with five other centres in the UK the MRC-ALPHA project forms part of the MRC multicentre incidence study of dementia and cognitive decline. An age- and sex-stratified random sample of 5222 subjects aged 65 was interviewed at home using the Geriatric Mental State-AGECAT package to provide computer diagnoses. The overall age-standardized prevalence rates for organic disorder (4.7%) depressive illness (10.0%) and the neuroses (2.5%) are consistent with levels found in previous smaller studies that have used MS-AGECAT. Each of these diagnoses is more common in females than males. A rise in organic disorder with age is confirmed as continuing into the oldest age groups for both sexes. An apparent decline with age observed for depression and neurosis diagnoses disappears when organic cases are excluded from the analysis.}, number = {5}, pages = {838--847}, volume = {22}, year = {1993}, date-added = {2010-01-03 19:36:10 +0100}, date-modified = {2010-01-03 19:36:10 +0100}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1099}, rating = {0} } @article{Bauer:2004p13728, author = {Daniel J Bauer and Patrick J Curran}, journal = {Psychological Methods}, title = {The integration of continuous and discrete latent variable models: potential problems and promising opportunities}, abstract = {Structural equation mixture modeling (SEMM) integrates continuous and discrete latent variable models. Drawing on prior research on the relationships between continuous and discrete latent variable models, the authors identify 3 conditions that may lead to the estimation of spurious latent classes in SEMM: misspecification of the structural model, nonnormal continuous measures, and nonlinear relationships among observed and/or latent variables. When the objective of a SEMM analysis is the identification of latent classes, these conditions should be considered as alternative hypotheses and results should be interpreted cautiously. However, armed with greater knowledge about the estimation of SEMMs in practice, researchers can exploit the flexibility of the model to gain a fuller understanding of the phenomenon under study.}, affiliation = {Department of Psychology, North Carolina State University, Raleigh, NC 27695-7801, USA. dan_bauer@ncsu.edu}, number = {1}, pages = {3--29}, volume = {9}, year = {2004}, month = {Mar}, language = {eng}, keywords = {Psychology, Models: Psychological, Factor Analysis: Statistical, Humans}, date-added = {2010-07-24 11:23:01 +0200}, date-modified = {2010-07-24 11:23:09 +0200}, doi = {10.1037/1082-989X.9.1.3}, pii = {2004-12158-001}, pmid = {15053717}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Bauer-2004-Psychological%20Methods_The%20integration%20of%20c.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13728}, rating = {4} } @article{Buckby:2008p4875, author = {Joe A Buckby and Sue M Cotton and Elizabeth M Cosgrave and Eoin J Killackey and Alison R Yung}, journal = {BMC Psychiatry}, title = {A factor analytic investigation of the Tripartite model of affect in a clinical sample of young Australians}, abstract = {BACKGROUND: The Mood and Anxiety Symptom Questionnaire (MASQ) was designed to specifically measure the Tripartite model of affect and is proposed to offer a delineation between the core components of anxiety and depression. Factor analytic data from adult clinical samples has shown mixed results; however no studies employing confirmatory factor analysis (CFA) have supported the predicted structure of distinct Depression, Anxiety and General Distress factors. The Tripartite model has not been validated in a clinical sample of older adolescents and young adults. The aim of the present study was to examine the validity of the Tripartite model using scale-level data from the MASQ and correlational and confirmatory factor analysis techniques. METHODS: 137 young people (M = 17.78, SD = 2.63) referred to a specialist mental health service for adolescents and young adults completed the MASQ and diagnostic interview. RESULTS: All MASQ scales were highly inter-correlated, with the lowest correlation between the depression- and anxiety-specific scales (r = .59). This pattern of correlations was observed for all participants rating for an Axis-I disorder but not for participants without a current disorder (r = .18). Confirmatory factor analyses were conducted to evaluate the model fit of a number of solutions. The predicted Tripartite structure was not supported. A 2-factor model demonstrated superior model fit and parsimony compared to 1- or 3-factor models. These broad factors represented Depression and Anxiety and were highly correlated (r = .88). CONCLUSION: The present data lend support to the notion that the Tripartite model does not adequately explain the relationship between anxiety and depression in all clinical populations. Indeed, in the present study this model was found to be inappropriate for a help-seeking community sample of older adolescents and young adults.}, affiliation = {ORYGEN Youth Health Research Centre, Melbourne, Australia. jbuckby@unimelb.edu.au}, pages = {79}, volume = {8}, year = {2008}, month = {Jan}, language = {eng}, keywords = {Questionnaires, Female, Reproducibility of Results, Adolescent, Anxiety Disorders, Humans, Factor Analysis: Statistical, Young Adult, Affect, Depressive Disorder: Major, Male}, date-added = {2010-02-01 20:30:54 +0100}, date-modified = {2010-02-01 20:30:54 +0100}, doi = {10.1186/1471-244X-8-79}, pii = {1471-244X-8-79}, pmid = {18799017}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p4875}, rating = {0} } @article{Borsboom:2008p5508, author = {D Borsboom and A Z Scholten}, journal = {Theory Psychology}, title = {The Rasch Model and Conjoint Measurement Theory from the Perspective of Psychometrics}, abstract = {Kyngdon argues that psychometricians have erroneously claimed the Rasch model to be an instance of representational measurement, because the Rasch model does not map a bona fide empirical relational system (ERS) into a numerical relational system (NRS). While we agree that one does not automatically achieve a conjoint measurement representation upon fitting a Rasch model, we do not agree that the Rasch model could not in principle yield such a representation. In our view, whether this is possible depends on what one is prepared to accept as an empirical relational system. This is a philosophical question that extends beyond the scope of the formal struc- tures advanced in representationalism and psychometrics; a question, more- over, that is not currently settled. We examine some of the ways in which one may react to this question, and conclude that Kyngdon's argument depends on a specific, and perhaps too strong, interpretation of representa- tionalism and psychometric models.}, number = {1}, pages = {111--117}, volume = {18}, year = {2008}, date-added = {2010-02-12 14:56:09 +0100}, date-modified = {2010-02-12 14:57:17 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Borsboom-2008-Theory%20Psychology_The%20Rasch%20Model%20and.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5508}, rating = {0} } @article{Page:2010p3633, author = {E B Page}, title = {Statistical and linguistic strategies in the computer grading of essays}, date-added = {2010-01-16 19:20:21 +0100}, date-modified = {2010-01-16 19:20:53 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Page--_Statistical%20and%20ling.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3633}, rating = {0} } @inbook{McKay:1996, author = {RB McKay and MJ Breslow and RL Sangster and SM Gabbard and RW Reynolds and JM Nakamoto}, journal = {Book}, title = {Advances in survey research}, chapter = {Translating survey questionnaires: Lessons learned}, pages = {93--104}, year = {1996}, date-added = {2010-01-03 19:34:17 +0100}, date-modified = {2010-07-29 19:21:41 +0200}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1000}, rating = {0} } @article{Lesch:2005p9138, author = {Klaus-Peter Lesch}, journal = {Eur J Pharmacol}, title = {Alcohol dependence and gene x environment interaction in emotion regulation: Is serotonin the link?}, abstract = {Alcohol dependence is characterized by frequent, compulsive and uncontrolled consumption of alcohol associated with behavior of maladaption and destruction. It is an etiologically and clinically heterogeneous syndrome, moderately to highly heritable, and caused by interaction of genes and environment. Alcohol dependence is related to other psychiatric diseases by common neurobiological pathways, including those that modulate reward, behavioral control as well as anxiety and stress response. Alcohol induces adaptive changes in brain function providing the basis for tolerance, craving, withdrawal, and emotional disturbance. The differentiation of psychobiological traits of addictive behavior reflecting neurobiological processes is therefore of particular importance for the dissection of the complex genetic susceptibility to alcohol dependence. A central serotonin (5-HT) deficit is thought to be involved in the pathogenesis of alcohol dependence by modulating motivational behavior, neuroadaptive processes, and resulting emotional disturbance. 5-HT-related impulsive, aggressive, and suicidal behavior has been linked to a primordial personality that is susceptible to alcohol dependence. Although variations in many of the genes that encode receptors, enzymes, and transporters of the 5-HT system have been tested as risk factors for alcohol dependence, genetic analyses of 5-HT signaling in alcohol dependence have mainly been focused on the 5-HT transporter (5-HTT) gene. Due to its central role in the fine-tuning serotonergic neurotransmission, a regulatory variant of the 5-HTT, which is associated with anxiety related traits, is not only a key player in the neurobiological mechanism of gene x environment interaction in the etiology of depression, but also contributes to the risk to develop alcohol dependence with antisocial behavior and suicidality. Evidence for a modulatory effect of allelic variation of 5-HTT function on limbic circuit responses to emotional stimuli suggests that genotype-endophenotype correlations may be accessible to molecular functional imaging of the brain. These new developments have broad implications for our understanding how genetic vulnerability to alcohol dependence is manifested in the brain's response to emotional stimuli.}, affiliation = {Department of Psychiatry and Psychotherapy, University of W{\"u}rzburg, F{\"u}chsleinstr. 15, Germany. kplesch@mail.uni-wuerzburg.de}, number = {1-3}, pages = {113--24}, volume = {526}, year = {2005}, month = {Dec}, language = {eng}, keywords = {Humans, Emotions, Models: Psychological, Models: Neurological, Stress: Psychological, Genetic Variation, Serotonin Plasma Membrane Transport Proteins, Serotonin, Risk, Animals, Alcoholism}, date-added = {2010-03-22 13:30:18 +0100}, date-modified = {2010-03-22 13:30:18 +0100}, doi = {10.1016/j.ejphar.2005.09.027}, pii = {S0014-2999(05)00972-6}, pmid = {16288736}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Lesch-2005-Eur%20J%20Pharmacol_Alcohol%20dependence%20a.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p9138}, rating = {0} } @article{Hamre:2010p13427, author = {Harald J Hamre and Claudia M Witt and Anja Glockmann and Renatus Ziegler and Gunver S Kienle and Stefan N Willich and Helmut Kiene}, journal = {Eur J Health Econ}, title = {Health costs in patients treated for depression, in patients with depressive symptoms treated for another chronic disorder, and in non-depressed patients: a two-year prospective cohort study in anthroposophic outpatient settings}, abstract = {We studied costs of healthcare and productivity loss in 487 German outpatients starting anthroposophic treatment: Group 1 was treated for depression, Group 2 had depressive symptoms but were treated for another chronic disorder, while Group 3 did not have depressive symptoms. Costs were adjusted for socio-demographics, comorbidity, and baseline health status. Total costs in groups 1-3 averaged euro7,129, euro4,371, and euro3,532 in the pre-study year (P = 0.008); euro6,029, euro3,522, and euro3,353 in the first year (P = 0.083); and euro4,929, euro3,792, and euro4,031 in the second year (P = 0.460). In the 2nd year, costs were significantly reduced in Group 1. This study underlines the importance of depression for health costs, and suggests that treatment of depression could be associated with long-term cost reductions.}, affiliation = {Institute for Applied Epistemology and Medical Methodology, Zechenweg 6, 79111 Freiburg, Germany. harald.hamre@ifaemm.de}, number = {1}, pages = {77--94}, volume = {11}, year = {2010}, month = {Feb}, language = {eng}, date-added = {2010-07-01 19:37:33 +0200}, date-modified = {2010-07-01 19:37:33 +0200}, doi = {10.1007/s10198-009-0203-0}, pmid = {19911209}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Hamre-2010-Eur%20J%20Health%20Econ_Health%20costs%20in%20pati.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13427}, rating = {0} } @article{Muthen:2006p13759, author = {Bengt Muthen and Tihomir Asparouhov}, journal = {Addict Behav}, title = {Item response mixture modeling: application to tobacco dependence criteria}, abstract = {This paper illustrates new hybrid latent variable models that are promising for phenotypical analyses. The hybrid models combine features of dimensional and categorical analyses seen in the conventional techniques of factor analysis and latent class analysis. The paper focuses on the analysis of categorical items, which presents especially challenging analyses with hybrid models and has recently been made practical in the Mplus program. The hybrid models are typically seen to fit data better than conventional models of factor analysis (IRT) and latent class analysis. An illustration is given in the form of analysis of tobacco dependence in a general population survey.}, affiliation = {UCLA, United States. bmuthen@ucla.edu}, number = {6}, pages = {1050--66}, volume = {31}, year = {2006}, month = {Jun}, language = {eng}, keywords = {Psychometrics, Humans, Alcoholism, Aged, Phenotype, Tobacco Use Disorder, Adolescent, Diagnostic and Statistical Manual of Mental Disorders, Adult, Factor Analysis: Statistical, Models: Statistical}, date-added = {2010-07-24 12:54:35 +0200}, date-modified = {2010-07-24 12:54:43 +0200}, doi = {10.1016/j.addbeh.2006.03.026}, pii = {S0306-4603(06)00096-7}, pmid = {16675147}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Muthen-2006-Addictive%20Behaviors_Item%20response%20mixtur.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13759}, read = {Yes}, rating = {5} } @article{Novembre:2008p915, author = {John Novembre and Toby Johnson and Katarzyna Bryc and Zolt{\'a}n Kutalik and Adam R Boyko and Adam Auton and Amit Indap and Karen S King and Sven Bergmann and Matthew R Nelson and Matthew Stephens and Carlos D Bustamante}, journal = {Nature}, title = {Genes mirror geography within Europe}, abstract = {Understanding the genetic structure of human populations is of fundamental interest to medical, forensic and anthropological sciences. Advances in high-throughput genotyping technology have markedly improved our understanding of global patterns of human genetic variation and suggest the potential to use large samples to uncover variation among closely spaced populations. Here we characterize genetic variation in a sample of 3,000 European individuals genotyped at over half a million variable DNA sites in the human genome. Despite low average levels of genetic differentiation among Europeans, we find a close correspondence between genetic and geographic distances; indeed, a geographical map of Europe arises naturally as an efficient two-dimensional summary of genetic variation in Europeans. The results emphasize that when mapping the genetic basis of a disease phenotype, spurious associations can arise if genetic structure is not properly accounted for. In addition, the results are relevant to the prospects of genetic ancestry testing; an individual's DNA can be used to infer their geographic origin with surprising accuracy-often to within a few hundred kilometres.}, affiliation = {Department of Ecology and Evolutionary Biology, Interdepartmental Program in Bioinformatics, University of California-Los Angeles, Los Angeles, California 90095, USA. jnovembre@ucla.edu}, number = {7218}, pages = {98--101}, volume = {456}, year = {2008}, month = {Nov}, language = {eng}, keywords = {Polymorphism: Single Nucleotide, Phylogeny, Humans, Emigration and Immigration, Genetic Variation, Genotype, Europe, Sample Size, Genome: Human, Principal Component Analysis, Genome-Wide Association Study, Genetics: Population, Geography, Quantitative Trait: Heritable}, date-added = {2010-01-03 19:01:04 +0100}, date-modified = {2010-01-03 19:01:04 +0100}, doi = {10.1038/nature07331}, pii = {nature07331}, pmid = {18758442}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Novembre-2008-Nature_Genes%20mirror%20geograp.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p915}, rating = {0} } @article{Hays:2009p11766, author = {Ron D Hays and Seongeun Kim and Karen L Spritzer and Robert M Kaplan and Steve Tally and David Feeny and Honghu Liu and Dennis G Fryback}, journal = {Value Health}, title = {Effects of mode and order of administration on generic health-related quality of life scores}, abstract = {OBJECTIVE: We evaluate the effects of mode and order of administration on health-related quality of life (HRQOL) scores. METHOD: We analyzed HRQOL data from the Clinical Outcomes and Measurement of Health Study (COMHS). In COMHS, we enrolled patients with heart failure or cataracts at three sites (University of California, San Diego, University of California, Los Angeles, and University of Wisconsin). Patients completed self-administered HRQOL instruments at baseline and months 1 and 6 post-baseline, including the EuroQol (EQ-5D), Health Utilities Index (HUI), Quality of Well-Being Scale--self-administered (QWB-SA), and the Short Form (SF)-36v2. At the 6 months follow-up, individuals were randomized to mail or telephone administration first, followed by the other mode of administration. We used repeated measures mixed effects models, adjusting for site, patient age, education, gender, and race. RESULTS: Included were 121 individuals entering a heart failure program and 326 individuals scheduled for cataract surgery who completed the survey by mail or phone at the 6-month follow-up. The majority of the sample was female (53%) and white (86%). About a quarter of the sample had high school education or less (26%). The average age was 66 (36-91 range). HRQOL scores were higher (more positive) for phone administration following mail administration. The largest differences in scores between phone and mail responses occurred for comparisons of telephone responses for those who were randomized to a mail survey first compared with mail responses for those randomized to a telephone survey first (i.e., mode effects for responses that were given on the second administration of the HRQOL measures). The QWB-SA was the only measure that did not display the pattern of mode effects. The biggest differences between modes were 4 points on the SF-36v2 physical health and mental health component summary scores, 0.06 on the SF-6D, 0.03 on the QWB-SA, 0.08 on the EQ-5D, 0.04 on the HUI2, and 0.10 on the HUI3. CONCLUSIONS: Telephone administration yields significantly more positive HRQOL scores for all of the generic HRQOL measures except for the QWB-SA. The magnitude of effects was clearly important, with some differences as large as a half-standard deviation. These findings confirm the importance of considering mode of administration when interpreting HRQOL scores.}, affiliation = {UCLA Department of Medicine, UCLA, Los Angeles, CA 90095-1736, USA. drhays@ucla.edu}, number = {6}, pages = {1035--9}, volume = {12}, year = {2009}, month = {Sep}, language = {eng}, keywords = {Wisconsin, Cataract, Telephone, Middle Aged, California, Quality of Life, Adult, Heart Failure, Postal Service, Aged: 80 and over, Interviews as Topic, Humans, Cross-Over Studies, Male, Research Design, Sickness Impact Profile, Aged, Female}, date-added = {2010-05-23 10:35:43 +0200}, date-modified = {2010-05-23 10:35:44 +0200}, doi = {10.1111/j.1524-4733.2009.00566.x}, pii = {VHE566}, pmid = {19473334}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Hays-2009-Value%20Health_Effects%20of%20mode%20and.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11766}, rating = {0} } @inproceedings{Allegre:2003, author = {E All{\`e}gre and P Dessus}, journal = {Proceedings}, title = {Un syst{\`e}me d'observation et d'analyse en direct de s{\'e}ances d'enseignement}, year = {2003}, date-added = {2010-01-10 11:33:24 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/All%C3%A8gre-2003-Proceedings_Un%20syst%C3%A8me%20d'observa.PDF}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1964}, rating = {0} } @article{Gorwood:1998p1328, author = {P Gorwood and M Bouvard and M C Mouren-Sim{\'e}oni and A Kipman and J Ad{\`e}s}, journal = {Psychiatr Genet}, title = {Genetics and anorexia nervosa: a review of candidate genes}, abstract = {Anorexia nervosa is a severe disorder which seems likely to have a multifactorial aetiology. However, several studies have stressed that genetic factors play a significant role. Epidemiological studies have shown that the lifetime risk for first-degree relatives of a patient with an eating disorder is 6% compared to 1% among relatives of controls, and a twin study performed on 34 pairs of twins has shown a higher concordance rate in monozygotic twins (55%) compared to dizygotic twins (7%). The vulnerability component of anorexia nervosa that can be attributed to genetic influences has been estimated from twin studies to be around 70%. Despite this, few genetic studies have been performed testing the role of candidate genes which code for proteins potentially implicated in the aetiopathogenesis of the disorder. In this review, genes encoding components of the dopamine, serotonin, opiate, and noradrenaline systems are assessed for their role in anorexia nervosa. Attention is paid to psychological dimensions, clinical symptoms, co-morbidity frequency, pharmacological data, and biological measures that characterize anorexia nervosa.}, affiliation = {Psychiatric Department, Hospital Louis Mourier, Colombes, France. pgorwood@imaginet.fr}, number = {1}, pages = {1--12}, volume = {8}, year = {1998}, month = {Jun}, language = {eng}, keywords = {Anorexia Nervosa, Nuclear Family, Twin Studies as Topic, Endorphins, Twins: Dizygotic, Animals, Dopamine, Serotonin, Norepinephrine, Risk Factors, Diseases in Twins, Humans, Twins: Monozygotic}, date-added = {2010-01-07 11:37:19 +0100}, date-modified = {2010-01-07 11:37:19 +0100}, pmid = {9564681}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1328}, rating = {0} } @article{Holman:2003p1822, author = {Rebecca Holman and Cees A W Glas and Rob J de Haan}, journal = {Controlled Clinical Trials}, title = {Power analysis in randomized clinical trials based on item response theory}, abstract = {Patient relevant outcomes, measured using questionnaires, are becoming increasingly popular endpoints in randomized clinical trials (RCTs). Recently, interest in the use of item response theory (IRT) to analyze the responses to such questionnaires has increased. In this paper, we used a simulation study to examine the small sample behavior of a test statistic designed to examine the difference in average latent trait level between two groups when the two-parameter logistic IRT model for binary data is used. The simulation study was extended to examine the relationship between the number of patients required in each arm of an RCT, the number of items used to assess them, and the power to detect minimal, moderate, and substantial treatment effects. The results show that the number of patients required in each arm of an RCT varies with the number of items used to assess the patients. However, as long as at least 20 items are used, the number of items barely affects the number of patients required in each arm of an RCT to detect effect sizes of 0.5 and 0.8 with a power of 80%. In addition, the number of items used has more effect on the number of patients required to detect an effect size of 0.2 with a power of 80%. For instance, if only five randomly selected items are used, it is necessary to include 950 patients in each arm, but if 50 items are used, only 450 are required in each arm. These results indicate that if an RCT is to be designed to detect small effects, it is inadvisable to use very short instruments analyzed using IRT. Finally, the SF-36, SF-12, and SF-8 instruments were considered in the same framework. Since these instruments consist of items scored in more than two categories, slightly different results were obtained.}, affiliation = {Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, The Netherlands. R.Holman@amc.uva.nl}, number = {4}, pages = {390--410}, volume = {24}, year = {2003}, month = {Aug}, language = {eng}, keywords = {Kidney Failure: Chronic, Renal Dialysis, Randomized Controlled Trials as Topic, Health Status, Peritoneal Dialysis, Humans, Sample Size, Probability, Models: Statistical, Questionnaires, Treatment Outcome}, date-added = {2010-01-09 23:00:24 +0100}, date-modified = {2010-06-15 22:46:09 +0200}, pii = {S0197245603000618}, pmid = {12865034}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Holman-2003-Controlled%20Clinical%20Trials_Power%20analysis%20in%20ra.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1822}, rating = {3} } @article{Rommelse:2010p5730, author = {Nanda N J Rommelse and Barbara Franke and Hilde M Geurts and Catharina A Hartman and Jan K Buitelaar}, journal = {Eur Child Adolesc Psychiatry}, title = {Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder}, abstract = {Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are both highly heritable neurodevelopmental disorders. Evidence indicates both disorders co-occur with a high frequency, in 20-50% of children with ADHD meeting criteria for ASD and in 30-80% of ASD children meeting criteria for ADHD. This review will provide an overview on all available studies [family based, twin, candidate gene, linkage, and genome wide association (GWA) studies] shedding light on the role of shared genetic underpinnings of ADHD and ASD. It is concluded that family and twin studies do provide support for the hypothesis that ADHD and ASD originate from partly similar familial/genetic factors. Only a few candidate gene studies, linkage studies and GWA studies have specifically addressed this co-occurrence, pinpointing to some promising pleiotropic genes, loci and single nucleotide polymorphisms (SNPs), but the research field is in urgent need for better designed and powered studies to tackle this complex issue. We propose that future studies examining shared familial etiological factors for ADHD and ASD use a family-based design in which the same phenotypic (ADHD and ASD), candidate endophenotypic, and environmental measurements are obtained from all family members. Multivariate multi-level models are probably best suited for the statistical analysis.}, affiliation = {Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, Reinier Postlaan 10, 6525 GC, Nijmegen, The Netherlands, n.lambregts-rommelse@psy.umcn.nl.}, pages = {}, year = {2010}, month = {Feb}, language = {ENG}, date-added = {2010-02-15 20:28:44 +0100}, date-modified = {2010-07-29 19:26:12 +0200}, doi = {10.1007/s00787-010-0092-x}, pmid = {20148275}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5730}, rating = {0} } @article{Erosheva:2007p1772, author = {Elena Erosheva and Emily C Walton and David T Takeuchi}, journal = {Med Care}, title = {Self-rated health among foreign- and U.S.-born Asian Americans: a test of comparability}, abstract = {OBJECTIVES: We investigated differences between foreign- and U.S.-born Asian Americans in self-rating their physical and mental health. In particular, we tested whether the foreign-born respondents underreport the extreme categories of the scale as compared with U.S.-born respondents. METHODS: We analyzed data from the National Latino and Asian American Study to examine whether immigrants are less likely to use the extreme ends of the 5-category self-rated health scales than their U.S.-born counterparts. We used propensity score matching to derive groups of U.S.- and foreign-born Asian Americans who share similar demographic and health characteristics. We defined propensity scores as predicted probabilities of being U.S. born, given individual background characteristics. The propensity score framework allowed us to make descriptive comparisons of self-rated health responses controlling for background characteristics. We used log-linear symmetry models to examine cross-tabulations of self-rated physical and mental health reports in matched pairs by the 2 (extreme and nonextreme) and 5 ("excellent," "very good," "good," "fair," and "poor") categories. RESULTS: Controlling for background characteristics, we found no evidence that foreign-born Asian Americans are less likely to endorse extreme categories in self-rated physical or mental health than U.S.-born Asian Americans, as well as no evidence of imbalances in endorsement of any particular self-rated health category between the 2 groups. CONCLUSIONS: Controlling for demographic and health characteristics, we find no systematic differences between foreign- and U.S.-born Asian Americans in reporting self-rated physical and mental health on the 5-category scales from "excellent" to "poor."}, affiliation = {Department of Statistics, School of Social Work, University of Washington, Seattle 98195, USA. erosheva@u.washington.edu}, number = {1}, pages = {80--7}, volume = {45}, year = {2007}, month = {Jan}, language = {eng}, keywords = {Health Status, Emigration and Immigration, Humans, Asian Americans, Mental Health, Questionnaires}, date-added = {2010-01-09 21:31:41 +0100}, date-modified = {2010-07-29 19:39:29 +0200}, doi = {10.1097/01.mlr.0000241114.90614.9c}, pii = {00005650-200701000-00011}, pmid = {17279024}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Erosheva-2007-Med%20Care_Self-rated%20health%20am.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1772}, rating = {0} } @phdthesis{Hardouin:2005, author = {Jean-Benoit Hardouin}, journal = {PhD Thesis}, title = {Construction d'{\'e}chelles d'items unidimensionnelles en qualit{\'e} de vie}, affiliation = {Universit{\'e} Ren{\'e} Descartes}, year = {2005}, date-added = {2010-01-10 11:33:25 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Hardouin-2005-PhD%20Thesis_Construction%20d'%C3%A9chel.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2108}, rating = {0} } @misc{Al-Kandari:1993, author = {N Al-Kandari}, journal = {Miscellaneous}, title = {Variable Selection and Principal Component Analysis}, year = {1993}, date-added = {2010-01-10 11:33:20 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Al-Kandari-1993-Miscellaneous_Variable%20Selection%20a.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2173}, rating = {0} } @article{North:2007p11371, author = {Kari E North and Nora Franceschini and Ingrid B Borecki and C Charles Gu and Gerardo Heiss and Michael A Province and Donna K Arnett and Cora E Lewis and Michael B Miller and Richard H Myers and Steven C Hunt and Barry I Freedman}, journal = {Diabetes}, title = {Genotype-by-sex interaction on fasting insulin concentration: the HyperGEN study}, abstract = {Recent studies have demonstrated the importance of sex effects on the underlying genetic architecture of insulin-related traits. To explore sex-specific genetic effects on fasting insulin, we tested for genotype-by-sex interaction and conducted linkage analysis of fasting insulin in Hypertension Genetic Epidemiology Network families. Hypertensive siblings and their first-degree relatives were recruited from five field centers. We performed a genome scan for quantitative trait loci influencing fasting insulin among 1,505 European Americans and 1,616 African Americans without diabetes. Sex-stratified linear regression models, adjusted for race, center, and age, were explored. The Mammalian Genotyping Service typed 391 microsatellite markers, spaced roughly 9 cM. Variance component linkage analysis was performed in SOLAR using ethnic-specific marker allele frequencies and multipoint IBDs calculated in MERLIN. We detected a quantitative trait locus influencing fasting insulin in female subjects (logarithm of odds [LOD] = 3.4) on chromosome 2 at 95 cM (between GATA69E12 and GATA71G04) but not in male subjects (LOD = 0.0, P for interaction = 0.007). This sex-specific signal at 2p13.2 was detected in both European-American (LOD = 2.1) and African-American (LOD = 1.2) female subjects. Our findings overlap with several other linkage reports of insulin-related traits and demonstrate the importance of considering complex context-dependent interactions in the search for insulin-related genes.}, affiliation = {Department of Epidemiology, University of North Carolina Chapel Hill, Bank of America Center, 137 E. Franklin St., Suite 306, Chapel Hill, NC 27514, USA. kari_north@unc.edu}, number = {1}, pages = {137--42}, volume = {56}, year = {2007}, month = {Jan}, language = {eng}, keywords = {Phenotype, Male, Fasting, Genotype, Sex Characteristics, Smoking, Alcohol Drinking, Female, Middle Aged, Insulin, Humans}, date-added = {2010-04-26 23:09:18 +0200}, date-modified = {2010-04-26 23:09:18 +0200}, doi = {10.2337/db06-0624}, pii = {56/1/137}, pmid = {17192475}, local-url = {file://localhost/Users/chl/Dropbox/Papers/North-2007-Diabetes_Genotype-by-sex%20inte.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11371}, rating = {0} } @article{Attia:2009p1302, author = {Evelyn Attia}, journal = {Annu Rev Med}, title = {Anorexia Nervosa: Current Status and Future Directions}, abstract = {Anorexia nervosa (AN) is a serious mental illness categorized by a failure to maintain a minimally normal weight, a fear of gaining weight or becoming fat, and preoccupations about body shape or weight. AN is associated with significant morbidity and a mortality rate as high as that seen in any psychiatric illness. Biological factors, including genetic predisposition, appear to play a role in the development of AN. Treatment is challenging both because interventions with clear empirical support have not been identified and because individuals affected by AN are typically reluctant to undergo weight restoration. Preliminary studies suggest that family-based treatment may be useful for younger patients with AN. Treatment development for adults with AN and pursuit of neurobiological correlates of AN remain high-priority research areas. Expected final online publication date for the Annual Review of Medicine Volume 61 is January 07, 2010. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.}, affiliation = {Columbia Center for Eating Disorders, Columbia University Medical Center, New York, NY; email: ea12@Columbia.edu.}, pages = {}, year = {2009}, month = {Aug}, language = {ENG}, date-added = {2010-01-07 11:36:39 +0100}, date-modified = {2010-01-07 11:36:39 +0100}, doi = {10.1146/annurev.med.050208.200745}, pmid = {19719398}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1302}, rating = {0} } @article{Luce:2002p6592, author = {R D Luce}, journal = {Psychological Review}, title = {A psychophysical theory of intensity proportions, joint presentations, and matches}, abstract = {Empirically testable assumptions relate 3 psychophysical primitives: presentations of pairs of physical intensities (e.g., pure tones of the same frequency and phase to the 2 ears or 2 successive tones to both ears); a respondent's ordering of such signal pairs by perceived intensity (e.g., loudness); and judgments about 2 pairs of stimuli being related as some proportion (numerical factor, as in magnitude production). Explicit behavioral assumptions lead to 2 families of psychophysical functions, one corresponding to unbiased joint presentations and the other to biased ones. Under an invariance assumption, the psychophysical functions in the unbiased case are approximate power functions, and those in the biased case are exact power functions. A number of testable predictions are made. The mathematics involved draws from publications in utility theory and mathematics but with a reinterpretation of the primitives.}, affiliation = {Department of Cognitive Science, University of California, Irvine 92697-5100, USA. rdluce@uci.edu}, number = {3}, pages = {520--32}, volume = {109}, year = {2002}, month = {Jul}, language = {eng}, keywords = {Psychological Theory, Models: Psychological, Loudness Perception, Psychoacoustics, Humans}, date-added = {2010-02-24 20:39:25 +0100}, date-modified = {2010-03-06 19:49:08 +0100}, pmid = {12088243}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Luce-2002-Psychological%20Review_A%20psychophysical%20the.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6592}, rating = {0} } @article{Veenstra:2010p9370, author = {Marja Y Veenstra and Patricia N Walsh and Henny M J van Schrojenstein Lantman-de Valk and Meindert J Haveman and Mike P Kerr and Germain Weber and Luis Salvador-Carulla and Alexandra Carmen-Cara and Bernard Azema and Serafino Buono and Arunas Germanavicius and Jan Tossebro and Tuomo Maatta and Geert van Hove and Dasa Moravec}, journal = {Journal of Clinical Epidemiology}, title = {Sampling and ethical issues in a multicenter study on health of people with intellectual disabilities}, abstract = {OBJECTIVES: To study health inequalities in persons with intellectual disabilities, representative and unbiased samples are needed. Little is known about sample recruitment in this vulnerable group. This study aimed to determine differences in ethical procedures and sample recruitment in a multicenter research on health of persons with intellectual disabilities. Study questions regarded the practical sampling procedure, how ethical consent was obtained in each country, and which person gave informed consent for each study participant. STUDY DESIGN AND SETTING: Exploratory, as part of a multicenter study, in 14 European countries. After developing identical guidelines for all countries, partners collected data on health indicators by orally interviewing 1,269 persons with intellectual disabilities. Subsequently, semistructured interviews were carried out with partners and researchers. RESULTS: Identification of sufficient study participants proved feasible. Sampling frames differed from nationally estimated proportions of persons with intellectual disabilities living with families or in residential settings. Sometimes, people with intellectual disabilities were hard to trace. Consent procedures and legal representation varied broadly. Nonresponse data proved unavailable. CONCLUSION: To build representative unbiased samples of vulnerable groups with limited academic capacities, international consensus on respectful consent procedures and tailored patient information is necessary.}, affiliation = {Department of General Practice, CAPHRI Care and Public Health Research Institute, University of Maastricht.}, pages = {}, year = {2010}, month = {Mar}, language = {ENG}, date-added = {2010-03-23 18:42:39 +0100}, date-modified = {2010-03-23 18:42:39 +0100}, doi = {10.1016/j.jclinepi.2009.12.001}, pii = {S0895-4356(09)00386-2}, pmid = {20304607}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Veenstra-2010-Journal%20of%20Clinical%20Epidemiology_Sampling%20and%20ethical-1.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p9370}, rating = {0} } @article{Candido:2010p12840, author = {E Candido and P Kurdyak and D A Alter}, journal = {Journal of Clinical Epidemiology}, title = {Item nonresponse to psychosocial questionnaires was associated with higher mortality after acute myocardial infarction}, abstract = {Objective: To examine the relationship between selective nonresponse to a psychosocial questionnaire and mortality after acute myocardial infarction (AMI). Study Design and Setting: Two thousand six hundred and ninety AMI survivors after AMI hospitalization were recruited to complete a 30-day follow-up interview. Patients were classified into four groups (survey nonparticipation and complete, partial, and no item nonre- sponse) according to their degree of response to the Medical Outcomes Study (MOS) Social Support Survey (MOS-SSS). Cox proportional hazard models, adjusted for baseline sociodemographic, clinical, and psychosocial (i.e., social isolation) characteristics, were used to examine all-cause mortality, 3 years post-AMI, across the response levels. Results: 13.9%oftheeligiblepatientsrefusedfollow-upparticipation;MOS-SSSitemnonresponsewaspresentinupto14.7%ofparticipants and was more frequent among the elderly, socially disadvantaged, and those with higher clinical risk. A nonresponse mortality gradient existed, ranging from 8.9% (no item nonresponse) to 18.7% (complete item nonresponse) (P ! 0.001). After adjusting for baseline characteristics, complete item nonresponse remained significantly associated with mortality (hazard ratio: 1.33; 95% confidence interval: 1.02e1.73). Conclusions: Itemnonresponsetoasocialsupportquestionnaireisassociatedwithhighermortalitypost-AMI.Althoughexplanatoryfactors may include age and baseline clinical risk, additional psychosocial and/or unmeasured factors may account for the poorer prognosis.}, year = {2010}, date-added = {2010-06-21 20:05:34 +0200}, date-modified = {2010-06-21 20:06:22 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Candido-2010-Journal%20of%20Clinical%20Epidemiology_Item%20nonresponse%20to.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12840}, rating = {0} } @article{Huynh:2010p4185, author = {H Huynh and P Meyer}, journal = {Practical Assessment Research \{\&} Evaluation}, title = {Use of Robust z in Detecting Unstable Items in Item Response Theory Models}, abstract = {The first part of this paper describes the use of the robust zR statistic to link test forms using the Rasch (or one-parameter logistic) model. The procedure is then extended to the two-parameter and three-parameter logistic and two-parameter partial credit (2PPC) models. A real set of data was used to illustrate the extension. The linking results illustrate the efficacy of the robust zR vis-{\`a}-vis some of the most commonly used processes such as the Stocking and Lord (1983) linking process.}, number = {2}, volume = {15}, year = {2010}, date-added = {2010-01-21 07:54:18 +0100}, date-modified = {2010-07-29 19:44:42 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Huynh-2010-Practical%20Assessment%20Research%20%20&%20Evaluation_Use%20of%20Robust%20z%20in%20D.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p4185}, rating = {0} } @article{Lewis:2005p2331, author = {J B Lewis and D A Linzer}, journal = {Political Analysis}, title = {Estimating Regression Models in Which the Dependent Variable Is Based on Estimates}, abstract = {Researchers often use as dependent variables quantities estimated from auxiliary data sets. Estimated dependent variable (EDV) models arise, for example, in studies where counties or states are the units of analysis and the dependent variable is an estimated mean, proportion, or regression coefficient. Scholars fitting EDV models have generally recognized that variation in the sampling variance of the observations on the dependent variable will induce heteroscedasticity. We show that the most common approach to this problem, weighted least squares, will usually lead to inefficient estimates and underestimated standard errors. In many cases, OLS with White's or Efron heteroscedastic consistent standard errors yields better results. We also suggest two simple alternative FGLS approaches that are more efficient and yield consistent standard error estimates. Finally, we apply the various alternative estimators to a replication of Cohen's (2004) cross-national study of presidential approval.}, pages = {345--364}, volume = {13}, year = {2005}, date-added = {2010-01-10 13:14:03 +0100}, date-modified = {2010-01-10 13:14:53 +0100}, doi = {10.1093/pan/mpi026}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Lewis-2005-Political%20Analysis_Estimating%20Regressio.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2331}, rating = {0} } @article{Murrell:2001p2769, author = {P Murrell}, journal = {DSC 2001 Proceedings of the 2nd International Workshop on Distributed Statistical Computing}, title = {R Lattice Graphics}, abstract = {Lattice is an add-on package or library for the R statistical computing en- vironment. It provides an alternative set of user-level functions for producing graphical output. Compared to the base R graphical functions, the Lattice functions provide greater control over the specification of where graphical output appears on the page. In addition, Lattice graphics functions return graphical objects, which may be used to interactively edit the graphical out- put.}, year = {2001}, date-added = {2010-01-13 14:26:02 +0100}, date-modified = {2010-01-13 14:26:35 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Murrell-2001-DSC%202001%20Proceedings%20of%20the%202nd%20International%20Workshop%20on%20Distributed%20Statistical%20Computing_R%20Lattice%20Graphics.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2769}, rating = {0} } @article{Landauer:2004, author = {T K Landauer and D Laham and M Derr}, journal = {Proceedings of the National Academy of Sciences USA}, title = {From paragraph to graph: latent semantic analysis for information visualization}, abstract = {Most techniques for relating textual information rely on intellectually created links such as author-chosen keywords and titles, authority indexing terms, or bibliographic citations. Similarity of the semantic content of whole documents, rather than just titles, abstracts, or overlap of keywords, offers an attractive alternative. Latent semantic analysis provides an effective dimension reduction method for the purpose that reflects synonymy and the sense of arbitrary word combinations. However, latent semantic analysis correlations with human text-to-text similarity judgments are often empirically highest at approximately 300 dimensions. Thus, two- or three-dimensional visualizations are severely limited in what they can show, and the first and/or second automatically discovered principal component, or any three such for that matter, rarely capture all of the relations that might be of interest. It is our conjecture that linguistic meaning is intrinsically and irreducibly very high dimensional. Thus, some method to explore a high dimensional similarity space is needed. But the 2.7 x 10(7) projections and infinite rotations of, for example, a 300-dimensional pattern are impossible to examine. We suggest, however, that the use of a high dimensional dynamic viewer with an effective projection pursuit routine and user control, coupled with the exquisite abilities of the human visual system to extract information about objects and from moving patterns, can often succeed in discovering multiple revealing views that are missed by current computational algorithms. We show some examples of the use of latent semantic analysis to support such visualizations and offer views on future needs.}, number = {Suppl 1}, pages = {5214--5219}, volume = {101}, year = {2004}, date-added = {2010-01-10 11:33:25 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Landauer-2004-Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20USA_From%20paragraph%20to%20gr.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2214}, rating = {0} } @article{Ramasundarahettige:2009p6907, author = {Chinthanie F Ramasundarahettige and Allan Donner and G Y Zou}, journal = {Stat Med}, title = {Confidence interval construction for a difference between two dependent intraclass correlation coefficients}, abstract = {Inferences for the difference between two dependent intraclass correlation coefficients (ICCs) may arise in studies in which a sample of subjects are each assessed several times with a new device and a standard. The ICC estimates for the two devices may then be compared using a test of significance. However, a confidence interval for a difference between two ICCs is more informative since it combines point estimation and hypothesis testing into a single inference statement. We propose a procedure that uses confidence limits for a single ICC to recover variance estimates needed to set confidence limits for the difference. An advantage of this approach is that it provides a confidence interval that reflects the underlying sampling distribution. Simulation results show that this method performs very well in terms of overall coverage percentage and tail errors. Two data sets are used to illustrate this procedure.}, affiliation = {Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ont., Canada N6A 5C1.}, number = {7}, pages = {1041--53}, volume = {28}, year = {2009}, month = {Mar}, language = {eng}, keywords = {Clinical Trials as Topic, Confidence Intervals, Data Interpretation: Statistical, Models: Statistical, Reproducibility of Results}, date-added = {2010-03-06 12:22:31 +0100}, date-modified = {2010-03-06 12:22:31 +0100}, doi = {10.1002/sim.3523}, pmid = {19142855}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Ramasundarahettige-2009-Stat%20Med_Confidence%20interval.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6907}, rating = {0} } @article{Hwang:2009p13734, author = {H Hwang and Y Takane}, title = {Nonlinear Generalized Structured Component Analysis}, abstract = {Generalized Structured Component Analysis (GSCA) represents component- based structural equation modeling. Currently, GSCA is geared only for the analysis of quantitative data. In this paper, GSCA is extended to deal with qualitative data through data transformation. In particular, the optimal scaling approach is adopted for data transformation as it can be readily coupled with the GSCA estimation procedure. An alternating least-squares algorithm is developed that involves two phases for estimation of model and data parameters. Two empirical applications are presented to demonstrate the usefulness of the proposed method.}, year = {2009}, date-added = {2010-07-24 11:38:46 +0200}, date-modified = {2010-07-24 11:39:33 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Hwang-2009-_Nonlinear%20Generalize.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13734}, rating = {4} } @article{Barnett:2009p818, author = {J H Barnett and J W Smoller}, journal = {Neuroscience}, title = {The genetics of bipolar disorder}, abstract = {Bipolar disorder is a mood disorder characterized by impairing episodes of mania and depression. Twin studies have established that bipolar disorder is among the most heritable of medical disorders and efforts to identify specific susceptibility genes have intensified over the past two decades. The search for genes influencing bipolar disorder has been complicated by a paucity of animal models, limited understanding of pathogenesis, and the genetic and phenotypic complexity of the syndrome. Linkage studies have implicated several chromosomal regions as harboring relevant genes, but results have been inconsistent. It is now widely accepted that the genetic liability to bipolar disorder reflects the action of many genes of individually small effect, a scenario for which linkage studies are poorly suited. Thus, association studies, which are more powerful for the detection of modest effect loci, have become the focus of gene-finding research. A large number of candidate genes, including biological candidates derived from hypotheses about the pathogenesis of the disorder and positional candidates derived from linkage and cytogenetic studies, have been evaluated. Several of these genes have been associated with the disorder in independent studies (including BDNF, DAOA, DISC1, GRIK4, SLC6A4, and TPH2), but none has been established. The clinical heterogeneity of bipolar disorder and its phenotypic and genetic overlap with other disorders (especially schizophrenia, schizoaffective disorder, and major depressive disorder) have raised questions about the optimal phenotype definition for genetic studies. Nevertheless, genomewide association analysis, which has successfully identified susceptibility genes for a variety of complex disorders, has begun to implicate specific genes for bipolar disorder (DGKH, CACNA1C, ANK3). The polygenicity of the disorder means that very large samples will be needed to detect the modest effect loci that likely contribute to bipolar disorder. Detailed genetic dissection of the disorder may provide novel targets (both pharmacologic and psychosocial) for intervention.}, affiliation = {Center for Human Genetic Research, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA.}, number = {1}, pages = {331--43}, volume = {164}, year = {2009}, month = {Nov}, language = {eng}, date-added = {2010-01-03 17:25:56 +0100}, date-modified = {2010-01-03 17:25:56 +0100}, doi = {10.1016/j.neuroscience.2009.03.080}, pii = {S0306-4522(09)00576-4}, pmid = {19358880}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p818}, rating = {0} } @article{Austin:2010p6559, author = {Peter C Austin}, journal = {Journal of Clinical Epidemiology}, title = {Absolute risk reductions, relative risks, relative risk reductions, and numbers needed to treat can be obtained from a logistic regression model}, abstract = {OBJECTIVE: Logistic regression models are frequently used in cohort studies to determine the association between treatment and dichotomous outcomes in the presence of confounding variables. In a logistic regression model, the association between exposure and outcome is measured using the odds ratio (OR). The OR can be difficult to interpret and only approximates the relative risk (RR) in certain restrictive settings. Several authors have suggested that for dichotomous outcomes, RRs, RR reductions, absolute risk reductions, and the number needed to treat (NNT) are more clinically meaningful measures of treatment effect. STUDY DESIGN AND SETTING: We describe a method for deriving clinically meaningful measures of treatment effect from a logistic regression model. This method involves determining the probability of the outcome if each subject in the cohort was treated and if each subject was untreated. These probabilities are then averaged across the study cohort to determine the average probability of the outcome in the population if all subjects were treated and if they were untreated. RESULTS: Risk differences, RRs, and NNTs were derived using a logistic regression model. CONCLUSIONS: Clinically meaningful measures of effect can be derived from a logistic regression model in a cohort study. These methods can also be used in randomized controlled trials when logistic regression is used to adjust for possible imbalance in prognostically important baseline covariates.}, affiliation = {Institute for Clinical Evaluative Sciences, Toronto, Ontario M4N 3M5, Canada. peter.austin@ices.on.ca}, number = {1}, pages = {2--6}, volume = {63}, year = {2010}, month = {Jan}, language = {eng}, date-added = {2010-02-24 20:36:54 +0100}, date-modified = {2010-02-24 20:36:55 +0100}, doi = {10.1016/j.jclinepi.2008.11.004}, pii = {S0895-4356(08)00316-8}, pmid = {19230611}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Austin-2010-Journal%20of%20Clinical%20Epidemiology_Absolute%20risk%20reduct.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6559}, rating = {0} } @article{AnkraBadu:2010p11343, author = {Georgina A Ankra-Badu and Daniel Shriner and Elisabeth Le Bihan-Duval and Sandrine Mignon-Grasteau and Fr{\'e}d{\'e}rique Pitel and Catherine Beaumont and Michel J Duclos and Jean Simon and Tom E Porter and Alain Vignal and Larry A Cogburn and David B Allison and Nengjun Yi and Samuel E Aggrey}, journal = {BMC Genomics}, title = {Mapping main, epistatic and sex-specific QTL for body composition in a chicken population divergently selected for low or high growth rate}, abstract = {BACKGROUND: Delineating the genetic basis of body composition is important to agriculture and medicine. In addition, the incorporation of gene-gene interactions in the statistical model provides further insight into the genetic factors that underlie body composition traits. We used Bayesian model selection to comprehensively map main, epistatic and sex-specific QTL in an F2 reciprocal intercross between two chicken lines divergently selected for high or low growth rate. RESULTS: We identified 17 QTL with main effects across 13 chromosomes and several sex-specific and sex-antagonistic QTL for breast meat yield, thigh + drumstick yield and abdominal fatness. Different sets of QTL were found for both breast muscles [Pectoralis (P) major and P. minor], which suggests that they could be controlled by different regulatory mechanisms. Significant interactions of QTL by sex allowed detection of sex-specific and sex-antagonistic QTL for body composition and abdominal fat. We found several female-specific P. major QTL and sex-antagonistic P. minor and abdominal fatness QTL. Also, several QTL on different chromosomes interact with each other to affect body composition and abdominal fatness. CONCLUSIONS: The detection of main effects, epistasis and sex-dimorphic QTL suggest complex genetic regulation of somatic growth. An understanding of such regulatory mechanisms is key to mapping specific genes that underlie QTL controlling somatic growth in an avian model.}, affiliation = {Department of Poultry Science/Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA.}, pages = {107}, volume = {11}, year = {2010}, month = {Jan}, language = {eng}, date-added = {2010-04-26 23:07:24 +0200}, date-modified = {2010-07-29 19:20:00 +0200}, doi = {10.1186/1471-2164-11-107}, pii = {1471-2164-11-107}, pmid = {20149241}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Ankra-Badu-2010-BMC%20Genomics_Mapping%20main%20epista.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11343}, rating = {0} } @article{Borsboom:2006p5505, author = {D Borsboom}, journal = {Psychometrika}, title = {The attack of the psychometricians}, abstract = {This paper analyzes the theoretical, pragmatic, and substantive factors that have hampered the integration between psychology and psychometrics. Theoretical factors include the operationalist mode of thinking which is common throughout psychology, the dominance of classical test theory, and the use of ``construct validity'' as a catch-all category for a range of challenging psychometric problems. Pragmatic factors include the lack of interest in mathematically precise thinking in psychology, inadequate representation of psychometric modeling in major statistics programs, and insufficient mathematical training in the psychological curriculum. Substantive factors relate to the absence of psychological theories that are sufficiently strong to motivate the structure of psychometric models. Following the identification of these problems, a number of promising recent developments are discussed, and suggestions are made to further the integration of psychology and psychometrics.}, number = {3}, pages = {425--440}, volume = {71}, year = {2006}, date-added = {2010-02-12 14:49:15 +0100}, date-modified = {2010-02-12 14:51:07 +0100}, doi = {10.1007/s11336-006-1447-6}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Borsboom-2006-Psychometrika_The%20attack%20of%20the%20ps-1.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5505}, rating = {0} } @article{Cohen:1994p7065, author = {J Cohen}, journal = {American Psychologist}, title = {The earth is round (p<.05)}, number = {12}, pages = {997--1003}, volume = {49}, year = {1994}, date-added = {2010-03-06 20:09:17 +0100}, date-modified = {2010-03-06 20:10:06 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Cohen-1994-American%20Psychologist_The%20earth%20is%20round.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7065}, rating = {4} } @techreport{Monseur:2007, author = {C Monseur and H Sibbens and D Hastedt}, journal = {Techreport}, title = {Equating errors in international surveys in education}, affiliation = {IEA Data Processing Center}, year = {2007}, date-added = {2010-01-10 11:33:20 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Monseur-2007-Techreport_Equating%20errors%20in%20i.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2035}, rating = {0} } @article{Batki:2009p7873, author = {Steven L Batki and Kelly M Canfield and Emily Smyth and Robert Ploutz-Snyder}, journal = {Drug Alcohol Depend}, title = {Health-related quality of life in methadone maintenance patients with untreated hepatitis C virus infection}, abstract = {OBJECTIVE: To assess health-related quality of life (HRQOL) in methadone maintenance treatment (MMT) patients with untreated chronic HCV infection and to determine the clinical factors that predict HRQOL. METHOD: HRQOL was measured in 100 MMT patients entering an HCV treatment trial. Subjects were mostly male (61%) and white (81%) with a mean age of 43 (+/-10). 57% had a current non-substance use psychiatric disorder. 55% had a current (past 12 months) substance use disorder, including 44% with current opioid or cocaine abuse/dependence. HRQOL in our sample was compared to published reports for the general population as well as for non-MMT HCV patients. To assess predictors of SF-36 HRQOL, hierarchical multiple regression techniques were used to assess model improvement with four blocks of baseline predictors: Demographics, Medical Severity, Addiction Severity, and Depression Severity. RESULTS: HRQOL scores were significantly lower than scores for the general population and were also lower than scores reported for untreated HCV patients not in MMT. Regression analysis demonstrated a consistent pattern whereby Depression Severity increased predictive accuracy for HRQOL measures over simpler models. Beck Depression Inventory scores significantly predicted quality of life across both the mental and physical composite scores and all eight sub-scales of the SF-36. CONCLUSIONS: Untreated HCV patients in MMT had lower HRQOL than HCV patients not in MMT. Depression Severity was associated with significantly lower quality of life measures, suggesting that psychiatric evaluation and intervention prior to the start of HCV treatment may improve overall quality of life and could influence HCV treatment outcomes in MMT patients.}, affiliation = {University of California, San Francisco, Department of Psychiatry, and San Francisco VA Medical Center, 4150 Clement St. (116P), San Francisco, CA 94110, USA. steven.batki@ucsf.edu}, number = {3}, pages = {176--82}, volume = {101}, year = {2009}, month = {May}, language = {eng}, keywords = {Methadone, Viral Load, Substance-Related Disorders, Severity of Illness Index, Quality of Life, Continental Population Groups, Hepatitis C, Middle Aged, Psychiatric Status Rating Scales, Ethnic Groups, Depression, Questionnaires, Adult, Random Allocation, Humans, Health Status, Mental Health}, date-added = {2010-03-20 19:14:15 +0100}, date-modified = {2010-03-20 19:14:16 +0100}, doi = {10.1016/j.drugalcdep.2008.12.012}, pii = {S0376-8716(09)00017-9}, pmid = {19233573}, URL = {http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T63-4VP12HP-2&_user=10&_coverDate=05%252F01%252F2009&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=75eee685c0deebd8490897c70609242a}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7873}, rating = {0} } @article{Feeney:2006p7285, author = {G F X Feeney and J P Connor and R McD Young and J Tucker and A McPherson}, journal = {Addict Behav}, title = {Improvement in measures of psychological distress amongst amphetamine misusers treated with brief cognitive-behavioural therapy (CBT)}, abstract = {This trial of cognitive-behavioural therapy (CBT) based amphetamine abstinence program (n=507) focused on refusal self-efficacy, improved coping, improved problem solving and planning for relapse prevention. Measures included the Severity of Dependence Scale (SDS), the General Health Questionnaire-28 (GHQ-28) and Amphetamine Refusal Self-Efficacy. Psychiatric case identification (caseness) across the four GHQ-28 sub-scales was compared with Australian normative data. Almost 90% were amphetamine-dependent (SDS 8.15+/-3.17). Pre-treatment, all GHQ-28 sub-scale measures were below reported Australian population values. Caseness was substantially higher than Australian normative values {Somatic Symptoms (52.3%), Anxiety (68%), Social Dysfunction (46.5%) and Depression (33.7%)}. One hundred and sixty-eight subjects (33%) completed and reported program abstinence. Program completers reported improvement across all GHQ-28 sub-scales {Somatic Symptoms (p<0.001), Anxiety (p<0.001), Social Dysfunction (p<0.001) and Depression (p<0.001)}. They also reported improvement in amphetamine refusal self-efficacy (p<0.001). Improvement remained significant following intention-to-treat analyses, imputing baseline data for subjects that withdrew from the program. The GHQ-28 sub-scales, Amphetamine Refusal Self-Efficacy Questionnaire and the SDS successfully predicted treatment compliance through a discriminant analysis function (p<.001).}, affiliation = {Alcohol and Drug Assessment Unit, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia. Gerald_Feeney@health.qld.gov.au}, number = {10}, pages = {1833--43}, volume = {31}, year = {2006}, month = {Oct}, language = {eng}, keywords = {Stress: Psychological, Patient Compliance, Female, Adult, Humans, Cognitive Therapy, Adaptation: Psychological, Male, Self Disclosure, Treatment Outcome, Amphetamine-Related Disorders, Aged, Middle Aged}, date-added = {2010-03-10 20:16:51 +0100}, date-modified = {2010-07-29 19:12:35 +0200}, doi = {10.1016/j.addbeh.2005.12.026}, pii = {S0306-4603(05)00319-9}, pmid = {16431030}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Feeney-2006-Addict%20Behav_Improvement%20in%20measu.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7285}, rating = {0} } @article{Wolf:1988, author = {PA Wolf and RB D'Agostino and WB Kannel and R Bonita and AJ Belanger}, journal = {JAMA}, title = {Cigarette smoking as a risk factor for stroke. The Framingham Study}, abstract = {The impact of cigarette smoking on stroke incidence was assessed in the Framingham Heart Study cohort of 4255 men and women who were aged 36 to 68 years and free of stroke and transient ischemic attacks. During 26 years of follow-up, 459 strokes occurred. Regardless of smoking status and in each sex, hypertensive subjects had twice the incidence of stroke. Using the Cox proportional hazard regression method, smoking was significantly related to stroke after age and hypertension were taken into account. Even after pertinent cardiovascular disease risk factors were added to the Cox model, cigarette smoking continued to make a significant independent contribution to the risk of stroke generally and brain infarction specifically. The risk of stroke increased as the number of cigarettes smoked increased. The relative risk of stroke in heavy smokers (greater than 40 cigarettes per day) was twice that of light smokers (fewer than ten cigarettes per day). Lapsed smokers developed stroke at the same level as nonsmokers soon after stopping. Stroke risk decreased significantly by two years and was at the level of nonsmokers by five years after cessation of cigarette smoking.}, number = {7}, pages = {1025--1029}, volume = {259}, year = {1988}, date-added = {2010-01-03 19:36:10 +0100}, date-modified = {2010-07-29 20:00:58 +0200}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1073}, rating = {0} } @article{Borsboom:2002p5506, author = {D Borsboom and G J Mellenbergh}, journal = {Intelligence}, title = {True scores, latent variables, and constructs: A comment on Schmidt and Hunter}, abstract = {This paper comments on an article by Schmidt and Hunter [Intelligence 27 (1999) 183.], who argue that the correction for attenuation should be routinely used in theory testing. It is maintained that Schmidt and Hunter's arguments are based on mistaken assumptions. We discuss our critique of Schmidt and Hunter in terms of two arguments against a routine use of the correction for attenuation within the classical test theory framework: (1) corrected correlations do not, as Schmidt and Hunter claim, provide correlations between constructs, and (2) corrections for measurement error should be made using modern test theory models instead of the classical model. The arguments that Schmidt and Hunter advance in favor of the correction for attenuation can be traced to an implicit identification of true scores with construct scores. First, we show that this identification confounds issues of validity and issues of reliability. Second, it is pointed out that equating true scores with construct scores is logically inconsistent with the classical test theory model itself. Third, it is argued that the classical model is not suited for detecting the dimensionality of test scores, which severely limits the interpretation of the corrected correlation coefficients. It is concluded that most measurement problems in psychology concern issues of validity, and that the correction for attenuation within classical test theory does not help in solving them.}, pages = {505--514}, volume = {30}, year = {2002}, date-added = {2010-02-12 14:52:07 +0100}, date-modified = {2010-07-29 19:29:16 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Borsboom-2002-Intelligence_True%20scores%20latent.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5506}, rating = {4} } @article{Lindstrom:2009p10192, author = {Kara M Lindstrom and Amanda E Guyer and Karin Mogg and Brendan P Bradley and Nathan A Fox and Monique Ernst and Eric E Nelson and Ellen Leibenluft and Jennifer C Britton and Christopher S Monk and Daniel S Pine and Yair Bar-Haim}, journal = {Brain Res}, title = {Normative data on development of neural and behavioral mechanisms underlying attention orienting toward social-emotional stimuli: an exploratory study}, abstract = {The ability of positive and negative facial signals to influence attention orienting is crucial to social functioning. Given the dramatic developmental change in neural architecture supporting social function, positive and negative facial cues may influence attention orienting differently in relatively young or old individuals. However, virtually no research examines such age-related differences in the neural circuitry supporting attention orienting to emotional faces. We examined age-related correlations in attention-orienting biases to positive and negative face emotions in a healthy sample (N=37; 9-40 years old) using functional magnetic resonance imaging and a dot-probe task. The dot-probe task in an fMRI setting yields both behavioral and neural indices of attention biases towards or away from an emotional cue (happy or angry face). In the full sample, angry-face attention bias scores did not correlate with age, and age did not correlate with brain activation to angry faces. However, age did positively correlate with attention bias towards happy faces; age also negatively correlated with left cuneus and left caudate activation to a happy bias fMRI contrast. Secondary analyses suggested age-related changes in attention bias to happy faces. The tendency in younger children to direct attention away from happy faces (relative to neutral faces) was diminished in the older age groups, in tandem with increasing neural deactivation. Implications for future work on developmental changes in attention-emotion processing are discussed.}, affiliation = {Mood and Anxiety Program, National Institutes of Mental Health, National Institute of Health, Bethesda, MD 20892-2670, USA. lindstrk@mail.nih.gov}, pages = {61--70}, volume = {1292}, year = {2009}, month = {Oct}, language = {eng}, keywords = {Attention, Cues, Female, Neuropsychological Tests, Magnetic Resonance Imaging, Child, Emotions, Male, Adolescent, Photic Stimulation, Facial Expression, Young Adult, Humans, Brain, Social Perception, Adolescent Development, Child Development, Aging, Adult, Brain Mapping}, date-added = {2010-04-01 18:16:01 +0200}, date-modified = {2010-07-29 19:21:52 +0200}, doi = {10.1016/j.brainres.2009.07.045}, pii = {S0006-8993(09)01479-6}, pmid = {19631626}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Lindstrom-2009-Brain%20Res_Normative%20data%20on%20de.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p10192}, rating = {0} } @article{Dell:2008p2334, author = {Gary S Dell and Alfonso Caramazza}, journal = {Cogn Neuropsychol}, title = {Introduction to special issue on computational modelling in cognitive neuropsychology}, affiliation = {University of Illinois, Urbana-Champaign, IL, USA.}, number = {2}, pages = {131--5}, volume = {25}, year = {2008}, month = {Mar}, language = {eng}, keywords = {Humans, Cognition Disorders, Neural Networks (Computer), Brain, Neuropsychological Tests}, date-added = {2010-01-10 13:18:43 +0100}, date-modified = {2010-01-10 13:18:43 +0100}, doi = {10.1080/02643290802000683}, pii = {793768502}, pmid = {18568815}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Dell-2008-Cogn%20Neuropsychol_Introduction%20to%20spec.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2334}, rating = {0} } @article{Sourial:2009p11511, author = {Nadia Sourial and Christina Wolfson and Bin Zhu and Jacqueline Quail and John Fletcher and Sathya Karunananthan and Karen Bandeen-Roche and Fran{\c c}ois B{\'e}land and Howard Bergman}, journal = {Journal of Clinical Epidemiology}, title = {Correspondence analysis is a useful tool to uncover the relationships among categorical variables}, abstract = {OBJECTIVE: Correspondence analysis (CA) is a multivariate graphical technique designed to explore the relationships among categorical variables. Epidemiologists frequently collect data on multiple categorical variables with the goal of examining associations among these variables. Nevertheless, CA appears to be an underused technique in epidemiology. The objective of this article is to present the utility of CA in an epidemiological context. STUDY DESIGN AND SETTING: The theory and interpretation of CA in the case of two and more than two variables are illustrated through two examples. RESULTS: The outcome from CA is a graphical display of the rows and columns of a contingency table that is designed to permit visualization of the salient relationships among the variable responses in a low-dimensional space. Such a representation reveals a more global picture of the relationships among row-column pairs, which would otherwise not be detected through a pairwise analysis. CONCLUSION: When the study variables of interest are categorical, CA is an appropriate technique to explore the relationships among variable response categories and can play a complementary role in analyzing epidemiological data.}, affiliation = {Solidage Research Group, Centre for Clinical Epidemiology and Community Studies, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.}, pages = {}, year = {2009}, month = {Nov}, language = {ENG}, date-added = {2010-05-01 17:33:28 +0200}, date-modified = {2010-05-01 17:33:32 +0200}, doi = {10.1016/j.jclinepi.2009.08.008}, pii = {S0895-4356(09)00237-6}, pmid = {19896800}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Sourial-2009-Journal%20of%20Clinical%20Epidemiology_Correspondence%20analy.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11511}, rating = {4} } @article{Cook:2007p10853, author = {Karon F Cook and Cayla R Teal and Jakob B Bjorner and David Cella and Chih-Hung Chang and Paul K Crane and Laura E Gibbons and Ron D Hays and Colleen A McHorney and Katja Ocepek-Welikson and Anastasia E Raczek and Jeanne A Teresi and Bryce B Reeve}, journal = {Qual Life Res}, title = {IRT health outcomes data analysis project: an overview and summary}, abstract = {BACKGROUND: In June 2004, the National Cancer Institute and the Drug Information Association co-sponsored the conference, "Improving the Measurement of Health Outcomes through the Applications of Item Response Theory (IRT) Modeling: Exploration of Item Banks and Computer-Adaptive Assessment." A component of the conference was presentation of a psychometric and content analysis of a secondary dataset. OBJECTIVES: A thorough psychometric and content analysis was conducted of two primary domains within a cancer health-related quality of life (HRQOL) dataset. RESEARCH DESIGN: HRQOL scales were evaluated using factor analysis for categorical data, IRT modeling, and differential item functioning analyses. In addition, computerized adaptive administration of HRQOL item banks was simulated, and various IRT models were applied and compared. SUBJECTS: The original data were collected as part of the NCI-funded Quality of Life Evaluation in Oncology (Q-Score) Project. A total of 1,714 patients with cancer or HIV/AIDS were recruited from 5 clinical sites. MEASURES: Items from 4 HRQOL instruments were evaluated: Cancer Rehabilitation Evaluation System-Short Form, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Functional Assessment of Cancer Therapy and Medical Outcomes Study Short-Form Health Survey. RESULTS AND CONCLUSIONS: Four lessons learned from the project are discussed: the importance of good developmental item banks, the ambiguity of model fit results, the limits of our knowledge regarding the practical implications of model misfit, and the importance in the measurement of HRQOL of construct definition. With respect to these lessons, areas for future research are suggested. The feasibility of developing item banks for broad definitions of health is discussed.}, affiliation = {Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, Washington, USA. karonc2@u.washington.edu}, pages = {121--32}, volume = {16 Suppl 1}, year = {2007}, month = {Jan}, language = {eng}, keywords = {Health Status, Psychometrics, Outcome Assessment (Health Care), Software, Stress: Psychological, Female, Data Interpretation: Statistical, HIV Infections, Humans, Quality of Life, Neoplasms, Male, Questionnaires}, date-added = {2010-04-10 03:34:05 +0200}, date-modified = {2010-07-29 19:48:28 +0200}, doi = {10.1007/s11136-007-9177-5}, pmid = {17351824}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Cook-2007-Qual%20Life%20Res_IRT%20health%20outcomes.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p10853}, rating = {4} } @article{Perry:2008p11963, author = {Jennifer L Perry and Marilyn E Carroll}, journal = {Psychopharmacology (Berl)}, title = {The role of impulsive behavior in drug abuse}, abstract = {BACKGROUND: Impulsivity is a multifaceted construct that has recently been recognized as a factor contributing to enhanced vulnerability to drug abuse. OBJECTIVES: In the present review, we focus on two facets of impulsivity (and tasks that measure them): (1) impulsive choice (delay discounting task) and (2) inhibitory failure (go/no-go, stop signal reaction time, and five-choice serial reaction time tasks). We also describe how performance on each of these tasks is associated with drug-related behavior during phases of drug abuse that capture the essential features of addiction (acquisition, escalation, and reinstatement of drug-seeking after drug access has terminated). Three hypotheses (H) regarding the relationship between impulsivity and drug abuse are discussed: (1) increased levels of impulsivity lead to drug abuse (H1), (2) drugs of abuse increase impulsivity (H2), and (3) impulsivity and drug abuse are associated through a common third factor (H3). CONCLUSION: Impulsivity expressed as impulsive choice or inhibitory failure plays a role in several key transition phases of drug abuse. There is evidence to support all three nonexclusive hypotheses. Increased levels of impulsivity lead to acquisition of drug abuse (H1) and subsequent escalation or dysregulation of drug intake. Drugs of abuse may increase impulsivity (H2), which is an additional contributor to escalation/dysregulation. Abstinence, relapse, and treatment may be influenced by both H1 and H2. In addition, there is a relationship between impulsivity and other drug abuse vulnerability factors, such as sex, hormonal status, reactivity to nondrug rewards, and early environmental experiences that may impact drug intake during all phases of addiction (H3). Relating drug abuse and impulsivity in phases of addiction via these three hypotheses provides a heuristic model from which future experimental questions can be addressed.}, affiliation = {Minneapolis Medical Research Foundation, S-3, 860, 914 South 8th Street, Minneapolis, MN 55404, USA. perry050@umm.edu}, number = {1}, pages = {1--26}, volume = {200}, year = {2008}, month = {Sep}, language = {eng}, keywords = {Humans, Risk Factors, Task Performance and Analysis, Impulsive Behavior, Behavior: Addictive, Animals, Reward, Inhibition (Psychology), Sex Factors, Reaction Time, Substance-Related Disorders}, date-added = {2010-05-23 17:17:34 +0200}, date-modified = {2010-05-23 17:17:39 +0200}, doi = {10.1007/s00213-008-1173-0}, pmid = {18600315}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Perry-2008-Psychopharmacology%20(Berl)_The%20role%20of%20impulsiv.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11963}, rating = {5} } @article{Saucier:1996p13846, author = {G Saucier and L R Goldberg}, title = {The Language af Personality: Lexical Perspectives on the Five-Factor Model}, year = {1996}, date-added = {2010-07-29 17:22:06 +0200}, date-modified = {2010-07-29 17:22:59 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Saucier-1996-_The%20Language%20af%20Pers.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13846}, rating = {0} } @article{Liu:2008p1567, author = {J Liu and O Demirci and V D Calhoun}, journal = {IEEE Signal Processing Letters}, title = {A Parallel Independent Component Analysis Approach to Investigate Genomic Influence on Brain Function}, abstract = {Relationships between genomic data and functional brain images are of great interest but require new analysis ap- proaches to integrate the high-dimensional data types. This letter presents an extension of a technique called parallel independent component analysis (paraICA), which enables the joint analysis of multiple modalities including interconnections between them. We extend our earlier work by allowing for multiple interconnections and by providing important overfitting controls. Performance was assessed by simulations under different conditions, and indicated reliable results can be extracted by properly balancing overfitting and underfitting. An application to functional magnetic resonance images and single nucleotide polymorphism array produced inter- esting findings.}, pages = {413--416}, volume = {15}, year = {2008}, date-added = {2010-01-07 16:53:13 +0100}, date-modified = {2010-01-07 16:54:51 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Liu-2008-IEEE%20Signal%20Processing%20Letters_A%20Parallel%20Independe.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1567}, rating = {0} } @article{vanGinkel:2010p6244, author = {J R van Ginkel and K Sijtsma and L Andries van der Ark and J K Vermunt}, journal = {Methodology}, title = {Incidence of Missing Item Scores in Personality Measurement, and Simple Item-Score Imputation}, abstract = {The focus of this study was the incidence of different kinds of missing-data problems in personality research and the handling of these problems. Missing-data problems were reported in approximately half of more than 800 articles published in three leading personality journals. In these articles, unit nonresponse, attrition, and planned missingness were distinguished but missing item scores in trait measurement were reported most frequently. Listwise deletion was the most frequently used method for handling all missing-data problems. Listwise deletion is known to reduce the accuracy of parameter estimates and the power of statistical tests and often to produce biased statistical analysis results. This study proposes a simple alternative method for handling missing item scores, known as two-way imputation, which leaves the sample size intact and has been shown to produce almost unbiased results based on multi-item questionnaire data.}, number = {1}, pages = {17--30}, volume = {6}, year = {2010}, date-added = {2010-02-19 21:20:16 +0100}, date-modified = {2010-07-29 20:42:55 +0200}, doi = {10.1027/1614-2241/a000003}, local-url = {file://localhost/Users/chl/Dropbox/Papers/van%20Ginkel-2010-Methodology_Incidence%20of%20Missing.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6244}, read = {Yes}, rating = {0} } @article{Yu:2005, author = {C H Yu and S E O Popp}, journal = {Practical Assessment Research \{\&} Evaluation}, title = {Test Equating by Common Items and Common Subjects: Concepts and Applications}, number = {4}, volume = {10}, year = {2005}, date-added = {2010-01-10 11:33:09 +0100}, date-modified = {2010-07-29 19:44:42 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Yu-2005-Practical%20Assessment%20Research%20%20&%20Evaluation_Test%20Equating%20by%20Com.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2047}, rating = {0} } @article{Kimmel:2007p3359, author = {Gad Kimmel and Michael I Jordan and Eran Halperin and Ron Shamir and Richard M Karp}, journal = {Am J Hum Genet}, title = {A randomization test for controlling population stratification in whole-genome association studies}, abstract = {Population stratification can be a serious obstacle in the analysis of genomewide association studies. We propose a method for evaluating the significance of association scores in whole-genome cohorts with stratification. Our approach is a randomization test akin to a standard permutation test. It conditions on the genotype matrix and thus takes into account not only the population structure but also the complex linkage disequilibrium structure of the genome. As we show in simulation experiments, our method achieves higher power and significantly better control over false-positive rates than do existing methods. In addition, it can be easily applied to whole-genome association studies.}, affiliation = {Computer Science Division, University of California Berkeley, Berkeley, CA 94720, USA. kimmel@cs.berkeley.edu}, number = {5}, pages = {895--905}, volume = {81}, year = {2007}, month = {Nov}, language = {eng}, keywords = {Models: Genetic, Genetic Predisposition to Disease, Genome: Human, Polymorphism: Single Nucleotide, Algorithms, Humans, Databases: Genetic}, date-added = {2010-01-15 14:37:37 +0100}, date-modified = {2010-01-15 14:37:38 +0100}, doi = {10.1086/521372}, pii = {S0002-9297(07)63867-1}, pmid = {17924333}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3359}, rating = {0} } @article{Endres:2006p3992, author = {Heinz G Endres and Christian Hucke and Tim Holland-Letz and Hans-Joachim Trampisch}, journal = {BMC Cardiovasc Disord}, title = {A new efficient trial design for assessing reliability of ankle-brachial index measures by three different observer groups}, abstract = {BACKGROUND: The usual method of assessing the variability of a measure such as the ankle brachial index (ABI) as a function of different observer groups is to obtain repeated measurements. Because the number of possible observer-subject combinations is impractically large, only a few small studies on inter- and intraobserver variability of ABI measures have been carried out to date. The present study proposes a new and efficient study design. This paper describes the study methodology. METHODS: Using a partially balanced incomplete block design, six angiologists, six primary-care physicians and six trained medical office assistants performed two ABI measurements each on six individuals from a group of 36 unselected subjects aged 65-70 years. Each test subject is measured by one observer from each of the three observer groups, and each observer measures exactly six of the 36 subjects in the group. Each possible combination of two observers occurs exactly once per patient and is not repeated on a second subject. The study involved four groups of 36 subjects (144), plus standbys. RESULTS: The 192 volunteers present at the study day were similar in terms of demographic characteristics and vascular risk factors: mean age 68.6 +/- 1.7; mean BMI 29.1 +/- 4.6; mean waist-hip ratio 0.92 +/- 0.09; active smokers 12%; hypertension 60.9%; hypercholesterolemia 53.4%; diabetic 17.2%. A complete set of ABI measurements (three observers performing two Doppler measurements each) was obtained from 108 subjects. From all other subjects at least one ABI measurement was obtained. The mean ABI was 1.08 (+/- 0.13), 15 (7.9%) volunteers had an ABI < 0.9, and none had an ABI > 1.4, i.e. a ratio that may be associated with increased stiffening of the arterial walls. CONCLUSION: This is the first large-scale study investigating the components of variability and thus reliability in ABI measurements. The advantage of the new study design introduced here is that only one sixth of the number of theoretically possible measurements is required to obtain information about measurement errors. Bland-Altman plots show that there are only small differences and no systematic bias between the observers from three occupational groups with different training backgrounds.}, affiliation = {Department of Medical Informatics, Biometry and Epidemiology, Ruhr-University, Bochum, D-44801 Bochum, Germany. heinz.endres@ruhr-uni-bochum.de}, pages = {33}, volume = {6}, year = {2006}, month = {Jan}, language = {eng}, keywords = {Blood Pressure, Ankle, Brachial Artery, Regional Blood Flow, Humans, Peripheral Vascular Diseases, Observer Variation, Female, Male, Research Design, Aged, Reproducibility of Results}, date-added = {2010-01-17 23:23:50 +0100}, date-modified = {2010-01-17 23:23:50 +0100}, doi = {10.1186/1471-2261-6-33}, pii = {1471-2261-6-33}, pmid = {16872534}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Endres-2006-BMC%20Cardiovasc%20Disord_A%20new%20efficient%20tria.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3992}, rating = {0} } @article{Smits:2006p12894, author = {D J M Smits and Paul De Boeck}, journal = {European Journal of Personality}, title = {From BIS/BAS to the Big Five}, abstract = {Gray (1987) proposed two systems that underlie much of our behaviour and personality. One system relates to avoidance or withdrawal behaviour, called the Behavioural Inhibition System (BIS), whereas the other system relates to approach behaviour, called the Behavioural Approach System (BAS). In two samples, it was investigated whether individual differences in surface of personality as described by the Big Five can be explained by BIS/BAS. Neuroticism and Extraversion could be explained well by BIS/BAS, but also for Agreeableness and Conscientiousness consistent findings were obtained.}, pages = {255--270}, volume = {20}, year = {2006}, date-added = {2010-06-24 13:44:46 +0200}, date-modified = {2010-07-29 20:46:12 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Smits-2006-European%20Journal%20of%20Personality_From%20BISBAS%20to%20the.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12894}, rating = {5} } @article{Parmigiani:2007p3298, author = {G Parmigiani and J Lin and S Boca and T Sjoblom and K W Kinzler and V E Velculescu and B Vogelstein}, journal = {Johns Hopkins University, Dept. of Biostatistics Working Papers}, title = {STATISTICAL METHODS FOR THE ANALYSIS OF CANCER GENOME SEQUENCING DATA}, abstract = {The purpose of cancer genome sequencing studies is to determine the nature and types of alterations present in a typical cancer and to discover genes mutated at high frequencies. In this article we discuss statistical methods for the analysis of data generated in these studies. We place special emphasis on a two-stage study design introduced by Sjoblom et al.[1]. In this context, we describe statistical methods for constructing scores that can be used to prioritize candidate genes for further investigation and to assess the statistical signicance of the candidates thus identfied.}, number = {126}, year = {2007}, date-added = {2010-01-14 21:26:56 +0100}, date-modified = {2010-01-14 21:27:51 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Parmigiani-2007-Johns%20Hopkins%20University%20Dept.%20of%20Biostatistics%20Working%20Papers_STATISTICAL%20METHODS.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3298}, rating = {0} } @article{Parker:2009p3157, author = {Michael Parker and Susan J Bull and Jantina de Vries and Tsiri Agbenyega and Ogobara K Doumbo and Dominic P Kwiatkowski}, journal = {PLoS Med}, title = {Ethical data release in genome-wide association studies in developing countries}, affiliation = {Ethox Centre, University of Oxford, Oxford, United Kingdom. michael.parker@ethox.ox.ac.uk}, number = {11}, pages = {e1000143}, volume = {6}, year = {2009}, month = {Nov}, language = {eng}, date-added = {2010-01-14 20:23:25 +0100}, date-modified = {2010-07-29 19:43:47 +0200}, doi = {10.1371/journal.pmed.1000143}, pmid = {19956792}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Parker-2009-PLoS%20Med_Ethical%20data%20release.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3157}, rating = {0} } @article{Brauer:2005p3653, author = {M Brauer and G McClelland}, journal = {L'Ann{\'e}e psychologique}, title = {L'utilisation des contrastes dans l'analyse des donn{\'e}es : Comment tester les hypoth{\`e}ses sp{\'e}cifiques dans la recherche en psychologie ?}, abstract = {Les tests omnibus plusieurs degr{\'e}s de libert{\'e}s ne fournissent que des r{\'e}ponses vagues alors que la plupart des hypoth{\`e}ses que nous d{\'e}rivons de nos mod{\`e}les th{\'e}oriques/ont des pr{\'e}dictions relativement pr{\'e}cises Pour r{\'e}pondre ce niveau de pr{\'e}cision nous sugg{\'e}rons de tester des contrastes sp{\'e}cifiques plut{\^o}t que effectuer des tests omnibus Deux conditions se doivent {\^e}tre satisfaites avant que on puisse affirmer un contraste donn{\'e} est une description parci monieuse des moyennes observ{\'e}es le contraste lui-m{\^e}me doit expliquer une partie significative de la variance et si on contr{\^o}le statistiquement les effets de ce contraste la variance intergroupe r{\'e}siduelle doit {\^e}tre non significa tive aide exemples concrets article pr{\'e}sente les analyses permettant de tester ces deux conditions avec diff{\'e}rents plans exp{\'e}rimentaux Mots cl{\'e}s contraste test omnibus variance r{\'e}siduelle degr{\'e} de liberte}, number = {2}, pages = {273--305}, volume = {105}, year = {2005}, date-added = {2010-01-16 20:04:26 +0100}, date-modified = {2010-07-29 19:38:38 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Brauer-2005-L'Ann%C3%A9e%20psychologique_L'utilisation%20des%20co-1.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3653}, rating = {0} } @techreport{Klein:2005, author = {John P Klein and Niels Keiding and Svend Kreiner}, journal = {Techreport}, title = {Graphical models for panel studies, illustrated on data from the framingham heart study}, affiliation = {Department of Biostatistics, University of Copenhagen}, year = {2005}, date-added = {2010-01-10 11:33:25 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Klein-2005-Techreport_Graphical%20models%20for.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2212}, rating = {0} } @article{King:2004p7022, author = {G King and C J L Murray and J A Salomon and A Tandon}, journal = {American Political Science Review}, title = {Enhancing the Validity and Cross-Cultural Comparability of Measurement in Survey Research}, abstract = {We address two long-standing survey research problems: measuring complicated concepts, such as political freedom and efficacy, that researchers define best with reference to examples; and what to do when respondents interpret identical questions in different ways. Scholars have long addressed these problems with approaches to reduce incomparability, such as writing more concrete questions---with uneven success. Our alternative is to measure directly response category incomparability and to correct for it. We measure incomparability via respondents' assessments, on the same scale as the self-assessments to be corrected, of hypothetical individuals described in short vignettes. Because the actual (but not necessarily reported) levels of the vignettes are invariant over respondents, variability in vignette answers reveals incomparability. Our corrections require either simple recodes or a statistical model designed to save survey administration costs. With analysis, simulations, and cross-national surveys, we show how response incomparability can drastically mislead survey researchers and how our approach can alleviate this problem.}, number = {1}, pages = {191--207}, volume = {98}, year = {2004}, date-added = {2010-03-06 19:57:31 +0100}, date-modified = {2010-03-06 19:58:27 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/King-2004-American%20Political%20Science%20Review_Enhancing%20the%20Validi.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7022}, rating = {0} } @article{Boulesteix:2007p460, author = {Anne-Laure Boulesteix}, journal = {Bioinformatics}, title = {WilcoxCV: an R package for fast variable selection in cross-validation}, abstract = {In the last few years, numerous methods have been proposed for microarray-based class prediction. Although many of them have been designed especially for the case n << p (much more variables than observations), preliminary variable selection is almost always necessary when the number of genes reaches several tens of thousands, as usual in recent data sets. In the two-class setting, the Wilcoxon rank sum test statistic is, with the t-statistic, one of the standard approaches for variable selection. It is well known that the variable selection step must be seen as a part of classifier construction and, as such, be performed based on training data only. When classifier accuracy is evaluated via cross-validation or Monte-Carlo cross-validation, it means that we have to perform p Wilcoxon or t-tests for each iteration, which becomes a daunting task for increasing p. As a consequence, many authors often perform variable selection only once using all the available data, which can induce a dramatic underestimation of error rate and thus lead to misleadingly reporting predictive power. We propose a very fast implementation of variable selection based on the Wilcoxon test for use in cross-validation and Monte Carlo cross-validation (also known as random splitting into learning and test sets). This implementation is based on a simple mathematical formula using only the ranks calculated from the original data set. Availability: Our method is implemented in the freely available R package WilcoxCV which can be downloaded from the Comprehensive R Archive Network at http://cran.r-project.org/src/contrib/Descriptions/WilcoxCV.html.}, affiliation = {Sylvia Lawry Centre for Multiple Sclerosis Research, Hohenlindenerstr. 1, D-81677 Munich, Germany. boulesteix@slcmsr.org}, number = {13}, pages = {1702--4}, volume = {23}, year = {2007}, month = {Jul}, language = {eng}, keywords = {Data Interpretation: Statistical, Reproducibility of Results, Gene Expression Profiling, Sensitivity and Specificity, Oligonucleotide Array Sequence Analysis, Statistics: Nonparametric, Software, Algorithms}, date-added = {2010-01-03 12:29:15 +0100}, date-modified = {2010-01-03 12:29:15 +0100}, doi = {10.1093/bioinformatics/btm162}, pii = {btm162}, pmid = {17495999}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Boulesteix-2007-Bioinformatics_WilcoxCV%20an%20R%20packa.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p460}, rating = {0} } @techreport{Diaz:2006a, author = {T E Diaz and H A Le and L L Wise}, journal = {Techreport}, title = {NAEP-QA FY06 Special Study: 12th Grade Math Trend Estimates}, affiliation = {US Department of Education}, year = {2006}, date-added = {2010-01-10 11:33:10 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Diaz-2006-Techreport_NAEP-QA%20FY06%20Special.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2132}, read = {Yes}, rating = {0} } @article{Krabbe:1999p7243, author = {P F Krabbe and M E Stouthard and M L Essink-Bot and G J Bonsel}, journal = {Journal of Clinical Epidemiology}, title = {The effect of adding a cognitive dimension to the EuroQol multiattribute health-status classification system}, abstract = {A methodological study was conducted to examine the effect of extending a frequently used simple multiattribute health-status classification system by adding a cognitive dimension. The EQ-5D questionnaire is a generic instrument to value health, developed by the EuroQol Group. The EQ-5D defines health according to five dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. We defined 18 different health states according to the standard EQ-5D classification. A second set of health states was constructed similar to the first, except for the addition of a cognitive dimension (EQ-5D+C). Valuations of both sets of health states were statistically analyzed to detect the effect of the additional dimension. The cognitive dimension generated systematically different values compared with the standard EQ-5D version, whereas the content validity improved. Both systems evoked equally reliable values. Analyses showed that a simple additive model to predict summary values for health states was not optimal for both systems. Although there is a current lack of consensus regarding the domains that are selected to represent health status, this study has shown the importance of considering the inclusion of a cognitive domain.}, affiliation = {Department of Public Health, Faculty of Medicine, Erasmus University, Rotterdam, The Netherlands.}, number = {4}, pages = {293--301}, volume = {52}, year = {1999}, month = {Apr}, language = {eng}, keywords = {Pain, Research Design, Questionnaires, Cognition, Reproducibility of Results, Activities of Daily Living, Female, Adult, Humans, Male, Health Status Indicators, Anxiety}, date-added = {2010-03-10 20:12:20 +0100}, date-modified = {2010-03-10 20:12:20 +0100}, pii = {S0895-4356(98)00163-2}, pmid = {10235169}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Krabbe-1999-Journal%20of%20Clinical%20Epidemiology_The%20effect%20of%20adding.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7243}, rating = {0} } @article{Muthen:1989p13808, author = {B Muth{\'e}n}, journal = {British Journal of Mathematical {\&} Statistical Psychology}, title = {Multiple-group structural modelling with non-normal continuous variables}, pages = {55--62}, volume = {42}, year = {1989}, date-added = {2010-07-29 12:26:00 +0200}, date-modified = {2010-07-29 19:22:12 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Muth%C3%A9n-1989-British%20Journal%20of%20Mathematical%20&%20Statistical%20Psychology_Multiple-group%20struc.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13808}, rating = {0} } @article{Patrick:2000p8803, author = {D L Patrick and Y P Chiang}, journal = {Med Care}, title = {Measurement of health outcomes in treatment effectiveness evaluations: conceptual and methodological challenges}, abstract = {Major challenges in the evaluation of the "end results" of health services include ensuring that concepts are correctly defined and measured, that the validity of measures used in different applications and populations is well documented, and that observed effects can be clearly interpreted. Health status is the most widely interpretable concept to apply in the context of health services. Quality of life connotes inclusion of the environment outside the context of the person and of health care and may or may not be health related, depending on the evaluation context and the impact of disease and treatment. All concepts and constructs must be defined in reference to their theoretical origin and to a model of relationships among different concepts. Modern test theory offers the potential for individualized, comparable assessments and for the careful examination and application of different measurement models. Selection and critique of measures should be based on the intended application and accumulated evidence for that application. Thus, there are no valid instruments per se. Validity in use, including responsiveness, interpretation of effects, and generalizability to diverse populations, is the most important measurement characteristic for treatment effectiveness. An evaluation of the validity of preference-based measures is particularly important for the interpretation and comparability of outcomes in cost-effectiveness evaluations. The successful translation of research into policy and practice is limited by the extent to which these critical issues are addressed in actual treatment evaluations.}, affiliation = {Department of Health Services, University of Washington, Seattle 98195-7600, USA. donald@u.washington.edu}, number = {9 Suppl}, pages = {II14--25}, volume = {38}, year = {2000}, month = {Sep}, language = {eng}, keywords = {Treatment Outcome, Humans, Randomized Controlled Trials as Topic, Research Design, Psychometrics, Health Status, Quality of Life, Evaluation Studies as Topic, Reproducibility of Results, Outcome Assessment (Health Care), Health Services Research}, date-added = {2010-03-22 12:08:22 +0100}, date-modified = {2010-07-29 19:39:29 +0200}, pmid = {10982087}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8803}, rating = {0} } @misc{Jackel:2003, author = {P J{\"a}ckel}, journal = {Miscellaneous}, title = {A note on multivariate Gauss-Hermite quadrature}, year = {2003}, date-added = {2010-01-10 11:33:22 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/J%C3%A4ckel-2003-Miscellaneous_A%20note%20on%20multivaria.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1992}, rating = {0} } @article{Hinrichs:2009p824, author = {Anthony L Hinrichs and Emma K Larkin and Brian K Suarez}, journal = {Genet Epidemiol}, title = {Population stratification and patterns of linkage disequilibrium}, abstract = {Although the importance of selecting cases and controls from the same population has been recognized for decades, the recent advent of genome-wide association studies has heightened awareness of this issue. Because these studies typically deal with large samples, small differences in allele frequencies between cases and controls can easily reach statistical significance. When, unbeknownst to a researcher, cases and controls have different substructures, the number of false-positive findings is inflated. There have been three recent developments of purely statistical approaches to assessing the ancestral comparability of case and control samples: genomic control, structured association, and multivariate reduction analyses. The widespread use of high-throughput technology has allowed the quick and accurate genotyping of the large number of markers required by these methods. Group 13 dealt with four population stratification issues: single-nucleotide polymorphism marker selection, association testing, nonstandard methods, and linkage disequilibrium calculations in stratified or mixed ethnicity samples. We demonstrated that there are continuous axes of ethnic variation in both data sets of Genetic Analysis Workshop 16. Furthermore, ignoring this structure created P-value inflation for a variety of phenotypes. Principal-components analysis (or multidimensional scaling) can control inflation as covariates in a logistic regression. One can weigh for local ancestry estimation and allow the use of related individuals. Problems arise in the presence of extremely high association or unusually strong linkage disequilibrium (e.g., in chromosomal inversions). Our group also reported a method for performing an association test controlling for substructure, when genome-wide markers are not available, to explicitly compute stratification.}, affiliation = {Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA. tony@fire.wustl.edu}, pages = {S88--92}, volume = {33 Suppl 1}, year = {2009}, month = {Jan}, language = {eng}, date-added = {2010-01-03 17:48:03 +0100}, date-modified = {2010-01-03 17:48:03 +0100}, doi = {10.1002/gepi.20478}, pmid = {19924707}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p824}, rating = {0} } @article{Charland:1996, author = {H Charland and G C{\^o}t{\'e}}, journal = {Revue qu{\'e}b{\'e}coise de psychologie}, title = {Fid{\'e}lit{\'e} et validit{\'e} de la version fran{\c c}aise du "Children of Alcoholics Screening Test" (CAST)}, number = {1}, pages = {45--62}, volume = {17}, year = {1996}, date-added = {2010-01-10 11:33:21 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Charland-1996-Revue%20qu%C3%A9b%C3%A9coise%20de%20psychologie_Fid%C3%A9lit%C3%A9%20et%20validit%C3%A9.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1982}, rating = {0} } @article{Bech:2008p6718, author = {P Bech}, journal = {European Psychiatric Review}, title = {The Use of Rating Scales in Affective Disorders}, pages = {14--18}, year = {2008}, date-added = {2010-03-05 22:11:14 +0100}, date-modified = {2010-03-05 22:14:26 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Bech-2008-European%20Psychiatric%20Review_The%20Use%20of%20Rating%20Sc.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6718}, rating = {3} } @article{Vermunt:2001a, author = {J K Vermunt and M F Rodrigo and M Ato-Garcia}, journal = {Sociological Methods {\&} Research}, title = {Modeling joint and marginal distributions in the analysis of categorical panel data}, pages = {170--196}, volume = {30}, year = {2001}, date-added = {2010-01-10 11:33:22 +0100}, date-modified = {2010-07-29 19:50:37 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Vermunt-2001-Sociological%20Methods%20&%20Research_Modeling%20joint%20and%20m.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2127}, rating = {0} } @article{Wrobel:2005p11909, author = {Gunnar Wrobel and Fr{\'e}d{\'e}ric Chalmel and Michael Primig}, journal = {Bioinformatics}, title = {goCluster integrates statistical analysis and functional interpretation of microarray expression data}, abstract = {MOTIVATION: Several tools that facilitate the interpretation of transcriptional profiles using gene annotation data are available but most of them combine a particular statistical analysis strategy with functional information. goCluster extends this concept by providing a modular framework that facilitates integration of statistical and functional microarray data analysis with data interpretation. RESULTS: goCluster enables scientists to employ annotation information, clustering algorithms and visualization tools in their array data analysis and interpretation strategy. The package provides four clustering algorithms and GeneOntology terms as prototype annotation data. The functional analysis is based on the hypergeometric distribution whereby the Bonferroni correction or the false discovery rate can be used to correct for multiple testing. The approach implemented in goCluster was successfully applied to interpret the results of complex mammalian and yeast expression data obtained with high density oligonucleotide microarrays (GeneChips). AVAILABILITY: goCluster is available via the BioConductor portal at www.bioconductor.org. The software package, detailed documentation, user- and developer guides as well as other background information are also accessible via a web portal at http://www.bioz.unibas.ch/gocluster CONTACT: michael.primig@unibas.ch}, affiliation = {Biozentrum and Swiss Institute of Bioinformatics, Klingelbergstrasse 50-70, CH-4056 Basel, Switzerland.}, number = {17}, pages = {3575--7}, volume = {21}, year = {2005}, month = {Sep}, language = {eng}, keywords = {Software, Oligonucleotide Array Sequence Analysis, Systems Integration, Algorithms, Computer Simulation, Gene Expression Profiling, Cluster Analysis, Artificial Intelligence, Models: Statistical, Models: Genetic, Pattern Recognition: Automated}, date-added = {2010-05-23 11:56:01 +0200}, date-modified = {2010-05-23 11:56:09 +0200}, doi = {10.1093/bioinformatics/bti574}, pii = {bti574}, pmid = {16020468}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Wrobel-2005-Bioinformatics_goCluster%20integrates.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11909}, rating = {3} } @article{Cacioppo:2009p12792, author = {J T Cacioppo and J Decety}, journal = {Perspectives on Psychological Science}, title = {What Are the Brain Mechanisms on Which Psychological Processes Are Based?}, abstract = {That the human brain is the organ of the mind is not in dispute, but we know remarkably little about the brain mechanisms underlying the mind. What are the functional structures and computational processes of the human brain that subserve cognition, emotion, and be- havior? Given the complexity of the human brain, progress in understanding the functional organization and struc- ture of the human brain depends on sophisticated theo- retical specifications of the psychological representations and processes that differentiate two or more comparison conditions. Psychological scientists, therefore, are well positioned to lead the search for brain mechanisms un- derlying psychological processes. Doing so constitutes an expansion of the purview of psychological science beyond a science of behavior, and beyond a science of the mind, to include a science of the brain. Such an expansion of the mission of psychological science has implications for the infrastructure and training needs of the discipline.}, number = {1}, pages = {10--18}, volume = {4}, year = {2009}, date-added = {2010-06-18 21:10:42 +0200}, date-modified = {2010-06-18 21:13:15 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Cacioppo-2009-Perspectives%20on%20Psychological%20Science_What%20Are%20the%20Brain%20M.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12792}, rating = {0} } @article{Degenholtz:2006p3502, author = {H B Degenholtz and M J Miller and R A Kane and L J Cutler and R L Kane}, journal = {Journal of Housing for the Elderly}, title = {Developing a Typology of Nursing Home Environmentsv}, number = {1/2}, pages = {5--29}, volume = {20}, year = {2006}, date-added = {2010-01-15 15:33:01 +0100}, date-modified = {2010-01-15 15:34:37 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Degenholtz-2006-Journal%20of%20Housing%20for%20the%20Elderly_Developing%20a%20Typolog.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3502}, rating = {0} } @article{Lantieri:2009p3375, author = {Francesca Lantieri and Min A Jhun and Jungsun Park and Taesung Park and Marcella Devoto}, journal = {BMC Proc}, title = {Comparative analysis of different approaches for dealing with candidate regions in the context of a genome-wide association study}, abstract = {ABSTRACT : Genome-wide association studies (GWAS) test hundreds of thousands of single-nucleotide polymorphisms (SNPs) for association to a trait, treating each marker equally and ignoring prior evidence of association to specific regions. Typically, promising regions are selected for further investigation based on p-values obtained from simple tests of association. However, loci that exert only a weak, low-penetrant role on the trait, producing modest evidence of association, are not detectable in the context of a GWAS. Implementing prior knowledge of association in GWAS could increase power, help distinguish between false and true positives, and identify better sets of SNPs for follow-up studies.Here we performed a GWAS on rheumatoid arthritis (RA) patients and controls (Problem 1, Genetic Analysis Workshop 16). In order to include prior information in the analysis, we applied four methods that distinctively deal with markers in candidate genes in the context of GWAS. SNPs were divided into a random and a candidate subset, then we applied empirical correction by permutation, false-discovery rate, false-positive report probability, and posterior odds of association using different prior probabilities. We repeated the same analyses on two different sets of candidate markers defined on the basis of previously reported association to RA following two different approaches. The four methods showed similar relative behavior when applied to the two sets, with the proportion of candidate SNPs ranked among the top 2,000 varying from 0 to 100%. The use of different prior probabilities changed the stringency of the methods, but not their relative performance.}, affiliation = {The Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, Pennsylvania 19104, USA. f.lantieri@unige.it.}, pages = {S93}, volume = {3 Suppl 7}, year = {2009}, month = {Jan}, language = {eng}, date-added = {2010-01-15 14:41:02 +0100}, date-modified = {2010-01-15 14:41:05 +0100}, pmid = {20018090}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3375}, rating = {3} } @article{Nicodemus:2010p5843, author = {Kristin K Nicodemus and Joseph H Callicott and Rachel G Higier and Augustin Luna and Devon C Nixon and Barbara K Lipska and Radhakrishna Vakkalanka and Ina Giegling and Dan Rujescu and David St Clair and Pierandrea Muglia and Yin Yao Shugart and Daniel R Weinberger}, journal = {Hum Genet}, title = {Erratum to: Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging}, affiliation = {Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Room 4S-235, 10 Center Drive, Bethesda, MD, 20892, USA, kristin.nicodemus@well.ox.ac.uk.}, pages = {}, year = {2010}, month = {Feb}, language = {ENG}, date-added = {2010-02-17 10:18:16 +0100}, date-modified = {2010-07-29 19:28:44 +0200}, doi = {10.1007/s00439-010-0793-8}, pmid = {20127117}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5843}, rating = {0} } @article{vanderSluis:2008p9132, author = {Sophie van der Sluis and Gonneke Willemsen and Eco J C de Geus and Dorret I Boomsma and Danielle Posthuma}, journal = {Behav Genet}, title = {Gene-environment interaction in adults' IQ scores: measures of past and present environment}, abstract = {Gene-environment interaction was studied in a sample of young (mean age 26 years, N = 385) and older (mean age 49 years, N = 370) adult males and females. Full scale IQ scores (FSIQ) were analyzed using biometric models in which additive genetic (A), common environmental (C), and unique environmental (E) effects were allowed to depend on environmental measures. Moderators under study were parental and partner educational level, as well as urbanization level and mean real estate price of the participants' residential area. Mean effects were observed for parental education, partner education and urbanization level. On average, FSIQ scores were roughly 5 points higher in participants with highly educated parents, compared to participants whose parents were less well educated. In older participants, IQ scores were about 2 points higher when their partners were highly educated. In younger males, higher urbanization levels were associated with slightly higher FSIQ scores. Our analyses also showed increased common environmental variation in older males whose parents were more highly educated, and increased unique environmental effects in older males living in more affluent areas. Contrary to studies in children, however, the variance attributable to additive genetic effects was stable across all levels of the moderators under study. Most results were replicated for VIQ and PIQ.}, affiliation = {Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, Amsterdam 1081 BT, The Netherlands. s.van.der.sluis@psy.vu.nl}, number = {4}, pages = {348--60}, volume = {38}, year = {2008}, month = {Jul}, language = {eng}, keywords = {Intelligence, Models: Biological, Speech, Twins: Dizygotic, Twins: Monozygotic, Adult, Models: Genetic, Male, Intelligence Tests, Psychometrics, Netherlands, Female, Environment, Humans}, date-added = {2010-03-22 13:27:48 +0100}, date-modified = {2010-07-29 20:09:06 +0200}, doi = {10.1007/s10519-008-9212-5}, pmid = {18535898}, local-url = {file://localhost/Users/chl/Dropbox/Papers/van%20der%20Sluis-2008-Behav%20Genet_Gene-environment%20int.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p9132}, rating = {0} } @article{Dray:2008p809, author = {St{\'e}phane Dray}, journal = {Computational Statistics}, title = {On the number of principal components: A test of dimensionality based on measurements of similarity between matrices}, abstract = {An important problem in principal component analysis (PCA) is the estimation of the correct number of components to retain. PCA is most often used to reduce a set of observed variables to a new set of variables of lower dimensionality. The choice of this dimensionality is a crucial step for the interpretation of results or subsequent analyses, because it could lead to a loss of information (underestimation) or the introduction of random noise (overestimation). New techniques are proposed to evaluate the dimensionality in PCA. They are based on similarity measurements, singular value decomposition and permutation procedures. A simulation study is conducted to evaluate the relative merits of the proposed approaches. Results showed that one method based on the RV coefficient is very accurate and seems to be more efficient than other existing approaches.}, affiliation = {Laboratoire de Biom{\'e}trie et Biologie Evolutive, Universit{\'e} de Lyon; Universit{\'e} Lyon 1; CNRS; UMR 5558, 43 boulevard du 11 novembre 1918, Villeurbanne F-69622, France}, pages = {2228--2237}, volume = {52}, year = {2008}, month = {Oct}, keywords = {Simulation study, Permutation procedure, Co-inertia criterion, Singular value decomposition, RV coefficient, Stopping rules}, date-added = {2010-01-03 17:15:42 +0100}, date-modified = {2010-07-29 19:24:31 +0200}, doi = {10.1016/j.csda.2007.07.015}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Dray-2008-Computational%20Statistics_On%20the%20number%20of%20pri.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p809}, rating = {0} } @article{Lubke:2001p11600, author = {G H Lubke and CV Dolan and H Kelderman}, journal = {Multivariate Behavioral Research}, title = {Investigating Group Differences on Cognitive Tests Using Spearman's Hypothesis: An Evaluation of Jensen's Method}, abstract = {Jensen has posited a research method to investigate group differences in cognitive tests. This method consists of first extracting a general intelligence factor by means of exploratory factor analysis. Secondly, similarity of factor loadings across groups is evaluated in an attempt to ensure that the same constructs are measured. Finally, the correlation is computed between the loadings of the tests on the general intelligence factor and the mean differences between groups on the tests. This part is referred to as a test of ``Spearman's Hypothesis'', which essentially states that differences in g account for the main part of differences in observed scores. Based on the correlation, inferences are made with respect to group differences in general intelligence. The validity of these inferences is investigated and compared to the validity of inferences based on multi-group confirmatory factor analysis. For this comparison, population covariance matrices are constructed which incorporate violations of the central assumption underlying Jensen's method concerning the existence of g and/or violations of Spearman's Hypothesis. It is demonstrated that Jensen's method is quite insensitive to the violations. This lack of specificity is observed consistently for all types of violations introduced in the present study. Multi-group confirmatory factor analysis emerges as clearly superior to Jensen's method.}, number = {3}, pages = {299--324}, volume = {36}, year = {2001}, date-added = {2010-05-09 21:28:43 +0200}, date-modified = {2010-05-09 21:29:43 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Lubke-2001-Multivariate%20Behavioral%20Research_Investigating%20Group.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11600}, rating = {0} } @article{Harvey:2004p2591, author = {R J Harvey and E Hollander}, title = {Benchmarking rWG Interrater Agreement Indices: Let's Drop the .70 Rule-Of-Thumb}, abstract = {Variance-based interrater agreement indices in the rWG family are often interpreted using rules-of- thumb derived for reliabilities (e.g., ≥ .70 = acceptable). Monte Carlo results suggest that far more stringent standards are needed, especially for maximum-variance rWG, as values > .70 can routinely be obtained from totally random ratings.}, year = {2004}, date-added = {2010-01-12 22:35:51 +0100}, date-modified = {2010-01-12 22:36:36 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Harvey-2004-_Benchmarking%20rWG%20Int.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2591}, rating = {0} } @article{Sprangers:2002p8512, author = {Mirjam A G Sprangers and Carol M Moinpour and Timothy J Moynihan and Donald L Patrick and Dennis A Revicki and Clinical Significance Consensus Meeting Group}, journal = {Mayo Clin Proc}, title = {Assessing meaningful change in quality of life over time: a users' guide for clinicians}, abstract = {The objective of this article is to help clinicians interpret trial-based quality of life (QOL) changes over time. We address a series of questions and provide guidelines that are fundamental to assessing and interpreting change. The issues addressed are as follows: (1) What are the characteristics of the population for whom changes in QOL are reported? (2) Is the QOL questionnaire reliable, valid, and responsive to change? (3) Are the timing and frequency of assessments adequate? (4) Is the study adequately powered? (5) How are multiple QOL outcomes addressed in analyses? (6) How are multiple time points handled? (7) Can alternative explanations account for the observed change or lack of observed change (eg, handling of missing data, survival differences, and changes in patient's QOL perspective over time)? and (8) How is statistical significance translated into meaningful change? These guidelines will support clinicians in reviewing the clinical trial literature, which in turn can help them use the data in the treatment decision process.}, affiliation = {Department of Medical Psychology, Academic Medical Center, University of Amsterdam, The Netherlands.}, number = {6}, pages = {561--71}, volume = {77}, year = {2002}, month = {Jun}, language = {eng}, keywords = {Reproducibility of Results, Clinical Trials as Topic, Antineoplastic Agents: Hormonal, Physician's Practice Patterns, Female, Practice Guidelines as Topic, Flutamide, United States, Adenocarcinoma, Prostatic Neoplasms, Humans, Sickness Impact Profile, Outcome Assessment (Health Care), Clinical Competence, Questionnaires, Quality of Life, Male, Patient Satisfaction, Orchiectomy, Androgen Antagonists}, date-added = {2010-03-21 20:37:36 +0100}, date-modified = {2010-03-21 20:37:36 +0100}, pmid = {12059127}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Sprangers-2002-Mayo%20Clin%20Proc_Assessing%20meaningful.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8512}, rating = {0} } @article{Eldridge:2008p6416, author = {Sandra Eldridge and Deborah Ashby and Catherine Bennett and Melanie Wakelin and Gene Feder}, journal = {BMJ}, title = {Internal and external validity of cluster randomised trials: systematic review of recent trials}, abstract = {OBJECTIVES: To assess aspects of the internal validity of recently published cluster randomised trials and explore the reporting of information useful in assessing the external validity of these trials. DESIGN: Review of 34 cluster randomised trials in primary care published in 2004 and 2005 in seven journals (British Medical Journal, British Journal of General Practice, Family Practice, Preventive Medicine, Annals of Internal Medicine, Journal of General Internal Medicine, Pediatrics). DATA SOURCES: National Library of Medicine (Medline) via PubMed. DATA EXTRACTION: To assess aspects of internal validity we extracted data on appropriateness of sample size calculations and analyses, methods of identifying and recruiting individual participants, and blinding. To explore reporting of information useful in assessing external validity we extracted data on cluster eligibility, cluster inclusion and retention, cluster generalisability, and the feasibility and acceptability of the intervention to health providers in clusters. RESULTS: 21 (62%) trials accounted for clustering in sample size calculations and 30 (88%) in the analysis; about a quarter were potentially biased because of procedures surrounding recruitment and identification of patients; individual participants were blind to allocation status in 19 (56%) and outcome assessors were blind in 15 (44%). In almost half the reports, information relating to generalisability of clusters was poorly reported, and in two fifths there was no information about the feasibility and acceptability of the intervention. CONCLUSIONS: Cluster randomised trials are essential for evaluating certain types of interventions. Issues affecting their internal validity, such as appropriate sample size calculations and analysis, have been widely disseminated and are now better addressed by researchers. Blinding of those identifying and recruiting patients to allocation status is recommended but is not always carried out. There may be fewer barriers to internal validity in trials in which individual participants are not recruited. External validity seems poorly addressed in many trials, yet is arguably as important as internal validity in judging quality as a basis for healthcare intervention.}, affiliation = {Centre for Health Sciences, Barts and The London School of Medicine and Dentistry, London E1 2AT. s.eldridge@qmul.ac.uk}, number = {7649}, pages = {876--80}, volume = {336}, year = {2008}, month = {Apr}, language = {eng}, keywords = {Cluster Analysis, Sample Size, Reproducibility of Results, Randomized Controlled Trials as Topic}, date-added = {2010-02-23 08:26:42 +0100}, date-modified = {2010-02-23 08:26:43 +0100}, doi = {10.1136/bmj.39517.495764.25}, pii = {bmj.39517.495764.25}, pmid = {18364360}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6416}, rating = {0} } @article{Zihl:2010p4022, author = {Josef Zihl and Simone Reppermund and Sonja Thum and Kathrin Unger}, journal = {J Psychiatr Res}, title = {Neuropsychological profiles in MCI and in depression: Differential cognitive dysfunction patterns or similar final common pathway disorder?}, abstract = {The concept of "mild cognitive impairment" (MCI) refers to alterations in cognition in the transition between normal aging and dementia. However, from a neuropsychological point of view the conventional diagnostic criteria appear not sufficiently valid. In particular, it is still difficult to differentiate between subjects with MCI and subjects with depression plus cognitive deficits on the basis of their neuropsychological profiles. The aim of this study is to compare cognitive deficit patterns of subjects with MCI and with depression. 24 subjects with MCI, 50 subjects with depression (DEP) and 20 healthy control subjects were included (age: 55-74years). The neuropsychological assessment consisted of standardized tests to assess attention, memory, and executive functions. Compared to healthy controls both subject groups showed significantly lower performance in all cognitive domains. However, we did not find significant differences in cognitive performance between MCI and DEP subjects, neither at baseline nor at follow-up. In addition, preliminary results of follow-up assessments after 2 (DEP) and 6months (MCI), respectively, revealed no significant changes in cognition in subjects with depression, regardless of whether depressive symptoms had improved. Subjects with MCI also showed no changes in cognition at follow-up. The comparable neuropsychological patterns identified in the two subject groups may be understood as a consequence of similar alterations in cognitive systems, supporting the idea of a final common pathway disorder. Thus, the cognitive deficits present in a subgroup of subjects with depression may possibly better be understood in the context of MCI.}, affiliation = {Max Planck Institute of Psychiatry, Munich, Germany; University of Munich, Department Psychology, Neuropsychology, Munich, Germany.}, pages = {}, year = {2010}, month = {Jan}, language = {ENG}, date-added = {2010-01-19 08:21:55 +0100}, date-modified = {2010-01-19 08:21:55 +0100}, doi = {10.1016/j.jpsychires.2009.12.002}, pii = {S0022-3956(09)00274-X}, pmid = {20060127}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Zihl-2010-J%20Psychiatr%20Res_Neuropsychological%20p.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p4022}, rating = {0} } @article{Gelernter:2005p3533, author = {Joel Gelernter and Carolien Panhuysen and Roger Weiss and Kathleen Brady and Victor Hesselbrock and Bruce Rounsaville and James Poling and Marsha Wilcox and Lindsay Farrer and Henry R Kranzler}, journal = {Am J Med Genet B Neuropsychiatr Genet}, title = {Genomewide linkage scan for cocaine dependence and related traits: significant linkages for a cocaine-related trait and cocaine-induced paranoia}, abstract = {Risk for cocaine dependence (CD) is genetically influenced. We recruited a sample of small nuclear families (528 full and 155 half sibpairs) with at least one subject affected with CD. The sample was classified via Bayesian clustering as 45.5% European American (EA) and 54.5% African American (AA). Assessment, via the Semi-Structured Assessment for Drug Dependence and Alcoholism, allowed for detailed evaluation of substance dependence-related traits. To define subgroups with increased genetic homogeneity, consistent with our a priori analytic plan, we used cluster analytic methods to identify six cocaine-related symptom clusters; membership was shown to be significantly heritable. We then completed a genomewide linkage scan (409 markers) for the CD diagnosis, cocaine-induced paranoia (CIP; an outcome that occurs in some cocaine users) and the clusters (three of which contained >80% of the CD subjects). We observed a "suggestive" linkage signal on chromosome 10 for the trait of CD in the full sample; and two "suggestive" linkage signals at different locations on chromosome 3, in the EA part of the sample. We observed a genomewide-significant lod score of 3.65 for the trait of CIP on chromosome 9, in the AA part of the sample only. Our strongest results were observed for the cluster membership traits, including a lod score of 4.66 for membership in the "Heavy Use, Cocaine Predominant" cluster on chromosome 12 (in EAs only) and a lod score of 3.35 for membership in the "Moderate Cocaine and Opioid Abuse" cluster on chromosome 18. These results provide a basis for the identification of specific genes contributing to risk for these traits.}, affiliation = {Yale University School of Medicine, Department of Psychiatry, Division of Human Genetics; and VA CT Healthcare Center, West Haven, CT 06516, USA. joel.gelernter@yale.edu}, number = {1}, pages = {45--52}, volume = {136B}, year = {2005}, month = {Jul}, language = {eng}, keywords = {Paranoid Disorders, Gene Frequency, Alcoholism, Linkage (Genetics), Phenotype, Adult, Bayes Theorem, Male, Cocaine-Related Disorders, Female, Models: Genetic, Microsatellite Repeats, Family Health, Genotype, Genome: Human, Humans}, date-added = {2010-01-15 20:50:31 +0100}, date-modified = {2010-01-15 20:50:31 +0100}, doi = {10.1002/ajmg.b.30189}, pmid = {15909294}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3533}, rating = {0} } @article{deLeeuw:1986p11676, author = {Jan de Leeuw}, journal = {NATO Advanced Research Workshop on Numerical Ecology}, title = {Nonlinear multivariate analysis with optimal scaling}, year = {1986}, date-added = {2010-05-14 21:16:11 +0200}, date-modified = {2010-07-29 20:45:39 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/de%20Leeuw-1986-NATO%20Advanced%20Research%20Workshop%20on%20Numerical%20Ecology_Nonlinear%20multivaria.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11676}, rating = {0} } @article{Kates:2009p8907, author = {Wendy R Kates and Ichiro Ikuta and Courtney P Burnette}, journal = {Autism Res}, title = {Gyrification patterns in monozygotic twin pairs varying in discordance for autism}, abstract = {In order to disentangle genetic and environmental contributions to cortical anomalies in children with autism, we investigated cortical folding patterns in a cohort of 14 monozygotic (MZ) twin pairs who displayed a range of phenotypic discordance for autism, and 14 typically developing community controls. Cortical folding was assessed with the gyrification index, which was calculated on high resolution anatomic MR images. We found that the cortical folding patterns across most lobar regions of the cerebral cortex was highly discordant within MZ twin pairs. In addition, children with autism and their co-twins exhibited increased cortical folding in the right parietal lobe, relative to age- and gender-matched typical developing children. Increased folding in the right parietal lobe was associated with more symptoms of autism for co-twins. Finally, the robust association between cortical folding and IQ observed in typical children was not observed in either children with autism or their co-twins. These findings, which contribute to our understanding of the limits of genetic liability in autism, suggest that anomalies in the structural integrity of the cortex in this PDD may disrupt the association between cortical folding and intelligence that has been reported in typical individuals, and may account, in part, for the deficits in visual spatial attention and in social cognition that have been reported in children with autism.}, affiliation = {Department of Psychiatry and Behavioral Sciences, State University of New York at Upstate Medical University, Syracuse, New York 13210, USA. katesw@upstate.edu}, number = {5}, pages = {267--78}, volume = {2}, year = {2009}, month = {Oct}, language = {eng}, keywords = {Twins: Monozygotic, Intelligence, Image Processing: Computer-Assisted, Male, Adolescent, Magnetic Resonance Imaging, Cerebral Cortex, Autistic Disorder, Cohort Studies, Child, Child: Preschool, Brain Mapping, Imaging: Three-Dimensional, Female, Humans}, date-added = {2010-03-22 12:56:24 +0100}, date-modified = {2010-03-22 12:56:24 +0100}, doi = {10.1002/aur.98}, pmid = {19890876}, URL = {http://www3.interscience.wiley.com/journal/122672650/abstract}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Kates-2009-Autism%20Res_Gyrification%20pattern.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8907}, rating = {0} } @article{Grimison:2009p11768, author = {Peter S Grimison and R John Simes and H Malcolm Hudson and Martin R Stockler}, journal = {Value Health}, title = {Preliminary validation of an optimally weighted patient-based utility index by application to randomized trials in breast cancer}, abstract = {OBJECTIVES: To optimize, apply, and validate a scoring algorithm that provides a utility index from a cancer-specific quality of life questionnaire called the Utility-Based Questionnaire-Cancer (UBQ-C) using data sets from randomized trials in breast cancer. The index is designed to reflect the perspective of cancer patients in a specific clinical context so as to best inform clinical decisions. METHODS: We applied the UBQ-C scoring algorithm to trials of chemotherapy for advanced (n = 325) and early (n = 126) breast cancer. The algorithm converts UBQ-C subscales into a subset index, and combines it with a global health status item into an overall HRQL index, which is then converted to a utility index using a power transformation. The optimal subscale weights were determined by their correlations with the global scale in the relevant data set. The validity of the utility index was tested against other patient characteristics. RESULTS: Optimal weights (range 0-1) for the subset index in advanced (early) breast cancer were: physical function 0.20 (0.09); social/usual activities 0.23 (0.25); self-care 0.04 (0.01); and distresses 0.53 (0.64). Weights for the overall HRQL index were health status 0.66 (0.63) and subset index 0.34 (0.37). The utility index discriminated between breast cancer that was advanced rather than early (means 0.88 vs. 0.94, P < 0.0001) and was responsive to the toxic effects of chemotherapy in early breast cancer (mean change 0.07, P < 0.0001). CONCLUSIONS: The scoring algorithm for the UBQ-C utility index can be optimized in different clinical contexts to reflect the relative importance of different aspects of quality of life to the patients in a trial. It can be used to generate sensitive and responsive utility scores, and quality-adjusted life-years that can be used within a trial to compare the net benefit of treatments and inform clinical decision-making.}, affiliation = {NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia. Peter.Grimison@ctc.usyd.edu.au}, number = {6}, pages = {967--76}, volume = {12}, year = {2009}, month = {Sep}, language = {eng}, keywords = {Algorithms, Australia, Quality-Adjusted Life Years, Health Status, Humans, Randomized Controlled Trials as Topic, Questionnaires, Adult, Quality of Life, Fluorouracil, Multicenter Studies as Topic, Sickness Impact Profile, Breast Neoplasms, Aged, New Zealand, Female, Antimetabolites: Antineoplastic, Young Adult, Outcome Assessment (Health Care), Survival Analysis, Deoxycytidine, Adolescent, Middle Aged}, date-added = {2010-05-23 10:38:44 +0200}, date-modified = {2010-05-23 10:38:44 +0200}, doi = {10.1111/j.1524-4733.2009.00536.x}, pii = {VHE536}, pmid = {19490566}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Grimison-2009-Value%20Health_Preliminary%20validati.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11768}, rating = {0} } @article{Ali:2009p13760, author = {Niloufer S Ali and Badar S Ali and Iqbal S Azam}, journal = {BMC Public Health}, title = {Post partum anxiety and depression in peri-urban communities of Karachi, Pakistan: a quasi-experimental study}, abstract = {BACKGROUND: Postpartum anxiety and depression is a major public health concern because of its adverse effects on the cognitive and social development of the infant. Globally postpartum depression has been widely investigated but as anxiety is a more prominent feature of postpartum depression we assessed the prevalence of anxiety and depression and their associated factors in post partum women. METHODS: A quasi-experimental study investigating the impact of postpartum anxiety and depression on child growth and development was conducted in two peri-urban, multiethnic, communities of Karachi, a mega city of Pakistan. A house to house questionnaire based survey was done by trained field workers; 420 consenting pregnant women were identified and data for socio-demographic, home environment and family relationship variables was collected between 36 weeks of pregnancy and within 10 days of childbirth. Mother's levels of anxiety and depression were assessed after one month, two months, six months and twelve months of childbirth; this was two step process: initially an indigenous, validated screening instrument Aga Khan University Anxiety and Depression Scale was used and diagnostic confirmation was done through a psychologist's interview based on DSM IV criteria. Women found to be anxious and depressed at least once out of four assessments were considered for the computation of overall prevalence of postpartum anxiety and depression as well as its risk factors. However, point prevalence's of postpartum anxiety and depression were also reported at each assessment time. Two sixty seven women could be followed for one year. Data was analyzed using SPSS. Chi-square test, simple and multiple logistic regression were used to see the association of different factors. RESULTS: The overall prevalence of postpartum anxiety and depression was found to be 28.8 percent. Domestic violence, difficulty in breast feeding at birth and unplanned current pregnancy were found to be significantly associated with postpartum anxiety and depression. CONCLUSION: Domestic violence and not having the right to plan pregnancy are related to the patriarchal culture and lack of empowerment of women. The association with difficulties in breast feeding needs to be further explored in future studies.}, affiliation = {Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan, Stadium Road, PO Box 3500, Karachi 74800, Pakistan. niloufer.ali@aku.edu}, pages = {384}, volume = {9}, year = {2009}, month = {Jan}, language = {eng}, date-added = {2010-07-28 23:02:53 +0200}, date-modified = {2010-07-28 23:02:53 +0200}, doi = {10.1186/1471-2458-9-384}, pii = {1471-2458-9-384}, pmid = {19821971}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Ali-2009-BMC%20Public%20Health_Post%20partum%20anxiety.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13760}, rating = {0} } @misc{Fox:2007a, author = {J-P Fox}, journal = {Miscellaneous}, title = {Multilevel IRT Model Assessment}, year = {2007}, date-added = {2010-01-10 11:33:18 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Fox-2007-Miscellaneous_Multilevel%20IRT%20Model.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2054}, read = {Yes}, rating = {0} } @phdthesis{Fox:2001a, author = {Jean-Paul Fox}, journal = {PhD Thesis}, title = {Multilevel IRT: A bayesian perspective on estimating parameters and testing statistical hypotheses}, affiliation = {Twente University}, year = {2001}, date-added = {2010-01-10 11:33:22 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Fox-2001-PhD%20Thesis_Multilevel%20IRT%20A%20ba.PDF}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2150}, rating = {0} } @article{Arking:2008p6061, author = {Dan E Arking and David J Cutler and Camille W Brune and Tanya M Teslovich and Kristen West and Morna Ikeda and Alexis Rea and Moltu Guy and Shin Lin and Edwin H Cook and Aravinda Chakravarti}, journal = {Am J Hum Genet}, title = {A common genetic variant in the neurexin superfamily member CNTNAP2 increases familial risk of autism}, abstract = {Autism is a childhood neuropsychiatric disorder that, despite exhibiting high heritability, has largely eluded efforts to identify specific genetic variants underlying its etiology. We performed a two-stage genetic study in which genome-wide linkage and family-based association mapping was followed up by association and replication studies in an independent sample. We identified a common polymorphism in contactin-associated protein-like 2 (CNTNAP2), a member of the neurexin superfamily, that is significantly associated with autism susceptibility. Importantly, the genetic variant displays a parent-of-origin and gender effect recapitulating the inheritance of autism.}, affiliation = {McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.}, number = {1}, pages = {160--4}, volume = {82}, year = {2008}, month = {Jan}, language = {eng}, keywords = {Male, Female, Genome: Human, Autistic Disorder, Oligonucleotide Array Sequence Analysis, Membrane Proteins, Nerve Tissue Proteins, Child, Genetic Predisposition to Disease, Humans}, date-added = {2010-02-19 17:02:19 +0100}, date-modified = {2010-02-19 17:02:19 +0100}, doi = {10.1016/j.ajhg.2007.09.015}, pii = {S0002-9297(07)00021-3}, pmid = {18179894}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6061}, rating = {0} } @article{Agid:2000p10247, author = {O Agid and Y Kohn and B Lerer}, journal = {Biomed Pharmacother}, title = {Environmental stress and psychiatric illness}, abstract = {It has long been recognized that environmental stress plays a pivotal role in the pathogenesis of psychiatric disorders. The relationship is complex and the neurobiological mechanisms that mediate the contribution of stressful experiences to the manifestation of illness are not well understood. In considering this relationship, it is important to differentiate between the role of environmental stressors as vulnerability factors that predispose the individual to psychiatric illness and may be temporally distant from its clinical onset, and their role as direct precipitants of the illness. Furthermore, environmental stressors must be considered in the context of constitutional vulnerability factors, such as genetic predisposition, with which such stressors may interact. Genetic predisposition may influence not only vulnerability to illness but also the nature of the individual's response to stress and the likelihood of exposure to stressful events. In this paper, we focus on two areas that illustrate the complexity of the field and the important findings that have emerged--the role of early parental loss (EPL) in adult psychopathology, particularly major depression, and the relationship between recent significant life events and depressive episodes. We conclude with a preliminary conceptual framework for considering the relationship between genetic susceptibility and environmental stress in the pathogenesis of psychiatric illness.}, affiliation = {Department of Psychiatry, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.}, number = {3}, pages = {135--41}, volume = {54}, year = {2000}, month = {Apr}, language = {eng}, keywords = {Depressive Disorder, Mental Disorders, Humans, Environment, Animals, Stress: Psychological}, date-added = {2010-04-02 10:50:49 +0200}, date-modified = {2010-07-29 19:19:27 +0200}, doi = {10.1016/S0753-3322(00)89046-0}, pii = {S0753-3322(00)89046-0}, pmid = {10840590}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Agid-2000-Biomed%20Pharmacother_Environmental%20stress.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p10247}, rating = {0} } @article{Reich:2001p3546, author = {D E Reich and D B Goldstein}, journal = {Genet Epidemiol}, title = {Detecting association in a case-control study while correcting for population stratification}, abstract = {Case-control studies are subject to the problem of population stratification, which can occur in ethnically mixed populations and can lead to significant associations being detected at loci that have nothing to do with disease. Here, we describe a way to measure and correct for stratification by genotyping a moderate number of unlinked genetic markers in the same set of cases and controls in which a candidate association was found. The average of association statistics across the markers directly measures stratification. By dividing the candidate association statistic by this average, a P-value can be obtained that corrects for stratification.}, affiliation = {Whitehead Institute/MIT Center for Genome Research, Cambridge, Massachusetts 02142, USA. reich@genome.wi.mit.edu}, number = {1}, pages = {4--16}, volume = {20}, year = {2001}, month = {Jan}, language = {eng}, keywords = {Ethnic Groups, Selection Bias, Polymorphism: Single Nucleotide, Models: Genetic, Case-Control Studies, Chromosome Mapping, Gene Frequency, Humans, Linkage Disequilibrium}, date-added = {2010-01-15 20:59:34 +0100}, date-modified = {2010-01-15 20:59:34 +0100}, doi = {10.1002/1098-2272(200101)20:1<4::AID-GEPI2>3.0.CO;2-T}, pii = {10.1002/1098-2272(200101)20:1<4::AID-GEPI2>3.0.CO;2-T}, pmid = {11119293}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Reich-2001-Genet%20Epidemiol_Detecting%20associatio.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3546}, rating = {0} } @article{Aleman:2008p8883, author = {Andr{\'e} Aleman and Marte Swart and Sophie van Rijn}, journal = {Biol Psychol}, title = {Brain imaging, genetics and emotion}, abstract = {This paper reviews the published evidence on genetically driven variation in neurotransmitter function and brain circuits involved in emotion. Several studies point to a role of the serotonin transporter promoter polymorphism in amygdala activation during emotion perception. We also discuss other polymorphisms (e.g. the COMT val158met polymorphism, tryptophan hydroxylase-2 -703 G/T) and putative effects on affective processing in cortical and limbic regions. A different line of research concerns studies with genetic disorders. Although at a less fine-grained level, studies with individuals with aneuploidies of the X chromosome (Turner syndrome and Klinefelter syndrome), who display impairments in emotion processing, have resulted in new insights and hypotheses with regard to X chromosomal influences on brain systems supporting cognition and emotion. These have also implicated a key role for the amygdala. Integration of the emerging evidence, suggests that the study of polymorphisms using brain imaging can potentially elucidate biological pathways and mechanisms contributing to individual differences in brain circuits that may bias behavior and affect risk for psychiatric illness.}, affiliation = {BCN Neuroimaging Center, University Medical Center Groningen, University of Groningen, The Netherlands. a.aleman@med.umcg.nl}, number = {1}, pages = {58--69}, volume = {79}, year = {2008}, month = {Sep}, language = {eng}, keywords = {Emotions, Brain, Molecular Biology, Genetic Variation, Brain Chemistry, Animals, Neurotransmitter Agents, Humans, Polymorphism: Genetic}, date-added = {2010-03-22 12:49:50 +0100}, date-modified = {2010-03-22 12:49:50 +0100}, doi = {10.1016/j.biopsycho.2008.01.009}, pii = {S0301-0511(08)00028-8}, pmid = {18329779}, URL = {http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T4T-4RRFNGC-4&_user=2432700&_coverDate=09%252F30%252F2008&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000057263&_version=1&_urlVersion=0&_userid=2432700&md5=5342bce22b63df34a2ae66c8e4595667}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Aleman-2008-Biol%20Psychol_Brain%20imaging%20genet.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8883}, rating = {0} } @article{Basker:2007p14003, author = {Mona Basker and Prabhakar D Moses and Sushila Russell and Paul Swamidhas Sudhakar Russell}, journal = {Child Adolesc Psychiatry Ment Health}, title = {The psychometric properties of Beck Depression Inventory for adolescent depression in a primary-care paediatric setting in India}, abstract = {BACKGROUND: There is increasing interest in identifying adolescents with depression in primary care settings by paediatricians in India. This article studied the diagnostic accuracy, reliability and validity of Beck Depression Inventory (BDI) while used by paediatricians in a primary care setting in India. METHODS: 181 adolescents attending 3 schools were administered a back translated Tamil version of BDI by a paediatrician to evaluate its psychometric properties along with Children's Depression Rating Scale (CDRS-R) for convergent validity. Clinical diagnosis of depressive disorders, for reference standard, was based on ICD-10 interview by an independent psychiatrist who also administered the Impact of Event Scale (IES) for divergent validity. Appropriate analyses for validity and diagnostic accuracy both at the item and scale levels were conducted. RESULTS: A cut-off score of >or= 5 (Sn = 90.9%, Sp = 17.6 %) for screening and cut-off score of >or= 22 (Sn = 27.3%, Sp = 90%) for diagnostic utility is suggested. The 4 week test - retest reliability was good (r = 0.82). In addition to the adequate face and content validity, BDI has very good internal consistency (alpha = 0.96), high convergent validity with CDRS-R (r = 0.72; P = 0.001), and high discriminant validity with IES (r = 0.26; P = 0.23). There was a moderate concordance rate with the reference standard (54.5%) in identifying depression among the adolescents. Factor analysis replicated the 2-factor structure explaining 30.5 % of variance. CONCLUSION: The BDI proved to be a psychometrically sound measure for use by paediatricians in a primary care setting in India. The possibility of screening for depressive disorders through the use of BDI may be helpful in identifying probable cases of the disorder among adolescents.}, affiliation = {Department of Child Health, Christian Medical College, Vellore, India. mona_thilak@cmcvellore.ac.in}, number = {1}, pages = {8}, volume = {1}, year = {2007}, month = {Jan}, language = {eng}, date-added = {2010-08-04 09:28:21 +0200}, date-modified = {2010-08-04 09:28:21 +0200}, doi = {10.1186/1753-2000-1-8}, pii = {1753-2000-1-8}, pmid = {17688697}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Basker-2007-Child%20Adolesc%20Psychiatry%20Ment%20Health_The%20psychometric%20pro.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p14003}, rating = {0} } @article{Stevanovic:2009p7980, author = {Dejan Stevanovic}, journal = {Health Qual Life Outcomes}, title = {Serbian KINDL questionnaire for quality of life assessments in healthy children and adolescents: reproducibility and construct validity}, abstract = {BACKGROUND: The KINDL questionnaire is frequently used to evaluate quality of life (QOL) and the impacts of health conditions on children's everyday living. The objectives of this study were to assess the reproducibility and construct validity of the Serbian KINDL for QOL assessments in healthy children and adolescents. METHODS: Five hundred and sixty-four healthy children and adolescents completed the KINDL. Reproducibility was analyzed using the intraclass correlation coefficient (ICC). Confirmatory factor analysis (CFA) was performed to assess the structure of the KINDL construct validity. RESULTS: The intraclass correlation coefficients ranged from 0.03 to 0.84 for the subscales and total score. A second order CFA model as originally hypothesized was tested: items (24), primary factors (six subscales), and one secondary factor (QOL). The fit indexes derived from a CFA failed to yield appropriate fit between the data and the hypothesized model. CONCLUSION: Majority of the subscales and total KINDL possess appropriate reproducibility for group comparisons. However, a CFA failed to confirm the structure of the original measurement model, indicating that the Serbian version should be revised before wider use for QOL assessments in healthy children and adolescent.}, affiliation = {Department of Psychiatry, General Hospital Sombor, Sombor, Serbia. dejanstevanovic@eunet.rs}, pages = {79}, volume = {7}, year = {2009}, month = {Jan}, language = {eng}, keywords = {Male, Quality of Life, Female, Humans, Child, Adolescent, Factor Analysis: Statistical, Questionnaires, Serbia}, date-added = {2010-03-20 19:33:08 +0100}, date-modified = {2010-03-20 19:33:09 +0100}, doi = {10.1186/1477-7525-7-79}, pii = {1477-7525-7-79}, pmid = {19715576}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Stevanovic-2009-Health%20and%20Quality%20of%20Life%20Outcomes_Serbian%20KINDL%20questi.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p7980}, rating = {0} } @article{Petrov:2005p14179, author = {Alexander A Petrov and John R Anderson}, journal = {Psychological Review}, title = {The dynamics of scaling: a memory-based anchor model of category rating and absolute identification}, abstract = {A memory-based scaling model--ANCHOR--is proposed and tested. The perceived magnitude of the target stimulus is compared with a set of anchors in memory. Anchor selection is probabilistic and sensitive to similarity, base-level strength, and recency. The winning anchor provides a reference point near the target and thereby converts the global scaling problem into a local comparison. An explicit correction strategy determines the final response. Two incremental learning mechanisms update the locations and base-level activations of the anchors. This gives rise to sequential, context, transfer, practice, and other dynamic effects. The scale unfolds as an adaptive map. A hierarchy of models is tested on a battery of quantitative measures from 2 experiments in absolute identification and category rating.}, affiliation = {Department of Cognitive Sciences, University of California, Irvine, Irvine, CA 92697, USA. apetrov@uci.edu}, number = {2}, pages = {383--416}, volume = {112}, year = {2005}, month = {Apr}, language = {eng}, keywords = {Retrospective Studies, Psychological Tests, Humans, Models: Psychological, Psychological Theory, Memory}, date-added = {2010-08-22 20:16:03 +0200}, date-modified = {2010-08-22 20:16:03 +0200}, doi = {10.1037/0033-295X.112.2.383}, pii = {2005-02750-004}, pmid = {15783291}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p14179}, rating = {0} } @article{Beretvas:2002, author = {S N Beretvas and D A Pastor}, journal = {Educational and Psychological Measurement}, title = {Using mixed-effects models in Reliability Generalization studies}, volume = {62}, year = {2002}, date-added = {2010-01-10 11:33:21 +0100}, date-modified = {2010-01-10 11:33:25 +0100}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2008}, rating = {0} } @article{Steyerberg:2000p4065, author = {E W Steyerberg and M J Eijkemans and F E Harrell and J D Habbema}, journal = {Stat Med}, title = {Prognostic modelling with logistic regression analysis: a comparison of selection and estimation methods in small data sets}, abstract = {Logistic regression analysis may well be used to develop a prognostic model for a dichotomous outcome. Especially when limited data are available, it is difficult to determine an appropriate selection of covariables for inclusion in such models. Also, predictions may be improved by applying some sort of shrinkage in the estimation of regression coefficients. In this study we compare the performance of several selection and shrinkage methods in small data sets of patients with acute myocardial infarction, where we aim to predict 30-day mortality. Selection methods included backward stepwise selection with significance levels alpha of 0.01, 0.05, 0. 157 (the AIC criterion) or 0.50, and the use of qualitative external information on the sign of regression coefficients in the model. Estimation methods included standard maximum likelihood, the use of a linear shrinkage factor, penalized maximum likelihood, the Lasso, or quantitative external information on univariable regression coefficients. We found that stepwise selection with a low alpha (for example, 0.05) led to a relatively poor model performance, when evaluated on independent data. Substantially better performance was obtained with full models with a limited number of important predictors, where regression coefficients were reduced with any of the shrinkage methods. Incorporation of external information for selection and estimation improved the stability and quality of the prognostic models. We therefore recommend shrinkage methods in full models including prespecified predictors and incorporation of external information, when prognostic models are constructed in small data sets.}, affiliation = {Center for Clinical Decision Sciences, Department of Public Health, Erasmus University, Rotterdam, The Netherlands. steyerberg@mgz.fgg.eur.nl}, number = {8}, pages = {1059--79}, volume = {19}, year = {2000}, month = {Apr}, language = {eng}, keywords = {Sample Size, Models: Statistical, Forecasting, Female, Myocardial Infarction, Regression Analysis, Age Factors, Prognosis, Aged, Risk Factors, Humans, Male, Sex Factors, Logistic Models}, date-added = {2010-01-19 15:48:37 +0100}, date-modified = {2010-01-19 15:48:37 +0100}, pii = {10.1002/(SICI)1097-0258(20000430)19:8<1059::AID-SIM412>3.0.CO;2-0}, pmid = {10790680}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Steyerberg-2000-Stat%20Med_Prognostic%20modelling.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p4065}, rating = {0} } @article{Geisser:1982p6281, author = {S Geisser}, journal = {Biometrics}, title = {Aspects of the Predictive and Estimative Approaches in the Determination of Probabilities}, pages = {75--85}, volume = {38}, year = {1982}, date-added = {2010-02-20 18:05:13 +0100}, date-modified = {2010-02-20 18:05:58 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Geisser-1982-Biometrics_Aspects%20of%20the%20Predi.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6281}, rating = {0} } @article{Pocock:1992, author = {SJ Pocock}, journal = {British Medical Journal}, title = {When to stop a clinical trial}, abstract = {Most randomised clinical trials require periodic monitoring of the accumulating data. While the efficiency of trial management is enhanced by data monitoring, ethical reasons should primarily dictate the need to terminate or change a trial in response to interim findings. This article focuses on the ethical dilemma of when to stop a clinical trial and places statistical stopping rules in the context of such ethical decision making. Other issues include the organisation of data monitoring committees and the problems of premature publication and exaggerated estimation in trials that stop early. Several topical examples are used to convey the relevance of these issues to current practice.}, pages = {235--240}, volume = {305}, year = {1992}, date-added = {2010-01-03 19:36:10 +0100}, date-modified = {2010-01-03 19:36:10 +0100}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1047}, rating = {0} } @article{Mols:2010p4759, author = {Floortje Mols and Johan Denollet}, journal = {Health Qual Life Outcomes}, title = {Type D personality in the general population: a systematic review of health status, mechanisms of disease, and work-related problems}, abstract = {ABSTRACT: BACKGROUND: The objective was to review all available literature concerning Type D (distressed) personality among the general population and to discuss its implications for research on health status, disease-promoting mechanisms and work-related problems in non-clinical populations. METHODS: A computerized search of the literature was performed independently and in duplicate by both investigators on December 21st, 2009. Published research reports were included if they studied Type D personality among the general population. Nineteen articles were selected and they were subjected to an 11-item standardised quality checklist by both investigators. RESULTS: The methodological quality of the selected studies was adequate to high. The studies included in this review showed that the presence of Type D characteristics had a negative impact on mental health status (more symptoms of depression, anxiety, post-traumatic stress disorder, mental distress, passive coping, and less social support) and physical health status (more somatic complaints, lower health status, more influenza-like illness reporting). Other studies reported on behavioral and biological mechanisms of disease in apparently healthy individuals with a Type D personality. Finally, some studies also showed a negative effect of Type D personality on work-related problems (higher absence-leave, higher levels of vital exhaustion and burnout, and more work-related stress). CONCLUSIONS: Type D personality is a vulnerability factor for general psychological distress that affects mental and physical health status and is associated with disease-promoting mechanisms and work-related problems in apparently healthy individuals.}, number = {1}, pages = {9}, volume = {8}, year = {2010}, month = {Jan}, language = {ENG}, date-added = {2010-02-01 12:42:36 +0100}, date-modified = {2010-02-01 12:42:36 +0100}, doi = {10.1186/1477-7525-8-9}, pii = {1477-7525-8-9}, pmid = {20096129}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Mols-2010-Health%20and%20Quality%20of%20Life%20Outcomes_Type%20D%20personality%20i-1.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p4759}, rating = {0} } @article{Browne:2010p8342, author = {Dillon T Browne and Adefowope Odueyungbo and Lehana Thabane and Carolyn Byrne and Lindsay A Smart}, journal = {Child Adolesc Psychiatr Clin N Am}, title = {Parenting-by-gender interactions in child psychopathology: attempting to address inconsistencies with a Canadian national database}, abstract = {ABSTRACT: BACKGROUND: Research has shown strong links between parenting and child psychopathology. The moderating role of child gender is of particular interest, due to gender differences in socialization history and in the prevalence of psychiatric disorders. Currently there is little agreement on how gender moderates the relationship between parenting and child psychopathology. This study attempts to address this lack of consensus by drawing upon two theories (self-salience vs. gender stereotyped misbehaviour) to determine how child gender moderates the role of parenting, if at all. METHODS: Using generalized estimating equations (GEE) associations between three parenting dimensions (hostile-ineffective parenting, parental consistency, and positive interaction) were examined in relationship to child externalizing (physical aggression, indirect aggression, and hyperactivity-inattention) and internalizing (emotional disorder-anxiety) dimensions of psychopathology. A sample 4 and 5 year olds from the National Longitudinal Survey of Children and Youth (NLSCY) were selected for analysis and followed over 6 years (N = 1214). Two models with main effects (Model 1) and main effects plus interactions (Model 2) were tested. RESULTS: No child gender-by-parenting interactions were observed for child physical aggression and indirect aggression. The association between hostile-ineffective parenting and child hyperactivity was stronger for girls, though this effect did not reach conventional levels of statistical significance (p = .059). The associations between parenting and child emotional disorder did vary as a function of gender, where influences of parental consistency and positive interaction were stronger for boys. DISCUSSION: Despite the presence of a few significant interaction effects, hypotheses were not supported for either theory (i.e. self-salience or gender stereotyped misbehaviour). We believe that the inconsistencies in the literature regarding child gender-by-parenting interactions is due to the reliance on gender as an indicator of a different variable which is intended to explain the interactions. This may be problematic because there is likely within-gender and between-sample variability in such constructs. Future research should consider measuring and modelling variables that are assumed to explain such interactions when conducting gender-by-parenting research.}, affiliation = {Department of Psychology, University of Guelph, Guelph, Canada. dbrowne@uoguelph.ca.}, pages = {5}, volume = {4}, year = {2010}, month = {Jan}, language = {eng}, date-added = {2010-03-21 12:43:23 +0100}, date-modified = {2010-07-29 19:23:03 +0200}, doi = {10.1186/1753-2000-4-5}, pii = {1753-2000-4-5}, pmid = {20181023}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Browne-2010-Child%20Adolesc%20Psychiatr%20Clin%20N%20Am_Parenting-by-gender.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8342}, rating = {0} } @article{Wray:2005p6090, author = {John Wray and Natalie Silove and Helen Knott}, journal = {Med J Aust}, title = {7. Language disorders and autism}, abstract = {Early diagnosis of language disorders and autism is important, and early intervention for autism and some language disorders makes a difference. Developmental surveillance of children to detect these disorders should be a routine part of medical practice. The persistence and pervasiveness of communication and socialising deficits differentiate children with autism from those with specific developmental language disorders. Hearing and vision assessment is essential in any communication disorder. Interventions, targeted to identified areas of need, should encompass communication enhancement, behavioural therapy, educational modification, parent education and family support. Pharmacological interventions have an important but discrete role in autism, but there are no magic bullets. It is important to remember that the normal childhood illnesses occur in children with developmental disorders. Parents should be directed to reliable websites on the Internet, and given information and books to read as well as phone numbers of relevant services (eg, autism associations). There is a need for increased government financial support for early intervention programs.}, affiliation = {c/o State Child Development Centre, Women's and Children's Health Service, West Perth, WA, Australia. john.wray@health.wa.gov.au}, number = {7}, pages = {354--60}, volume = {182}, year = {2005}, month = {Apr}, language = {eng}, keywords = {Family, Diagnosis: Differential, Autistic Disorder, Early Diagnosis, Child, Language Disorders, Humans, Social Support, Caregivers}, date-added = {2010-02-19 17:05:18 +0100}, date-modified = {2010-07-29 19:52:48 +0200}, pii = {wra10330_fm}, pmid = {15804229}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6090}, rating = {0} } @inbook{Tourangeau:1992, author = {R Tourangeau}, journal = {Book}, title = {Context effects in social and psychological research}, chapter = {Attitudes as memory structures: Belief sampling and context effects}, pages = {35--47}, year = {1992}, date-added = {2010-01-03 19:34:17 +0100}, date-modified = {2010-07-29 19:21:41 +0200}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p938}, rating = {0} } @article{Cannon:1999, author = {M Cannon and P Jones and MO Huttunen and A Tanskanen and T Huttunen and S Rabe-Hesketh and RM Murray}, journal = {Arch Gen Psychiatry}, title = {School performance in Finnish children and later development of schizophrenia. A population-based longitudinal study}, abstract = {BACKGROUND: We examined whether children who are diagnosed as having schizophrenia in adulthood could be distinguished from their peers on performance in elementary school. METHODS: We used a case-control study design nested within a population-based birth cohort of all individuals born in Helsinki, Finland, between January 1, 1951, and December 31, 1960. Case ascertainment was from 3 national health care registers. Elementary school records were obtained for 400 children who were diagnosed as having schizophrenia in adulthood and for 408 controls. Results were analyzed for the 4 years of schooling (ages 7-11 years) that were common to all pupils. School subjects were entered into a principal components analysis and produced 3 factors: academic, nonacademic, and behavioral. These factors were compared between cases and controls after adjusting for sex and social group. Eligibility for high school and progression to high school were investigated among cases and controls. RESULTS: Cases performed significantly worse than controls only on the nonacademic factor (which loaded sports and handicrafts). There were no differences between the groups on the academic or behavioral factors, and there were no significant clinical correlates of factor scores. Cases were significantly less likely than controls to progress to high school, despite similar eligibility. CONCLUSIONS: Poor performance in sports and handicrafts during elementary school, which may indicate a motor coordination deficit, appears to be a risk factor for later schizophrenia. Poor academic performance in elementary school was not a risk factor for schizophrenia in this study. Lack of expected progression to high school among cases, despite good academic grades, provides evidence for deteriorating premorbid functional adjustment in schizophrenia.}, pages = {457--463}, volume = {56}, year = {1999}, date-added = {2010-01-03 19:36:10 +0100}, date-modified = {2010-01-03 19:36:10 +0100}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1059}, rating = {0} } @article{Efron2004, author = {B Efron and T Hastie and I Johnstone and R Tibshirani}, journal = {The Annals of Statistics}, title = {Least angle regression}, number = {2}, pages = {407--499}, volume = {32}, year = {2004}, date-added = {2010-01-12 14:26:48 +0100}, date-modified = {2010-07-29 19:51:51 +0200}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2528}, rating = {0} } @article{Burmeister:2008p2499, author = {Margit Burmeister and Melvin G McInnis and Sebastian Z{\"o}llner}, journal = {Nat Rev Genet}, title = {Psychiatric genetics: progress amid controversy}, abstract = {Several psychiatric disorders--such as bipolar disorder, schizophrenia and autism--are highly heritable, yet identifying their genetic basis has been challenging, with most discoveries failing to be replicated. However, inroads have been made by the incorporation of intermediate traits (endophenotypes) and of environmental factors into genetic analyses, and through the identification of rare inherited variants and novel structural mutations. Current efforts aim to increase sample sizes by gathering larger samples for case-control studies or through meta-analyses of such studies. More attention on unique families, rare variants, and on incorporating environment and the emerging knowledge of biological function and pathways into genetic analysis is warranted.}, affiliation = {Molecular and Behavioral Neuroscience Institute, University of Michigan, 5061 BSRB, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109-2200, USA. margit@umich.edu}, number = {7}, pages = {527--40}, volume = {9}, year = {2008}, month = {Jul}, language = {eng}, keywords = {Genetic Predisposition to Disease, Humans, Genetic Variation, Genome: Human, Mental Disorders, Animals, Risk Factors}, date-added = {2010-01-12 13:35:21 +0100}, date-modified = {2010-07-29 19:40:47 +0200}, doi = {10.1038/nrg2381}, pii = {nrg2381}, pmid = {18560438}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Burmeister-2008-Nat%20Rev%20Genet_Psychiatric%20genetics.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2499}, rating = {0} } @article{Sherry:2005p10351, author = {Alissa Sherry and Robin K Henson}, journal = {J Pers Assess}, title = {Conducting and interpreting canonical correlation analysis in personality research: a user-friendly primer}, abstract = {The purpose of this article is to reduce potential statistical barriers and open doors to canonical correlation analysis (CCA) for applied behavioral scientists and personality researchers. CCA was selected for discussion, as it represents the highest level of the general linear model (GLM) and can be rather easily conceptualized as a method closely linked with the more widely understood Pearson r correlation coefficient. An understanding of CCA can lead to a more global appreciation of other univariate and multivariate methods in the GLM. We attempt to demonstrate CCA with basic language, using technical terminology only when necessary for understanding and use of the method. We present an entire example of a CCA analysis using SPSS (Version 11.0) with personality data.}, affiliation = {Counseling Psychology Program, University of Texas at Austin, USA.}, number = {1}, pages = {37--48}, volume = {84}, year = {2005}, month = {Feb}, language = {eng}, keywords = {Behavioral Research, Analysis of Variance, United States, Humans, Personality Assessment}, date-added = {2010-04-02 18:21:02 +0200}, date-modified = {2010-04-02 18:21:02 +0200}, doi = {10.1207/s15327752jpa8401_09}, pmid = {15639766}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Sherry-2005-Journal%20of%20Personality%20Assessment_Conducting%20and%20inter.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p10351}, rating = {0} } @article{Eap:2008p13869, author = {Sopagna Eap and David S Degarmo and Ayaka Kawakami and Shelley N Hara and Gordon C N Hall and Andra L Teten}, journal = {Journal of Cross-Cultural Psychology}, title = {Culture and Personality Among European American and Asian American Men}, abstract = {Personality differences between Asian American (N = 320) and European American men (N = 242) and also among Asian American ethnic groups (Korean, Chinese, Japanese, Filipino, and mixed Asian) are examined on the Big Five personality dimension. Personality structures for Asian Americans and European Americans closely replicate established norms. However, congruence is greater for European American and highly acculturated Asian American men than for low acculturated Asian American men. Similar patterns are found for the construct loss of face (LOF). Asian American men with a high concern for LOF are less similar in their personality structure to European American men than Asian American men with low LOF concern. Mean differences are also found among Asian American and European American men, who differ significantly on Extraversion, Conscientiousness, Openness, and Neuroticism. Results indicate that acculturation and LOF are significantly associated with these four personality dimensions for both Asian American and European American men.}, affiliation = {University of Oregon.}, number = {5}, pages = {630--643}, volume = {39}, year = {2008}, month = {Sep}, language = {ENG}, date-added = {2010-07-29 17:44:29 +0200}, date-modified = {2010-07-29 17:44:29 +0200}, doi = {10.1177/0022022108321310}, pmid = {19169434}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13869}, rating = {0} } @article{Sham:2000p11299, author = {P C Sham and J H Zhao and S S Cherny and J K Hewitt}, journal = {Genet Epidemiol}, title = {Variance-Components QTL linkage analysis of selected and non-normal samples: conditioning on trait values}, abstract = {Standard variance-components quantitative trait loci (QTL) linkage analysis can produce an elevated rate of type 1 errors when applied to selected samples and non-normal data. Here we describe an adjustment of the log-likelihood function based on conditioning on trait values. This leads to a likelihood ratio test that is valid in selected samples and non-normal data, and equal in power to alternative methods for analyzing selected samples that require knowledge of the ascertainment procedure or the trait values of non-selected individuals.}, affiliation = {Social, Genetic and Developmental Psychiatry Research Center and Department of Psychiatry, Institute of Psychiatry, Denmark Hill, London, United Kingdom. p.sham@iop.kcl.ac.uk}, pages = {S22--8}, volume = {19 Suppl 1}, year = {2000}, month = {Jan}, language = {eng}, keywords = {Quantitative Trait: Heritable, Linkage (Genetics), Computer Simulation, Analysis of Variance}, date-added = {2010-04-26 22:34:09 +0200}, date-modified = {2010-04-26 22:34:09 +0200}, doi = {10.1002/1098-2272(2000)19:1+<::AID-GEPI4>3.0.CO;2-S}, pmid = {11055366}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Sham-2000-Genet%20Epidemiol_Variance-Components.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11299}, rating = {0} } @article{LasHayas:2010p8322, author = {Carlota Las Hayas and Jose M Quintana and Jesus A Padierna and Amaia Bilbao and Pedro Munoz}, journal = {Health Qual Life Outcomes}, title = {Use of rasch methodology to develop a short version of the Health Related Quality of life for Eating Disorders questionnaire: a prospective study}, abstract = {ABSTRACT: BACKGROUND: To confirm the internal structure of the Health Related Quality of Life for Eating Disorders version 2 questionnaire (HeRQoLEDv2) and create and validate a shortened version (HeRQoLED-S). METHODS: 324 patients with eating disorders were assessed at baseline and one year later (75.6% of whom responded). We performed a confirmatory factor analysis of the HeRQoLEDv2 using baseline data, and then a Rasch analysis to shorten the questionnaire. Data obtained at year one was used to confirm the structure of the HeRQoLED short form and evaluate its validity and reliability. RESULTS: Two latent second-order factors -- social maladjustment and mental health and functionality -- fit the data for the HeRQoLEDv2. Rasch analysis was computed separately for the two latent second-order factors and shortened the HeRQoLEDv2 to 20 items. Infit and outfit indices were acceptable, with the confirmatory factor analysis of the HeRQoLED short form giving a root mean square error of approximation of 0.07, a non-normed fit index and a comparative fit index exceeding 0.90. The validity was also supported by the correlation with the convergent measures: the social maladjustment factor correlated 0.82 with the dieting concern factor of the Eating Attitudes Test-26 and the mental health and functionality factor correlated -0.69 with the mental summary component of the Short Form-12. Cronbach alphas exceeded 0.89. CONCLUSIONS: Two main factors, social maladjustment and mental health and functionality, explain the majority of HeRQoLEDv2 scores. The shortened version maintains good psychometric properties, though it must be validated in independent samples.}, number = {1}, pages = {29}, volume = {8}, year = {2010}, month = {Mar}, language = {ENG}, date-added = {2010-03-21 09:28:01 +0100}, date-modified = {2010-03-21 09:28:07 +0100}, doi = {10.1186/1477-7525-8-29}, pii = {1477-7525-8-29}, pmid = {20298556}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Las%20Hayas-2010-Health%20and%20Quality%20of%20Life%20Outcomes_Use%20of%20rasch%20methodo-1.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8322}, rating = {3} } @article{BarnettPage:2009p440, author = {Elaine Barnett-Page and James Thomas}, journal = {BMC Med Res Methodol}, title = {Methods for the synthesis of qualitative research: a critical review}, abstract = {BACKGROUND: In recent years, a growing number of methods for synthesising qualitative research have emerged, particularly in relation to health-related research. There is a need for both researchers and commissioners to be able to distinguish between these methods and to select which method is the most appropriate to their situation. DISCUSSION: A number of methodological and conceptual links between these methods were identified and explored, while contrasting epistemological positions explained differences in approaches to issues such as quality assessment and extent of iteration. Methods broadly fall into 'realist' or 'idealist' epistemologies, which partly accounts for these differences. SUMMARY: Methods for qualitative synthesis vary across a range of dimensions. Commissioners of qualitative syntheses might wish to consider the kind of product they want and select their method - or type of method - accordingly.}, affiliation = {Evidence for Policy and Practice Information and Co-ordinating Centre, Social Science Research Unit, 18 Woburn Square, London WC1H 0NS, UK. e.barnett-page@ioe.ac.uk}, pages = {59}, volume = {9}, year = {2009}, month = {Jan}, language = {eng}, date-added = {2010-01-03 12:26:51 +0100}, date-modified = {2010-01-03 12:26:51 +0100}, doi = {10.1186/1471-2288-9-59}, pii = {1471-2288-9-59}, pmid = {19671152}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Barnett-Page-2009-BMC%20Med%20Res%20Methodol_Methods%20for%20the%20synt.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p440}, rating = {0} } @article{Fassino:2004p13046, author = {S Fassino and G Abbate Daga and N Delsedime and L Rogna and S Boggio}, journal = {Drug Alcohol Depend}, title = {Quality of life and personality disorders in heroin abusers}, abstract = {OBJECTIVE: The aim of this study is to describe the personality disorders (PD) and personality profile of heroin-abusers and their quality of life (QoL), and to investigate the correlation between the two. METHOD: One hundred and eighty heroin-abusers during their residential treatment participated in the study. The Structured Clinical Interview-II (SCID-II) allowed the identification of two subgroups of heroin-abusers on the basis of presence/absence of a PD. All patients filled in the Temperament and Character Inventory (TCI), the McGill QoL Questionnaire (MQOL) and an anamnestic sheet. A control group of 63 non-clinical subjects was recruited. RESULTS: Abusers with a PD differ in their personality profile from abusers without PD and score lower on the total MQOL. As regards TCI scales, novelty seeking (NS), reward dependence (RD) and self-directedness (SD) predict the age of onset of the abuse, while cooperativeness (C) is a predictor of the number of community admissions. DISCUSSION: Low scores on self-directedness and cooperativeness in abusers support the hypothesis of an immature character and relational difficulties. Novelty seeking is the only dimension which is altered both in abusers with and without a PD and is not strictly dependent on Axis II comorbidity. QoL is lower in abusers than in controls, according to their physical, psychological and existential suffering. Last, an interesting link emerged between personality and perceived QoL.}, affiliation = {Department of Neuroscience, Psychiatric Institute, University of Turin, Via Cherasco 11, 10126 Torino, Italy. secondo.fassino@unito.it}, number = {1}, pages = {73--80}, volume = {76}, year = {2004}, month = {Oct}, language = {eng}, keywords = {Female, Quality of Life, Male, Personality Disorders, Humans, Analysis of Variance, Cross-Sectional Studies, Adult, Heroin Dependence}, date-added = {2010-06-26 09:37:26 +0200}, date-modified = {2010-06-26 09:37:26 +0200}, doi = {10.1016/j.drugalcdep.2004.04.005}, pii = {S0376871604001024}, pmid = {15380291}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Fassino-2004-Drug%20Alcohol%20Depend_Quality%20of%20life%20and.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13046}, rating = {0} } @article{Nakagami:2008p5489, author = {Eri Nakagami and Bin Xie and Maanse Hoe and John S Brekke}, journal = {Schizophr Res}, title = {Intrinsic motivation, neurocognition and psychosocial functioning in schizophrenia: testing mediator and moderator effects}, abstract = {BACKGROUND: This study examined the nature of the relationships among neurocognition, intrinsic motivation, and psychosocial functioning for persons with schizophrenia. Hypotheses concerning both mediator and moderator mechanisms were tested. METHOD: 120 individuals diagnosed with schizophrenia were recruited as they entered outpatient psychosocial rehabilitation programs. Measures of psychosocial functioning and intrinsic motivation were administered at baseline. Measures of neurocognition were administered at baseline by testers blind to scores on other study variables. Data were analyzed using latent construct modeling to test for mediator and moderator effects. RESULTS: There were strong bivariate relationships between neurocognition, intrinsic motivation, and psychosocial functioning. The results demonstrated that intrinsic motivation strongly mediated the relationship between neurocognition and psychosocial functioning. This mediation was evidenced by: (i) the direct path from neurocognition to functional outcome no longer being statistically significant after the introduction of motivation into the model, (ii) the statistical significance of the indirect path from neurocognition through motivation to functional outcome. There was no support for the two moderation hypotheses: the level of neurocognition did not influence the relationship between intrinsic motivation and psychosocial functioning, nor did the level of intrinsic motivation influence the relationship between neurocognition and psychosocial functioning. CONCLUSIONS: Neurocognition influences psychosocial functioning through its relationship with intrinsic motivation. Intrinsic motivation is a critical mechanism for explaining the relationship between neurocognition and psychosocial functioning. Implications for the theoretical understanding and psychosocial treatment of intrinsic motivation in schizophrenia are discussed.}, affiliation = {University of Southern California, School of Social Work, CA, USA. nakagami@usc.edu}, number = {1-3}, pages = {95--104}, volume = {105}, year = {2008}, month = {Oct}, language = {eng}, keywords = {Personal Autonomy, Cognition Disorders, Female, Schizophrenic Psychology, Neuropsychological Tests, Self Efficacy, Adult, Community Mental Health Services, Motivation, Adaptation: Psychological, Models: Psychological, Humans, Schizophrenia, Outcome Assessment (Health Care), Psychiatric Status Rating Scales, Social Adjustment, Brief Psychiatric Rating Scale, Male, Social Perception}, date-added = {2010-02-12 14:44:15 +0100}, date-modified = {2010-07-29 19:50:06 +0200}, doi = {10.1016/j.schres.2008.06.015}, pii = {S0920-9964(08)00285-5}, pmid = {18715756}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5489}, rating = {0} } @article{Wuthrich:2001p11677, author = {V Wuthrich and T C Bates}, journal = {Personality and Individual Differences}, title = {Schizotypy and latent inhibition: non-linear linkage between psychometric and cognitive markers}, abstract = {Auditory latent inhibition (LI) and schizotypy were measured in (n=54), showing that LI was an inver- ted-U function of schizotypy score. Only average levels of schizotypy were associated with undiminished LI while both low- and high-SPQ subjects showed reduced LI. No relationship was found between LI and either psychoticism or any of the {\textregistered}ve NEO PI-R domains. These results complement the similar complex relationship of neuroleptic drug dose effects on LI in normals and schizophrenics. A priming task and the unusual uses and pattern meanings measures of creativity were related to personality measures of schizo- typy, N, E, and O (but not the EPQ-R psychoticism, LI, or priming performance). Priming effects tracked the inverted-U function of schizotypal personality questionnaire (SPQ) scale scores shown in the LI task. It is suggested that LI is dependent on a non-linear interaction with masking task load and attentional allo- cation, modulated by schizotypy.}, pages = {783--798}, volume = {30}, year = {2001}, date-added = {2010-05-14 21:17:54 +0200}, date-modified = {2010-05-14 21:19:26 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Wuthrich-2001-Personality%20and%20Individual%20Differences_Schizotypy%20and%20laten.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11677}, rating = {4} } @article{Verkuilen:2006p6252, author = {J Verkuilen}, title = {The Fisher Information Function in Ideal Point Item Response Models For Pick Any/n Data}, abstract = {In the last two decades, researchers have developed a number of item response models for the analysis of preference data in which the regression between latent trait θ and item responses, P(θ), is single-peaked. As opposed to the monotonic functions such as the logistic function common to IRT for dominance data, these models are probabilistic analogues of Coombs' deterministic unfolding models. One potential barrier to the wider acceptance of such models is the curious fact that most ideal point item response models have bimodal item information functions. Unfortunately, mathematically rigorous explanations for this unusual behavior have not been provided by authors. More broadly, properties of the information function of ideal point IRT models are unknown. This article proves several theorems about the IIFs of ideal point models, in particular, showing that the IIF can be bimodal, unimodal, or singular depending on qualitative characteristics of P (θ), in particular the maximum value of P(θ) and P′′(θ). The importance of these results for test construction is also discussed and illustrated through a simple empirical example.}, year = {2006}, date-added = {2010-02-19 21:28:19 +0100}, date-modified = {2010-02-19 21:28:49 +0100}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Verkuilen-2006-_The%20Fisher%20Informati.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6252}, rating = {0} } @article{Dorard:2008p13994, author = {G{\'e}raldine Dorard and Sylvie Berthoz and Mark G Haviland and Olivier Phan and Maurice Corcos and Catherine Bungener}, journal = {Compr Psychiatry}, title = {Multimethod alexithymia assessment in adolescents and young adults with a cannabis use disorder}, abstract = {The value of alexithymia assessments in medical and psychiatric research is well documented, but such assessments in cannabis abusers are scarce. Moreover, despite repeated calls for multimethod alexithymia evaluations, researchers typically use 1 self-report only: the 20-item Toronto Alexithymia Scale. Herein, we evaluated (1) the psychometric properties of the Observer Alexithymia Scale (OAS), (2) the correspondence between 3 alexithymia measures, (3) OAS raters' affect and its relationship to OAS scores, and (4) cannabis abusers' alexithymic features. Eighty-seven cannabis abusers completed self-reports measuring alexithymia (Toronto Alexithymia Scale, Bermond-Vorst Alexithymia Questionnaire-B), depression (13-item Beck Depression Inventory), and anxiety (State and Trait Anxiety Inventory-Form Y) and asked relatives to rate them using the OAS. The raters also completed the self-report scales. The OAS met acceptable reliability and validity standards, with the exception of relatively low interrater reliability for one of its subscales. Rater affect appeared to influence OAS scores, albeit slightly. Patients' OAS scores were higher than scores reported for people-in-general samples and lower than those for outpatient clinical samples. Alexithymia rates were similar to those previously reported in cannabis abusers. Our results demonstrated the adequacy and appropriateness of the OAS in these (and related) clinical samples, which may encourage multimethod alexithymia assessments in both research and clinical practice.}, affiliation = {Laboratory of Clinical Psychopathology and Neuropsychology, Paris Descartes University, Paris, France. geraldinedorard@yahoo.fr}, number = {6}, pages = {585--92}, volume = {49}, year = {2008}, month = {Jan}, language = {eng}, keywords = {Male, Humans, Adolescent, Reproducibility of Results, Marijuana Abuse, Female, Adult, Affective Symptoms, Psychometrics, Psychological Tests, Diagnosis: Dual (Psychiatry), France, Observer Variation}, date-added = {2010-08-04 09:22:25 +0200}, date-modified = {2010-08-04 09:22:25 +0200}, doi = {10.1016/j.comppsych.2008.05.001}, pii = {S0010-440X(08)00072-2}, pmid = {18970907}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Dorard-2008-Compr%20Psychiatry_Multimethod%20alexithy.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13994}, rating = {0} } @article{Johnson:2004p11157, author = {M S Johnson}, title = {Item response models and their use in measuring food insecurity and hunger}, abstract = {This paper aims to give a general discussion of parametric item response theory models, paying close atten- tion to the Rasch model and its extensions for the analysis of multiple dichotomous and polytomous items. As part of this discussion the paper reviews both the models commonly used in IRT and the procedures utilized to estimate the parameters of these models, and their implications. After giving a general introduction to IRT models the paper examines the appropriateness of these models for the measurement of food security and hunger. Specifically, the paper examines how appropriate IRT is for the analysis of the food security items by examining a subset of data from the 2002 CPS, and then asks the question of whether or not the propensity measured by the food security items is in fact related to true food insecurity. Finally, the paper examines how one might classify survey respondents into one of the three food security classes and/or estimate the proportions of individuals in the population that fall into each of these classes.}, year = {2004}, date-added = {2010-04-25 19:26:33 +0200}, date-modified = {2010-04-25 19:27:07 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Johnson-2004-_Item%20response%20models.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11157}, rating = {0} } @article{Smits:2003p12895, author = {D J Smits and Paul De Boeck and M Hoskens}, journal = {Applied Psychological Measurement}, title = {Examining the Structure of Concepts: Using Interactions Between Items}, abstract = {A framework is presented for modeling the relational structure of concepts using item response theory (IRT) models with interactions between the items, so-called models with local item dependency (LID). The proposed approach works for unidimensional and multidimensional concepts. For the relational structure of a concept to be analyzed, two types of items are used: items that directly refer to the concept and items that refer to the underlying components. The dependencies (the LIDs) are included in the model to analyze the mutual relations between the components and between the components and the concept. In a study on guilt, it was found that a unidimensional model complemented with situation-specific dependencies could explain the data that were gathered. Because of its flexibility, the approach is a promising tool for a structural analysis of concepts.}, number = {6}, pages = {415--439}, volume = {27}, year = {2003}, date-added = {2010-06-24 13:49:26 +0200}, date-modified = {2010-07-29 20:46:12 +0200}, doi = {10.1177/0146621603259277}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Smits-2003-Applied%20Psychological%20Measurement_Examining%20the%20Struct.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12895}, rating = {4} } @article{Farmer:2008p13926, author = {Richard F Farmer and Lewis R Goldberg}, journal = {Psychol Assess}, title = {A psychometric evaluation of the revised Temperament and Character Inventory (TCI-R) and the TCI-140}, abstract = {The psychometric properties of the newest version of the Temperament and Character Inventory (the TCI-R) were evaluated in a large (n = 727) community sample, as was the TCI-140, a short inventory derivative. Facets-to-scale confirmatory and exploratory factor analyses of the TCI-R did not support the organization of temperament and character facet scales within their superordinate domains. Five of the 29 facet scales also displayed relatively low internal consistency (a < .70). Factor analyses of the TCI-140 item set yielded only limited support for hypothesized item-to-scale memberships. Harm Avoidance, Novelty Seeking, and Self-Directedness items, in particular, were not well differentiated. Although psychometrically comparable, the TCI-R and the TCI-140 demonstrate many of the limitations of earlier inventory versions. Implications associated with the use of the TCI-R and TCI-140 and C. R. Cloninger's theory of personality are discussed.}, affiliation = {Oregon Research Institute, Eugene, OR 97403, USA. rfarmer@ori.org}, number = {3}, pages = {281--91}, volume = {20}, year = {2008}, month = {Sep}, language = {eng}, keywords = {Humans, Male, Female, Personality Inventory, Character, Psychometrics, Temperament, Middle Aged}, date-added = {2010-07-29 18:55:37 +0200}, date-modified = {2010-07-29 19:45:39 +0200}, doi = {10.1037/a0012934}, pii = {2008-12234-009}, pmid = {18778164}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Farmer-2008-Psychol%20Assess_A%20psychometric%20evalu.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13926}, rating = {4} } @article{Summerfeldt:1999p6852, author = {L J Summerfeldt and M A Richter and M M Antony and R P Swinson}, journal = {Behaviour Research and Therapy}, title = {Symptom structure in obsessive-compulsive disorder: a confirmatory factor-analytic study}, abstract = {Although obsessive-compulsive disorder (OCD) has long been a unitary diagnosis, there is much recent interest in its potential heterogeneity, as manifested by symptom subgroups. This study evaluated existing models of symptom structure in a sample of 203 individuals with OCD. Using confirmatory factor analysis, we examined the ability of each model to account for two levels of data: a priori symptom groupings (second-order) and individual symptoms, identified by the Yale-Brown Obsessive Compulsive Scale symptom checklist. Four models were examined: a single-factor, a two-factor (i.e., obsessions and compulsions), and two multidimensional models, comprising three and four factors. Adequate fit was found solely for the four-factor model--specifying obsessions/checking, symmetry/ordering, contamination/cleaning, and hoarding--but only at the second-order level; it did not account for relationships among discrete symptoms. Parameter estimates showed within-factor heterogeneity, as well as overlap between factors, most notably the two representing checking and contamination-related symptoms. The implications of these findings are discussed. Results provide evidence for the multidimensionality of OCD symptoms, but suggest that a comprehensive model has yet to be identified. They also point to the inadequacy of groupings based solely upon overt behavioural similarities (e.g., 'checking'). Recommendations are made for future research.}, affiliation = {Psychology Department, St. Joseph's Hospital, Hamilton, Ontario, Canada. Isummerf@stjosham.on.ca}, number = {4}, pages = {297--311}, volume = {37}, year = {1999}, month = {Apr}, language = {eng}, keywords = {Chi-Square Distribution, Obsessive Behavior, Male, Female, Models: Psychological, Adult, Reproducibility of Results, Compulsive Behavior, Humans, Obsessive-Compulsive Disorder, Factor Analysis: Statistical}, date-added = {2010-03-06 10:31:25 +0100}, date-modified = {2010-07-29 19:18:49 +0200}, pii = {S000579679800134X}, pmid = {10204276}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6852}, rating = {0} } @article{Li:1997p2692, author = {M N F Li and S Olejnik}, journal = {Applied Psychological Measurement}, title = {The Power of Rasch Person-Fit Statistics in Detecting Unusual Response Patterns}, number = {3}, pages = {215--231}, volume = {21}, year = {1997}, date-added = {2010-01-13 10:12:24 +0100}, date-modified = {2010-07-29 19:16:53 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Li-1997-Applied%20Psychological%20Measurement_The%20Power%20of%20Rasch%20P.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2692}, rating = {0} } @article{Wittes:2002p6420, author = {Janet Wittes}, journal = {Epidemiol Rev}, title = {Sample size calculations for randomized controlled trials}, affiliation = {Statistics Collaborative, Inc., 1710 Rhode Island Avenue NW, Suite 200, Washington, DC 20036, USA. janet@statcollab.com}, number = {1}, pages = {39--53}, volume = {24}, year = {2002}, month = {Jan}, language = {eng}, keywords = {Humans, Research Design, Bias (Epidemiology), Sample Size, Randomized Controlled Trials as Topic, Data Interpretation: Statistical}, date-added = {2010-02-23 08:27:10 +0100}, date-modified = {2010-02-23 08:27:13 +0100}, pmid = {12119854}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Wittes-2002-Epidemiol%20Rev_Sample%20size%20calculat.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p6420}, rating = {3} } @article{Yin:1996p3695, author = {Y Yin and C W Carter}, journal = {Nucleic Acids Res}, title = {Incomplete factorial and response surface methods in experimental design: yield optimization of tRNA(Trp) from in vitro T7 RNA polymerase transcription}, abstract = {We have studied the yield of Escherichia coli tRNA(Trp) obtained from in vitro T7 RNA polymerase transcription using incomplete factorial and response surface methods. Incomplete factorial experiments were first used to estimate the relative impact of six variables on the yield of tRNA(Trp). Fifteen trials were performed according to a balanced and randomized design. The correlation between observed yield and all experimental variables was identified by stepwise multiple linear regression analysis. The concentrations of T7 RNA polymerase, DNA template, NTP and MgCl2 proved to be significantly correlated with the yield of tRNA(Trp). We then optimized the yield with respect to each of these four variables simultaneously with a designed, response surface experiment based on the Hardin-Sloane minimum prediction variance algorithm. Twenty experiments were performed, in duplicate, to sample the quadratic surface relating the yield to the four significant variables. Coefficients of the quadratic function with all two-factor interactions were evaluated by stepwise regression using least squares, and significant coefficients were retained. Partial differentiation of the resulting quadratic model showed it to possess an optimum. Transcription performed at the corresponding conditions yielded 6-fold more tRNA(Trp) than the initial conditions, confirming the predictive value of the experimentally determined response surface.}, affiliation = {Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill 27599-7260, USA.}, number = {7}, pages = {1279--86}, volume = {24}, year = {1996}, month = {Apr}, language = {eng}, keywords = {DNA-Directed RNA Polymerases, Magnesium Chloride, Viral Proteins, RNA: Transfer: Trp, Base Composition, Regression Analysis, Templates: Genetic, Ribonucleotides, Transcription: Genetic, Research Design}, date-added = {2010-01-16 20:34:28 +0100}, date-modified = {2010-01-16 20:34:28 +0100}, pii = {5b0287}, pmid = {8614631}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Yin-1996-Nucleic%20Acids%20Res_Incomplete%20factorial.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p3695}, rating = {0} } @article{ReichbornKjennerud:2010p13516, author = {Ted Reichborn-Kjennerud}, journal = {Dialogues Clin Neurosci}, title = {The genetic epidemiology of personality disorders}, abstract = {Genetic epidemiologic studies indicate that all ten personality disorders (PDs) classified on the DSM-IV axis II are modestly to moderately heritable. Shared environmental and nonadditive genetic factors are of minor or no importance. No sex differences have been identified, Multivariate studies suggest that the extensive comorbidity between the PDs can be explained by three common genetic and environmental risk factors. The genetic factors do not reflect the DSM-IV cluster structure, but rather: i) broad vulnerability to PD pathology or negative emotionality; ii) high impulsivity/low agreeableness; and iii) introversion. Common genetic and environmental liability factors contribute to comorbidity between pairs or clusters of axis I and axis II disorders. Molecular genetic studies of PDs, mostly candidate gene association studies, indicate that genes linked to neurotransmitter pathways, especially in the serotonergic and dopaminergic systems, are involved. Future studies, using newer methods like genome-wide association, might take advantage of the use of endophenotypes.}, affiliation = {Division of Mental Health, Norwegian Institute of Public Health Institute of Psychiatry, University of Oslo, Norway. ted.reichborn-kjennerud@fhi.no}, number = {1}, pages = {103--14}, volume = {12}, year = {2010}, month = {Jan}, language = {eng}, keywords = {Diagnostic and Statistical Manual of Mental Disorders, Risk Factors, Humans, Personality Disorders, Molecular Epidemiology, Personality Inventory, Environment, Genetic Predisposition to Disease, Genetic Association Studies}, date-added = {2010-07-07 21:05:13 +0200}, date-modified = {2010-07-07 21:05:18 +0200}, pmid = {20373672}, URL = {http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=20373672&dopt=abstractplus}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p13516}, rating = {0} } @article{Ioannidis:2009p10852, author = {John P A Ioannidis}, journal = {CMAJ}, title = {Integration of evidence from multiple meta-analyses: a primer on umbrella reviews, treatment networks and multiple treatments meta-analyses}, affiliation = {Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece. jioannid@cc.uoi.gr}, number = {8}, pages = {488--93}, volume = {181}, year = {2009}, month = {Oct}, language = {eng}, keywords = {Humans, Practice Guidelines as Topic, Evidence-Based Medicine, Clinical Trials as Topic}, date-added = {2010-04-10 03:32:17 +0200}, date-modified = {2010-07-29 19:23:30 +0200}, doi = {10.1503/cmaj.081086}, pii = {cmaj.081086}, pmid = {19654195}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Ioannidis-2009-CMAJ_Integration%20of%20evide.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p10852}, rating = {4} } @article{Purcell2007, author = {S Purcell and B Neale and K Todd-Brown and L Thomas and M A R Ferreira and D Bender and J Maller and P Sklar and P I W de Bakker and M J Daly and P C Sham}, journal = {American Journal of Human Genetics}, title = {PLINK: a toolset for whole-genome association and population-based linkage analysis}, number = {3}, pages = {559--575}, volume = {81}, year = {2007}, date-added = {2010-01-12 14:26:40 +0100}, date-modified = {2010-01-12 14:26:52 +0100}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2526}, rating = {0} } @article{KoniakGriffin:1988p8587, author = {D Koniak-Griffin and M Rummell}, journal = {Matern Child Nurs J}, title = {Temperament in infancy: stability, change, and correlates}, abstract = {The present study investigated whether temperament categories and diagnoses of the Revised Infant Temperament Questionnaire (RITQ) remain stable during infancy. Additionally, the relationships between RITQ ratings and scores on the Brazelton Neonatal Behavioral Assessment Scale and the Bayley Scales of Infant Development were evaluated. The sample included 79 nonrisk infants. The results indicate that most categories of temperament, as well as diagnostic clusters, remain stable from 4 to 8 months of life. The majority of NBAS dimensions and Bayley mental scores were not significantly associated with temperament ratings. The antecedents of ratings of infants' difficultness were similarly unidentified by mothers' perceptions of their infant's behavior.}, number = {1}, pages = {25--40}, volume = {17}, year = {1988}, month = {Jan}, language = {eng}, keywords = {Child Psychology, Autonomic Nervous System, Male, Female, Adult, Temperament, Psychological Tests, Infant, Personality, Humans, Adaptation: Psychological, Age Factors}, date-added = {2010-03-22 00:10:31 +0100}, date-modified = {2010-03-22 00:10:31 +0100}, pmid = {3393027}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p8587}, rating = {0} } @techreport{Cull:2002, author = {A Cull and M Sprangers and K Bjordal and Neil K Aaronson and K West and A Bottomley}, journal = {Techreport}, title = {Translation Procedure}, affiliation = {EORTC Quality of Life Group}, year = {2002}, month = {Feb}, date-added = {2010-01-10 11:33:09 +0100}, date-modified = {2010-07-29 20:13:56 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Cull-2002-Techreport_Translation%20Procedur.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p2080}, rating = {0} } @article{Mather:2003p10206, author = {Mara Mather and Laura L Carstensen}, journal = {Psychol Sci}, title = {Aging and attentional biases for emotional faces}, abstract = {We examined age differences in attention to and memory for faces expressing sadness, anger, and happiness. Participants saw a pair of faces, one emotional and one neutral, and then a dot probe that appeared in the location of one of the faces. In two experiments, older adults responded faster to the dot if it was presented on the same side as a neutral face than if it was presented on the same side as a negative face. Younger adults did not exhibit this attentional bias. Interactions of age and valence were also found for memory for the faces, with older adults remembering positive better than negative faces. These findings reveal that in their initial attention, older adults avoid negative information. This attentional bias is consistent with older adults' generally better emotional well-being and their tendency to remember negative less well than positive information.}, affiliation = {University of California, Santa Cruz, CA 95064, USA. mather@ucsc.edu}, number = {5}, pages = {409--15}, volume = {14}, year = {2003}, month = {Sep}, language = {eng}, keywords = {Male, Adult, Facial Expression, Pattern Recognition: Visual, Female, Humans, Aging, Emotions, Middle Aged, Aged: 80 and over, Perceptual Defense, Adolescent, Reaction Time, Aged, Mental Recall, Adaptation: Psychological, Attention}, date-added = {2010-04-01 18:19:51 +0200}, date-modified = {2010-07-29 19:46:15 +0200}, pii = {psci_1455}, pmid = {12930469}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Mather-2003-Psychol%20Sci_Aging%20and%20attentiona.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p10206}, rating = {0} } @article{Wu:2008p11432, author = {X Wu and V Kumar and J R Quinlan and J GhoshQ Yang and H Motoda and G J McLachlan and A Ng and B Liu and P S Yu and Z H Zhou and M Steinbach and D J Hand and D Steinberg}, journal = {Knowl Inf Syst}, title = {Top 10 algorithms in data mining}, abstract = {This paper presents the top 10 data mining algorithms identified by the IEEE International Conference on Data Mining (ICDM) in December 2006: C4.5, k-Means, SVM, Apriori, EM, PageRank, AdaBoost, kNN, Naive Bayes, and CART. These top 10 algorithms are among the most influential data mining algorithms in the research community. With each algorithm, we provide a description of the algorithm, discuss the impact of the algorithm, and review current and further research on the algorithm. These 10 algorithms cover classification, clustering, statistical learning, association analysis, and link mining, which are all among the most important topics in data mining research and development.}, pages = {1--37}, volume = {14}, year = {2008}, date-added = {2010-05-01 17:13:05 +0200}, date-modified = {2010-05-01 17:15:35 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Wu-2008-Knowl%20Inf%20Syst_Top%2010%20algorithms%20in.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11432}, rating = {0} } @article{Pan:2007p11232, author = {Lin Pan and Carole Ober and Mark Abney}, journal = {Genet Epidemiol}, title = {Heritability estimation of sex-specific effects on human quantitative traits}, abstract = {Recent studies have suggested that sex-specific genetic architecture could be because of the effects of autosomal genes that are differentially expressed in males and females. Yet, few studies have explored the effects of X-linked genes on sex-specific genetic architecture. In this study, we extended the variance component, maximum likelihood method to evaluate the relative contributions of sex-specific effects on both autosomes and the X chromosome to estimates of heritability of 20 quantitative human phenotypes in the Hutterites. Seventeen of these traits were previously analyzed in this population under a model that did not include X chromosomal effects; three traits are analyzed for the first time (age at menarche, percent fat and fat-free mass [FFM]). Seven traits (systolic blood pressure (SBP), adult height, fasting insulin, triglycerides, lipoprotein (a) [Lp(a)], serotonin, and age at menarche) showed significant X-linked effects; three of these (SBP, adult height, and triglycerides) showed X-linked effects only in males. Four traits (Lp(a), low-density lipoprotein cholesterol, ratio of percent predicted forced expiratory volume at 1 s/forced vital capacity, and FFM) showed significant sex-environment interactions, and two traits (high-density lipoprotein cholesterol and FFM) showed significant sex-specific autosomal effects. Our analyses demonstrate that sex-specific genetic effects may not only be common in human quantitative traits, but also that the X chromosome both plays a large role in these effects and has a variable influence between the sexes.}, affiliation = {Department of Human Genetics, The University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA.}, number = {4}, pages = {338--47}, volume = {31}, year = {2007}, month = {May}, language = {eng}, keywords = {Quantitative Trait: Heritable, Humans, Founder Effect, South Dakota, Models: Genetic, Sex Characteristics, Genes: X-Linked, Male, Female, Adult, Chromosomes: Human: X, Phenotype}, date-added = {2010-04-25 21:31:01 +0200}, date-modified = {2010-04-25 21:31:01 +0200}, doi = {10.1002/gepi.20214}, pmid = {17323368}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Pan-2007-Genet%20Epidemiol_Heritability%20estimat.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11232}, rating = {0} } @article{Schmiedek:2007p1542, author = {Florian Schmiedek and Klaus Oberauer and Oliver Wilhelm and Heinz-Martin S{\"u}ss and Werner W Wittmann}, journal = {J Exp Psychol Gen}, title = {Individual differences in components of reaction time distributions and their relations to working memory and intelligence}, abstract = {The authors bring together approaches from cognitive and individual differences psychology to model characteristics of reaction time distributions beyond measures of central tendency. Ex-Gaussian distributions and a diffusion model approach are used to describe individuals' reaction time data. The authors identified common latent factors for each of the 3 ex-Gaussian parameters and for 3 parameters central to the diffusion model using structural equation modeling for a battery of choice reaction tasks. These factors had differential relations to criterion constructs. Parameters reflecting the tail of the distribution (i.e., tau in the ex-Gaussian and drift rate in the diffusion model) were the strongest unique predictors of working memory, reasoning, and psychometric speed. Theories of controlled attention and binding are discussed as potential theoretical explanations.}, affiliation = {Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany. schmiedek@mpib-berlin.mpg.de}, number = {3}, pages = {414--29}, volume = {136}, year = {2007}, month = {Aug}, language = {eng}, keywords = {Multivariate Analysis, Adult, Normal Distribution, Problem Solving, Male, Orientation, Semantics, Individuality, Humans, Intelligence, Reaction Time, Choice Behavior, Female, Pattern Recognition: Visual, Concept Formation, Statistics as Topic, Memory: Short-Term}, date-added = {2010-01-07 16:29:04 +0100}, date-modified = {2010-01-07 16:29:04 +0100}, doi = {10.1037/0096-3445.136.3.414}, pii = {2007-11669-004}, pmid = {17696691}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Schmiedek-2007-J%20Exp%20Psychol%20Gen_Individual%20differenc.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p1542}, rating = {0} } @article{Burton:2007p5769, author = {Paul R Burton and David G Clayton and Lon R Cardon and Nick Craddock and Panos Deloukas and Audrey Duncanson and Dominic P Kwiatkowski and Mark I McCarthy and Willem H Ouwehand and Nilesh J Samani and John A Todd and Peter Donnelly and Jeffrey C Barrett and Dan Davison and Doug Easton and David Evans and Hin-Tak Leung and Jonathan L Marchini and Andrew P Morris and Chris C A Spencer and Martin D Tobin and Antony P Attwood and James P Boorman and Barbara Cant and Ursula Everson and Judith M Hussey and Jennifer D Jolley and Alexandra S Knight and Kerstin Koch and Elizabeth Meech and Sarah Nutland and Christopher V Prowse and Helen E Stevens and Niall C Taylor and Graham R Walters and Neil M Walker and Nicholas A Watkins and Thilo Winzer and Richard W Jones and Wendy L Mcardle and Susan M Ring and David P Strachan and Marcus Pembrey and Gerome Breen and David St Clair and Sian Caesar and Katherine Gordon-Smith and Lisa Jones and Christine Fraser and Elaine K Green and Detelina Grozeva and Marian L Hamshere and Peter A Holmans and Ian R Jones and George Kirov and Valentina Moskvina and Ivan Nikolov and Michael C O'donovan and Michael J Owen and David A Collier and Amanda Elkin and Anne Farmer and Richard Williamson and Peter Mcguffin and Allan H Young and I Nicol Ferrier and Stephen G Ball and Anthony J Balmforth and Jennifer H Barrett and D Timothy Bishop and Mark M Iles and Azhar Maqbool and Nadira Yuldasheva and Alistair S Hall and Peter S Braund and Richard J Dixon and Massimo Mangino and Suzanne Stevens and John R Thompson and Francesca Bredin and Mark Tremelling and Miles Parkes and Hazel Drummond and Charles W Lees and Elaine R Nimmo and Jack Satsangi and Sheila A Fisher and Alastair Forbes and Cathryn M Lewis and Clive M Onnie and Natalie J Prescott and Jeremy Sanderson and Christopher G Mathew and Jamie Barbour and M Khalid Mohiuddin and Catherine E Todhunter and John C Mansfield and Tariq Ahmad and Fraser R Cummings and Derek P Jewell and John Webster and Morris J Brown and G Mark Lathrop and John Connell and Anna Dominiczak and Carolina A Braga Marcano and Beverley Burke and Richard Dobson and Johannie Gungadoo and Kate L Lee and Patricia B Munroe and Stephen J Newhouse and Abiodun Onipinla and Chris Wallace and Mingzhan Xue and Mark Caulfield and Martin Farrall and Anne Barton and The Biologics in RA Genetics and Genomics Braggs and Ian N Bruce and Hannah Donovan and Steve Eyre and Paul D Gilbert and Samantha L Hider and Anne M Hinks and Sally L John and Catherine Potter and Alan J Silman and Deborah P M Symmons and Wendy Thomson and Jane Worthington and David B Dunger and Barry Widmer and Timothy M Frayling and Rachel M Freathy and Hana Lango and John R B Perry and Beverley M Shields and Michael N Weedon and Andrew T Hattersley and Graham A Hitman and Mark Walker and Kate S Elliott and Christopher J Groves and Cecilia M Lindgren and Nigel W Rayner and Nicholas J Timpson and Eleftheria Zeggini and Melanie Newport and Giorgio Sirugo and Emily Lyons and Fredrik Vannberg and Adrian V S Hill and Linda A Bradbury and Claire Farrar and Jennifer J Pointon and Paul Wordsworth and Matthew A Brown and Jayne A Franklyn and Joanne M Heward and Matthew J Simmonds and Stephen C L Gough and Sheila Seal and Breast Cancer Susceptibility Collaboration Uk and Michael R Stratton and Nazneen Rahman and Maria Ban and An Goris and Stephen J Sawcer and Alastair Compston and David Conway and Muminatou Jallow and Kirk A Rockett and Suzannah J Bumpstead and Amy Chaney and Kate Downes and Mohammed J R Ghori and Rhian Gwilliam and Sarah E Hunt and Michael Inouye and Andrew Keniry and Emma King and Ralph McGinnis and Simon Potter and Rathi Ravindrarajah and Pamela Whittaker and Claire Widden and David Withers and Niall J Cardin and Teresa Ferreira and Joanne Pereira-Gale and Ingileif B Hallgrimsd|[Oacute]|Ttir and Bryan N Howie and Zhan Su and Yik Ying Teo and Damjan Vukcevic and David Bentley and Alistair Compston}, journal = {Nature}, title = {Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls}, number = {7145}, pages = {661}, volume = {447}, year = {2007}, month = {Jun}, language = {en}, date-added = {2010-02-16 15:45:36 +0100}, date-modified = {2010-02-16 15:45:39 +0100}, doi = {doi:10.1038/nature05911}, URL = {http://www.nature.com/nature}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Burton-2007-Nature_Genome-wide%20associat.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p5769}, read = {Yes}, rating = {0} } @article{Thissen:2005p11591, author = {D Thissen and M C Edwards}, journal = {NCME}, title = {Diagnostic Scores Augmented Using Multidimensional Item Response Theory: Preliminary Investigation of MCMC Strategies}, abstract = {The procedures for computing augmented subscores described by Wainer et al. (2001) may be thought of as a multi-stage estimation procedure for proficiency estimates within a special case of a multidimensional item response theory (MIRT) model, with as many dimensions as there are subscales. In this paper we describe steps toward a simultaneous (one-stage) estimation system for constrained MIRT models, using Markov chain Monte Carlo (MCMC) approaches to obtain the item parameters and conventional IRT computation to produce scale scores that are augmented subscores. Such a system would provide, in a single integrated analysis, more efficient estimates of subscores for mutually exclusive sets of items (``independent clustering'') that are computed by the Wainer et al. (2001) procedure, as well as subscores for tests in which the assignment of items to subscales is not mutually exclusive (the latter has been referred to as ``multi-component mapping''). Combined with modification of a test's item specifications to include items that more specifically measure individual skills, and multi-component mapping, useful subscores (or ``skill scores'') may be computable from data obtained with tests very much like current large-scale assessments.}, year = {2005}, date-added = {2010-05-09 21:13:34 +0200}, date-modified = {2010-05-09 21:14:29 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Thissen-2005-NCME_Diagnostic%20Scores%20Au.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p11591}, rating = {0} } @article{Marlin:2009p12321, author = {B M Marlin and M Schmidt and K P Murphy}, title = {Group Sparse Priors for Covariance Estimation}, abstract = {Recently it has become popular to learn sparse Gaussian graphical models (GGMs) by imposing l1 or group l1,2 penalties on the elements of the precision matrix. This penalized likelihood approach results in a tractable convex optimization problem. In this paper, we reinterpret these results as per- forming MAP estimation under a novel prior which we call the group l1 and l1,2 positive- definite matrix distributions. This enables us to build a hierarchical model in which the l1 regularization terms vary depending on which group the entries are assigned to, which in turn allows us to learn block struc- tured sparse GGMs with unknown group as- signments. Exact inference in this hierarchi- cal model is intractable, due to the need to compute the normalization constant of these matrix distributions. However, we derive up- per bounds on the partition functions, which lets us use fast variational inference (optimiz- ing a lower bound on the joint posterior). We show that on two real world data sets (mo- tion capture and financial data), our method which infers the block structure outperforms a method that uses a fixed block structure, which in turn outperforms baseline methods that ignore block structure.}, year = {2009}, date-added = {2010-06-12 09:39:18 +0200}, date-modified = {2010-06-12 09:40:33 +0200}, local-url = {file://localhost/Users/chl/Dropbox/Papers/Marlin-2009-_Group%20Sparse%20Priors.pdf}, uri = {papers://58407365-8DEB-4C7D-995B-6322E39C7022/Paper/p12321}, rating = {